G:pfcaug04.pdf
VOL 10, NO. 8, August 2004
Patents related to
non patentable status of living
Of the 600 applications, 96
organisms changed with the
applications relates to fermentation
bacteria, virus and landmark decision of the Supreme (fig 1). Main applicants are CSIR
fungi - the Indian
Court, USA in Diamond vs.
(13), Gist Brocades (8), Biocon India
Chakraborty in 1980 when the
(5), and F. Hoffmann L Roche (5).
genetically modified bacterium was
Among the 294 applications
granted a patent. In India such
relating to bacteria, 110 applications
The number of patent applications
landmark decision was made on
pertain to the compounds having
related to bacteria, virus and fungi
15th January 2002 where Kolkata
antibacterial activity and processes
filed in India has recorded substantial
High Court granted patent to
for the preparation of the same.
increase in the years 2001 and
Dimminaco A.G. for invention
While 15 patent applications belong
2002. In the last issue we had
to modification of bacterial genome.
presented a broader view of patent
In India 600 applications related
23 patent applications are related
applications filed in India in the
to bacteria, virus and fungi have
to the prophylactic use of lactic
area of biotechnology. This time,we focus on patents related tomicroorganisms. Bacteria, fungi
Patent applications related to Fermentation
and virus constitute the major groupof microorganisms. These
microorganisms have been exploited
extensively by biotechnologists.
The genetic material of these
microorganisms serving as raw
materials, are tailored by the
biotechnologists with the scissors
of restriction endonucleases, stitch
with ligases and converted into
desirable form using sophisticated
techniques of genetic engineering.
The field of application of genetic
engineering is broad and covers,
for example, the use of fungi in
been filed since 1995 till June
acid bacteria and 11 applications
bakery, wine and antibiotic industry,
2003. Of these 600 applications,
related to the genetic use of Bacillus
bacteria for the manufacture of
thuringiensis. 7 patent applications
vaccines, modification of plants/
applications, 45 are convention
have been filed for the detection of
insects genome (transgenic plants)
applications and 299 are non
bacteia. Forty six applications speak
and the like.
convention applications. Two
about the industrial use of bacteria
For over two hundred years living
hundred and ninety four (294)
viz., production of enzymes
organisms have been excluded from
applications are related to bacteria,
(amylase, protease, cellulose,
patent laws; life forms were
189 applications to virus and 21
lactamase) and polyhydroxy-
considered a ‘product of nature' applications to fungi.
butyrates, extraction of metals, bio-
and not a human invention. The
Visit us at www.indianpatents.org.in
bleaching, lignin degradation,
viral proteins and peptides. There
of applications for inventions involving
bioremediation of petroleum products,
are 26 patent applications for methods
viruses were filed as shown below
soil nutrition and functional group
of detection of virus. Methodologies
transformation etc.
of detection involve the use of
Main applicants are enlisted in
The maximum number of applications
polymerase chain reaction (PCR)
Table 2 below. Indian companies
were filed in year 2002 (69) followed
using specific primers in kits,
seem to be very active in this area.
by 48 in year 2001 as shown in fig 2.
chemical and immunodetection. Six
Main applicants filing bacteria
applications have been filed for
Patent Applications related to bacteria
Cadila Pharmaceuticals
Reliance Life Sciences
Asgrow Seed company
Another microorganism we have
mentioned above is fungi. Only 21
applications have been filed in the
area of fungi. Out of these
applications, 8 applications involvethe methods and composition of
anti fungal compounds. Rest of the
applications belongs to the culture
media for growth of fungi and
related applications are given
virus cell lines. Virus is used as a
increasing the fatty acid content.
vehicle for carrying foreign gene
CSIR (8) and BASFAktiengesellschaft (7) are main
and transferring to the host genome.
There are 7 patent applications
applicants in this field while other
where virus has been used as vector.
applicants are Novo Nordisk (2),
These applications disclose the
Max Planck (1), Tata Energy
use of Baculovirus, retrovirus,
Research Institute (1).
