En.microgen.ru

Federal State Scientific-Industrial Company for Immunobiological Medicines of the Ministry of
Health of the Russian Federation MICROGEN is a first-rate company in Russian medical industry with
leading role in development and production of immunobiological preparations, diagnosticums and
drugs.
Priority in company's work is given to production of vaccines for dangerous infectious diseases,
including those for the National Vaccination Schedule of Russia and influenza vaccines.
Microgen is actively collaborating with leading Russian research centers in order to develop and
manufacture unique products of biotechnology and immunobiology.
Highly skilled staff, rigid manufacturing standards and strict control of every production stage
guaranty the best quality of the company's products.
Consortium MICROGEN was founded in May, 2003 under the aegis of Public Health Ministry of the Russian Federation in order to preserve and develop the domestic production of medical immunolobiological preparations. The newly established company was to become an advanced enterprise of medical immunobiology that could ensure the realization of national programs of biological security and preservation of epidemiologic and sanitary welfare, switching to international standards of drug production and practical application of new preparations developed by Russian scientists.
The staff of the 14 subsidiaries of MICROGEN comprises more than 7500 persons, including 7 professors, 21 doctors of science and 177 candidates of science. MICROGEN subsidiaries are located in 13 cities of the Russian Federation: Moscow, Ekaterinburg, Irkutsk, Makhachkala, Nizhny Novgorod, Omsk, Perm, Stavropol, Tomsk, Tumen, Ufa, Khabarovsk and Belorechensk.
MICROGEN manufactures more than 70 percent of all the domestic immunobiological products: vaccines, allergens, therapeutic and diagnostic serums, eubiotics, bacteriophages, donor blood products, human immunoglobulins and drug preparations. The total nomenclature of immunobiological products of MICROGEN exceeds 300 items.
In collaboration with leading Russian scientists the company is striving to develop and manufacture new high-quality and moderately priced preparations. At present more than 15 novel preparations are being prepared for commercial production, e.g. new influenza and smallpox vaccines, diphtheria and tetanus toxoids and pertussis vaccine, hepatitis B vaccine, avian influenza vaccine, etc.
By taking part in WHO international programs for eradication of smallpox, measles, rubella, tuberculosis, whooping cough, diphtheria, tetanus allows the company specialists to keep abreast of the modern developments in immunobiology.
Production facilities of the MICROGEN company allow it to manufacture the whole range of vital immunobiological preparations in the necessary quantities.
The main aims of the company are: complete provision of immunobiological preparations for the maintenance of Russia epidemiologic and sanitary welfare, primarily vaccines for the National Vaccination Schedule of Russia and vaccines for socially important infectious diseases; maintenance and development of efficient supply of immunobiological preparations to Russian Federation subjects; development of a unified program of development, funding and modernization of production and research; improving the international image of the Russian science and producers of immunobiological preparations.
gradual transfer of all enterprises of the consortium to the GMP international quality standard.
MEDICAL IMMUNOBIOLOGICAL PREPARATIONS
MEDICAL IMMUNOBIOLOGICAL PREPARATIONS
The medical immunobiological preparations are those medicinal agents that are used for immunological prophylaxis, diagnistics and therapy of human diseases.
VACCINES AND TOXOIDS (ANATOXINS)
Vaccines are "preparations containing antigen material and used for the prevention of infectious diseases. Disease prevention is implemented by the use of vaccines based on live, attenuated or inactivated microorganisms, immunogens that are isolated from them combined with adjuvants, specific microorganism RNA or microorganism genetic material (including modified one)"1.
Anatoxins are a type of vaccine that is produced from bacterial exotoxins and is devoid of toxicity but retains antigenic and immunogenic exotoxin properties. Anatoxins cause the development of antitoxic immunity and are used for prevention and treatment of several infectious diseases.
"According to WHO data, vaccines yearly save lives of 3 million children. Modern vaccination system is a deciding factor of the decrease in children mortality and the increase of the life-span and the quality of life of all age groups of the population. Vaccines not only create the specific protection from certain types of infection but also have a strong non-specific effect by stimulating the many factors of natural resistance"2.
The domestic production of the greater part of vaccines and anatoxins is concentrated in the manufacturing facilities of the MICROGEN company.
1 Yarilin A.A. "Basic Immunology" (Osnovy Immunologii), Moscow, 1999.
2 Medunitzin N.V. "Vaccinology" (Vakzinologia), 2nd edition, revised and expanded. Moscow, 2004.
Appendix 1To the order № 229 of the minister of Public Health of the Russian Federation of 27.06.2001 THE NATIONAL VACCINATION SCHEDULE OF RUSSIA
neonates (first 12 hours of life) first vaccination against viral hepatitis B neonates (3-7 days old) vaccination against tuberculosis second vaccination against viral hepatitis Bfirst vaccination against diphtheria, whooping cough, tetanus, poliomyelitissecond vaccination against diphtheria, whooping cough, tetanus, poliomyelitisthird vaccination against diphtheria, whooping cough, tetanus, poliomyelitisthird vaccination against viral hepatitis Bvaccination against measles, rubella, epidemic parotitisfirst booster against diphtheria, whooping cough, tetanus, poliomyelitis second booster against poliomyelitisbooster against measles, rubella, epidemic parotitisbooster against tuberculosis second booster against diphtheria, tetanusrubella vaccination (girls) vaccination against viral hepatitis B (without previous vaccinations)third vaccination against diphtheria, tetanus, booster against tuberculosis,third booster against poliomyelitisbooster against diphtheria, tetanus – every 10 years counting from the last booster NOTE:Immunization within the framework of The National Vaccination Schedule of Russia is made with vaccines of domestic and foreign manufacturing that are registered and approved for use according to the established order and the instructions for their use.
DIPHTHERIA AND TETANUS ANATOXIN (TOXOID), PURIFIED, ADSORBED, LIQUID
suspension for injection
Administration according to the established scheme results in the specific antitoxic immunity to diphtheria and tetanus. Used as protection against diphtheria and tetanus
for children up to the age of  years:
• children who had whooping cough (aged from 3 months up to 6 years);• children with contraindications for DTP-vaccine;• children over 4 years old without previous diphtheria and tetanus vaccinations.
Produced in 1ml ampoules (two doses) in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Perm and Ufa.
DIPHTHERIA AND TETANUS ANATOXIN (TOXOID), PURIFIED, ADSORBED, WITH THE
REDUCED ANTIGEN CONTENT, LIQUID
suspension for intramuscular or subcutaneous use
Administration of the preparation according to the established scheme results in the specific antitoxic immunity to diphtheria and tetanus .
Used as protection against diphtheria and tetanus for
children over  years of age, adolescents and adults in:
• scheduled booster vaccinations at the ages of 7 and 14 years and then every 10 years without age limitations; • vaccinations of children over 7 years of age without previous diphtheria and tetanus • replacement of DTP-vaccine for children with severe general reactions (fever higher than 400C) or with post-vaccination complications for the above-mentioned preparations; • vaccination schemes for adults without previous diphtheria and tetanus • preventive vaccinations in diphtheria high-incidence area.
Produced in 1ml ampoules (two doses) in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Perm and Ufa.
DIPHTHERIA ANATOXIN (TOXOID), PURIFIED, ADSORBED, WITH THE REDUCED ANTIGEN
CONTENT, LIQUID
suspension for intramuscular or subcutaneous use
Results in the specific antitoxic immunity to diphtheria.
Used in the prophylaxis against diphtheria for children
after  years old, adolescents and adults.
The anatoxin may be administered with one month's delay or simultaneously with
poliomyelitis vaccine and other preparations of the National Vaccination Schedule of
Russia.
Produced in 1ml ampoules (two doses) in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Perm and Ufa.
TETANUS ANATOXIN (TOXOID), PURIFIED, ADSORBED, LIQUID
suspension for injection
Administration according to the established scheme results in the specific antitoxic immunity to tetanus.
Used for active immunization against tetanus and emergency
specific prophylaxis against tetanus in cases of:
• traumas with the compromised integrity of skin and mucosa;• frostbites and deep burns;• out-of hospital abortions;• out-of hospital births;• gangrene and necrosis of tissues of any kind, indolent abscesses;• animal bites;• penetrating wounds of gastrointestinal tract.
For emergency tetanus prophylaxis tetanus anatoxin is used in conjunction with antitetanic human immunoglobulin or antitetanic horse serum, purified, concentrated, liquid. The choice of preventive measures for emergency specific prophylaxis is made according to the scheme.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Perm and Ufa.
"COCAV": ANTIRABIC TISSUE CULTURE VACCINE, CONCENTRATED, PURIFIED, INACTIVATED
lyophilizate for solution preparation for intramuscular injection
Inactivated vaccine virus of rabies, strain Vnukovo-32. Administration according to the established scheme results in immunity to rabies pathogen.
Used for preventive health care against rabies.
Produced in kits of 1 ampoule of vaccine (not less than 2.5 IU) and 1 ampoule of solvent (1ml
of injection water) in 5-kit packs.
Period of validity: 1.5 years.
Manufacturer: MICROGEN subsidiary in Ufa.
"RABIVAC-VNUKOVO-": RABIES TISSUE CULTURE VACCINE, CONCENTRATED, PURIFIED,
INACTIVATED, FOR HUMAN IMMUNIZATION
lyophilizate for intramuscular and subcutaneous use
Administration according to the established scheme results in immunity to rabies pathogen.
Used for preventive health care against rabies.
Produced in kits of 1 ampoule of vaccine (not less than 0.5 IU) and 1 ampoule of solvent (3ml
of injection water) in 5-kit packs.
Period of validity: 1.5 years.
Manufacturer: MICROGEN subsidiary in Ufa.
BRUCELLOSIS VACCINE, LIVE, DRY
lyophilizate for solution preparation for epicutaneous and subcutaneous use
Results in immunity to brucellosis. In 20 – 30 days the vaccination provides immunity that persists for 10 – 12 months.
Used for prevention of brucellosis of goat and sheep type in adults.
Vaccinations are indicated for people employed in:
• purchase, storage and processing of agricultural products from the farms with registered cases of animal brucellosis; • slaughter of brucellar animals, storage and processing of their meet, as well as farm workers and veterinarians in establishments that are enzooticfor brucellosis; persons working with live cultures of brucella.
Produced in 1ml ampoules (4–10 cutaneous tests) in 5-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Omsk and Perm.
GONOCOCCAL VACCINE, INACTIVATED, LIQUID (GONOVACCINE)
suspension for intramuscular use
Increases specific reactivity.
Used for diagnostic purposes (establishing recovery from
gonorrhea: provocation test) and as a supplementary therapy
for gonococcal infections from  years of age.
Administration of gonococcal vaccine is indicated for patients after unsuccessful
antibiotic therapy in sluggish recurrences, new torpid and chronic forms of disease, for
males with complicated gonorrhea and females with ascending gonorrhea (after reduction
of acute inflammatory symptoms), in obstetrical practice in inflammation treatment.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Perm and Tomsk.
INFLUENZA VIRUS VACCINE, EGG-DERIVED, INTRANASAL, LIVE, DRY
lyophilizate for solution preparation for intranasal administration
Recombinant flu viruses of A and B types obtained from virus-infected allantois liquid of chick embryos (strain content of the vaccine is changed yearly according to WHO recommendations).
Results in specific immunity to influenza viruses of A and B types.
Protective effect is typically achieved in 3 weeks after vaccination and persists for 10 – 12 months.
Used for active flu prophylaxis for adults without limitations and for
children over  years of age, once a year in autumn or winter time.
The vaccination is recommended to people with high complication risk and to professionals with high risk of contacting and spreading the infection: • people over 60, people with chronic somatic diseases and prone to URI;• pre-school and schoolchildren, medical care workers, workers in consumer services, transport and education system.
Produced in 0.5ml ampoules (one dose) with a disposable atomizer.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Irkutsk.
INFLUENZA VIRUS VACCINE, INACTIVATED, ELUATE-CENTRIFUGED, LIQUID
suspension for subcutaneous use
Results in specific immunity to influenza viruses of A and B types (antigen content of the vaccine is changed yearly according to epidemic situation and WHO recommendations).
Protective effect is typically achieved in 3 weeks after vaccination and persists for 10–12 months.
Used for active flu prophylaxis and in after-flu complications
and also for alleviation of disease course in adults over .
Produced in 0.5ml ampoules (one dose) in 10-ampoule packs.
Period of validity: 1 year
Manufacturer: MICROGEN subsidiary in Ufa.
"GRIPPOL"® (INFLUENZA VIRUS VACCINE, TRIVALENT, POLYMER-SUBUNIT, LIQUID)
solution for intramuscular and subcutaneous use
Contains surface glycoproteins (hemagglutinin and neuraminidase) obtained from purified flu viruses of A and B type in complex with water-soluble high-molecular weight immunostimulant N-oxidized derivative of poly-1,4-ethylentpiperazine (Polyoxidonium).
Results in high specific immunity to influenza viruses of A and B types (antigen content of the vaccine is changed yearly according to epidemic situation and WHO recommendations).
Used for active flu prophylaxis in infants from  months of age,
children, adolescents and adults without age limitations.
Vaccination is provided yearly in autumn or winter time.
Vaccination at the start epidemic outbreak is possible.
Vaccine is injected intramuscularly (into deltoid muscle) or deeply subcutaneously into
the upper third of exterior shoulder, young children are injected into exterior thigh
surface.
Infants from 6 months to 3 years of age:
• 0.25ml twice with a 4-week interval;• 0.5ml once if the child was vaccinated against flu during previous season.
Children over 3 years of age and adults without age limitations are vaccinated oncewith 0.5ml.
Immunodeficient patients may be vaccinated twice with 0.5ml with a 4-week interval.
Produced in ampoules and injectors of 0.5ml (one dose) in packs of 1, 5 or 10 ampoules.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Ufa.
TYPHOID VACCINE E, COMBINED, LIVE
lyophilizate for suspension preparation for subcutaneous use
One dose of vaccine produces specific immunity to typhus pathogen.
Used for specific typhus prophylaxis.
Vaccination and boosters are possible for people from 18 to 60 years of age.
Produced in kits: an ampoule with 20 doses of vaccine and solution vial (0.9% sodium chloride
solution, 5 ml). A pack contains 5 kits.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
DIPHTHERIA AND TETANUS TOXOIDS AND PERTUSSUS VACCINE, ADSORBED, LIQUID
(DTP-vaccine)
suspension for injection
Results in specific immunity to whooping cough, diphtheria and tetanus.
Used for prevention of whooping cough, diphtheria and tetanus in children.
DTP immunization is made from 3 months of age until 3 years 11 months and 29 days
(children who had whooping cough are immunizes by diphtheria and tetanus toxoids).
Produced in ampoules of 0.5ml (one dose) or 1ml (two doses) in 10-ampoule packs.
Period of validity: 1.5 years.
Manufacturer: MICROGEN subsidiary in Ufa.
MEASLES VIRUS VACCINE, TISSUE CULTURED, LIVE
lyophilizate for solution preparation for subcutaneous use
Induces measles antibodies production in seronegative children in 21–28 days after vaccination.
Used for planned and emergency measles prophylaxis.
Planned vaccinations are made twice: at the ages of 12–15 months and 6 years to children
who did not have measles.
Emergency prophylaxis is provided to children from one year of age, adolescents and adults
exposed to measles who had not had measles and had not been immunized against the
infection. In the absence of contraindications the vaccine is administered not later than
72 hours after the exposure.
Produced in ampoules with 1, 2 or 5 doses in 10-ampoule packs.
Period of validity: 15 months.
Manufacturer: MICROGEN subdivision in Moscow.
MENINGOCOCCAL VACCINE OF A GROUP, POLYSACCHARIDAL, DRY
lyophilizate for solution preparation for subcutaneous use
Results in active specific immunity to meningococcal meningitis pathogen (Neisseria meningitidis) of group A serum. Used for prevention of meningitis of serum group A
in endemic areas or during epidemics.
Produced in ampoules with 250 micrograms of polysaccaride of serum group A (5 – 10 doses
depending on the age of immunized persons).
A pack contains 5 vaccine ampoules and 5 ampoules of potassium chloride for injection.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Moscow.
SMALLPOX VACCINE, LIVE, DRY
lyophilizate for solution preparation for epicutaneous use
Results in specific immunity to smallpox that persists no less than 5 years.
Used for natural smallpox prevention according to epidemiological
indications as well as for immunization of persons working with
smallpox vaccine viruses and animal smallpox pathogenic to humans.
Produced in 0.1 or 0.2ml ampoules (10 or 20 doses respectively). Solvent is produced in
two-ended capillary ampoules of 0.2ml for 0.1ml of vaccine, or 0.3 for 0.2ml of vaccine. One
pack contains: 5 ampoules of vaccine and 5 ampoules of solvent; 10 ampoules of vaccine and
10 ampoules of solvent. Or 10 ampoules of vaccine and 10 ampoules of solvent (in separate
packs).
Period of validity: for vaccine – 2 years, for the solvent – 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
MUMPS VACCINE, TUSSUE CULTURED, LIVE, DRY (PAROTITIS VACCINE)
lyophilizate for solution preparation for subcutaneous use
Induces parotitis antibodies in seronegative children the level of which reaches maximum level in 6–7 weeks after vaccination.
Used for planned and emergency prophylaxis
against epidemic parotitis in children.
Planned vaccinations are administered twice: at 12 month and 6 years of age to children
who did not have mumps.
Emergency vaccinations are administered to children from 12 months of age, adolescents
and adults exposed to parotitis who had not had parotitis and had not been immunized.
In the absence of contraindications vaccine should be administered not later than 72
hours after the exposure.
