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Bio/Bio News – January 2015
Mitochondria are structures found in the cells of all BIO/BIO FAC ULTY IN THE NEW S
eukaryotes, organisms with one or more cells containing a nuclei and organelles that perform specific tasks. Enclosed in OLD DRUG MAY TEACH NEW TRICKS IN
membrane, mitochondria are responsible for supplying the cell with energy and are connected to a cell's life and death. TREATING INFECTIOUS DISEASES, CANCER
"When that drug screen identified meclizine, it was a bit of a surprise for us, because this compound had been in the Meclizine, an over-the-counter market for several years and had never been linked to drug used for decades to treat mitochondrial respiration," Gohil said. "It's a known drug, nausea and motion sickness, has and was known to target a few of the molecules within the the potential for new uses to treat certain infectious diseases and some forms of cancer, according But unlike other classes of antihistamine, he noted, meclizine to Dr. Vishal M. Gohil, an assistant professor of biochemistry has a unique property, which allows it to be used for the and biophysics at Texas A&M University. The research on treatment of nausea and motion sickness, while most other meclizine appears in the current online version of the Journal antihistamines cannot. of Biological Chemistry "So there was this unique thing about this particular Dr. Vishal Gohil, (Photo courtesy of Texas A&M AgriLife antihistamine," Gohil noted. "And it is well-tolerated so the Research) Texas A&M AgriLife Research reports, "Clearly toxicological profile is very acceptable, so it doesn't have to this drug has many potential new applications," Gohil said. be sold under strict regulations." "And now that we know its new target within the cell, we can start to explore ways of using it to treat other diseases. We "With that kind of profile, when we saw it in our drug screen can ‘repurpose' this drug." The research on meclizine we got excited about it because we could see that it decreases appears in the current online version of the Journal of cellular oxygen consumption or respiration," he said. "We Biological Chemistry. started trying to figure out the mechanism and to see if it could have any clinical benefit and application." "We found a particular enzyme which is inhibited by meclizine has been proposed (in other research) to be a drug Gohil said for certain diseases like stroke, heart attack and target for the treatment of many diseases, including infectious some neurological diseases, previous medical research has diseases like malaria and African sleeping sickness," Gohil shown that if mitochondrial respiration can be turned said. "And this pathway has also been proposed to be a down, it could be beneficial for treatment. critical pathway for the proliferation of cancer cells." "The way many of the cells die during the heart attack or Gohil said his research, which included collaboration with stroke is connected to mitochondrial respiration, so the idea scientists at Harvard Medical School and Massachusetts was that if you can turn down the respiration, then it will General Hospital, the University of Rochester and the prevent death," he said. "This is exactly what we found when University of Guelph, had already shown that the drug also used meclizine in models of heart attack, stroke and even works in the treatment of heart attack and stroke. Huntington disease. We have a drug with a known clinical Meclizine is an antihistamine, synthesized in the 1950s and use and have identified a new biochemical target within the later found to be useful for treating nausea, motion sickness cells, so that opens up new applications." Gohil, who also is a Texas A&M AgriLife He said when he and colleagues started studying the Research biochemist, said he started working mechanism of this drug in terms of how it is inhibiting on the compound when he identified it in a mitochondrial respiration, they made a couple of fundamental observations. "First, when we add this drug to the whole discovering compounds or drugs that inhibit cells, we see reduced respiration, not rapidly but slowly," he mitochondrial respiration, a process that provides energy to cells.