Societe des Produits
adenovirus and vaccinia virus as
Dr. Reddys Research
One single area which has been
vector. These applications mainly
addressed in these applications is
relate to hepatitis virus (38), human
the area of health and it is good to see
immunodeficiency virus (21), herpes
that a few Indian agencies are in the
virus (11) and rabies virus (8).
forefront. Does it forecast the
It was in the years 2001 and
emergence of the Indian biotechnology
2002 when the maximum number
industry? Perhaps yes!
10. F Hoffmann La Roche
Patent applications related to virus
Virus is a unique microorganism
that lies on the threshold of life. It
behaves live inside the body and
can be crystallized if brought out.
189 applications have been filed
that are related to virus directly or
indirectly. Among these, 66
applications belong to control of
virus that includes herbal
compositions, vaccines, antibody
production using attenuated virus,
Visit us at www.indianpatents.org.in
No more needle
be absorbed directly through themucous membranes and epithelium
pricking for drug
of the respiratory tract, thereby
minimizing initial inactivation ofbioactive substances by the liver.
Case study on applicator for
Inhalational delivery provides drugs
inhalational or mucosal delivery
directly to therapeutic sites of action
(such as the lungs or the sinuses).
This mode of administration has
been particularly effective for the
New medical technology invented
delivery of pulmonary drugs (such
by Hewlett Packard Development
as asthma medications) and peptide
Company would eliminate the need
based drugs (usually via intranasal
for injections for administration of
administration), using metered dose
inhalers (MDIs).
particularly for peptide drugs like
insulin. The method works on theprinciple of delivering the drug directly
The present invention addresses
into the lungs through inhalation
the problems of the prior art by
rather than injecting it like they do
devising a method and device for
it at present. Although the method
improving the topical or inhalational
is not universally applicable to all
application of drugs, or mucosal
illnesses, it could be one of the
delivery of drugs, by using applicators
most important breakthroughs for
based on inkjet technologies. The
the treatment of diabetes and a
applicator for inhalational or mucosal
welcome relief for diabetic patients,
delivery of a bioactive composition
to a subject, such as a pulmonary
especially when a majority of them
uses a jet dispenser, such as a
inhaler for the mouth of a person.
have to constantly monitor their
piezoelectric or thermal jet dispenser.
The system consists of a dispenser
glucose levels by self-administering
The dispenser includes a container
30 connected to one or more ejection
insulin through injections or
or reservoir for holding the bioactive
heads, such as fluid ejection heads
automatic injectors attached to the
composition and delivering it to a
40, 42, 44 and 46, by conduit fluid
body. A US patent has been granted
fluid ejection head for ejection through
tubing system 58. The ejection
to Hewlett Packard's technology
a dispenser orifice, or an array of
heads are held in place within spacer
on February 3, 2004.
dispenser orifices contained on one
35 by intermediate spacer wall 48,
or more ejection heads. The thermal
and each ejection head contains
Background of the Invention
or piezoelectric jet dispenser propels
at least one orifice for ejection of
Administration of therapeutically
precise amounts of droplets from
droplets of the bioactive composition
effective doses of many medications
the dispenser toward a mucosal
from the dispenser. Ejection heads
can be difficult in some instances.
For example, some drugs
according to principles in the
The applicator is suitable for
(particularly peptide based drugs,
thermal inkjet technology, using
use in a variety of ways. For example,
such as insulin) are partially or
piezoelectric ejection techniques,
the applicator may be intermittently
totally inactivated by the highly
or other manners of fluid ejection.
used to introduce an agent into a
acidic environment of the stomach
Indeed, the ejection of some
target body orifice, such as the
if orally ingested. Another problem
chemicals may be benefited by a
mouth, for administration of the
is the "first pass" effect, which
thermal ink ejection technology,
bioactive agent. Alternatively, the
refers to the partial inactivation of
in which elevated temperature can
applicator may be used to apply
orally ingested drugs in the liver
activate the agent. In contrast,
the agent to an area of skin for
after they have been absorbed from
other agents may chemically
topical application of a bioactive
the gastrointestinal system and
degrade and lose some or all
composition, or used to transdermally
before they have exerted their full
bioactivity when heated in a thermal
introduce the bioactive agent.
therapeutic effect.
system, and such compositions
Inhalational administration has been
Fig. 1 illustrates a mucosal or
used as an alternative route of
inhalational application system for
piezoelectric or other non-thermal
drug delivery. Inhaled drugs can
administering a bioactive composition
ejecting head technology.