Produced in ampoules of 1, 2 or 5 doses in 10-ampoule packs.
Period of validity: 15 months.
Manufacturer: MICROGEN subdivision in Moscow.
MUMPS AND MEASLES VIRUS VACCINE, TISSSUE CULTURED, LIVE, DRY (MEASLES-MUMPS
VACCINE)
lyophilizate for solution preparation for subcutaneous use
Results in immunity to measles and epidemic parotitis.
Used for prophylaxis against epidemic parotitis and measles.
Vaccine is administered twice: at 12 months and 6 years of age to children who did not
have measles and mumps. Emergency prophylaxis is provided to children from the age of
12 months, adolescents and adults exposed to measles or mumps who had not had these
diseases and had not been immunized.
Produced in ampoules of one vaccination dose in 10-ampoule packs with solvent.
Period of validity: 12 months.
Manufacturer: MICROGEN subdivision in Moscow.
HEPATITIS B VIRUS VACCINE, RECOMBINANT-DNA, YEAST (HEPATITIS B VACCINE)
suspension for intramuscular use
Vaccination course results in specific antibodies to hepatitis B virus, found in protection titer in over 90 percent of vaccinated persons.
Used for hepatitis B prophylaxis in children within the national
vaccination program and in the high risk group for hepatitis B:
• children and adults in families with HBsAg-carrier or a patient with chronic hepatitis B;• children in orphanages and boarding schools;• children and adults who regularly receive whole blood or blood products as well as hemodialysis and oncohematologic patients; • persons exposed to material infected by hepatitis B virus;• health care workers in contact with blood;• persons involved in production of immunobiological preparations from donor and • students of medical colleges and medical vocational schools (primarily graduates);• intravenous drug abusers.
Besides the above-mentioned categories vaccinations may be given to all population groups.
Vaccination course may be provided according to standard or emergency scheme.
Produced in ampoules of 1ml (one adult dose) and 0.5ml (one dose for a child) in 10-ampoule
packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
TUBERCULOSIS VACCINE FOR SPARING IMMUNIZATION (VACCINE OF CALMETTE AND
GUERIN-M, BCG-M VACCINE)
lyophilizate for suspension preparation for intracutaneous use
Results in lasting immunity to tuberculosis due to the use of living strain of micobacterium tuberculosis of the BCG-1 strain (immunization dose contains 0.025mg of BCG cells in 0.1 ml of solvent).
Used for active specific prophylaxis of tuberculosis.
BCG-M vaccine is administered:
• in maternity departments to all healthy neonates with the birth weight of 2000 grams and more on the 3rd – 7th day of life or on the day of the discharge from the hospital in areas with tuberculosis morbidity not higher than 80 in 100000; • in maternity departments to premature neonates with birth weight of 2000 grams and more after the recovery of the initial weight on the eve or on the day of discharge; • in neonatal intensive care department of hospitals (2nd stage of care) to infants with body weight of 2300g or more before the discharge; • in child clinics to children who were not immunized in maternity departments due to medical contraindications but who need the immunization after contraindication removal.
Produced in kits with 0,5mg ampoules of the preparation (20 doses) and 2ml ampoule of
solvent (0.9% solution of potassium chloride for injections), in 5-kit packs.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Stavropol.
TUBERCULOSIS VACCINE (VACCINE OF CALMETTE AND GUERIN, BCG VACCINE)
lyophilizate for suspension preparation for intracutaneous use
Results in lasting immunity to tuberculosis due to the use of living strain of micobacterium tuberculosis of the BCG-1 strain (immunization dose contains 0.05mg of BCG cells in 0.1ml of solvent).
Used for active specific prophylaxis of tuberculosis:
• primary vaccination of healthy neonates on the 3rd – 7th day of life; boosters at 7 and 14 years of age.
Produced in kits with ampoules with 0,5mg of the preparation (10 doses) or 1mg (20 doses)
and 1 or 2ml ampoule of solvent respectively (0.9% solution of potassium chloride for
injections), in 5-kit packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Stavropol.
TULAREMIA VACCINE, LIVE, DRY
lyophilizate for solution preparation for intracutaneous or cutaneous use
Results in immunity to tularemia up to 5 years duration. Used for tularemia prevention from  years of age
(from 14 in high-incidence area).
Immunization are provided to population in the tularemia enzootic areas and persons who
come to these territories and working in:
• agricultural, irrigation or drainage, building jobs, or other jobs connected with soil removal and replacement, purchasing, commercial fishing or hunting, geological, survey, dispatch, deratization and disinfecting jobs; • logging, or forestry jobs or in improvements of public recreational zones.
Produced in kits. Each kit consists in one ampoule of vaccine (15-60 doses) and 1 ampoule of
water for injection. A pack contains 5 kits.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Omsk.
TETRATOXOID, PURIFUED, ADSORBED, LIQUID
suspension for subcutaneous use
Results in specific antitoxic immunity to botulism and tetanus toxoids that persists no less than 5 years.
Used for prevention of botulism and tetanus in persons
from  to 0 years of age (women to ).
Produced in 3ml ampoules (3 doses) in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ufa.
TRITOXOID, PURIFUED, ADSORBED, LIQUID
suspension for subcutaneous use
Results in specific antitoxic immunity to anatoxins of botulism and tetanus that persists no less than 5 years.
Used for prevention of botulism and tetanus in
persons from  to 0 (women to ).
Produced in 3ml ampoules (3 doses) in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ufa.
ENCEVIR® (TICK-BORNE ENCEPHALITIS VACCINE, TISSUE CULTURED, PURIFIED,
CONCENTRATED, INACTIVATED, SORBED, LIQUID)
suspension for intramuscular use
Results in specific immunity to tick-borne encephalitis, produced from virus strain isolated in Russia. Protects against all subtypes of tick-borne encephalitis.
Used for active prophylaxis against of tick-borne
encephalitis in persons from  years of age.
Vaccination is indicated to:
• population of areas endemic to tick-born encephalitis;• persons who come to these territories to work in agricultural, irrigation or drainage, building, purchasing, commercial fishing or hunting, geological, survey, dispatch, deratization and disinfecting jobs; as well as in soil removal or replacement, logging, or forestry jobs or in improvements of public recreational zones; • persons working with live cultures of tick-borne encephalitis pathogen;• donors whose blood is used for specific immunoglobulin production.
Results in specific immunity to tick-borne encephalitis virus; protects from both Asian and European viral strains.
Produced in 0.5ml ampoules (one dose) in 3, 5 or 10 ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Tomsk
The acting agents of human immunoglobulin preparations produced by the MICROGEN subsidiaries are highly purified immunoglobulins isolated from blood plasma of healthy donors.
In order to rule out the use of blood plasma from donors in incubation period of some infectious disease all doses of received plasma go through an obligatory quarantine for the minimal time of 3 months.
Blood plasma used for the production goes through additional three tests to establish the absence of human immunodeficience virus (HIV-1 and HIV-2), and during the production additional stages ensure the high level of viral safety of the end products.
According to the antibody spectrum, human immunoglobulin preparations can be used for prevention and treatment of dangerous infections, allergies and immunodeficiencies, as well as for increasing organism immunocompetence in reconvalescence periods after infectious diseases.
Normal human immunoglobulins are produced from blood plasma of more than 1000 donors. They contain high concentrations of antibodies against infectious agents that are more common to Russia and posses a high range of antiviral and antibacterial activity. Specific immunoglobulins contain the highest concentration of antibodies against a certain pathogen and are meant for the therapy of the corresponding infectious disease.
NORMAL HUMAN IMMUNOGLOBULINS
IMMUNE GLOBULIN INTRAVENOUS (HUMAN)
solution for intravenous use
Concentrate of immunologically active protein fraction of blood plasma from healthy donors that contains antibodies of various specificity. The preparation is also endowed with non-specific activity which is realized in increased general resistance.
Used in children and adults for therapy of severe toxic forms of bacterial
and viral infections, postoperative complications with septicemia.
For adults a single dose of the preparation is 20-50ml.
Produced in 25ml vials.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Nishny Novgorod and Khabarovsk.
IMMUNOVENIN (IMMUNE GLOBULIN INTRAVENOUS HUMAN)
lyophilized porous mass
Concentrate of immunologically active protein fraction of blood plasma from healthy donors that contains antibodies of various specificity. The preparation is also endowed with non-specific activity which is realized in raised general resistance.
Used in treatment of children and adults with inborn or acquired
immunodeficiency, hypogammaglobulinemia, severe forms of bacteriotoxic
and viral infections, postoperative complications with bacteremia and sepsis.
Preparation lyophilized from 25 or 50ml volume is presented in 25 or 50ml vials and solvent
(25 or 50ml, water for injection).
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
IMMUNE GLOBULIN INTRAMUSCULAR (HUMAN)
solution for intramuscular injection
Concentrate of immunologically active protein fraction of blood plasma from healthy donors that contains antibodies of various specificity. The preparation is also endowed with non-specific activity which is realized in raised general resistance. The immunoglobin series is produced from the plasma from 1000 healthy donors who are individually tested for the absence of surface antigen of viral hepatitis B (HBsAg) antibodies against hepatitis C and HIV-1 and HIV-2.
Used for profylaxis of viral hepatitis A, measles, flu, whooping
cough, meningococcal infection, poliomyelitis; for therapy of
hypo- and agammaglobulinemia and in order to increase general
resistance during convalescence period of infectious diseases.
Produced in 1.5ml ampoules (1 dose) in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Ekaterinburg, Irkutsk, Omsk, Perm, Tomsk, Ufa and
Khabarovsk.
IMBIOGAM® (IMMUNE GLOBULIN INTRAMUSCULAR HUMAN)
solution for intramuscular injection
Manufacturer: MICROGEN subsidiary in Nishny Novgorod. IMMUNOGLOBULIN COMPLEX PREPARATION FOR ENTERAL ADMINISTRATION (KIP)
lyophilizate for solution preparation for oral administration
Immunologically active protein fractions of human blood serum from healthy donors.
Used for therapy of acute intestinal infections caused by
enterobacteria in children from  month to  years of age.
Produced in vials with 300±25mg of protein (1 dose) in 5-vial packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Moscow.
SPECIFIC HUMAN IMMUNOGLOBULINS
ANTISTAPHYLOCOCCUS HUMAN IMMUNOGLOBULIN
solution for intramuscular injection
Concentrate of immunologically active protein fraction of blood plasma from healthy donors with antibodies against staphylococcal exotoxins.
Used in various diseases of staphylococcal etiology in children and adults.
In generalized staphylococcal infection minimal single dose of the preparation is 5 IU
for 1kg of weight, in localized forms no less than 100 IU. The preparation is intended for
intramuscular injection only.
Produced in ampoules of 100 IU (1 dose) with 3 to 5ml volume.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Perm, Nishny Novgorod, Omsk, Tomsk, Ufa,
Ekaterinburg, Irkutsk and Khabarovsk.
ANTITETANUS HUMAN GLOBILIN
solution for intramuscular injection
Purified concentrate of immunologically active protein fraction of blood plasma from healthy donors immunized with tetanus toxoid. 1 ml contains not less than 50 IU of antibodies against tetanus toxin.
Maximum concentration of antibodies in blood is achieved in 24 hours after the preparation administration.
Used in emergency tetanus prophylaxis in adults and children
who had not recieved the complete course of tetanus toxoid
immunization or have an unknown immunization history.
Produced in 1-dose ampoules not larger than 5ml, in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
ANTIHEP (ANTIHEPATITIS B HUMAN GLOBULIN)
solution for injection
Produced from blood serum (plasma) of healthy donors immunized by hepatitis B vaccine (recombinant, yeast, liquid).
Used for emergency prophylaxis of hepatitis B in children and adults:
• neonates of mothers who carry HbsAg or have acute hepatitis B;• persons without previous hepatitis B vaccination or with HBs-antibody levels lower than the protective one after an inadvertent infection because of the contact with an infected material; • persons from risk groups for hepatitis B infection.
Produced in 2ml ampoules (200 IU one dose), in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
IMMUNOGLOBULIN HUMAN AGAINST ENCEPHALITIS IXODICUM
solution for intramuscular injection
Produced from blood plasma from healthy donors. Acting agents are immunoglobulins of class G that have active antibodies neutralizing tick-borne encephalitis virus. The preparation also has non-specific properties that increase immunocompetence.
Used for emergency prophylaxis and therapy of tick-
borne encephalitis in adults and children.
For emergency prophilaxis after a tick bite (not later than the 4th day) the preparation is
administered to persons without immunization against tick-borne encephalitis or with an
incomplete immunization course as well as in suspected laboratory infection by the virus.
In cases of high infection risk the immunoglobulin is administered to immunized persons.
The preparation can be used before possible contact with the virus of tick-borne
encephalitis. The protective action appears in 24 - 48 hours and persists for about 4 weeks.
For therapeutic purposes the immunoglobulin is administered as early as possible after the
disease onset in various doses depending on body mass, clinical infection form, severity
and disease stage.
Produced in 1ml and 3ml ampoules (with titer 1:320, 1:160; 1:80) in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Tomsk, Perm, Ufa, Ekaterinburg, Irkutsk, Omsk,
Khabarovsk, Nizhny Novgorod.
ANTIALLERGIC HUMAN IMMUNOGLOBULINS
HISTAGLOBULIN
lyophilizate for solution preparation for subcutaneous use
Complex of human blood serum immunoglobulin and histamine dihydrochloride on administration increases blood serum ability to activate free histamine.
Used in therapy of allergic states in adults and children:
chronic recurrent urticaria, allergic (atopic) dermatitis, eczemas, allergic migraines,
bronchial asthma, asthmatic bronchitis, allegric rhinosinusopathy, allergic conjunctivitis,
pollinosis (recommended use before flowering season), recurrent Quincke's edema
(excluding inherited angioneurotic edema).
Therapy course is implemented in remission period.
Produced in kits of 1 histaglobulin ampoule (one dose) and 1 ampoule of solvent (isotonic
solution of sodium hydrochlorate for injections) in 5-kit packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Tomsk and Ufa.
ANTIALLERGIC HUMAN GLOBULIN, LIQUID
solution for intramuscular use
Purified concentrate of immunologically active protein fraction of blood plasma from healthy donors (not less than 1000 persons per every preparation batch).
Used in therapy of immediate-type allergy,
of mild to medium severity in remission stage in adults and children over 1 year of
age: pollinosis with various clinical manifestations, atopical bronchial asthma, allergic
recurrent urticaria and Quincke's edema, allergic dermatosis.
Produced in ampoules of 1ml (1 dose) and 2ml (2 doses) in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod and Ufa.
These are preparations of blood serum obtained from animals immunized by certain antigen and containing specific antibodies against these antigens. Heterologous serums are used for specific passive immunotherapy of several dangerous infections, i.e. botulism, tetanus, gas gangrene, diphtheria. The condition necessary for a heterologous serum use is the determination of the patient sensitivity. It is ascertained by intracutaneous test with a diluted preparation.
The effectiveness of the preparation administration is the higher the earlier it is introduced into the organism of the person with the diagnosed or suspected disease.
ANTIBOTULINIC SERUMS OF A, D, E TYPES, PURIFIED, CONCENTRATED, LIQUID
suspension for injections
Preparations of antibotulinic serums contain antitoxins that neutralise botulinic toxins of corresponding type.
Used for therapy and prevention of botulism.
Monovalent antibotulinic serums are produced in ampoules containing one treatment dose
for every botulinic toxin. A pack contains 5 ampoules of antibotulinic serum of one type and 5
ampoules of horse serum diluted 1:100 for determining a person's sensitivity to foreign protein.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Stavropol and Ufa.
ANTIGANGRENE SERUM, POLYVALENT, PURIFIED, CONCENTRATED, HORSE, LIQUID
solution for injection
Neutralizes toxins of anaerobic microbes Clostridium perfingens type A, edomatiens and septicum.
Used for therapy and prevention of gas gangrene.
Preventive administration of the serum is intramuscular, whereas the therapeutic one is
performed by intravenous infusion.
Produced in ampoules with 30000 IU (one dose) of serum packaged with horse serum
diluted 1:100.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
ANTIDIPHTHERIC SERUM, HORSE, PURIFIED, CONCENTRATED, LIQUID
solution for intramuscular and subcutaneous use
Neutralizes toxins of diphtheria bacteria.
Used for therapy of patients with diphtheria.
Produced in ampoules with 10000 IU (1 dose). A pack contains 5 ampoules of antidiphtheric
serum and 5 ampoules of serum diluted 1:100.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Stavropol, Perm and Ufa.
ATNITETANIC SERUM, HORSE, PURIFIED, CONCENTRATED, LIQUID
solution for intramuscular use
Neutralizes tetanus toxin.
Used for emergency specific prophylaxis and therapy of tetanus.
Produced in 1ml ampoules (3000 IU) with 1ml of horse serum diluted 1:100, in 5-kit packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ufa.
ANTI-VIPER (ANTI-ADDER) VENOM SERUM, HORSE, PURIFIED, CONCENTRATED, LIQUID
solution for injection
Contains antitoxins neutralizing adder (Vipera bents) venom.
Used for treating persons after a snakebite.
Produced in ampules (150 IU – one dose) in kits with sterile syringe and needle.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Stavropol.
CYTOKINES (INTERFERONS AND INTERLEUKINS)
Cytokines are "protein products of predominantly activated immune system cells devoid of specificity in respect to antigens and providing intercellular communication in hemopoiesis, inflammation, immune response and intersystem interactions"1. These proteins act by means of receptor interaction. Cytokines include interferons, interleukins, tumor necrosis factors, growth and colony-stimulating factors and chemokines. Cytokines were the basis for the development of immunotherapeutic preparations that are used in conjunction with other treatments for many pathologic processes that are accompanied by the reduced activity of the organism immune system.