The researchers then added the drug to isolated mitochondria, the species lives. In humans, that would be equivalent to which is the main site of respiration within the cells. "But another dozen or so years of healthy living. we did not see an effect, so that gave us the idea that this drug may not be directly targeting one of the enzymes of Polymenis, who also is a professor in the biochemistry and mitochondria which are required for or participates in biophysics department at Texas A&M University, consuming oxygen," Gohil said. "We used that clue to figure collaborated with Dr. Brian Kennedy, the president and CEO out how non-mitochondrial pathways could be targeted by of the Buck Institute for Research on Aging in Novato, California, along with several researchers from Russia and the University of Washington. He used an unbiased metabolic profiling approach, a new technology that gives a snapshot of metabolite levels before Ibuprofen is a relatively safe and after the treatment of a drug so researchers can get an drug that was created in the idea of how this drug is perturbing these metabolites. early 1960s in England. It was "Through metabolic profiling, we found one particular prescription and then, after metabolite – phosphoethanolamine – was in fact ‘going through the roof' within a few hours of the treatment," Gohil over-the-counter said. "We got excited about that." throughout the world in the Ibuprofen, a common over-the-counter drug worldwide, added to the healthy lifespan of yeast, worms and flies in a recent study. He explained that phosphoethanolamine is an intermediate in (Texas A&M AgriLife Research photo by Kathleen Phillips) a biosynthetic pathway of a common phospholipid that forms the membrane around the cells. It is present in all living ibuprofen on their "List of Essential Medications" needed in matter from the lower organisms such as bacteria all the way a basic health system. Ibuprofen is described as to humans. Thus, finding that the metabolite that was a"nonsteroidal anti-inflammatory drug used for relieving elevated when cells were treated with meclizine indicated a pain, helping with fever and reducing inflammation." link between this pathway, or metabolite, and respiration. Polymenis said the three-year project showed that ibuprofen "Our research showed that if w e just take this metabolite and interferes with the ability of yeast cells to pick up tryptophan, directly add it to mitochondria, it actually inhibits the an amino acid found in every cell of every organism. respiration," Gohil said. "The reason we could use the drug Tryptophan is essential for humans, who get it from protein for infectious disease or cancer is not because it inhibits sources in the diet. respiration but because it inhibits a phospholipid biosynthetic enzyme that is required to form the building blocks of "We are not sure why this works, but it's worth exploring further. This study was a proof of principle to show that via Old drug may teach new tricks in treating infectious diseases, cancer common, relatively safe drugs in humans can extend the AgriLife Today. lifespan of very diverse organisms. Therefore, it should be Writer: Kathleen Phillips, 979-845-2872, [email protected] possible to find others like ibuprofen with even better ability Contact: Dr. Vishal Gohil, 979-847-6138, [email protected] to extend lifespan, with the aim of adding healthy years of life in people." IBUPROFEN USE LEADS TO EXTENDED
"Dr. Polymenis approached me with this idea of seeing how his cell cycle analysis corresponded with our aging studies," said Dr. Brian Kennedy, CEO at the Buck Institute for COLLEGE STATION — A common over-the-counter drug Research on Aging in Novato, California. "He had identified that tackles pain and fever may also hold keys to a longer, some drugs that had some really unique properties, and we healthier life, according to a Texas A&M AgriLife Research wanted to know if they might affect aging, so we did those scientist. Regular doses of ibuprofen extended the lifespan of studies in our lab. We're beginning to find not just ibuprofen, multiple species, according to research published in the but other drugs that affect aging, so we're really excited journal Public Library of Science-Genetics. "We first used baker's yeast, which is an "Our institute is interested in finding out why people get sick established aging model, and noticed that when they get old. We think that by understanding those the yeast treated with ibuprofen lived processes, we can intervene and find ways to extend human longer," said Dr. Michael Polymenis, an health span, keeping people healthier longer and slowing AgriLife Research biochemist in College down aging. That's our ultimate goal." Station. "Then we tried the same process Chong He, a postdoctoral fellow at Buck Institute and lead with worms and flies and saw the same author on the paper, said looking deeper into the common extended lifespan. Plus, these organisms not only lived drugs that target individual diseases might shed light on longer, but also appeared healthy." understanding the aging process. He said the treatment, given at doses comparable to the "We have some preliminary data on worms that showed that recommended human dose, added about 15 percent more to this drug also extended the health span in worms," she said. "It made them live not just longer but also more healthy. You

can measure the thrashing of the worms. If they're healthy, AWARDS PRESENTED FOR 2014 VICE
they do have a tendency to thrash a lot, and also we can CHANCELLOR'S AWARDS IN EXCELLENCE
measure the pumping as they swallow, because if they're healthy, the pumping is faster. "Ibuprofen is something that people have been taking for The Vice Chancellor's Awards in Excellence Program years, and no one actually knew that it can have some recognized outstanding achievements by personnel of Texas benefits for longevity and health span." A&M AgriLife, comprised of the College of Agriculture and Life Sciences at Texas A&M University, Texas A&M Funding for this research was by the National Science AgriLife Research, Texas A&M Extension Service, Texas Foundation, the National Institutes of Health, the Ellison A&M Forest Service, and the Texas A&M Veterinary Medical Foundation and the Glenn Foundation for Medical Medical Diagnostic Laboratory and recognizes these employees in 17 categories. Out of all of those programs and out of all of those award categories, the Department of For more information contact: Dr. Michael Polymenis, 979-458- Biochemistry and Biophysics claimed four of these awards 3259, [email protected] during the Texas A&M AgriLife Conference, which was held Writer: Kathleen Phillips, 979-324-4302, [email protected] on Tuesday, Jan. 6, 2015 at Rudder Theatre. Dr. James
Sacchettini was awarded the Research Award; Dr. Larry
Dangott was awarded the Technical and Programmatic Staff
Award; Mr. Robert Koenig was awarded the Graduate
Student Teaching Award and the Mr. Alfredo Erazo-
Oliveras was awarded the Graduate Student Research
Faculty & Staff Holiday
January 19
Award. Congratulations to these four recipients. The Faculty Meeting, N127, 3:30 PM
January 26
department agrees that these four individuals are a great Departmental Chili Cook-off
February 2
example of the Lone Star State of Mind of Shining a Light on Genetics Recruiting Weekend
February 6 & 7
BICH Recruiting Weekend
February 27 & 28
Spring Break, Faculty & Staff
March 18-20
TEACHING-­‐  Graduate Student Teaching  
Mr. Robert Koenig - Graduate Assistant, Laboratory of Dr.