Visit us at www.indianpatents.org.in
Contd from.3
crystal display 105, to indicate
distribution to multiple parts of the
No more needles .
which selections have been made
respiratory system, such as
The reservoirs 52-56 may be
using keypad 104. Alternatively,
distributing larger droplets throughout
inserted into receptacles formed
keypad may be eliminated, and
the bronchi and smaller droplets
within main body 32 accessible
the controller 100 programmed to
deep into the lungs, such as to
from the outside of the applicator
display various selections on screen
bronchioles or alveoli.
30. Thus, reservoirs 52-56 may be
105. Scrolling buttons 106 and 108
There are 30 claims out of which
removed from applicator 30 when
may allow different instructions or
the first claim is reproduced:
empty and new reservoirs 52-56
selections to be scrolled across,
inserted into applicator 30 without
or up and down along, screen 105,
1. An applicator for delivering a
breaking open main body 32.
including information such as desired
bioactive composition, comprising:
The conduit system 58 may
dosages, frequency, and potential
an inkjet dispenser comprising
include discrete fluid conduits, with
side effects.
an orifice for high-speed ejection
each conduit independently
The reservoir holding the bioactive
of droplets from the dispenser, the
connecting an individual replaceable
composition may be a fixed part of
inkjet dispenser further comprising
fluid reservoir to an individual fluid
the applicator or is replaceable.
ejection head. The conduits 62, 64
One or more bioactive compositions
a replaceable fluid reservoir for
and 66 deliver fluid from the respective
can be contained within multiple
holding and delivering the bioactive
reservoirs 52, 54 and 56 to their
replaceable reservoirs, for example,
composition to the orifice for ejection
respective associated ejection heads
a series of replaceable reservoirs
therethrough, the replaceable fluid
42, 44 and 46. For example,
could contain a single drug in
reservoir at least partially insertable
replaceable fluid reservoir 52 is in
sequentially increasing or decreasing
through the body; and
fluid connection with fluid ejection
concentrations, or a series of different,
a body orifice spacer positioned
head 42 via conduit 62, and
but related, drugs for the treatment
between the dispenser orifice and
replaceable fluid reservoir 56 is in
of a particular condition.
a target during ejection of the bioactive
fluid connection with fluid ejection
The bioactive composition may
composition to the target;
head 46 via conduit 66.
be in any of the forms, liquid, gel
wherein the dispenser comprises
The dispenser also includes a
or powder. One of the reservoirs
a first orifice and a second orifice,
controller 110 for manually or
can contain a bioactive agent in
the first orifice operable to dispense
automatically dispensing the
powder or other dry form and the
droplets of a predetermined size,
bioactive substance from the
powder can be dispensed from the
the second orifice operable to
dispenser at selected times. The
container, and may in some instances
dispense droplets of a predetermined
controller may take the form of an
be combined with a liquid en route
size different than the size of droplets
actuator that is manually depressed
to the target body orifice or mucosal
dispensed from the first orifice.
to activate the dispenser and
delivery site.
dispense the agent. The controller
The invention incorporates certain
The droplets of bioactive
could be a programmable device
novel features resulting in various
composition delivered by the
or could include an audible or visible
applicator can be of varying sizes.
cue, such as a tone or light, to
The applicator is capable of
• The inhalers presently available
alert the subject that a dose of the
dispensing very small and accurate
are thrown away after the drug
bioactive composition is ready to
amounts of fluids including liquids
is finished. The applicator in
be dispensed.
and powders. The droplets can be
the invention, on the other hand,
The applicator may include an
sized for respiratory inhalation or
contains multiple replaceable
input keypad, such as an alpha or
for delivery to bronchial airways or
reservoirs which provides a cost-
alphanumeric keypad. Using keypad,
to nasal membranes or passages.
effective alternative, since only
a physician, nurse, pharmacist, or
The droplet sizes that can be
the empty reservoirs and not
other health professional, or the
dispensed by the applicator is of
the entire applicator would need
subject 24 to which the fluid will be
the order of 2 to 8 micrometers or
to be thrown.