The MICROGEN company produces several drugs of this group.
1 A.A. Yarilin, "Basic Immunology", Moscow, 1999.
AFFINOLEUKIN ®
lyophilizate for solution preparation for subcutaneous use
Immunostimulator. Complex of low molecular weight proteins isolated from human leukocytes containing antigenspecific cytokines of T-cell origin.
Therapeutic indications.
Deep forms of acute and recurrent ophthalmoherpes in protracted cases and secondary
infections (as an addition to etiotropic medication) in adults and children over 4 years
of age.
Produced in ampoules with 0.5; 1.0 or 2.0 IU in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
SVEFERON ® (HUMAN LEUKOCYTE INTERFERON)
suppositories
Group of proteins produced by blood leukocytes of healthy donors in response to the action of interferonogenic virus. Has antiviral and immunostimulation effect.
Therapeutic indications.
Acute form of hepatitis B in children from 2 to 12 years of age (as part of a complex
therapy).
Produced in 10-suppositories packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
HUMAN LEUKOCYTE INTERFERON
(α-interferon), lyophilizate for solution preparation for intranasal administration
Contains proteins produced by donor blood leukocytes in response to the action of a interferon inductor virus.
Therapeutic indications.
Prevention and treatment of influenza and other acute respiratory viral infections.
Preparation is most effective in early therapy.
Produced in 1000 IU ampoules (4 doses) in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Perm, Tomsk and Ufa.
Bacteriophages (phages) are viruses that are able to infect bacterial cells, reproduce there and cause lysis or the transference into lysogenic state.
The process of bacteria destruction by phages (phagolysis) takes place in spontaneous recovery from a bacterial infection. Drugs containing bacteriophages act against certain types of bacterias, produce antibacterial effect, but do not affect human cells and do not destroy normal intestinal microflora (as opposed to most antibiotics).
At present in this country the production of bacteriophages for prevention and treatment of enteric infections and also "wound" bacteriophages against main pathogens of pyoinflammatory diseases has been organized. Chances of the development of microbe flora resistance to bacteriophages are very low because bacteriophages are constantly adapting to circulating bacteria strains by means of renewal of phage races.
Due to decreased therapeutic effectiveness of antibiotics barteriophage preparations are used in clinical practice as an alternative to other antibacterial agents. Bacteriophages do have no contraindications and can be combined with any other medicines.
The absence of contraindications and complications in the therapeutic use of bacteriophage preparations, their combinability with other medicines (including antibiotics), their effectiveness against antibiotic-resistant strains characterize bacteriophage preparations as highly effective and promising therapeutic means of treatment of pyoinflammatory and enteral diseases.
The necessary condition of effective phagotherapy is a preliminary determination of the pathogen phagosensitivity.
At present the subsidiaries of the MICROGEN company produce a wide range of bacteriophages for the therapy of various infectious diseases.
PSEUDOMONAS AERUGINOSA BACTERIOPHAGE
solution for oral, local and external use
Possesses the ability to lyse Pseudomonas aeruginosa bacilli.
Therapeutic indications.
Treatment and prevention of pyoinflammatory and intestinal diseases caused by the
Pseudomonas aeruginosa bacillus.
Used in therapy of ear, nose and throat diseases, respiratory and pulmonary diseases,
surgical infections (septic wounds, burns, abscess, phlegmon, furuncles, carbuncles,
hydradenitis, felons, paraproctitis, mastitis, bursitis, osteomyelitis); urogenital infections
(urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis); enteral
infections (gastroenterocolitis, cholecystitis); dysbacteriosis, generalized septic
diseases, pyoinflammatory diseases of neonates (omphalitis, pyodermia, conjunctivitis,
gastroenterocolitis, sepsis, etc.); other diseases caused by Pseudomonas aeruginosa.
In prophylaxis the preparation is used in debridement of surgical and newly infected
wounds as well as for prevention of hospital infections according to epidemic indications.
Produced in 20ml vials (4 or 10 vials per package) and in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Perm, Ufa and Nizhny Novgorod.
COLIPROTEIC BACTERIOPHAGE
solution for oral, local and external use
Possesses the ability to lyse enteropathogenic and Proteeae rods.
Therapeutic indications.
Treatment and prevention of pyoinflammatory and enteric diseases caused by
enteropathogenic and Proteeae rods.
Used in therapy of ear, nose and throat diseases, respiratory and pulmonary diseases
(inflammation of frontal sinuses and middle ear, tonsillitis, pharyngitis, laryngitis,
tracheitis, bronchitis, pneumonia, pleuritis); surgical infections (septic wounds, burns,
abscess, phlegmon, furuncles, carbuncles, hydradenitis, felons, paraproctitis, mastitis,
bursitis, osteomyelitis); urogenital infections (urethritis, cystitis, pyelonephritis, colpitis,
endometritis, salpingo-oophoritis); enteric infections (gastroenterocolitis, cholecystitis,
dysbacteriosis); generalized septic processes; pyoinflammatory diseases of neonates
(omphalitis, pyodermia, conjunctivitis, gastroenterocolitis, sepsis, etc.); other diseases
caused by Proteus and colibacillus.
In prophylaxis the preparation is used in debridement of surgical and newly infected
wounds as well as for prevention of hospital infections according to epidemic indications.
Produced in 20ml vials (4 or 10 vials per package) and in 100ml vials.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod and Ufa.
STAPHYLOCOCCAL BACTERIOPHAGE
solution for oral, local and external use
Possesses the ability to specifically lyse staphylococci.
Therapeutic indications.
Treatment and prevention of pyoinflammatory and enteric diseases caused by
staphylococci.
Used in therapy of ear, nose and throat diseases, respiratory and pulmonary diseases
(inflammation of frontal sinuses and middle ear, tonsillitis, pharyngitis, laryngitis,
tracheitis, bronchitis, pneumonia, pleuritis); surgical infections (septic wounds, burns,
abscess, phlegmon, furuncles, carbuncles, hydradenitis, felons, paraproctitis, mastitis,
bursitis, osteomyelitis); urogenital infections (urethritis, cystitis, pyelonephritis, colpitis,
endometritis, salpingo-oophoritis); enteric infections (gastroenterocolitis, cholecystitis,
dysbacteriosis); generalized septic processes; pyoinflammatory diseases of neonates
(omphalitis, pyodermia, conjunctivitis, gastroenterocolitis, sepsis, etc.); other diseases
caused by staphylococci.
In prophylaxis the preparation is used in debridement of surgical and newly infected
wounds as well as for prevention of hospital infections according to epidemic indications.
Produced in 20ml vials (4, 8 or 10 vials per package) and in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod, Perm, Khabarovsk and Ufa.
. DYSENTERIC BACTERIOPHAGE, POLYVALENT
tablets
. DYSENTERIC BACTERIOPHAGE, POLYVALENT
tablets with enteric coating
. DYSENTERIC BACTERIOPHAGE, POLYVALENT
solution for oral and rectal use
Cause specific lysis of Schigellae Zonnei and Flexneri.
Therapeutic indications.
Prevention and treatment of bacterial dysentery. Prescribed to children (from 6 months
of age) and adults. The use of the preparation is recommended for group diseases in
institutions and families.
Produced in tablet form with 25; 50 or 100 tablets in glass or plastic vials, in 50-tablet blister
packs or in 20ml vials (in 4 or 10 vial packages) or in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod, Khabarovsk and Ufa.
KLEBSIELLA BACTERIOPHAGE, POLYVALENT, PURIFIED
solution for oral, local and external use
Possesses the ability to specifically lyse bacteria Klebsiella pneumoniae, ozena and rhinoscleromatis.
Therapeutic indications.
Ozena, scleroma, and pyoinflammatory and enteric diseases caused by Klebsiella
pneumoniae, ozena and rhinoscleromatis.
Produced in 10 or 20ml vials in 4 or 10-vial packages.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
KLEBSIELLA PNEUMONIAE BACTERIOPHAGE, PURIFIED
solution for oral, local and external use
Possesses the ability to specifically lyse bacteria Klebsiella pneumoniae.
Therapeutic indications.
Surgical infections (septic wounds, peritonitis, pleuritis, burns, mastitis, abscess),
urogenital infections (cystitis, pyelonephritis, endometritis, salpingo-oophoritis);
pyoinflammatory ENT diseases (ozena, rhinoscleroma); enteric infections
(gastroenterocolitis, cholecystitis, dysbacteriosis); pyoinflammatory diseases of neonates
and infants (omphalitis, pyodermia, conjunctivitis, gastroenterocolitis, sepsis).
Produced in 10 or 20ml vials in 4 or 10-vial packages.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
KLEBSIPHAGE (KLEBSIELLA PNEUMONIAE BACTERIOPHAGE)
solution for internal and topical use
Sterile filtrate of Klebsiella pneumoniae phagolysate.
Therapeutic indications.
Prevention and treatment of pyoinflammatory diseases caused by Klebsiella pneumoniae.
Produced in 20ml vials in 4 or 10-vial packages.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
COLI BACTERIOPHAGE
solution for oral, local and external use
Possesses the ability to specifically lyse Escherichia coli bacillus.
Therapeutic indications.
Treatment and prevention of pyoinflammatory and enteric diseases caused by
enteropathogenic colibacillus.
Used in therapy of ear, nose and throat diseases, respiratory and pulmonary diseases
(inflammation of frontal sinuses and middle ear, pharyngitis, laryngitis, tracheitis,
bronchitis, pneumonia, pleuritis); surgical infections (septic wounds, burns, abscess,
phlegmon, furuncles, carbuncles, hydradenitis, felons, paraproctitis, mastitis, bursitis,
osteomyelitis); urogenital infections (urethritis, cystitis, pyelonephritis, colpitis,
endometritis, salpingo-oophoritis); gastroenteric infections (gastroenterocolitis,
cholecystitis, dysbacteriosis); generalized septic processes; pyoinflammatory diseases of
neonates (omphalitis, pyodermia, conjunctivitis, gastroenterocolitis, sepsis) and other
diseases caused by colibacillus.
In prophylaxis the preparation is used in debridement of surgical and newly infected
wounds as well as for prevention of hospital infections according to epidemic indications.
Produced in 20ml vials (4 or 10 vials per package) and in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Perm, Khabarovsk and Ufa.
PROTEUS BACTERIOPHAGE
solution for oral, local and external use
Possesses the ability to lyse Proteus vulgaris and mirabilis bacteria.
Therapeutic indications.
Ear, nose and throat diseases, respiratory and pulmonary diseases (inflammation of frontal
sinuses and middle ear, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia,
pleuritis); surgical infections (septic wounds, burns, abscess, phlegmon, furuncles,
carbuncles, hydradenitis, felons, paraproctitis, mastitis, bursitis, osteomyelitis); urogenital
infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis);
enteric infections (gastroenterocolitis, cholecystitis, dysbacteriosis); generalized septic
processes; pyoinflammatory diseases of neonates (omphalitis, pyodermia, conjunctivitis,
gastroenterocolitis, sepsis); other diseases caused by Proteus.
In prophylaxis the preparation is used in debridement of surgical and newly infected
wounds as well as for prevention of hospital infections according to epidemic indications.
The therapy of pyoinflammatory diseases with localized lesions should be provided both
topically and orally for 7 – 20 days (according to clinical indications).
Produced in 20ml vials (4 or 10 vials per package) and in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Perm, Khabarovsk and Ufa.
. SALMONELLOSIS OF ABCDE GROUPS BACTERIOPHAGE, LIQUID
solution for oral use
. SALMONELLOSIS OF ABCDE GROUPS BACTERIOPHAGE
tablets with enteric coating
. SALMONELLOSIS OF ABCDE GROUPS BACTERIOPHAGE
tablets
The preparations are based on sterile phagolysate filtrate of the more common salmonellae: group A – paratyphoid A, group B – paratyphoid B, group C – typhimurium, heidelberg, newport, choleraesuis, oranienburg, infantum; group D – dublin, enteritidis; group E – anatum, newlands. Bacteriophage preparations are able to lyse salmonellae of the above serotypes. Therapeutic indications.
Prevention and treatment of salmonellosis.
Produced in 100ml vials; in tablet form (50 in a vial or blister pack, one package containing 10
vials or 5 blister packs); in 25; 50 or 100-tablet glass or plastic vials.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod and Ufa.
STREPTOCOCCAL BACTERIOPHAGE
solution for oral, local and external use
Sterile filtrate of phagolysed streptococcal strains.
Therapeutic indications.
Prevention and treatment of diseases caused by streptococci.
Produced in 20ml vials (in 4 or 10 vial packages) and in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Perm and Ufa.
INTESTI-BACTERIOPHAGE
solution for oral and rectal use
Mixture of filtrates of phagolysates active against Shigella flexneri 1, 2, 3, 4, 6 serovars and Zonnei, salmonellae of paratyphoid A and B, typhimurium, cholerae suis, infantum, oranienburg, enteritidis; enteropathogenic colibacillus of etiologically significant serovariants, enterococci, staphylococci, Pseudomonas aeruginosa, Proteus vulgaris and mirabilis. Intesti-bacteriophage possesses the ability to specifically lyse the above-mentioned bacteria.
Therapeutic indications.
Prevention and treatment of gastro-intestinal diseases caused by the above-mentioned
pathogens or their combinations.
Produced in 20ml vials (in 4 or 10-vial packages) and in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Perm, Nizhny Novgorod and Ufa.
PYOPOLYPHAGE (PYOBACTERIOPHAGE COMBINED, LIQUID)
solution for oral and topical use
Possesses the ability to specifically lyse bacteria of staphylococci, streptococci (including enterococci), Proteus, pyocyaneus and coli-bacillus.
Therapeutic indications.
Prevention and treatment of pyoinflammatory diseases as well as dysbacterioses caused
by the above-mentioned pathogens. Used in treatment of ear, nose and throat diseases,
respiratory and pulmonary diseases (inflammation of frontal sinuses and middle ear,
tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleuritis); surgical
infections (septic wounds, burns, abscess, phlegmon, furuncles, carbuncles, hydradenitis,
felons, paraproctitis, mastitis, bursitis, osteomyelitis); urogenital infections (urethritis,
cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis); enteric infections
(gastroenterocolitis, cholecystitis); generalized septic processes; pyoinflammatory
diseases of neonates (omphalitis, pyodermia, conjunctivitis, gastroenterocolitis, sepsis)
and other diseases caused by the sensitive bacteria.
In prophylaxis the preparation is used in debridement of surgical and newly infected
wounds as well as for prevention of hospital infections according to epidemic indications.
Produced in 20ml vials (in 4 or 10-vial packages) and in 100ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
PYOBACTERIOPHAGE POLYVALENT, PURIFIED
solution for oral, local and external use
Possesses the ability to specifically lyse bacteria of staphylococci, streptococci, Proteus (mirabilis and vulgaris), Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli bacillus.
Therapeutic indications.
Prevention and treatment of various pyoinflammatory and gastrointestinal diseases
caused by the above-mentioned pathogens. Used in treatment of surgical infections
(septic wounds, pustulous skin lesions, burns, peritonitis, pleuritis, mastitis, bursitis,
osteomyelitis); urogenital infections (cystitis, pyelonephritis, endometritis, vulvitis,
bartholinitis, colpitis, salpingo-oophoritis); enteric infections (gastroenterocolitis,
cholecystitis, pancreatitis, intestinal dysbacteriosis); pyoinflammatory diseases of ear,
nose and throat, lungs and pleura (otitis, tonsillitis, pharyngitis, stomatitis, parodontitis,
sinusitis, pneumonia, pleuritis); post-traumatic conjunctivitis, keratoconjunctivitis,
purulent corneal ulcers and iridocyclitis; inflammatory diseases of neonates and infants,
septicemias, septicopyemias of various localizations, omphalitis, pyodermia, enteritis,
intestinal dysbacterioses.
Produced in 10 or 20ml vials in 4 or 10-vial packages.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
SEXTAPHAGE ® (PYOBACTERIOPHAGE POLYVALENT)
solution for oral, local and external use
Mixture of sterile filtrates of bacteria phagolysates of staphylococci, streptococci, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli bacillus. The preparation has the ability to specifically lyse bacteria of staphylococci, streptococci, Proteus (mirabilis and vulgaris), Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli (of various serogroups).
Therapeutic indications.
Prevention and treatment of various diseases caused by staphylococci, streptococci,
Proteus (mirabilis and vulgaris), Pseudomonas aeruginosa, Klebsiella pneumoniae,
Escherichia coli (of various serogroups) as well as dysbacteriosis.
Produced in 20ml vials in 4 or 10-vial packages.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
Probiotics are biological preparations of live strains of symbiotic intestinal microflora aimed at human microflora correction (in gastrointestinal tract and mucous linings). Probiotics have the ability to increase organism resistance during infectious diseases, in many cases they produce an antiallergic effect and normalize digestion. These preparations are prescribed for intestinal dysbacterioses, including those produced by antibacterial agents, in complex therapy of some allegric diseases, metabolic disbalance, obesity, etc.
Many probiotics have an immunotropic effect. Lactobacteria and bifidobacteria affect various components of the immune system and normalize nonspecific and specific, cell and humoral immunity. Such probiotics as Lactobacterin and Bifidobacterin are necessary components of birth preparation of pregnant women, especially from the risk group for pyoseptic diseases.