Gregory D. Reinhart, Dept. Of Biochemistry & Biophysics
Mr. Koenig is a senior graduate student who has been a teaching assistant for eight semesters in two different classes. He fosters The new Bio/Bio website was originally planned to launch in a great learning environment and tailors his March, but the downed status of the current site has forced teaching to each group of students. He learns the expedition of an early launch date. We will continue to over 60 student's names each semester. When improve the aesthetics, update the content, and smooth out he calls on a student to answer a question, he tailors the user interface issues on a separate staging site until the difficulty of the question to the student. All of this creates "relaunch" in March. For example, a photographer will be the camaraderie that is needed in small, interactive classes. coming to take professional images for various parts of the Mr. Koenig also puts a great deal of effort into presenting the lecture material. He differentiates his sections from the main lecture to prod the students' thinking. He incorporates jokes, In the meantime, please take a look at the current version of ask challenging questions and helps students see the common the new site ( ) pitfalls in problem solving. For Mr. Koenig, teaching is not a and send the website committee an email to Dr. Jennifer necessary chore to support his research but a responsibility Herman ([email protected]) if you notice any issues that and a privilege to help students go from struggling to require immediate attention, particularly with content updates that might be relevant to graduate recruitment or your lab status (program requirements, updates made to research Graduate Student Research
descriptions, etc.). If you would like your research Mr. Alfredo Erazo-Oliveras Ph.D. Laboratory of Dr.
descriptions updated, simply send a word file with the new Jean-Philippe Pellois, Dept. Of Biochemistry & Biophysics
text. We now have easy capability if you would like to have A top student in his department, Mr. Erazo- additional headings and paragraphs for different projects in Oliveras graduated from the University of the lab, so feel free to specify section headings if you desire Puerto Rico, Rio Piedras Campus, where he them. Finally, if you have any images you would like (that researched molecular enzyme inhibition. In can be) integrated into your research description, we can add summer 2007, he conducted NSF-sponsored these. Please send as jpg at reasonable resolution for web research in the laboratory of Dr. James Sacchettini, at Texas A&M through the REU program. He began his graduate studies here in 2008. His research focuses on developing a technology for introducing proteins into live cells with unprecedented

efficiency and control and with the complete absence of Award. The award, which honors university toxicity. This work could be a game-changer in the field of faculty for their use of innovative teaching novel drug delivery, and it required superb problem-solving methods and service to students, was skills in chemistry, biochemistry and cell biology. Among presented at the 127th Association of Public his publications is a first-author paper in the journal Nature and Land-grant Universities (APLU) Annual Methods, considered the highest among 75 journals in Meeting in Orlando, Florida. hiochemical research. Alfredo also won a graduate student teaching award in 2013. When reading comments such as - "When alumni recall their college days, they often think of teachers who had the biggest impact on them," said Ian Maw, vice president of Food, Dr. James Sacchettini – Professor and R. J. Wolfe=Welch
Agriculture and Natural Resources at APLU. "These Chair in Science, Dept. of Biochemistry and Biophysics
awardees are teachers who will always be remembered by the Director, Center for Structural Biology
students they inspire. They serve to inspire other educators Since   he   joined   the   Texas   A&M   faculty   in   through their commitment to the teaching profession and 1996,  Dr.  Sacchettini  has  gained  worldwide   their chosen disciplines," one must agree that Dr. Ellison was acclaim   for   his   work   to   understand   how   a great candidate for this award. enzymes  interact  with  their  substrates  and   ho   this   information   can   help   combat   Though he was not selected for this award we are very proud worldwide   diseases   such   as   tuberculosis   of his contributions to our department. Dr. Ellison, who has and   malaria.     He   has   obtained   an   been a professor at Texas A&M University since 1984, and impressive  amount  of  research  funding  and  assembled  a   lecturer for Genetics 301, he also team-teaches the newly laboratory   of   nearly   50   people.     His   team   identifies   and   developed Honors section of GENE 302. Thank you, Dr. studies   proteins   that   are   critical   to   the   life   cycle   of   Ellison, for your commitment to Texas A&M University. disease=causing   organisms,     and   then   designs,   creates,   and   test   molecules   that   can   inactivate   these   proteins,   WOMEN IN SCIENCE