administered, may input variations
less. The droplet size from the
• The multiple reservoirs in the
in the amount of and types of fluids
available inhalators is of the order
applicator also allow multiple
dispensed by fluid ejection heads
of a few picolitres. The jet dispenser
drug compositions to be
40-46. Applicator 30 also may include
is also capable of dispensing
dispensed simultaneously or
a display screen, such as liquid
differently sized droplets for
Visit us at www.indianpatents.org.in
Instacare and applied for interim
or of the Central Government or as
injunction restraining Instacare from
a counter-claim in a suit for
manufacturing the combination
infringement of the patent. According
drugs. The trial judge vacated the
to our view, the defendants
loses patent battle
initial ex parte ad-interim injunction
contentions relied on Section 64
granted to Cadila.
(1) (e) of the Act according to
A patent dispute over a process
patent for a combination drug held
Aggrieved, Cadila filed an appeal
which the patent must be revoked
by Cadila Pharmaceuticals settled
in the Gujarat High Court contending
on the ground that the invention
in the High Court of Ahmedabad on
so far as claimed in any claim
of the complete specification is
May 2, 2001 ultimately resulted in
• Cadila has been granted the
not new, having regard to what
revocation of the process patent
patent for the novel process
held by Cadila.
was publicly known or publicly
after satisfying the patent granting
used in India before the priority
The plaintiff/appellant, Cadila
procedure under the law which
date of the claim or to what was
Pharmaceuticals Ltd was granted
includes advertisement for
published in India or elsewhere
an Indian patent in March 2000
opposition from interested parties.
in any of the documents referred
(Patent no 183097) which claimed
Instacare, however, did not avail
to in Section 13.
a novel drug delivery process for a
the opportunity of issuing notice
combination medicine. The
of opposition before the patent
The contentions were further
combination medicine is a penicillin-
was granted nor did they seek
based on the fact that combination
based antibiotic combined with a
revocation of the patent after
drugs were already known to the
dose of microorganism lactobacilli,
the patent was granted. Cadila
pharmaceutical world and Cadila's
which counteracts the side effects
emphasized that Instacare
claim to have invented a new process
caused by the antibiotic such as
therefore had no right to defend
is wholly baseless and could not
nausea, vomiting, diarrhoea etc.
the action for infringement and
have been patented. Instacare also
The combination of lactobacilli with
Cadila cannot be deprived of
contended that they have been
the antibiotic normally affects the
the fruits of its invention.
marketing its Hipen LB and HiponexLB drugs since 1999 which was
lactobacilli which loses its virality
• Cadila's patent applications for
after a certain period. The plaintiff
prior to the grant of Cadila's process
protection in foreign countries
invented a novel drug delivery process
patent in 2000.
would be affected unless the
which involves delivering lactobacilli
patent was protected in the home
The court after hearing the
in combination with a penicillin-
arguments affirmed the trial
based antibiotic, but isolated by a
court's rejection of application
• The expert appointed by the
thin protective film which prevents
for interim injunction and held
court opined that the international
the antibiotic from reacting with
that though Instacare has chosen
search report relating to a
the lactobacilli. Such combination
not to serve notice of opposition
corresponding PCT application
medicine when consumed orally,
under Section 25 of the Patent
failed to reveal any valid citations
enables the lactobacilli to be effective
Act or apply for revocation of
relevant to the novelty and inventive
for a long time and also counteracts
the patent under Section 64 of
merit of the claimed invention,
the side effects of the antibiotic.
the Act, Section 107 of the Act
therefore establishing the novelty
Cadila thus claimed the exclusive
empowers Instacare to defend
and inventive merit of the present
right to manufacture and market
the suit for infringement. The
invention beyond doubt.
its innovative drug named LMX for
court also held that documentary
The defendant Instacare
evidence from various books
a period of five years and the right
Laboratories contentions relied on
to exclude others from
indicate that the process of
Section 107 of the Patent Act
manufacturing, distributing or selling
making combination drugs from
according to which Instacare had
a pharmaceutical product
a chemical substance (an anti-
the right to defend the infringement
infective agent such as penicillin)
incorporating the patented process.
suit on all grounds available in
Instacare Laboratories Pvt Ltd, the
and a microorganism (such as
Section 64 of the Act.
defendants were selling a similar
lactobacilli) and isolating one
Section 64 of the Patent Act
combination drug incorporating the
of the ingredients by giving it a
deals with the revocation of patents
coating of protective film are
patented process under the names
on various grounds based on the
‘Hipen LB' and ‘Hiponex LB'. Cadila
both known and well accepted
petition of any person interested
filed an infringement suit against
process. The process for making
Visit us at www.indianpatents.org.in
to educate the public about what
maker, and is pressing ahead with
it calls illegitimate Websites.