At present the Russian pharmaceutical market demands are met both by the domestic and foreign manufacturers. Domestic preparations have wider range of indications and can be used in various forms: for oral, rectal, intravaginal and external administration.
Probiotics have practically no contraindications and can be used as preventive agents by persons of both sexes and all ages and of all social groups.
The subsidiaries of the MICROGEN company produce a number of the most popular probiotics.
BIFIDUMBACTERIN, DRY
lyophilizate for solution preparation for topical and oral use
Contains live bifidobacteria that possess antagonistic activity against wide range of pathogenic and conditionally pathogenic microorganisms of the intestine (including staphylococci, proteus, enteropathogenic colibacillus, Schigellae, some yeastlike fungi). Restores the balance of intestinal and vaginal microflora, improves GI tract functioning, activates metabolism, enhances non-specific body resistance.
Therapeutic indications.
Solution for oral administration:
Dysbacteriosis of GI tract of various ethiologies (prevention and treatment), including
ulcers of the stomach and duodenum, pancreatitis and other gastro-intestinal diseases;
allergic diseases, use of antimicrobial preparations, hormones and non-steroid anti-
inflammatory drugs; acute intestinal infections (schigellosis, salmonellosis, staphylococcal
enterocolitis, rotaviral infection, etc.), food toxicoinfection, malabsorption syndrome,
chronic constipation or diarrhea in long-term antibacterial therapy; microbiocenosis
correction before and after the surgery on the intestine, liver, pancreas; prevention of
hospital infection and dysbacteriosis in patients with frequent URI.
Solution for topical administration:
Dysbacteriosis of urogenitary tract, acute and chronic inflammatory diseases of urogenitary
tract (uncluding sexually transmitted urogenitary infections); preparation for obstetric
surgery (in order to prevent postoperative complications); antepartum preparation of
pregnant women from risk group for inflammatory diseases (for prevention and treatment
of vaginal dysbacteriosis); prevention of mastitis in breastfeeding mothers from the risk
group.
Produced in vials of 5 or 10 doses in 10-vial packages: in 5-dose ampoules in 10-ampoule
packs.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Moscow, Nizhny Novgorod, Omsk, Perm, Stavropol,
Tomsk, Ufa and Tumen.
The preparation contains live bifidobacteria with antagonistic activity against a wide range of pathogenic and conditionally pathogenic microorganisms. Normalizes microflorae of the intestine and vagina, improves metabolism, prevents protracted forms of intestinal diseases, enhances non-specific resistance of the organism.
Therapeutic indications.
Dysbacteriosis and inflammatory processes in the large intestine and vagina.
Produced in 5-suppository contour packs, in 2-pack packages.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
BIFICOL, DRY
lyophilizate for solution preparation for oral use
Contains live bifidobarteria and colibacillus with antagonistic activity against pathogenic and conditionally pathogenic microorganisms, as well as immunomodulating and adjuvant activity due to bacterial antigens affecting the production of specific and non-specific protective factors (including local ones); stimulates local reparation processes in the intestine. Therapeutic indications.
Treatment of intestinal dysfunction due to dysbacterioses of various ethiology and
chronic colitis, states after acute intestinal infections accompanied by the ecxretion
of conditionally pathogenic microorganisms. Acute intestinal infections (in complex
therapy).
Produced in 5-dose vials (10 vials per package).
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
COLIBARTERIN, DRY
lyophilizate for solution preparation for oral use
Microbial cells of strain M-17 colibacillus contained in the preparation have antagonistic action against pathogenic and conditionally pathogenic microorganisms.
Therapeutic indications.
Chronic colitis of various ethiologies. Reconvalescence after acute intestinal infections,
intestinal dysfunction, pronounced dysbacteriosis, excretion of pathogenic and
conditionally pathogenic bacteria.
Produced in 5-dose vials (10 vials per package).
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod, Stavropol, Tyumen.
Lactobacilli from the preparation have antagonistic action against pathogenic and conditionally pathogenic microorganisms and create favorable conditions for normal vaginal microflora development. Lactobacterin suppositories are applied intravaginally.
Therapeutic indications.
Dysbacteriosis of various ethiology in children and adults.
Produced in packs of 10 suppositories.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Perm and Nizhny Novgorod.
LACTOBACTERIN, DRY
lyophilizate for solution preparation for topical application and oral use
Lactobacilli from the preparation have antagonistic action against pathogenic and conditionally pathogenic microorganisms and create favorable conditions for normal intestinal microflora development. Is administered orally and intravaginally.
Therapeutic indications.
Chronic colitis of various ethiologies including non-specific ulcerative colitis, somatic
diseases complicated by dysbarteriosis due to the antibiotics, sylfanilamide preparations
and other causes; acute intestinal infections (in reconvalescence period) in intestinal
dysfunction and excretion of pathogenic and conditionally pathogenic bacteria; non-
specific inflammatory diseases of genitalia and antepartum preparation of pregnant
women from the risk group with III-IV stage of vaginal secretion composition abnormality;
colpitis and vaginal dysbacteriosis after antibiotics.
Produced in 5-dose vials, in 10-vial packages.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod, Omsk, Perm, Tomsk, Tyumen, Ufa.
Medicinal human blood products manufactured by MICROGEN facilities are highly purified proteins produced from blood plasma of healthy donors.
The preparations are produced from blood plasma tested for the absence of human immunodeficiency virus (HIV-1 and HIV-2), viruses of hepatitis C and hepatitis B. In order to safeguard the production process against plasma from donors who gave their blood during incubating period of an infectious disease, all portions of plasma go through a mandatory quarantine of minimum 3 month duration. Production technologies include stages that provide additional viral safety of the end product.
The end product is again tested for the absence of human immunodeficiency virus (HIV-1 and HIV-2), viruses of hepatitis C and hepatitis B.
Blood products are generally used in various critical states that require emergency measures for the recovery of the vital functions. Depending on the main effect all products are used as plasma substitutes, fibrinolytics, antioxydants, mixtures for parenteral nutrition and as nonspecific biostimulants.
ALBUMIN SOLUTION, 0%
Plasma substitute produced from the blood plasma of human donors. The preparation compensates the lack of plasma albumin and maintains oncotic blood pressure and hemodynamic indices, possesses detoxifying effect. In transfusion 10 g of albumin are equivalent to 200 ml of blood plasma. The preparation is administered by instillation with the rate of 40 drops per minute or in a stream.
• albumin content in blood plasma below 3g/l, or colloid-osmotic pressure below 15 mm Hg, or overall protein level less than 5g/l; • hypoalbuminemia of various genesis (hemorrhagic, traumatic or thermal shock; acute blood loss – decrease of circulating blood volume more than by 25–30 percent; pyoseptic conditions; liver diseases with the impairment of albumin-synthesizing function; kidney diseases – nephritises and nephrotic syndrome; burn disease; • surgery with extracorporeal circulation;• therapeutic plasmophereses;• hemolitic disease of newborns in exchange transfusion;• pre-surgery hemodilution and autoblood component storage;• cerebral edema.
Produced in 100 and 200ml glass bottles for blood and transfusion products.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod, Ekaterinburg, Omsk, Perm, Tomsk,
Ufa and Khabarovsk.
Protein product of isogenous human blood plasma. This hyperoncotic preparation promotes tissue fluid retention in blood circulation and produces antianemic effect.
• traumatic and postoperative shock;• burns accompanied by dehydration and hemoconcentration;• hypoproteinemia and hypoalbuminemia of various ethiology including gastrointestinal tract pathologies with the nutrition disturbances (ulcerative disease, tumors, impeded gastrointestinal anastomosis patency); • hypoproteinemia developed in nutritional dystrophy, liver cirrhosis, prolonged suppurative processes, etc.; • clinical conditions whose genesis allows to suppose a decrease in erythropoiesis;• iron deficiency (in conjunction with an iron preparation).
Produced in 200ml bottles for transfusion preparations.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod, Ekaterinburg, Omsk.
PREPARATIONS FOR PARENTERAL NUTRITION
Contains all the essential and nonessential amino-acids, necessary for protein biosynthesis in the organism, does not contain proteins and peptides. Possesses anabolic, desintoxicating effect.
Used for parenteral nutrition in conditions
accompanied by protein deficit:
• period before surgery operation and in postoperative period;• sluggish wounds, fractures, burns;• acute infections, inflammatory processes in the lungs;• gastritis and gastroduodenitis;• inflammations of the rectum (administered in microenemas).
Absence of sugar makes it possible to use the preparation for diabetic patients.
Infusamin is administered intravenously by instillator.
Produced in 100 and 450ml vials.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod and Ekaterinburg.
FIBRINOLYSIN
powder for preparation of infusion solution
Fibrinolytic agent that promotes dissolving of fresh fibrin clots.
Used for:
• pulmonary embolism and embolism of peripheral arteries and cerebral vessels;• myocardial infarction;• acute thrombophlebitis and exacerbation of chronic thrombophlebitis;• thrombosis of the central retinal vein and its branches;• thrombosis of the central retinal artery (during first 24 hours);• hemorrhages into the anterior chamber of the eye, vitreous body of both the traumatic and endogenic nature.
Produced in dry form in bottles for blood, transfusion and infusion preparations with 20000
units.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
EYE FILMS WITH FIBRINOLYSIN
Fibrinolytic agent that promotes dissolving of fresh hemorrhages in various eye tissues.
Fibrinolysin is slowly released from the polymeric base and acts for 24 hours.
Used for:
• hemorrhages into the anterior chamber of the eye (hyphema), vitreous body (hemophthalmus), retina of both the traumatic and endogenic nature; • thrombosis of the central retinal vein and its branches;• occlusion of the central retinal artery and its branches (during first 24 hours).
The film is introduced into the conjunctival sac once a day after local anesthesia.
Produced in 10-film blister packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
CERULOPLASMIN
lyophilizate for solution preparation for intravenous infusion
Ceruloplasmin is a copper-containing enzyme of α -globulin fraction of human blood serum. It is a principal blood antioxidant and prevents peroxidation of cell membrane lipids, stimulates hemopoiesis, reduces intoxication and immunodepression.
Used for:
• hemopoiesis stimulation;• intoxication reduction and immunologic correction in complex therapy of oncologic • pre-surgery preparation for weakened patients with anemia;• early postoperative period in cases of massive blood loss during surgical procedure;• pyoseptical complications in early postoperative period;• combined chemotherapy of oncologic patients including those with hemoblastosis with non-acute intoxication; • complex therapy of patients with acute and chronic osteomyelitis.
Produced in ampoules with 0.1g of the preparation in 5-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Nizhny Novgorod and Ufa.
The preparation of human blood plasma or serum with the addition of glucose and sodium hydrocarbonate. Glunat enhances metabolic processes and accelerates tissue regeneration.
Used in order to accelerate regeneration processes
and stimulate body defense in persistent skin ulcers, gastric and duodenal ulcers,
pneumonia and other diseases.
Produced in 5ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
Human blood preparation.
Used as a nonspecific tissue therapy agent for:
• diseases of peripheral nervous system (neuralgia, neuritis, radiculitis, etc.) with pain • gastric and duodenal ulcers;• chronic inflammatory processes;• bronchial asthma;• nonspecific arthritis and chronic rheumatoid arthritis.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
DRUGS OF OTHER PHARMACOLOGICAL GROUPS
DRUGS OF OTHER PHARMACOLOGICAL GROUPS
This drug group consists of about 40 preparations with stable pharmaceutical demand.
The list of drugs is constantly changed and improved towards more effective preparations that have convincing factual base in the form of controlled clinical studies that comply with modern requirements.
Drugs that are manufactured by the MICROGEN subsidiaries are characterized by high quality and prices more attractive than those of the foreign analogues.
The produced preparations belong to the different groups of drugs.
NAPHTHISIN SOLUTION
nasal drops 0.1%
INN: NAPHAZOLINE
Alpha-adrenostimulating agent; topical application causes vasoconstriction in the mucosa (reduces congestion and exudation), facilitates nasal breathing during rhinitis.
Therapeutic indications.
Acute rhinitis, allergic rhinitis, sinusitis, eustachitis, laryngitis, allergic laryngeal edema,
post-radiation laryngeal edema, mucosal hyperemia after surgery on upper respiratory
tract, chronic conjunctivitis, astenotopic disorders (accomodation abnormalities in
excessive eye work), as additional medication in bacterial conjunctivitis. For epistaxis. For
rhinoscopy facilitation.
Produced in 5ml or 10ml vials; in 10ml or 20ml vial-droppers.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ekaterinburg.
PLATIPHYLLINE HYDROTARTARATE
solution for injection
Blocks m-choline receptors (similar to atropine) and also has direct myotropic spasmolytic effect. The preparation produces relaxation of smooth muscles of viscera and blood vessels, reduces gastrointestinal secretions, causes pupil dilation.
Therapeutic indications.
Gastric and duodenal ulcers, pylorospasm, intestinal, renal and hepatic colic, biliary
dyskinesia, pain syndrom in pancreatitis. Bronchial asthma; spasm of cerebral arteries;
arterial hypertension, angina pectoris (as part of combined therapy); algodysmenorrhea.
Acute inflammatory eye diseases (iritis, iridocyclitis, keratitis), eye traumas; for pupil
dilation in eye disease diagnostics and treatment.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Perm.
HEPARIN
solution for injection, 5000 units of activity/ml
INN: HEPARIN SODIUM
Direct-action anticoagulant that belongs to the group of medium-molecular weight heparins, retards fibrin formation.
Therapeutic indications.
Thrombosis of deep veins, pulmonary embolism, coronary thrombosis, thrombophlebitis,
unstable angina, acute myocardial infarction, fibrillating arrhythmia, prevention and
therapy of microthrombosis and microcirculation disruption, renal vein thrombosis,
hemolytic-uremic syndrome, mitral valvular disease (clottage prevention), bacterial
endocarditis, glomerulonephritis, lupus nephritis. Prevention of clotting in surgery with
extracorporeal blood circulation, in hemodialysis, hemosorption, peritoneal dialysis,
cytopheresis, forced diuresis, in venous catheter washing.
Prodused in 5ml ampoules or vials in packs of 5, in 1ml ampoules or vials in packs of 5 or 10,
in 2ml ampoules or vials in packs of 5 or 10.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
INHITRIL ®
lyophilizate for solution preparation for intravenous injection
INN: APROTININ
Polyvalent protease inhibitor with antiproteolytic, antifibrinolytic and hemostatic effect. The preparation inactivates main proteases (trypsin, chymotrypsin, kininogenase, kallikrein, including those that activate fibrinolysis).
Therapeutic indications.
Pancreatitis (acute and exacerbated chronic ones), pancreonecrosis. Diagnostic tests and
surgeries on pancreas (as a preventive measure against pancreas autolysis). Prevention
of acute nonspecific postoperative parotitis. Hemorrhage in hyperfibrinolytic states:
posttraumatic, postoperative, pre- and postpartum and during birth (including amniotic
fluid embolism), polymenorrhea. Angioneurotic edema. Shock (toxic, traumatic, burn
and hemorrhagic ones). Extensive and deep traumatic tissue damage. As an additional
therapy – in coagulopathies characterized by secondary hyperfibrinolysis (at initial stage,
before the effect of heparin administration and replacement of clotting factors); massive
hemorrhage (during thrombolytic therapy), in extracorporeal circulation. Prevention of
postoperative pulmonary embolisms and hemorrhages, fat embolism in multiple traumas,
especially those of lower extremities and cranial bones.
Produced in ampoules with 15 units of activity (15 units of activity = 10000 AtpU),
in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Tomsk and Omsk.
ERYTHROSTIM ®
solution for injection
INN: EPOETIN BETA
The agent stimulates erythropoiesis. Purified glycoprotein produced by genetic engineering techniques identical to human erithropoietin. Promotes red blood cell formation from precursor cells of erythrocytic series. Causes the increase in hemoglobin level and hematocrit, improves tissue blood supply and heart function. Effective in anemias connected with insufficient endogenic erythropoietin production. The most pronounced effect is observed in anemias caused by chronic renal diseases.
Therapeutic indications. Anemia:
• in chronic renal failure both after hemodialysis and before it:• after kidney transplantation;• in myeloblastosis;• with chemotherapy and radiation therapy of oncological patients;• after radiation exposure;• in neonates and premature infants;• in chemotherapy of HIV infection;• in rheumatoid arthritis.
Produced in 1ml ampoules with 500; 2000; 3000; 4000 or 10000 IU in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subdivision in Moscow.
PENTOXIFYLLINE
solution for injection, 2%
INN: PENTOXIFYLLINE
Spasmolytic, antiaggregation, angioprotective, vasodilating and improving microcirculation agent.
Therapeutic indications.
Peripheral circulation problems (atherosclerosis obliteration of limb vessels, diabetic
angiopathy, endarteritis obliterans, Raynaud's syndrome); brain circulation disruption
(ischemic stroke, cerebrovascular failure, discirculatory encephalopathy), viral
neuroinfection (prevention of possible microcirculation problems); states after myocardial
infarction; acute circulatory disruption in retina and choroid; otosclerosis, degeneration
with pathology of inner ear vessels and gradual hearing impairment: obstructive
bronchitis, bronchial asthma, pulmonary emphysema; impotence of vascular origin.
Produced in 5ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
EUPHYLLINE
solution for intravenous use
INN: AMINOPHYLLINE
Relaxes bronchial musculature, rapidly relieves bronchial spasm. Produces moderate inotropic and diuretic effect, reduces vascular resistance, reduces vascular tone (mainly in brain, skin and renal vessels), dilates coronary vessels, reduces pressure in pulmonary artery system, improves diaphragm contraction, increases mucocyliary clearance, inhibits mediator release (histamine and leukotriens) from mast cells, stimulates respiratory center, enhances adrenaline release, inhibits platelet aggregation, improves microcirculation.