killing   disease-­‐causing   agents.     He   applies   his   scientific   RESEARCH & MENTORING AWARDS
resources   to   the   discovery   of   new   drugs   for   infectious   Ethel Ashworth-Tsutsui Memorial
diseases,   drug-­‐resistant   bacterial   infections,   and   cancer.   The   team   has   published   in   some   of   the   best   scientific   Each year Women in Science and journals   in   the   world.     Dr.   Sacchettini   is   a   true   scientific   Engineering (WISE) sponsors an awards leader  and  a  generous  collaborator  to  faculty  within  and   program that recognizes the research and outside  Texas  A&M  University.   mentoring efforts of women on the Texas A&M campus. These awards are offered in Technical and Programmatic Staff
honor and remembrance of Ethel Ashworth-Tsutsui, a long Dr. Lawrence J. Dangott – Research Scientist, Depart. Of
time member of the faculty of the Biochemistry Department Biochemistry and Biophysics  
here at Texas A&M University. Dr. Tsutsui was a founding  Since   1997,   Dr.   Dangott   has   served   as   member of WISE and cared deeply about the retention and director   of   the   Protein   Chemistry   recognition of women in our graduate programs. Laboratory.    This  facility  offers  researchers   across   the   Texas   A&M   campus   services   Women graduate students are invited to apply for these such   as   protein   microsequencing,   amino   awards. Faculty members are encouraged to nominate acid   analysis,   peptide   synthesis,   and   deserving individuals. protein   mass   spectrometry.     Dr.   Dangott's   work   goes   far   beyond   these   requirements.     He   uses   his   Rachel Jordon, Genetics Graduate Student in the laboratory
many   years   of   expertise   to   solve   critical   research   of Dr. Mary Bryk has been named the recipient of the 2014 problems,   offer   suggestions   on   further   analysis,   and   Ethel Ashworth-Tsutsui Memorial Award for Mentoring. interpret   data.     For   many   of   the   facility's   clients,   Dr.   This award was established to honor women graduate Dangott   has   become   a   collaborator   and   a   co-­‐author.     In   students, postdoctoral researchers and research staff who take addition,   he   assists   with   student   training;   he   has   action to encourage and support women graduate students at mentored   graduate   students,   served   on   thesis   committees,   trained   undergraduates   in   protein   science   nominees must have completed at least two research,  and  taught  in  the  classroom.    All  these  activities   semesters at Texas A&M University and go   beyond   his   job   description,   but   he   gladly   varies   them   currently be enrolled. Nominations may be out  to  help  students  receive  the  best  possible  education.     made by a peer or by a Texas A&M faculty member. Award recipient will receive a DR JOHN ELLISON
$500 monetary award, certificate and plaque. RECEVIES NOMINATION
The 2014 Ethel Ashworth-Tsutsui Memorial Award for Dr. John Ellison, professor of Genetics and lecturer, was Research, established to honor women graduate students who nominated recently for the 2014 Food and Agricultural have demonstrated excellence in research, has been awarded Sciences Excellence in College and University Teaching to Amanda Hulse, Graduate student with the Texas A&M
University Genetics program. Nominees for this award must such as that seen in an article exploring personal identity as be women graduate students currently enrolled in a graduate seen through the eyes of Muslim student artist, and program at Texas A&M University. They must have MacArthur "genius" award winner Shahzia Sikander. completed at least two semesters of graduate study at Texas A&M University and be enrolled for at least six semester "We are so excited to see the continuing high quality of the credit hours during the semester in which they are nominated. research, scholarly and creative submissions we receive in all Nominations may be made by the candidate or by a Texas disciplines" says Dr. Sumana Datta, the executive director of A&M University faculty member. Award recipients will Honors and Undergraduate Research., "The support our receive a $500 monetary award, certificate and plaque. student authors and artists get from the faculty and The Association of Former Students is truly tremendous. I'm particularly proud of the initiative and dedication the student RESEARCH, PUBLICATION OF SCHOLARLY