The US Court of Appeals for the
other parts of the suit. Rambus is
The Tribune, August 5,
federal court has reversed the district
suing Infineon, Micron Technology
court's judgment that intertool failed
Inc. and Hynix Semiconductor Inc.
Mumbai based Sun Pharma has
to satisfy the written description
in Germany and the US, claiming
been sued by Medimmune Oncology
requirement. The court emphasized
they infringed patents after refusing
for a patent infringement by Sun's
the ‘complete and exacting' detail
to sign licensing agreements.
filing in the US market for generic
of the claimed structure and the
Business Line, July 21,2004
version of cancer-related drug Ethyol
preamble's lack of any additional
Luxury Jeweller Tiffany & Co
(amifostine). Sun Pharma had filed
structure that the specification had
has sued eBay Inc, claiming the
a Drug master File for generic Ethyol
emphasized as important. Thus
online auctioneer has contributed
earlier this year. The drug is reported
the preamble phrase was not
to violations of the Tiffany trademark
to have clocked revenues of $94
considered as a limitation.
by letting counterfeit items be sold
million in 2003 in the US and its
Patent World, July/August 2004
on its website. A study in certain
patens expire in July 2012/December
Microsoft responded to the
pieces of ‘Tiffany' jewelry sold on
2017. The patent-challenge route
European Commission's
eBay this year showed that 73%
adopted by Sun Pharma may be a
anticompetitive ruling against the
of the jewellery was counterfeit.
‘jackpot' if they win the case.
company by filing two requests at
The lawsuit asks the eBay be stopped
Business line, August 22, 2004
the Court of First Instance in
from listing any Tiffany merchandise
International sports apparel
Luxembourg. The first requests a
that is not genuine and for eBay to
company Lacoste had filed a lawsuit
suspension of the Commission's
account for profits it made on the
alleging that the Chennai-based
remedies, arguing that they harm
counterfeit Tiffany merchandise or
exporter, Global Impex India, used
software developers, website
else pay up to $1 million for each
its registered trademark "Lacoste"
developers as well as Microsoft.
type of fake Tiffany merchandise
and copyright logo "Crocodile" to
The second filing appeals against
sold on the website.
promote its goods and to confuse
the Commission's ruling arguing
The Economic Times, June 23,
the customer in believing that the
that the decision creates an untested
product was emanating from the
new law. It says that once IPRs
Data center gear makers Radware
international company. The Delhi
are lost they cannot be recovered
and F5 Networks battle over patents
High court has restrained the Indian
and hence a stay is necessary.
again. Radware, which makes
export firm from carrying out its
Patent World, July/August 2004
networking products that balance
business which was adversely
L.G.Phillips LCD, the world's
traffic between servers, has filed a
affecting Lacoste's reputation.
second biggest maker of flat screens
lawsuit against competitor F5
Asian Age, August 21, 2004
for laptops, computer monitors and
Networks for infringing on a April
televisions, has filed patent
2004 patent. The patent is for
largest drugmaker, gave up its fight
infringement lawsuit against US
technology that determines the
to protect a key ingredient in its
and Taiwanese rivals ViewSonic
proximity of devices within a network
leading anti-diabetes medicine sold
Corp and Tatung. L.G.Phillips LCD
when making load-balancing
in China, the second reverse in a
is a joint venture between LG
decisions. Radware is seeking an
month for a Western drug company
Electronics and Phillips Electronics.
undisclosed amount of monetary
in the $10-billion market. Glaxo
The Lawsuit is the latest in a series
damages as well as permanent
won't proceed with a counter-suit
of patent infringement suits in Asia
injunctive relief.
against Chinese drugmakers that
that reflect a sharp competition in
The Financial Express, July 23, 2004
challenged its patent for rosiglitazone,
the electronics market.