Therapeutic indications.
Bronchoobstructive syndrome in bronchial asthma, bronchitis, pulmonary emphysema,
cardiac asthma (mainly for attack relief); hypertension of pulmonary circulation. Ischemic
type brain circulation disturbance (as part of complex therapy). Left ventricle failure with
bronchospasm and Cheyne-Stokes repsiration (as part of complex therapy).
Produced in 5ml or 10ml ampoules with 24mg in 1ml of solution. A pack contains 10
ampoules.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
H ANTIHISTAMINE AGENTS
DIMEDROL
solution for injection, 1%
INN: DIPHENHYDRAMINE
Antihistamine agent, blocker of H -type histamine receptors. Has antiallergic, sedative- somnolent and antiemetic action; in high doses blocks ganglia and decreases arterial pressure. Has some m-cholinoblocking effect.
Therapeutic indications.
Acute allergic reactions (urticaria, hay fever, angioneurotic edema, capillary toxicosis),
allergic conjunctivitis, acute iridocyclitis, vasomotor rhinitis, rhinosinusopathy, allegric
dermatitis, itching dermatoses. Insomnia. Pregnancy vomiting, Meniere's syndrome, sea
and motion sickness, radiation sickness. Extensive traumatic injuries of skin and soft
tissuies, hemorrhagic vasculitis, serum sickness. Premedication.
Produced in 1ml ampoules of 1% solution, in 10-ampoule packs.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiaries in Stavropol and Ufa.
RIBOXIN
solution for injection, 2%
INN: INOSINE
Has anabolic, antihypoxic and anti-arrhythmic effect. Positively influences myocardial metabolism, improves coronary circulation, inhibits platelet aggregation, stimulates regenerative processes in tissues (particularly in myocardium and gastrointestinal lining).
Therapeutic indications.
Myocardial infarction, coronary deficiency, arrhythmias; cardiomyopathies of various
etiologies, congenital and acquired heart diseases, myocarditis, coronary atherosclerosis,
glycoside intoxication, myocardial dystrophy after great physical exertions and infections
and due to endocrine disorders. Liver cirrhosis, acute and chronic hepatitis, alcohol and
drug liver damages, fatty degeneration of liver , gastric and duodenal ulcer, porphyria. Drug
poisoning; alcoholism; prophylaxis of leukopenia during radiation treatments.
Produced in 5ml or 10ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Stavropol, Ufa, Perm, Tomsk.
VITAMINS AND VITAMIN-LIKE PREPARATIONS
ASCORBIC ACID
solution for injection, 5%
INN: ASCORBIC ASID
Vitamin preparation with wide range of biological effects. Takes part in redox processes, hydrocarbon metabolism, blood clotting, tissue regeneration. Enhances immunocompetence, reduced vascular permeability, has antioxidative effect.
Therapeutic indications.
Vitamin deficiency and avitaminosis, increased vitamin C requirement (formula feeding
and intensive growth period, hard work); for immune activation; prevention of URIs;
fatigue; anemia; tissue regeneration stimulation; reconvalescence after serious ilness;
liver diseases (hepatitis A, chronic hepatitis, liver cirrhosis), GI diseases (achylia, gastric
and duodenal ulcer, especially after hemorrhage, enteritis, colitis, helminthiasis),
cholecystitis, adrenal gland hypofunction (Addison's disease), dystrophy, pregnancy and
lactation period, hemosiderosis, erythrodermia, psoriasis, chronic extensive dermatosis.
As an antioxidant the preparation is indicated in atherosclerosis, bronchial asthma,
diffuse diseases of connective tissue (rheumatoid arthritis, scleroderma); anticoagulant
overdose: poisoning by foxbane, benzocaine, aniline, disulfiram, barbiturates, benzene,
dichlorethane, potassium permanganate, methanol, arsenic, carbon oxide, prussic acid,
sulphanilamides, thallium, phenols, quinine.
Produced in 2ml ampoules in 10-ampoule packs.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Tomsk.
THIAMINE CHLORIDE
solution for injection, 5%
INN: THIAMINE
Vitamin B . As the result of phosphorylation turns into cocarboxylase that serves as a coenzyme for many enzymatic reactions. Plays an important role in carbohydrate, protein and fat metabolism as well as in transmission of synaptic stimulation.
Therapeutic indications.
Vitamin deficiency and avitaminosis of B vitamin, including patients on enteral feeding,
hemodialisis, with malabsorption syndrome. Forms part of complex therapy of burns, prologned fever, neuritis and polyneuritis, radiculitis, neuralgia, peripheral pareses and paralyses, Wernicke encephalopathy, Korsakoff's psychosis, chronic liver damages, various intoxications, myocardiodystrophy, coronary circulation disruption, gastric and duodenal ulcers, atonic constipation, intestinal atony, sprue, thyrotoxicosis, diabetes mellitus, endarteritis, dermatoses with neurotrophic lesions and dysbolism, pyodermia. The preparation is used in prolonged physical and psychological stress, during pregnance and breastfeeding, in dieting.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Perm and Tomsk.
Vitamin B . Has hemopoietic and metabolic effects. In the form of coenzyme (adenosincobalamin) this agent is a part of many enzymes. It favorably influences hepatic and cardiac function and enhances tissue regeneration.
Therapeutic indications.
Chronic anemias with vitamin B deficiency (Addison-Birmer's disease, alimentary
macrocytal anemia) as part of complex anemia therapy. Chronic hepatitis, liver cyrrhosis, liver failure. Alcoholism, prolonged fever. Polyneuritis, radiculitis, neuralgia, hypotrophy, funicular myelosis, trauma of peripheral nerves, amyotrophic lateral sclerosis, infantile cerebral paralysis, Down's syndrome. Skin diseases.
Produced in 1ml ampoules in 10-ampoule packs.
Manufacturer: MICROGEN subsidiary in Perm.
COCARBOXYLASE HYDROCHLORIDE
for injection, 0.05g
INN: COCARBOXYLASE
This substance is thiamine (vitamin B ) coenzyme, promotes acetyl-coenzyme A formation and takes part in carbohydrate metabolism regulation.
Therapeutic indications.
Cocarboxylase is prescribed in complex therapy of kidney and liver failure, diabetic
pre-coma and coma, diabetic ketoacidosis, acute and chronic cardiovascular collapse
and and arrhythmias, peripheral neuritis, various cataleptic states that require
carbohydrate metabolism improvement. For children the preparation is prescribed with
similar indications. For neonates the preparation is used in complex therapy of states
connected with hypoxia and acidosis, including asphyxia during neonatal period, hypoxic
encephalopathy, circulatory insufficiency, pneumonia, sepsis, etc.
Produced in 5ml ampoules with 0.05 g of the preparation in 10-ampoule packs. In kits with
solvent – 5 ampoules of the preparation and 5 ampoules of water for injection (2ml ampoules).
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Stavropol, Ekaterinburg, Ufa, Omsk.
NICOTINIC ACID
solution for injection, 1%
INN: NICOTINIC ACID
Vitamin and hypolipidemic agent. Takes part in the metabolism of fats, proteins, purins, in tissue respiration, glycogenolysis, synthetic processes. Makes up vitamin PP (B ) deficiency, is a specific antipellagric (vitamin PP avitaminosis) agent. Has a wide range of hypolipidemic activity. Dilates small blood vessels, improves microcirculation, produces mild anticoagulatory effect (enhances fibrinolytic blood activity).
Therapeutic indications.
Vitamin PP deficiency and avitaminosis as well as states with increased vitamin PP
requirement (pellagra, malnutrition and poorly balanced diet, malabsorption, fast weight
loss), diabetes mellitus and its complications (diabetic polyneuropathy, microangiopathy),
prolonged fever, gastroectomy, Hartnup disease, hepatobiliary diseases, hyperthyroidism,
chronic infections, pregnancy, lactation period. Primary hyperlipidemia (Types IIa, IIb,
III, IV, V), ischemic disruptions of brain circulation, obliterating diseases of blood vessels
of extremities (endarteritis obliterans, Raynaud's syndrome), spasm of blood vessels of
extremities, biliary and urinary tracts, atherosclerosis, liver diseases (acute and chronic
hepatitis), neuritis of facial nerve, hypoacid gastritis, enterocolitis, colitis, sluggish wounds
and trophic ulces.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiaries in Ufa and Perm.
GLUCOSE
solution for infusion, 5%
GLUCOSE
solution for injection, 40%
Takes part in various metabolic processes, enhances redox processes, improves antitoxic liver function. Glucose solution infusion makes up water deficit. 5% solution has detoxifying, metabolic effect, acts as a source of easily metabolized nutrition. Hypertonic solutions increase osmotic blood pressure, improve metabolism; increase myocardial contractivity; improve antitoxic liver function, dilate blood vessels, increase diuresis. Therapeutic indications.
Hypoglycemia, deficit of dietal carbohydrates, toxicoinfections, intoxications of liver
diseases (hepatitis, liver dystrophy and atrophy, including liver failure), hemorrhagic
diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse,
shock. Serves as a component of blood substitutes and anti-shock fluids; in preparing
solutions of drugs for intravenous injection.
Produced in 10ml ampoules (40% solution) in 10-ampoule packs; in 200ml vials for blood
substitutes (5% solution).
Period of validity: 6 years.
Manufacturer: MICROGEN subsidiaries in Stavropol (40% solution) and Ufa (5% solution).
CARTILAGE AND BONE TISSUE METABOLISM CORRECTORS
CHONDROLON ®
lyophilizate for injection solution preparation
INN : CHONDROITIN SULFATE
High-molecular weight mucopolysaccharide produced from cattle cartilage tissue. Inhibits degenerative processes and promotes regeneration of joint cartilage and connective tissue, increases intraarticular fluid production, reduces joint pain.
Therapeutic indications.
Degenerative diseases of joints and spine: primary arthrosis, osteoarthrosis, arthropathies,
vertebral osteochondrosis.
Produced in 100 mg ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ufa.
MINERALS AND TRACE ELEMENTS
POTASSIUM CHLORIDE
solution for injection, 4%
Potassium preparation restores fluid balance. Reduces excitation, automatism and conduction as well as cardiac contractility.
Therapeutic indications.
Hypokalemia of various genesis (including diabetes mellitus, prologned diarrhea or
vomiting, certain hypotensive and diuretic medications). Overdose of cardiac glycosides.
Arrhythmia prevention in acute myocardial infarction.
Produced in 10ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Stavropol.
CALCIUM CHLORIDE
solution for injection, 10%
Calcium preparation with antiallergic, anti-inflammatory, hemostatic, antiintoxicating effect. Replenishes the deficiency of calcium which is necessary for various biochemical and physiological processes.
Therapeutic indications.
Higher calcium requirements during growth period, lactation, pregnancy; hemorrhages
of various etiology and localization, (pulmonary, gastrointestinal, nose, uteral, etc.);
allergic diseases (serum disease, urticaria, fever syndrome, itching, angioneurotic
edema); bronchial asthma, dystrophic alimentary edema, spasmophilia, tetany, pulmonary
tuberculosis, rickets, osteomalacia, lead colic; hypoparathyroidism, hypocalcemia,
vascular hyperpermeability (hemorrhagic vasculitis, radiation sickness), parenchymatous
hepatitis, toxic hepatitis, nephritis, eclampsia, powerless labor, poisoning by magnesium
salts, oxalic and fluoric acids; paroxysmal myoplegia (hypercaliemic form); inflammatory
and exudative processes (pneumonia, pleuritis, adnexitis, endometritis, etc.); eczema,
psoriasis. Insufficient dietary calcium, calcium malabsorption (pancreas enzyme
insufficiency, achlorhydria, after gastroectomy and extensive intestinal resections) or
increased excretion (chronic diarrhea, certain diuretics and antispasmodics). As antishock
preparation in reanimation procedures in hyperkalemia, hypocalcemia or overdose of
calcium-blocking preparations; in intoxication with magnesium salts, oxalates, phosphates
or fluorides, chlorine or other irritating gases; chlororganics, radioactive phosphorus,
strontium or radium; for hypocalcemia prevention.
Produced as a 10% solution in 5 or 10ml ampoules.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Ufa.
MAGNESIUM SULPHATE
solution for injection, 25%
On parenteral administration produces sedative, hypnotic, antispasmodic, tocolytic (myometrium relaxation) effect, in high doses has general anesthetic and curare-like (inhibition of neuromuscular transmission) effect. Magnesium is calcium physiological antagonist.
Therapeutic indications.
Hypertension stroke (including that with brain edema signs), eclampsy, encephalopathy,
myocardial infarction, acute hypomagnesemia, convulsive syndrome, premature labour,
some cardiac arrhythmias, heavy metal poisoning (mercury, arsenic, tetraethyl lead).
Produced in 5 and 10ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ufa.
SODIUM CHLORIDE
isotonic solution for infusion, 0.9%
SODIUM CHLORIDE
isotonic solution for injection, 0.9%
Plasma substitute. Has antiintoxicating and rehydrating effects. Replenishes sodium ion deficit in various pathologic states.
Therapeutic indications.
Massive losses of interstitial fluid or its insufficient uptake (toxic dyspepsia, cholera,
diarrhea, uncontrollable vomiting, extensive burns with massive exudation, etc.),
hypochloremia and hyponatremia with dehydration, ileus, intoxications; irrigation of
wounds, eyes, nasal mucosa. Solution and dilution of drugs and moistening of dressings.
Produced in 5ml ampoules in 10-ampoule packs. In 200ml and 400ml vials for blood
substitutes.
Period of validity: for ampoules – 5 years, for vials – 1 year.
Manufacturer: MICROGEN subsidiaries in Ufa (vials), Stavropol, Tomsk, Perm (ampoules).
ENZYMES AND ANTIENZYMES
LYDASE
lyophilizate for injection solution preparation, 64 units
INN: HYALURONIDASE
Enzyme proteolytic agent. Possesses hyaluronidase activity, increases tissue and vascular permeability, enhances scar tissue resorption, reduces contractures.
Therapeutic indications.
Scars after burns, traumas and surgery; joint contractures, ankylosing spondilarthritis;
surface soft tissue hematomas, chronic tendovaginitis, scleroderma, sluggish trophic
ulcers. Complex therapy of myocardial infarction, hydrocephaly, rheumatoid arthritis,
arachnoiditis, bronchial asthma, allergic rhinitis, pulmonary tuberculosis. Keratitis
(for finer scarring of corneal lesions). Improves drug absorption in subcutaneous and
intramuscular injection.
Produced in ampoules of 64 units of activity in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Tomsk, Perm, Omsk, Stavropol.
LYRASE ®
lyophilized powder for injection solution preparation, 64 units
INN: HYALURONIDASE
This enzyme preparation breaks up primary component of connective tissue interstitial substance, i.e. hyaluronic acid. It increases tissue and vascular permeability, facilitates fluid motion in interspaces of tissues; reduces tissue swelling, softens and flattens scars, increases joint motion range, reduced contractures and prevents their formation.
Therapeutic indications.
Scars after burns, traumas and surgery; sluggish ulcers (including those after radiation);
Dupuytren's contractures, joint rigidity and contracture (after inflammation or traumas),
osteoatrthrosis, ankylosing spondilarthritis; severe diseases of lumbar disks; chronic
tendovaginitis, scleroderma (skin manifestations), surface soft tissue hematomas;
preparation for plastic surgery on scar contractures, myocardial infarction, hydrocephaly,
pulmonary tuberculosis (complicated by nonspecific bronchial lesions), inflammations of
upper respiratory tract and bronchi with obstruction signs. Allergic rhinitis, rheumatoid
arthritis, arachnoiditis (as part of complex therapy). Traumatic lesions of nerve plexus
and peripheral nerves (plexitis, neuritis). Improves drug absorption in subcutaneous and
intramuscular injection. Keratitis (for finer scarring of corneal lesions).
Produced in ampoules with 64 units of activity in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
TRYPSIN CRYSTALLINE
powder for solution preparation for injection and external application
Proteolytic enzyme. On topical administration promotes necrotic tissue rejection, thins purulent masses and facilitates their secretion, enhances wound regeneration. Thins viscous secretions. Therapeutic indications.
Burns, bedsores, purulent wounds, iritis and iridocyclitis; hemorrhages into anterior
chamber of the eye; respiratory tract diseases with viscous secretion and exudate
accumulation, destructive forms of pulmonary and cervical lymph nodes tuberculosis,
pneumonia, postoperation atelectasis , pleural empyema, tracheitis, bronchitis.
Produced in 10mg ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Perm and Tomsk.
CHYMOTRYPSIN
lyophilizate for solution preparation for local and external application
INN: CHYMOTRYPSIN
Proteolytic agent of protein structure. Manufactured from cattle pancreas. On intramuscular injection has antiinflammatory effect. On topical application breaks up necrotic tissues and fibrinous masses, thins viscous secretions, exudate, liquefies blood clots.
Therapeutic indications.
Thrombophlebitis, periodontosis (inflammatory-dystrophic forms), osteomyelitis, sinusitis,
otitis, iritis, iridocyclitis, intracapsular cataract extraction, hemorrhages into anterior
chamber of the eye, periorbital edema after surgery or trauma; thracheitis, bronchitis,
pleural empyema, exudative pleuritis; burns, purulent wounds, bedsores (topically).
Produced in 10mg ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
SODIUM ADENOSINETRIPHOSPHATE
solution for injection 1%
INN: TRIPHOSADENIN
Metabolic agent, natural macroenergic compound with hypotensive and antiarrhythmic action. Dilates coronary and cerebral arteries. Improves tissue metabolism and enegry supply.