editorial and executive board members for Explorations ARTICLE OPPORTUNITIES OPEN TO TEXAS
exhibit. They embody the best of student leadership on this A&M UNDERGRADS
With articles ranging from research The Association of Former Students provides financial regarding weight discrimination to bacterial assistance to help make possible the publication of the meningitis study results, Texas A&M students' journal. University's undergraduate scholarly journal could be mistaken at first glance for one of Recently published articles embrace wide range of academic the older and better-established publications fields: music, creative poetry, forensics, cancer biology, to which the students' professors frequently astrophysics, nanomedicine, computer algorithms, business, contribute, adding to scientific and other literature. It's all in geosciences, sociology, aerospace engineering, and cultural the sixth edition of Explorations: The Texas A&M Undergraduate Journal,sponsored by the Honors and Undergraduate Research Office. BIO/BIO PARTICIPATES IN RUN THE CITY
Few universities have such research-oriented journals (BCS MARATHON AND HALF-MARATHON)
managed and edited by undergraduates and to which Article Submitted By Rafael Almanzar, BICH Acaademic Advisor undergraduates of all academic disciplines have the opportunity to submit an article. On December 14 2014, seven members from our department ran in the 4th Annual Baylor Scott and White Bryan-College The process for selection of articles to be published in Station Marathon. Nearly 5,000 runners ran into several Explorations is highly competitive, and less than 20 percent neighborhoods in Bryan and then up and through Texas of submitted proposals are accepted. A&M campus and ending back at Wolf Pen Creek. The BCS In addition to conducting their own research projects with marathon supports three charities, which are the Mercy advice provided by faculty members, many students at Texas Project, Scotty's A&M also have the opportunity to work closely with their House and Brazos professors on a variety of research endeavors. With more than $820 million invested in research annually, Texas A&M ranks first in Texas and among the leaders nationally in experiments and studies that enhance the basic to all the runners storehouse of knowledge, with much of such work also From L-R: Jessica Tracy, Anthony Pratt, Dr. Tatyana Igumenova, having major economic benefits, officials note. Terry Lovingshimer, Rafael Almanzar, Jeremy Weaver & Rachel Jordan. Not included in picture are Dr. Gary Kunkel; ,Kaitlyn McGrath, Michelle "Shelley" Vekasy, and James Vranish. In addition to an array of student-produced articles, the current Explorations includes a student photographer's very own-Rafael Almanzar, Dr. Tatyana Igumenova; (Full portraits highlighting the beauty of humanity and a student Marathon) Rachel Jordan (Half Marathon); Dr. Gary Kunkel researcher's study of how language revels the experiences of (Half Marathon); Terry Lovingshimer (Full Marathon); Kaitlyn McGrath (Full Marathon); Anthony Pratt (Half Guided by faculty and administrators, Explorations student Marathon); Jessica Tracy (Half Marathon); James Vranish editors select and publish student-authored articles and creative works of general interest in any area. Student researchers submit proposals for articles to an editorial board Special thanks to the comprised of students and faculty. If accepted, research and scholarly articles then undergo a second round of peer review volunteered in the BCS before publication. Creative pieces are vetted by faculty Marathon for the 3rd experts and student reviewers. "Personally it was a great Editors also point out that for the first time Explorations has feeling knowing that on BGA volunteering at the B/CS Marathon for the an extended online issue that more easily allows for mile 19.5, I will see the third year in a row submissions with video, music or extensive photography, supporting not only me but the thousands of runners Please bring your entries for the judging to room 106A by including those in our department who ran the BCS 11AM on Monday, February 2. Judging begins at 11:30AM marathon…plus they had beef jerky!" says our graduate and at 12 Noon the serving of the entries will begin. A advisor Rafael Almanzar. donation of $5 per bowl is kindly requested for the Flower Fund. The Baked Goods will also be available for lunch. For more information or if you are interested in the BCS Marathon, please visit their website at Along with the entries to the contest we also need volunteers to sign up to bring condiments such as crackers, chips, 2014 Biochemistry & Biophysics