The world's biggest drugmaker,
one of three patented ingredients
The Times of India, June 3, 2004
Pfizer Inc, is taking legal action
in Avandia. China wants to cut the
Rambus Inc, a computer-memory
against dozens of online pharmacies
price of Western medicines and
chip designer, withdrew parts of
which it alleges are selling counterfeit
make them widely available to
its patent infringement claim against
versions of the erectile dysfunction
Chinese patients.
Infineon Technologies AG, Europe's
drug Viagra. The company has
The Economic Times, August
launched an advertising campaign
Visit us at www.indianpatents.org.in
Patents for Opposition
Mysore silk is the next
The following patent applications have been accepted by the Patent
‘indegenous' product in line for a
Office and published in the Gazette of India. These can now be opposed
Geographical Indications (GI) tag.
by filing opposition applications within a period of four months from the
The GI registration accords unique
dates given. Six digit numbers allotted after acceptance by the Patent
identity to this silk, its source and
Office are given before the applicant names and patent application
processessing as a ‘traditional
numbers given in brackets. Names of the branches of the Patent Office
knowledge' product. Mysore silk
are denoted in the application number, e.g. ‘Bom' for Bombay branch.
will be the ninth such TK productthat has a unique geographic origin.
An opposition application should be submitted at the appropriate office
Eight products which have been
where the concerned application was originally filed.
granted GI include Darjeeling tea,Pochampalli sarees, Salem fabric,
May 22, 2004
Goan feni, Solapur fabric, Pavitra
192791. Jophnson And Johnson Medical
Bioabsorbable medical device from oxidized
modaram (ring) from Payyanur
Inc, United States (1209/CAL/97)
kerela, Chanderi saree and Aranmul
192792. The Trustees Of Princeton
A process for preparing a composite
kannadi (mirror) from Kerela.
University U S A (642/CAL/94)
consisting of a supporting substrate with
Deccan Herald, August 18, 2004
a photochemically active multi layeredfilm
Counterfeits and passoffs
192793. Copeland Corporation SA (342/
A scroll type machine
continue to trouble the FMGC
industry, with the Government
192794. Owens Corning Canada Inc
A machine for making chopped strand
estimated to lose close to Rs 900
Canada (801/CAL/97)
mat and a process for making choppedstrand mat
crore per annum in unpaid excise
192795. Kone Oy Finland (2032/CAL/97)
Sliding safety gear
duty, sales tax and other levies.
192796. Kabushiki Kaisha Mihama
FICCI informed that a raid conducted
Seisakusho Japan (1802/CAL/97)
An improved clamping band
by the Delhi Police in collaboration
192797. LG Electronics Inc Korea (1561/
with the Chamber's Brand Protection
Apparatus for supplying cold air an
Committee (BPC) during the
192798. Fianara Internation B V The
weekend in the Capital uncovered
Netherland (84/CAL/01)
Rs 5 crore worth of machinery and
192799. Steel Authority Of India Ltd India(1594/CAL/97)
A low cost process for producting low
packaging materials being used to
sulphur and phosphorus content ductile
manufacture counterfeit products.
192800. Kawasaki Thermal Engineering
Holographic plates of Sunsilk, Clinic
Co Ltd Japan (1224/CAL/97)
A nitrogen oxide reducing apparatus in
Plus, Chik Shampoo and Ariel
192801. Steel Authority Of India Limited
oil fired absorption refrigerating apparatus
detergent have been seized along
New Delhi (1185/DEL/95)
A completely cement free refractory
with large quantities of packing
castable composition (ZCC) and a process
material of many popular brands.