Therapeutic indications.
Paroxysmal tachycardia – for rapid relief of attacks.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Perm.
SIBAZON
solution for injection 0.5%
INN: DIAZEPAM
Anxiolytic (tranquilizer) of benzodiazepine family. Decreases the level of anxiety, fear, emotional tension, also has a sedative, hypnotic, amnestic, antispasmodic and central muscle-relaxing effect. Relieves sympathoadrenal and parasympathetic (vestibular including) paroxysms. In withdrawal syndrome of chronic alcoholism produces decrease of agitation, tremor, negativism.
Therapeutic indications.
Anxiety disorders, epileptic status, insomnia. Dysphoria (combined with other medication).
Spastic states of skeletal muscles of various etiologies (in local trauma, brain and
spinal cord injuries, arthritis, arthrosis, myositis, bursitis). Vertebral syndrome, tension
headache, angina pectoris (as an adjuvant). Alcohol withdrawal syndrome. Meniere's
disease. Premedication before surgical and endoscopy procedures, general anesthesia, as
a component of combined general anesthesia. Prolonged agitation of various etiologies in
neurology and psychiatry.
Produced in 2ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
LIDOCAINE HYDROCHLORIDE
solution for injection 2%
INN: LIDOCAINE
Local anesthetic and antiarrhythmic agent of IB class. Produces membrane stabilizing effect, inhibits ectopic excitation sites in conduction system of the heart.
Therapeutic indications.
As local anesthetic – for infiltration, conduction, spinal (epidural) anesthesia in various
surgical procedures, blocking of peripheral nerves and plexuses. As antiarrhythmic agent
– in prevention and treatment of ventricular arrhythmias (tachycardia, extrasystole, flutter,
fibrillation) in myocardial infarction, anesthesia, pacemaker implantation, overdose of
cardiac glycosides.
Produced in 2ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Stavropol and Tomsk.
NOVOCAINE
solution for injection 0.5%
INN: PROCAINE
Local anesthetic. Inhibits nerve transmission of pain impulses and impulses of other modality.
Therapeutic indications.
Infiltration anesthesia in various surgical procedures; paranephral block, circulatory and
paravertebral intracutaneous block in eczema and neurodermitis.
Produced in 2 and 5ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Ekaterinburg, Perm, Stavropol, Tomsk and Ufa.
PIRACETAM
solution for injection 20%
INN: PIRACETAM
This nootropic agent has good effect on metabolic processes in the brain. Improves integrative function, promotes memory consolidation, facilitates learning, provides protection in brain injuries due to hypoxia, intoxication, electric shock. Increases efficiency of mental work, improves cerebral circulation.
Therapeutic indications.
Chronic cerebrovascular insufficiency (impairment of memory, attention, speech, vertigo,
headache); residual effects of brain circulation disruption; nervous system diseases
with reduced intellective-mnestic function and abnormalities in emotional-volitional
sphere. Neurotic syndrome, asteno-depressive syndrome of various genesis; apathetic
defective states (schizophrenia, psychoorganic syndrome); depressive states resistant
to antidepressants, low tolerance of antipsychotic medication (in order to reduce their
side effects). Alcohol withdrawal syndrome, predelirious and delirious states, morphine
withdrawal syndrome, acute poisoning with ethanol, morphine, barbiturates, benzedrine;
chronic alcoholism. Sickle-cell anemia (as part of complex therapy). In pediatrics – when
necessary to accelerate learning process and eliminate perinatal brain defects caused by
hypoxia, birth trauma, in oligophrenia, mental retardation, cerebral palsy.
Produced in 5ml ampoules in 10-ampule packs.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Perm.
CEREBROLYSATE
solution for intramuscular injection
Concentrate of biologically active neuropeptides manufactured from animal brains. Stimulates protein synthesis in neural cells, increases brain tissue resistance to toxic effects, hypoxia, hypoglycemia. Enhances integrative processes in CNS, has positive effect on cognitive and emotional spheres.
Therapeutic indications.
CNS function disorders in adults caused by disruption of cerebral circulation;
dyscirculatory encephalopathy; post-traumatic astenic syndrome. Used in complex
therapy.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ufa.
NONNARCOTIC ANALGETICS, NONSTEROID ANTI-INFLAMMATORY AGENTS
ANALGIN
solution for intravenous and intramuscular use
INN: METAMIZOL SODIUM
This nonsteroid anti-inflammatory agent, pyrazolon derivative has an analgesic, antipyretic and mild anti-inflammatory effect.
Therapeutic indications.
Pain syndrome of mild and medium intensity of various origin (headache, migraine,
toothache, neuralgia, myalgia, dysmenorrhea). Visceral pains: combined with spasmolytics
for renal, intestinal and biliary colic. Pain relief after surgical and diagnostic procedures,
traumas, burns, in decompression sickness. Febrile states in infectious inflammatory
diseases, insect bites, posttransfusion complications. Drug administration advisability is
established according to the pain intensity, character and tolerance.
Produced in 2ml ampoules of 50% solution in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
ORTOPHEN
solution for injection 2.5%
INN: DICLOPHENAC
Nonsteroid anti-inflammatory agent, phenylacetic acid derivative. Effective as anti-inflammatory, analgesic, antirheumatic, antipyretic and anti-aggregation, mostly for pains of inflammatory character.
Therapeutic indications.
Inflammatory and degenerative diseases of skeletal-muscular system: arthrites of
various genesis (rheumatic, rheumatoid, psoriatic, gouty, etc.), ankylosing spondilitis,
osteochondrosis, osteochondrosis deformans. Lumbago, sciatica, neuralgia, myalgia.
Extraarticular tissue diseases (bursitis, tendovaginitis, rheumatic lesions of soft
tissues). Posttraumatic and postoperative pain syndrome. Pain syndrome of cancer
patients (combined with other analgesics). Renal and hepatic colic. Algodysmenorrhea,
inflammatory processes in pelvis minor organs (adnexitis). Infectious inflammatory
diseases of ENT-organs with pronounced pain syndrome (as part of complex therapy):
pharyngitis, tonsillitis, otitis.
Produced in 3ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
DALARGIN
lyophilizate for injection solution preparation
This is a synthetic hexapeptide, leucine enkephaline analog. Inhibits proteolysis and facilitates gastric and duodenal ulcer healing. Possesses moderate antisecretional activity, decreases gastric juice acidity. Inhibits external pancreatic secretion in response to various irritants (food, secretin, etc.). Has mild hypotensive effect.
Therapeutic indications.
Gastric and duodenal ulcer in exacerbation stage, acute pancreatitis, acute necrotic
pancreatitis.
The preparation is injected intravenously or intramuscularly.
Ptroduced in ampoules with 0.001g of the preparation in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Perm and Ufa.
"EQUINE"-NATURAL GASTRIC jUICE
solution for oral administration
Enzyme preparation of animal origin with proteolytic effect. Contains all enzymes of gastric juices; free hydrochloric acid content equals 0.45–0.51%.
Therapeutic indications.
Achylia, hypoacidic and anacidic gastritis, dyspepsias.
Produced in 100ml vials.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiaries in Stavropol and Ufa.
The preparation contains bee glue and has anti-inflammatory, antimicrobial, antipruritic, analgesic (local) and wound healing effect.
Therapeutic indications.
Microtraumas, surface lesions of skin and mucosa, otitis, pharyngitis, tonsillitis. Catarrhal
gungivitis, aphthous stomatitis, periodontosis. Infected wounds, persistent wounds,
trophic wounds (in complex therapy). Itching dermatitis, atopic dermatitis.
Produced in 25 and 50ml vials.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Tomsk and Ufa.
DIBASOL
solution for injection 1%
INN: BENDAZOL
Vasodilating agent with direct spasmolytic action upon smooth muscles of blood vessels and internal organs; lowers arterial pressure, stimulates spinal cord function, effects moderate immunostimulation. Therapeutic indications.
Spasm of peripheral arteries, coronary spasm, arterial hypertension (including hypertensive
stroke); smooth muscle spasm of internal organs; gastric and duodenal ulcer, intestinal,
renal and hepatic colic; residual effects of poliomyelitis, facial nerve peripheral paralysis,
polyneuritis.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 4 years.
Manufacturer: MICROGEN subsidiaries in Stavropol and Ufa.
PAPAVERINE HYDROCHLORIDE
solution for injection 2%
Spasmolytic hypotensive agent causing relaxation of smooth muscles of internal organs and blood vessels.
Therapeutic indications.
Spasm of smooth muscles of abdominal organs (hepatic colic, pylorospasm, renal colic),
of peripheral vessels (endarteritis), coronary vessels. Angina pectoris (as part of complex
therapy). Bronchial spasm (mild manifestation). For premedication in combination with
other preparations.
Produced in 2ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Stavropol, Perm and Ufa.
NITROGLYCERIN
solution for injection 0.1%
Antianginal, vasodilatory, coronary vasodilatory agent of nitrate group. Relaxes smooth muscles of blood vessels (mostly veins), bronchi, gastrointestinal organs, ureters. Produces fast reduction of myocardium oxygen requirement (by means of reduction of cardiac preload and afterload).
Therapeutic indications.
Acute myocardial infarction, unstable and postinfarction angina, angina pectoris refractory
to other therapies, central retinal artery occlusion.
Produced in 10ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Stavropol.
AGENTS AFFECTING PROSTATE METABOLISM
PROSTACOR ®
lyophilized powder for injection solution preparation
Extract of cattle prostate with positive organotropic effect on human prostate (reduces swelling, leukocytal infiltration and venule thrombosis, normalizes secretory function of epithelial cells), stimulates muscle tone of the bladder, has antiaggregant effect.
Therapeutic indications.
Chronic prostatitis (in complex therapy); after prostate surgery.
Produced in ampoules with 5mg of active agent in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Ufa.
OXYTOCIN
solution for injection 5 IU/ml
INN: OXYTOCIN
Synthetic polypeptide analogue of the hormone of the posterior lobe of the pituitary that increases the uterine tonus, stimulates labor and has lactotropic effect.
Therapeutic indications.
Primary or secondary uterine inertia, necessity of pre-term birth due to gestosis, rhesus
incompatibility, fetal death; postmature pregnancy (for labor induction), early moving
of waters, labor with pelvic presentation, cesarean section (during operation). Uterine
hypotonia after birth or abortion. Postpartum hypolactation. Painful premenstrual
syndrome with edema and body weight increase.
Produced in 1ml (5 IU) ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Ufa.
GENTAMYCIN SULPHATE
solution for injection 4%
INN: GENTAMYCIN
Wide-range antibiotic of the animoglycoside group, inhibitor of intracellular protein synthesis. Has bactericidal properties: in high concentrations reduces barrier functions of cytoplasmic membrane and cause microorganism destruction. Bacterial resistance to gentamycin develops slowly, however, strains resistant to neomycin and canamycin can also demonstrate resistance to gentamycin. It does not affect fungi, viruses and protozoa.
Therapeutic indications.
Bacterial infections caused by sensitive microflora: upper and lower respiratory
infections (bronchitis, pneumonia, pleural empyema), complicated urogenitary infections
(pyelonephritis, cistitis, urethritis, prostatitis, gonorrhea, endometritis), infections of
bones and joins, infections of skin and soft tissues, abdominal infections (peritonitis,
pelvioperitonitis), CNS infections (meningitis, etc.) sepsis, wound infection, burn infection,
otitis.
Produced in 2ml ampules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
LINCOMYCIN
solution for injection 30%
INN: LINCOMYCIN
Antibarterial agent, antibiotic of lincosamide group. Inhibits protein synthesis in bacterial cells. Effective mostly against aerobic gram-positive bacteria (staphylococci, including those resistant to several other antibiotics, streptococci, pneumococci, diphtheria bacillus) as well as clostridia, bacteroides, mycoplasmas. Lincomycin resistance develops slowly.
Therapeutic indications.
Bacterial infections caused by sensitive microorganisms: sepsis, subacute septic
endocarditis, chronic pneumonia, pulmonary abscess, pleural empyema, pleuritis,
otitis, osteomyelitis (acute and chronic), purulent arthritis, postoperative purulent
complications, wound infection, infections of skin and soft tissues (pyodermia,
furunculosis, phlegmon, erysipelas).
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Tomsk.
WATER FOR INjECTION
solution for injection preparation
Used as a carrier or dosing vehicle for preparation of sterile infusion (injection) solutions from powders, lyophilizates and concentrates.
Used in preparation of sterile solutions for subcutaneous,
intramuscular, intravenous and other injections.
Produced in 2 or 5ml ampoules in 10-ampoule packs.
Period of validity: 4 years.
Manufacturer: MICROGEN subsidiaries in Tomsk (2ml ampoules) and Stavropol (2 and 5ml
ampoules).
DIAGNOSTIC IMMUNOBIOLOGICAL AGENTS
DIAGNOSTIC IMMUNOBIOLOGICAL AGENTS
Modern diagnostics of infectious diseases requires new techniques that could allow to determine the genus, species or strain of the pathogen with high specificity, reliability and reproducibility.
At present the MICROGEN facilities produce standardized diagnostic microbiological preparations that make it possible to diagnose most of the widespread and dangerous infections, which comprise viral, ricketsial, salmonellial, shigellial, tularemic, chlamidic and some other diagnosticums. The diagnosticum action is based on serological test methods where specific reactions result in antigen-antibody complexes with the subsequent visualized agglutination and precipitation.
Microtest systems for the biochemical microorganism identification are systems of rapid diagnosing of infectious diseases used for differentiation of various pathogen groups. Microtest systems ensure reliability, constancy and comparability of bacteriologic test results with minimal labor expenditure. The reliability of these handy and simple testing is 98% and more.
A microtest system is disposable and consists of a polystyrene container with compartments. The bottom part of it is filled with dehydrated (dried in place) culture medium without agar. The tablet is freed from the film and bacteriologic inoculation is performed. After several hours of incubation the microorganisms can be identified according to the color map.
The immunobiologic diagnostic means also include preparations for disgnosis and therapy of allergic diseases – allergens and allergoids as well as the immunoenzyme allergodiagnostic systems.
ALLERGENS AND ALLERGOIDS
The MICROGEN company is the sole producer of pollen allergen preparation in The Russian Federation. According to leading diagnosticians and clinicians in the field of the diagnostics and therapy of allergic diseases, the allergens offered by the company possess high specific activity wich ensures their diagnistic and therapeutic efficiency in skin tests and specific hyposensitization procedures. The Stavropol MICROGEN subsidiary offers a wide range of pollen allergens and allergoids of the most common in Russia plants: Allergens from tree pollens: birch, oak, maple, alder, hazel and ash for diagnosis and therapy.
Allergens from pollens of wild and cultivated grasses: orchard grass, sheave, maize, fox-tail, fowl-grass, fescue, bent, couch-grass, ryegrass, rye, timothy-grass and dandelion.
Allergens from weed pollens: ambrosia (ragweed), wormwood, goose-foot, hemp, cycla-hen, dandelion and sunflower.
Mixt-allergen from tree pollens (birch, oak, maple, alder, hazel and ash) for diagnosis and therapy.
Mixt-allergen from pollens of wild grasses (timothy-grass, orchard grass, ryegrass sheave, fescue, fowl-grass, couch-grass, foxtail) for diagnosis and therapy.
Mixt-allergen from weed pollens: ambrosia, wormwood, goose-foot and sunflower for diagnosis and therapy.
Allergoids from wild grass (orchard grass, fecque, timothy-grass) and weed (ambrosia, wormwood) pollens for therapy.
Mixt-allergoid of pollen orchard grass, fescue and timothy-grass for therapy.
Mixt-allergoid of pollen alder, birch, hazel for therapy.
Besides pollen allergoids MICROGEN produces house dust allergoid for the therapy of patients with house dust allergy. Allergen preparations are water-salt extracts of plant pollen, their active substance being the protein-polysaccharide complex that provides for specific diagnostics and therapy of allergic diseases. The allergen ability to interact with specific antibodies (reagins) of pollinosis patient and cause reaction of the sensitized organism is the basis of the preparation diagnostic potential in both diagnostic tests in vivo and reactions in vitro. For diagnosis the preparation is used in skin tests (by scarification, intracutaneously and by prick test) as well as in challenge tests (nasal, conjunctival, inhalation). Among laboratory test methods are immunoenzymic, immunofluorescent analyses as well as the reaction of non-direct degranulation of rat mast cells.
The organism ability to form immunologic tolerancy in response to small doses of allergen is the basis for the use of these preparation in the therapy of allergic diseases (allergic rhinitis, bronchial asthma). Prolonged specific stimulation of the patient's immune system by subcutaneous administration of small doses of allergen produces hyposensitizing effect by means of production of blocking antibodies and results in the control of the disease.
Produced in kits for diagnosis and therapy: 1 vial with 5 ml of allergen (10000 PNU/ml), 1 vial
with 4.5 ml of test-control fluid, 7 vials of diluent (4.5 ml each), 1 empty sterile vial.
Period of validity: 2 years.
Allergoids differ from allergens in that the protein-polysaccharide complex extracted from the defatted pollen of a plant has been subjected to mild processing with formaldehyde. This process results in the protein molecule agglomeration and blocking of some portion of allergen determinants, the preparation possessing a reduced allergenicity but retaining its immunogenic properties. Allergoids can produce great therapeutic effect with less frequent administration than allergens do, causing fewer side effects even in hypersensitive patients. This allows to give higher doses of the preparation in shorter time periods and to greatly increase the allergoid total dose of the patient (as compared to immunotherapy with the corresponding allergen).