cheese, sour cream, etc. There is a sign up sheet in room 103 Annual Holiday Celebration
on the desk. We do appreciate your participation to help make this a GREAT success, and get some good chili and The 2014 Annual Bio/Bio Holiday Celebration was held on enjoy visiting with colleagues while doing so! Don't forget – Monday evening, December 22 at the Phillips Event Center, ENTER to win and come on down for a delicious HOT Briarcrest Country Club. lunch, Monday, February 2 at 12 Noon! Festivities began with the 6PM Social Hour, during which Diego, Natalia, Isabela Cruz-Reyes, Becca Walker, James Wu and Anna Barrington shared a repertoire of seasonal February 2 will be the date for the 2015 Bio/Bio musical numbers with the guests. There was a "special Departmental Chili Cook off. This will serve as our appearance" by our very one and only, Dr. Tim Meek! winter Flower Fund Raiser, and as we all know there will Departmental Awards were presented by Dr. Greg Reinhart be plenty of delicious chili and baked goods to be by all following the dinner. TAMU and AgriLife Years of Service for a donation to the Flowe r Fund. Pins were present to: Dr. Bryant Miles, TAMU 20 years, AgriLife 19 years; Dr. Gary Kunkel, TAMU 25 years; Dr. Entry forms for the chili and baked goods are available in John Ellison, TAMU and AgriLife 30 years. AgriLife Years room 103, for those of you who want to test your chili of Service Pins – 10 years, Ping Cui;, Terry Lovingshimer; making and baking skills. Entry forms should be turned in no later than Thursday, J Daisy Wilbert, Nishant Shetty, Dr. Shelley Pozzi, Dr. Nishant Shetty, Brock Weers, and Sherry Coronado, and Cathy Wolff, 20 years. Congratulations to each of you, and thank On Monday, February 2 all contestants should bring their you for your combined 110 years of service! entries to room 106A by 1 1AM for judging. Following the judging, that will beg in at 11:30 by our panel of Recipients for the Departmental Award of Excellence for volunteer judges; lunch w ill be served at 12 noon and Research – Denis Odokonyero, Research Assistant in the may be enjoyed by all for a donation of $5 (per bowl) to laboratory of Dr. Margy Glasner; Administrative Award – the Departmental Flower F und. Ms. Jenny Ponzio, Business Coordinator III in the Department of Biochemistry and Manish Rathi, Project Manager with the James Sacchettini Laboratory. Champion
(This could be YOU!!
The Administrative Staff of the Department of Biochemistry & Biophysics hosts various events throughout the year in the effort to raise funds for the Departmental Flower Fund. This fund provides the financial resources for the Department to send flowers, fruit baskets, etc., to faculty, staff and students who incur a hospitalization, birth or adoption in the immediate family, or the passing of a loved one, using designated funds. Since the weather has been so inclement this would be a "good excuse" for a Departmental Chili Cook-off and Baked Goods Contest. Enter as many categories as you wish. Four categories of chili and five categories of Baked Goods have been defined, but be creative – we'll accept any category – our faculty, staff and students love to eat, and the Flower Fund can certainly use the contributions! If you'd like to enter you can either fill out the Entry Form on line and email it back to [email protected] by Thursday afternoon, January 29, or stop by room 103 and fill out a form.


Autologous fat grafts placed around temporomandibular joint total joint prostheses to prevent heterotopic bone formation Larry M. Wolford, DMD, Carlos A. Morales-Ryan, DDS, MSD, Patricia Garcia Morales, DDS, MS, and Daniel Serra Cassano, DDS the treatment of ankylosis This study evaluated 1) the efficacy of packing autologous fat grafts of the temporomandibular around temporomandibular joint (TMJ) total joint prosthetic reconstruc-

Microsoft word - k1351460 -unep-pops-cop-6-inf-4-rev-1.doc

UNEP/POPS/COP.6/INF/4/Rev.1 Distr.: General 24 April 2013 Stockholm Convention on Persistent Organic Pollutants Conference of the Parties to the Stockholm Convention on Persistent Organic Pollutants Sixth meeting Geneva, 28 April–10 May 2013 Item 5 (a) (ii) of the provisional agenda∗ Matters related to the implementation of the Convention: measures to reduce or eliminate releases from intentional production and use: exemptions