As well as allergens, allergoids are used in specific immunotherapy of patients with allergic rhinitis and bronchial asthma sensitive to a plant pollen or house dust.
Mixt-allergens are produced in kits that contain 5ml of the mixt-allergen (10000 PNU/ml) in two
vials, 4.5ml of diluent in seven vials and 4.5 ml of test-control fluid in one vial.
Mixt-allergoids are produced in kits that contain one 5ml vial of the allergoid (10000 PNU/ml),
eight 5ml vials of diluent and 1 empty sterile vial.
Period of validity: 2 years.
Allergens and allergoids are administered subcutaneously in the upper third of the shoulder.
The use of mixt-allergens is especially convenient in screening diagnosis and specific
immunotherapy in polyvalent sensitization, and the use of allergoids makes possible speedy
specific pre-seasonal therapy even of the highly sensitive patients without the risk of increased
allergic complications.
The allergic preparation nomenclature is being constantly increased. New commercial products
include the mixt-allergoid of pollens of alder, birch, hazel as well as the mixt-allergoid of pollen
of orchard grass, fescue and timothy-grass for therapy.
Manufacturer: MICROGEN subsidiary in Stavropol.
Besides the allergens used for diagnosis and treatment of atopic diseases, MICROGEN produces infectious allergens for tularemia and brucellosis diagnosis.
BRUCELLOSIS ALLERGEN, FOR INTRACUTANEOUS ADMINISTRATION, LIQUID
Used for specific diagnosis of heightened sensitivity to brucella.
Produced in 1ml ampoules (10 doses) in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Omsk.
TULAREMIA ALLERGEN, FOR EPICUTANEOUS ADMINISTRATION, LIQUID (TULARIN)
suspension for external scarification application
Used to determine immunity against tularemia and the disease diagnostics.
Prodused in 1ml ampoules (20 doses) in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Omsk.
PREPARATION FOR SERUM DIAGNOSTICS OF INFECTIOUS DISEASES
DIPHTHERIA ANTITOXIN, PURIFIED BY ENZYMOLYSIS AND SPECIFIC SORPTION, DRY
powder for diagnostics
Contains antibodies isolated by immunosorption-desorption on immobilized diphtheria toxoid from horse diphtheria serum, liquid, concentrated.
Used for the determination of diphtheria germ
toxicogenity in precipitation reaction in dense gel.
Produced in 1ml ampoules (minimum 500 IU) in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Perm.
TULAREMIA DIAGNOSTICUM FOR BULK AND BLOOD-DROP AGGLUTINATION REACTION,
In agglutination reaction minimal 2/3 volume of diluted serum titer should be agglutinated with diagnostic tularemic serum (serum titer should not be less than 1:1600). In blood-drop agglutination reaction (with serum blood content of agglutinins in 1:100 titer and more) after mixing of the hemolysed blood with tularemia diagnosticum the reaction should be immediate.
Used for serum diagnostics of tularemia and discovery of specific
antibodies in immunized persons or in those who had tularemia.
Produced in 1ml ampoules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Omsk.
RICKETTSIA PROWAZEKII DIAGNOSTICUM FOR COMPLEMENT FIXATION TEST (CFT), DRY
lyophilizate for diagnosis
Lyophilized antigen complexes inactivated by phenol.
Used for serum diagnostics of epidemic typhus and Brill's disease.
Produced: diagnosticum-lyophilizate in 0.5ml ampoules and immune serum in 0.1ml ampoules
in packs with 10 diagnosticum ampoules and 3 serum ampoules.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Perm.
RICKETTSIA SIBERICA DIAGNOSTICUM FOR CFT, DRY
lyophilizate for diagnosis
Lyophilized antigen complexes isolated by ether treatment from Rickettsia siberica grown in yolk sacs of developing chick embryos and inactivated by phenol.
Used for serum diagnostics of Siberian tick typhus of North Asia.
Produced: diagnosticum in 1ml ampoules; serum in 0.1ml ampoules in packs with
10 diagnosticum ampoules and 3 ampoules of serum.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Perm.
RICKETTSIA TYPHI DIAGNOSTICUM FOR CFT
lyophilizate for diagnosis
Lyophilized antigen complexes isolated by ether treatment from Rickettsia typhi virulent strain "Isahanian" grown in yolk sacs of chick embryos and inactivated by phenol. The preparation working dilution contains not less then 4 antigen units in 1ml.
The diagnosticum reveals complement-fixating
antibodies against endemic flea-born typhus.
Produced: diagnosticum in 0.5ml ampoules; serum in 0.1ml ampoules in packs with
10 diagnosticum ampoules and 3 ampoules of serum.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Perm.
CHLAMYDIA DIAGNOSTICUN FOR CFT AND INDIRECT-CFT, DRY
diagnostic multicomponent kit
Lyophilized specific antigen complexes of Chlamydia psittaci isolated by ether-acetone extraction from warmed at 1000C homogenate of yolk sacs of chick embryos infected by Chlamydia psittaci.
Used for serum diagnostics of chlamydia infections of
people and animals (including birds) by the detection of
serum chlamydia antibodies in CFT and indirect-CFT.
Produced: dry chlamydia diagnosticum in 0.5ml ampoules with control diagnosticum in
ampoules and chlamydia serum in ampoules. The kit contains 3 ampoules of chlamydia
diagnosticum, 3 ampoules of control diagnosticum and 2 ampoules of chlamydia serum.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Perm.
SALMONELLOSIS ERYTHROCYTAL DIAGNOSTICUM, Vi-ANTIGEN, LIQUID
diagnostic suspension
The active agent of the diagnosticum is Vi-antigen fixed on erythrocyte surface. On contact with serums that contain antibodies against Vi-antigen erythrocytal agglutination occurs.
Used for detecting antibodies against Vi-antigen of Salmonella
typhi in human blood in passive hemoagglutination reaction.
Produced in 20ml ampoules in packs with 5 diagnosticum ampoules and 1 ampoule of
diagnostic salmonellosis serum adsorbed receptor-Vi, liquid.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Moscow.
SALMONELLOSIS ERYTHROCYTAL DIAGNOSTICUM, O-ANTIGEN, LIQUID
diagnostic suspension
The active agent of the diagnosticum are specific salmonella antigens fixed on erythrocyte surface. On interaction with serums containing antibodies against salmonellae erythrocytal agglutination occurs. O-antigen diagnosticums are produced for basic serum groups: A(1, 2, 12); B(1, 4, 12); C1(6, 7); C2(6, 8); D(1, 9, 12); E(3,10) as well as complex salmonellosis diagnosticum 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12.
Used for detection of antibodies against salmonellial O-antigens
in human blood by means of passive agglutination reaction.
Produced in 20ml ampoules in packs with 4 ampoules of diagnosticum of one serum group
and 1 ampoule (1ml) with homologous diagnostic unadsorbed salmonellosis serum for passive
hemagglutination reaction (PHAR); or with 4 ampoules with the complex diagnosticum and
6 ampoules (1ml) of diagnostic nonadsorbed salmonellosis serum for PHAR for separate
O serum groups and 1 ampoule (20ml) with 1% suspension of non-sensitized ram erythrocytes
(control).
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Moscow.
SHIGELLOSIS ERYTHROCYTAL DIAGNOSTICUMS: DISENTERY ; ; -; FLEXNERI -;
FLEXNERI  AND SONNEI, ANTIGENIC, LIQUID
diagnostic suspension
Suspension of formalinized ram erythrocytes sensitized by Shigella liposaccharide antigens in phosphate buffer solution. Formalin is used as a preservative. The active part of the diagnosticum are specific Shigella antigens fixed on erythrocyte surface. On contact with serums that contain antibodies against shigallae the erythrocyte agglutination phenomenon (PHAR) occurs.
Used for detection of specific antibodies against various shigella
types in passive hemagglutination reaction (PHAR).
Produced in 20ml ampoules. A pack contains 4 ampoules of diagnosticum and 1 ampoule with
1% nonsensitized formalinized ram erythrocytes (control erythrocytes), 1 ampoule (1ml) with
dry nonadsorbed diagnostic shigellosis serum.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Moscow.
MENINGOCOCCAL ERYTHROCYTAL IMMUNODIAGNOSTICUMS, POLYSACCHARIDAL OF
A, B, C, X, Y, Z, W- GROUPS AND LIPOSACCHARIDAL SPECIES-SPECIFIC, LIQUID
diagnostic suspension
1% suspension of human erythrocytes of 0 (1) blood type formalinized in phosphate buffer solution and sensitized by group-specific meningococcal antigens of serum groups A, B, C, X, Y, Z, W-135. Formalin is used as a preservative. The active part of the diagnosticum are meningococcal antigens of serum groups A, B, C, X, Y, Z, W-135 fixed on erythrocyte surface. On contact with serums that contain antibodies against the above-mentioned antigens the erythrocyte agglutination phenomenon (PHAR) occurs.
Used for detection of specific antibodies against
polysaccharide meningococcal antigens in human blood
serums in passive hemagglutination reaction (PHAR).
Produced in 20ml ampoules in 5-ampoule packs. The pack also contains 1 ampoule (1ml) of
homologous meningococcal diagnostic serum.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Moscow.
IMMUNOGLOBULIN ERYTHROCYTAL IMMUNODIAGNOSTICUMS FOR DETECTION OF SURFACE
ANTIGEN OF HEPATITIS B VIRUS (HBs-Ag), DRY "ROPGA-HBs-Ag"
diagnostic kit for 450 tests
A kit contains lyophilized chicken erythrocytes sensitized by goat antibodies (anti-HBs), reactants for test confirmation (Ig-1, Ig-2), and positive control specimen (C+).
Used for rapid detection of HBs-Ag in the blood serum of donors, patients with
hepatitis B, medical personnel and other persons for carrier determination by means
of reverse passive hemoagglutination reaction (RPHAR). Minimal detectible HBs-Ag
concentration is 0 ng/ml and higher, while test time does not exceed 0 minutes.
The kit for 400 tests and specificity confirmation of 50 specimens consists of 6 ampoules
of sensitized erythrocytes, 2 Ig-1 ampoules, 2 Ig-2 ampoules, 1 C+ ampoule, ampoule blade
and instruction.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
COMPLEMENT, DRY
lyophilizate for diagnostics
Has the property of adsorbing on antigen-antibody complex.
Used as an ingredient in complement fixation test (CFT).
Produced in 1ml ampoules in 10-ampoule packs; or in 5ml vials in 4-vial packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiaries in Tomsk, Perm and Ufa.
MICROTEST SYSTEMS FOR BIOCHEMICAL IDENTIFICATION OF MICROORGANISMS
Manufacturer: MICROGEN subsidiary in Makhachkala.
MICROTEST SYSTEM FOR BIOCHEMICAL IDENTIFICATION OF VIBRIOS (MTS-V)
Used for detection of enzyme activity of Vibrio genus
microorganisms and species identification
Produced in 10-container polyethylene packages. container has 12 isolated compartments
filled with substrate-indicator culture medium. The color of compartment contents depends on
the indicator used and substrate pH.
Period of validity: 1 year.
MICROTEST SYSTEM FOR BIOCHEMICAL IDENTIFICATION OF DIPHTHERIA CORYNEBACTERIA
Used for detection of biochemical activity of corynebacteria by
testing glucose, saccharose and starch utilization and urease
presence and for their differentiation by species.
Produced in 10-container polyethylene packages. The container is 88x13x14 mm large and
has 12 isolated compartments with dry culture substrate. Their numbers are marked on the
container wall.
Period of validity: 1 year.
MICROTEST SYSTEM FOR RAPID DETECTION OF ENZYME ACTIVITY OF ENTEROBACTERIACEAE
MTS compartments contain dried culture media with different hydrocarbons.
The MTS hydrocarbons are: glucose, lactose, saccharose,
mannitol, maltose. MTS-E is intended for the detection of
Enterobacteria family isolated during bacteriologic testing.
Produced in 10-container polyethylene packages. The container is 88x13x14 mm large and has
12 isolated compartments filled with substrate-indicator culture medium. One container holds
2 similar hydrocarbon lines.
Period of validity: 1 year.
MICROTEST SYSTEM FOR BIOCHEMICAL IDENTIFICATION OF ENTEROBACTERIACEAE
Used for detection of biochemical activity of enterobacteria by
means of  tests: utilization of sodium citrate, mannitol, sodium
malonate, glucose, lactose, production of hydrogen sulphide,
indol, presence of urease, β-galactosidase, lysine decarboxylase,
phenylalanine deaminase and for their differentiation by species.
Produced in 10-container polyethylene packages. The container is 88x13x14 mm large and
has 12 isolated compartments with dry culture substrate. Their numbers are marked on the
container wall.
Period of validity: 1 year.
MICROTEST SYSTEM FOR BIOCHEMICAL IDENTIFICATION OF STAPHYLOCCOCCI (MTS-S)
Used for detection of biochemical activity of staphylococci
by means of  tests: fermentation of glucose and mannitol,
oxydation of glucose and mannitol, utilization of lactose, xylose,
saccharose, maltose, mannose, galactose, presence of urease,
arginindehydrolase and for their differentiation by species.
Produced in 10-container polyethylene packages. The container has 12 isolated compartments
with substrate-indicator culture media that contain one of the test-indicators.
Period of validity: 1 year.
MICROTEST SYSTEM FOR RAPID IDENTIFICATION OF VIBRIO GROUPS BY HEIBERG TEST
Used for detection of vibrio enzyme activity and their
differentiation according to enzyme groups (Heiberg test).
Produced in 10-container polyethylene packages. The container has 12 isolated compartments
with substrate-indicator culture media that contain one of the test-indicators: D-saccharose,
D-mannose, L(+)-arabinose. Each container has 3 similar hydrocarbon lines with
compartments.
Period of validity: 1 year.
PAPER INDICATOR SYSTEMS (PIS) FOR MICROORGANISM IDENTIFICATION
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
KIT №.
PIS for vibrio identification (13 tests)
Used for Vibrio genus identification and rapid cholera diagnosis.
Allows to determine the following biochemical properties: utilization of glucose, lactose,
saccharose, mannose, arabinase, mannitol, inositol; presence of lysine and ornitine
decarboxylase, arginine dehydrolase, usease, oxydase; indole production.
KIT №.
PIS for intergenetic and speicies identification of enterobacteriaceae (13 tests).
Used for identification of microorganisms of
Enterobecteria family by genus and species.
Allows to determine the following biochemical properties: utilization of sorbitol, inositol,
sodium citrate, sodium malonate; presence of lysine and ornitine decarboxylase,
β-galactosidase, urease, phenylalanindeaminase, oxydase, acetylmethyl-carbinol (Foges-Proskauer reaction); production of indole and hydrogen sulphide.
KIT №.
PIS for water coli-index determination (2 tests).
Used for bacteriologic sanitary water monitoring: to determine the
presence of Enterobecteria family in water by titration technique.
Allows to determine the following biochemical properties: glucose utilization and oxydase
presence.
KIT №.
PIS for bacteriologic sanitary water monitoring (3 tests).
Used for bacteriologic sanitary drinking water monitoring: to
determine the presence of Enterobecteria family and heat tolerant
coliform bacteria in water by membrane filtration technique.
Allows to determine the following biochemical properties: glucose and lactose utilization
and oxydase presence.
KIT №.
PIS for diphtheria corynebacteria identification (4 tests).
Used for the determination of biochemical properties of
diphtheria corynebacteria isolated during bacteriological
testing and their biologic variant identification.
Allows to determine the following biochemical properties: utilization of glucose,
saccharose and starch and urease presence. Disk is placed in the test tube with the proper
testing medium (0.9% solution of sodium chloride, phosphate-salt buffer) where a full
loop of 24-hour agar culture is suspended and incubated at +370C. Reaction is recorded
according to the color change of the substrate solution.
PIS are produced in the form of slips in test tubes, disks in vials, 50 or 100 pieces for 50 or 100
tests respectively. On the consumer request kits №1 and №2 are supplemented by phosphate-
salt buffer solution pH 5.4–5.6.
Period of validity: 2 years.
IMMUNOENZYME TEST SYSTEMS
TEST SYSTEMS FOR VIRAL INFECTION DIAGNOSIS
These test systems are reactant kits for enzyme immunoassay (EIA) supplemented by polystyrene tablet with indentations where synthetic or recombinant viral antigens or viral-specific monoclonal antibodies are sorbed. Test systems manufactured by MICROGEN are intended for the detection of viral hepatitis B and C and tick-borne encephalitis. Test kits for the detection of hepatitis antigens and antibodies against these viruses are used mainly in screening of donors and risk groups in laboratories of hemotransfusion stations, State Health Monitoring centres and AIDS centres.
Test system for tick-borne encephalitis diagnosis allows to detect the antigen of tick-born encaphalitis virus in suspension of carriers (ticks) as well as in the blood of persons with the disease and in the blood and organ suspension of laboratory animals, culture fluid and infected cell cultures.
Immunoassay enzyme systems are highly sensitive and specific, are user-friendly and are widely used in virologic tests.
ENZYME IMMUNOASSAY SYSTEM FOR HEPATITIS B VIRUS SURFACE ANTIGEN DETECTION
(EIA-HBs-Ag)
kit №1, kit №2, diagnostic kit
Kit №
is aimed at detecting hepatitis B virus sufrace antigen (HBs-Ag) in blood serum and plasma
of donors, hepatitis B patients, and persons from risk groups.
Kit №
is additionally provided with reactants for the confirmation of positive result specificity
and therefore can be used both for screening purposes similar to Kit №1, and for
confirmation test. It allows to make either 192 screening tests or 96 confirmation tests.
The system can detect and confirm the specificity of positive results for specimens with
HBs-Ag concentrations of 0.5 ng/ml and higher.
Period of validity: 6 months.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
ENZYME IMMUNOASSAY SYSTEM FOR HEPATITIS C ANTIGEN DETECTION (EIA-anti-HCV)
kit for 192 tests (kit C-04), strips
Allows to detect antibodies against hepatitis C virus in blood
serum or plasma of donors and patients with hepatitis C.
Test system sensitivity and specificity is 100% when a standard serum panel of serums
for hepatitis C virus antibodies certified by the State Research Facility named
after L.A.Tarasevich is used.
Period of validity: 6 months.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
ENZYME IMMUNOASSAY SYSTEM FOR THE CONFIRMATION OF POSITIVE RESULTS IN
TESTING FOR HEPATITIS C VIRUS ANTIBODIES "SPECTRUM-"
diagnostic kit for 48 specimens
Intended for the confirmation of positive immunoassay
for hepatitis C virus antibodies in blood serum and
plasma of donors and patients with hepatitis C.
Test system sensitivity and specificity is 100% when a standard serum panel of serums
for hepatitis C virus antibodies certified by the State Research Facility named
after L.A.Tarasevich is used.
Period of validity: 6 months.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
ENZYME IMMUNOASSAY SYSTEM FOR THE DETECTION OF CLASS IgM ANTIBODIES AGAINST
HEPATITIS C VIRUS (EIA-HCV-IgM)
diagnostic kit
The test system is intended for detection of class IgM
antibodies against hepatitis C virus in in blood serum and
plasma of donors and patients with hepatitis C. The kit
allows to test  specimens including control ones.
Test system sensitivity and specificity is 100% when a standard serum panel of serums
for hepatitis C virus antibodies certified by the State Research Facility named
after L.A.Tarasevich is used. Test duration is not longer than 1.5 hours.
Period of validity: 6 months.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
ENZYME IMMUNOASSAY SYSTEM FOR THE DETECTION OF VIRUS ANTIGEN OF
THE TICK-BORNE ENCEPHALITIS
diagnostic kit, kit №1 – 176 tests, kit №2 – 98 tests, including controls
Used for detection of antigens of virus tick-borne encephalitis
in carrier suspensions (ticks) as well as in ill person blood,
in blood and organ suspension of infected laboratory animals,
culture broth of infected cell cultures. Produced in kits.
Period of validity: of kit №1 – 12 months, kit №2 – 6 months.
Manufacturer: MICROGEN subsidiary in Tomsk.
IMMUNOENZIME ALLERGODIAGNOSTIC TEST SYSTEMS
Manufacturer: MICROGEN subsidiary in Stavropol.
Allergodiagnostic test systems are used in the specific diagnosis complex for allergic diseases (bronchial asthma, atopic dermatitis, etc.).
ENZYME IMMUNOASSAY SYSTEM FOR THE DETERMINATION OF ALLERGEN SPECIFIC
Is intended for semi-quantitative detection of allergen-specific IgE
antibodies in blood serum by means of solid-phase immunoenzyme assay.
Allows testing with the 0 most common allergens
with blood serums of eight patients.
The following standard allergen panels are offered: chicken egg white The kit consists of three plates with sorbed allergens and reactant set for testing.
Period of validity: 6 months.
OTHER DIAGNOSTIC PREPARATIONS
RABBIT PLASMA, CITRATED, DRY
lyophilizate for diagnosis
This preparation is a vacuum lyophilizate of citrated rabbit plasma obtained from rabbit blood by means of mixing it with 5% solution of sodium citrate. Rabbit plasma of 1:5 dilution should clot on contact with (18+2)hour culture of coagulase-positive staphylococci and should not clot when mixed with coagulase-negative staphylococci.
Intended for identification of staphilococcal
species in plasmocoagulation reaction.
Produced in 1ml ampules in 10-ampoule packs.
Period of validity: 2 years.
Manufacturer: MICROGEN subsidiaries in Stavropol and Tomsk.
BOTULINIC SERUMS OF A, B, C, E, F TYPES, NATIVE, HORSE OR CATTLE, FOR BIOLOGIC
NEUTRALISING REACTION, DIAGNOSTIC, DRY
diagnostic kits
These preparations are produced from the blood of horses hyperimmunized with botulinic monoatoxins and toxins of the respective types.
Intended for diagnosis and identification of botulism pathogen type.
Am ampoule contains not less than 200 IU for type A, 100 IU for type B, 150 IU for type C,
200 IU for type E, 200 IU for type F.
Produced in 1ml ampoules in 5-ampoule packs.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Stavropol.
DIAGNOSTIC MONOSPECIFIC SERUMS AGAINST HUMAN IgG(H+L), IgG(H), IgM(H),
IgA(H), DRY
lyophilizate for diagnosis
These are blood serums of rabbits, goats or sheep that were hyperimmunized by human immunoglobulins IgG, IgM, IgA and containing antibodies against heavy chains of the respective immunoglobulins. The serum against IgG(H+L) also contains antibodies against light immunoglobulin chains. Control serum is a mixture of human blood serums (not less than 500 donors) with the set content of immunoglobulins IgG, IgM, IgA.
Monospecific serums are intended for qualitative and
quantitative detection of the respective immunoglobulins in
norm and pathology in serum products and biologic fluids.
The serums are used for diagnosis of various diseases as well as the assesment of
immunoglobulin content of immunologically active preparations produced from human
blood.
Produced in dry form in 1ml ampoules. A kit consists of 3 ampoules of each serum type
against IgG(H+L), IgG(H), IgM(H), IgA(H) and one ampoule of control human blood serum
(10 ampoules altogether).
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
DIAGNOSTIC MONOSPECIFIC SERUMS AGAINST KAPPA AND LAMBDA CHAINS OF HUMAN
IMMUNOGLOBULINS, DRY
lyophilizate for diagnosis
The preparations are manufactured from the blood of sheep, goats or rabbits immunized by normal IgG, myelogenic human IgG, or Bence Jones proteins (kappa and lambda types) containing antibodies against light chains of immunoglobulins.
Intended for qualitative and quantitative detection of the
respective immunoglobulin type proportion in blood serum and
free light chains (Bence jones proteins) in human urine.
Monospecific serums against kappa and lambda chains of human immunoglobulins for
qualitative test are used in immunoelectrophoresis and precipitation reaction; and for
quantitative assessment of kappa and lambda immunoglobulin types – in reaction of radial
immunodiffusion in gel.
Produced in dry form in 1ml ampoules in kits of one ampoule of each serum type (2 ampoules
altogether).
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
SERUM FOR IMMUNOELECTROPHORESIS AGAINST SERUM PROTEINS OF HUMAN BLOOD,
Blood serum product from sheep or rabbits hyperimmunized by normal serum of human blood. In reaction of immunoelectrophoresis with normal human blood serum it should demonstrate not less than 15 precipitin lines. They are detected visually.
Intended for immunoelectrophoretic assay of immunoglobulins and
other proteins in serum products and biologic fluids, as well as for the
control of commercial preparations produced from human blood serum.
Produced in dry form in 1ml ampoules in 10-ampoule packs.
Period of validity: 3 years.
Manufacturer: MICROGEN subsidiary in Nizhny Novgorod.
CATTLE BLOOD SERUM FOR CULTURES, DRY
lyophilizate for the preparation of diagnostic solutions
Growth-stimulating component of culture media for cell cultures.
Lyophilized cream colored porous mass; hygroscopic, sterile.
Produced in 500ml glass bottles containing 200g of the serum.
Period of validity: 5 years.
Manufacturer: MICROGEN subsidiary in Ekaterinburg.
CATTLE BLOOD SERUM FOR CULTURES, LIQUID
diagnostic solution
This native serum is produced from cattle blood by means of clotting, decanting of blood clots and erythrocytes and subsequent sterilizing filtration.
Used as a growth-stimulating component of culture media for
cell cultures. Added to the culture medium in quantities from  to
0% depending on the cell type and culturing conditions.
Produced in 400ml glass bottles.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Ekaterinburg.
Microbiologic studies play an important part in diagnosis and modern therapy of infectious diseases as well as in bacteriologic sanitary monitoring of environment.
The most important stage of the microbiologic study is pathogen isolation and identification, the use of culture media for the determination of genus, species and type of a microorganism.
Culture media (CM) are biologic preparations used for growing microorganism cultures and studying their morphological, cultural and biochemical properties, susceptibility to bacteriophages and antibacterial agents, including antibiotics.
CM are complex multicomponent systems that contain a substrate that acts as a source of nitrous supply and organic and inorganic elements.
The substrate (base) is formed by a protein hydrolysate, the product of protein breakup. To it growth factor or vitamin source (yeast extract) is added. Gelforming agar serves as a skeleton and influences microorganism growth. Depending on the CM purpose it is mixed with carbohydrates, indicators, inhibitors, organic or inorganic salts. Dry culture media produced by the MICROGEN company are characterized by their high quality and stability that are guaranteed by the long production history and constant monitoring of all the technological stages of production process.
In contrast to media produced in laboratories, commercial CM ensure reliability and uniformity of results as well as better quality and comparability of bacteriologic studies.
Depending on bacteria groups and application spheres CM are divided into groups. Below is the list of culture media manufactured at present.
The main manufacturer of culture media is the MICROGEN subsidiary in Makhachkala. Several culture media are produced by the subsidiaries in Stavropol and Ekaterinburg.
DRY CULTURE MEDIA
CULTURE BASE AND GROWTH FACTORS – SOURCES OF NITROUS SUPPLY AND VITAMINS
▶ Culture agar for microorganism culturing, dry ▶ Culture broth for microorganism culturing, dry ▶ Culture yeast extract for microbiological culture media, dry ▶ Casein hydrolyzate of medium breakup degree, enzymatic, dry MEDIA FOR ENTEROBACTERIACEAE: FOR ISOLATION, ACCUMULATION AND IDENTIFICATION
▶ Culture medium for isolation of shigellae and salmonellae, dry (Ploskirev's bactoagar) ▶ Culture medium for salmonellae isolation, dry (bismuth sulphite agar) ▶ Culture medium for enteric bacilli isolation, dry (Endo agar) ▶ Culture medium for isolation and differentiation of enteric bacilli, dry (Kod's medium) ▶ Culture medium for salmonellae accumulation, dry (Leifson's selenite broth) ▶ Culture medium for primary identification of enteric bacilli, dry (Ressel's medium) ▶ Culture medium for identification of enteric bacilli, dry (Hiss medium with glucose) ▶ Culture medium for identification of enteric bacilli, dry (Hiss medium with lactose) ▶ Culture medium for identification of enteric bacilli, dry (Hiss medium with maltose) ▶ Culture medium for identification of enteric bacilli, dry (Hiss medium with mannitol) ▶ Culture medium for identification of enteric bacilli, dry (Hiss medium with saccharose) ▶ Culture medium for generic identification of enteric bacilli, dry (Simmons' citrate agar) ▶ Culture medium for generic identification of enteric bacilli, dry (malonate agar) ▶ Culture medium for generic identification of enteric bacilli, dry (phenylalanin agar) ▶ Culture medium for generic identification of enteric bacilli, dry (glucose-phosphate broth) ▶ Culture medium for generic identification of enteric bacilli, dry (iron-glucose-lactose agar) MEDIA FOR CONDITIONALLY PATHOGENIC BACTERIA AND PSEUDOMONAS AERUGINOSA:
FOR ISOLATION, STORAGE AND TRANSPORTATION
▶ Culture medium for campilobacteria transportation, dry ▶ Culture medium for isolation and differentiation of aerobic infection pathogens, dry ▶ Culture medium for Pseudomonas aeruginosa isolation, dry (CPCH-agar) ▶ Culture medium for Pseudomonas aeruginosa identification, dry ▶ Culture medium for isolation of bacteria of Proteus, Providencia, Morganella genera, dry MEDIA FOR COCCAL BACTERIA GROUP: FOR ISOLATION AND CULTIVATION
▶ Culture medium base for isolation and cultivation of gonococci, dry (arginine agar) MEDIA FOR DIPHTHERIA CORYNEBACTERIA: FOR ISOLATION AND IDENTIFICATION
▶ Culture medium for isolation and differentiation of corynebacteria, dry (Buchin's medium) ▶ Culture medium for determination of diphtheria microbe toxigenicity, dry ▶ Culture medium for corynebacteria identification by cystin breakup test, dry MEDIA FOR YEASTLIKE FUNGI AND PROTOZOA: FOR IDENTIFICATION AND CULTIVATION
▶ Culture medium for isolation of Candida fungi, dry (candida agar) ▶ Culture medium for isolation of Candida albicans fungi (Chlamydospore agar) ▶ Culture medium base for isolation of vaginal trichomonas MEDIA FOR EXTREMELY DANGEROUS INFECTIONS
▶ Culture medium for brucellae isolation and cultivation, dry (erythrite agar) ▶ Culture medium for isolation and cultivation of cholera vibrio, dry (alkaline agar) ▶ Culture medium for brucellae accumulation, dry (erythrite broth) ▶ Basic pepton, dry MEDIA FOR ANTIBIOTICOGRAMS: FOR DETERMINATION OF MICROBIAL SENSITIVITY TO
▶ Culture medium for determination of microbial sensitivity to antibiotics, dry (АGВ medium) MEDIA FOR UREAPLASMAE: FOR INDICATION AND ISOLATION
▶ Culture medium base for Ureaplasma urealiticum indication, dry ▶ Culture medium base for ureaplasmae isolation (sulphate manganese agar) MEDIA FOR WHOOPING COUGH PATHOGENS: FOR ISOLATION AND CULTIVATION
▶ Culture medium for whooping cough microbe isolation and cultivation, dry MEDIA FOR TUBERCLE MYCOBACTERIA ISOLATION
▶ Culture medium for tubercle mycobacteria isolation, dry (Löwenstein-Jensen culture), lyophilizate for diagnosis ▶ Culture medium for tubercle mycobacteria isolation, dry (Finn-2 culture), lyophilizate for MEDIA FOR CONTROL OF STERILITY AND MICROBIOLOGICAL PURITY OF DRUGS
▶ Culture medium for sterility control, dry (thioglycol medium) ▶ Culture medium №1 for microbial contamination control ▶ Culture medium №2 for microbial contamination control (Sabouraud agar) ▶ Culture medium №3 for microbial contamination control ▶ Culture medium №4 for microbial contamination control, dry (Endo agar) ▶ Culture medium №5 for microbial contamination control, dry (bismuth sulphite agar) ▶ Culture medium №8 for microbial contamination control ▶ Culture medium №10 for microbial contamination control DESCRIPTION:
Dry media are fine powders, while media for tubercle mycobacteria isolation are lyophilizates
(fine-pored mass).
USAGE:
A specified quantity of the preparation (stated on the label) is solved in 1 l of distilled water,
filtered, autoclaved and poured out into Petri dishes or test tubes.
PACKAGING:
Polyethylene vials with 200g, 370g or 400g, or 200g bags of three-layered laminate.
PERIOD OF VALIDITY:
2–5 years depending on the medium composition.
LIQUID CULTURE MEDIA
CULTURE MEDIUM , LIQUID
Water-solved mixture of inorganic salts, amino acids, vitamins, glucose and phenol red indicator (or without the indicator), sterilized by filtration.
Used for the cultivation of the wide range of primary
and reinoculated human and animal cells.
Produced in 450ml glass bottles.
Manufacturer: MICROGEN subsidiary in Ekaterinburg.
HANK'S DIAGNOSTIC SOLUTION WITH PHENOL RED
HANK'S DIAGNOSTIC SOLUTION WITHOUT PHENOL RED
Water-solved mixture of inorganic salts, glucose, phenol red (or without it), sterilized by filtration through filters with 0.22 μm.
Used for producing culture media for the work with cell
cultures and as a solvent of dry preparations.
Produced in 450ml glass bottles.
Manufacturer: MICROGEN subsidiary in Ekaterinburg.
BIOLOGICALLY ACTIVE FOOD SUPPLEMENTS
BIOLOGICALLY ACTIVE FOOD SUPPLEMENTS
BIOLOGICALLY ACTIVE FOOD SUPPLEMENT "NARINE-TNC" ®
Health-improving effect of "Narine-TNC" is produced by acidophilic lactobacteria that are contained in the preparation. They enhance the production of vital amino acids, enzymes that provide digestion of proteins, fats and carbohydrates, vitamin synthesis of B-group, C, folic acid, etc. Bactericidal effect of lactobacteria is caused by the fact that during carbohydrate fermentation in the intestine they produce lactic acid, alcohol, lysozyme. As the result of lactobacteria interaction with other microorganisms, putrefactive and pyogenic enteric flora is inhibited thus reducing the possibility of pathogen penetration of the intestinal mucosa.
The preparation is recommended for normalization of intestinal
microflora, dysbacteriosis prevention and for enhancing nonspecific
resistance of children and adults, in therapy of chronic gastrointestinal
diseases, and when it is desirable to increase immune competence
of people exposed to adverse ecological and climatic factors.
"Narine-TNC" can be used either as an independent product or in conjunction with other
agents (their effect is then enhanced). "Narine-TNC" is recommended for the industrial
production of sour dairy products, in commercial production of formulas and dietetic
products by infant milk kitchens of the State Health System. "Narine-TNC" is effective
in dry, water-soluble and sour-milk forms.
Produced in glass vials or in combined packaging with 0.3g of the supplement; in 10-vial
(or packet) packs.
Period of validity: 1 year.
Manufacturer: MICROGEN subsidiary in Tomsk.

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