192802. Council Of Scientific And Industrial
of preparing the composition
Research New Delhi ( 437/DEL/95)
A process for the synthesis of 3s 2
Business line, August 18, 2004
substituted 1 2 3 4 tetrahydro 9h pyrido
The Economic Offences Wing (EOW)
3 4 b indole 3 carboxylic acids useful as
claims to have seized pirated software
192803. Steel Authority Of India Ltd New
potential anti cholecystokinin agents
Delhi (1279/DEL/95)
A shutter device for actuating a gamma
and VCDs/DVDs/MP3 worth Rs 7.15
ray source of fail safe pushing operation
crore during raids in New Delhi, (Farsh
192804. Saitec S R L An Italian Company
Bazar, Nehru Place, Palika Bazar
Italy (1314/DEL/95)
Apparatus for preparing solid forms with
and Shalimar Bagh) over the past two
controlled release of active ingredients
192805. De La Rue Glori Switzerland
and method carried out therein
The Hindustan Times, August 6, 2004
192806. LG Electronics Inc Korea (1899/
Karnal-based Directorate of Wheat
Apparatus for packing content of a
Research (DWR) has been granted
192807. Esco Corporation United States
a process patent to use a chemical
Of America (1571/DEL/95)
A lock pin fort coupling a point to an
agent for imparting sterility in the crop.
192808. Rameshwar Dayal Srivastava
adapter to form an excavating tooth
The patent has been granted by the
India (1423/DEL/95 )
Adjustable R.C.C. door frame
Indian Patent Office for a process
192809. Intel Corporation United StatesOf America (1876/DEL/95)
An encoding system
Visit us at www.indianpatents.org.in
192810. Laboratories Cusi S A Spain
A container for pharmaceutical substances
Contd from.7
and a process for assembling thereof
Domestic News .
192811. Maytag Corporation USA (1635/
of making the chemical used in
hybrid wheat seed production leading
192812. Sony Corporation Japan (2165/
A transmitting receiving apparatus
to a significant step towards
increasing wheat output by around
192813. Council Of Scientific And Industrial
A device for the measurement of thoracic
Research New Delhi (1794/DEL/95)
gas volume for diagnosis of lung diseases
20% to over 100 million tones. The
192814. Steel Authority Of India Limited
Process of manufacturing coiled spring
corresponding US patent application
New Delhi (1077/DEL/95)
is also pending in the USPTO since
192815. Steel Authority Of India Limited
An improved burner operable from lean
New Delhi (2234/DEL/95)
gases and low viscous oils suppliedsimultaneously or singly
Business line, August 30, 2004
192816. Council Of Scientific And Industrial
An improved process for the preparation
The Union Cabinet has referred
Research New Delhi (503/DEL/95)
of para di alkyl benzene
the Patents Amendment Bill to a
192817. Alcan International Ltd Canada
A process for manufacturing a metal
group of ministers to study the
strip and an apparatus for the same
implications of some of the
192818. Arun Kumar Delhi (1048/DEL/
A door viewer mounted in a door
contentious issues in the third Patents
Amendment Bill before approving
192819. Buehler Ag Switzerland (1446/
Micro metering device
it. The government is seeking
192820. Allied Tube And Conduit
Coating apparatus and method for applying
amendments to the Patents Act to
Corporation United States Of America
a coating to a length of horizontally oriented
fulfill India's obligations under the
commitment to the WTO of having
192821. Council Of Scientific And Industrial
An improved process for the production
in place product patents by 2005.
Research New Delhi (411/DEL/01)
of fructiooligosaccharides using cultureboth of aureobasidium pullulans
The group of ministers on Patents
192822. Council Of Scientific And Industrial
A process for the preparation of 1 arylaikyl
includes Defence Minister Shri P
Research New Delhi (1206/DEL/01)
5 oxo proline carboxamide aryalkyl 5 oxo
Mukherjee, Health Minister Shri A
proline carboxamide useful as thrombin
Ramdoss, Human Resources
Minister Shri A Singh, Commerce
192823. Council Of Scientific And Industrial
An improved process for the preparation
Research New Delhi (495/DEL/99)
of a hydrophilic bone inductive protein
and Industry Minister Shri Kamal
192824.Council Of Scientific And Industrial
An improved process for the preparation
Nath, Science and Technology
Research New Delhi (1355/DEL/99)
of soy protein hydrolysate from legumes
Minister Shri Kapil Sibbal, Chemical
192825. Council Of Scientific And Industrial
A process for the production of 6 0 beta
and Fertilizer Minister Shri Ram
Research New Delhi (1124/DEL/00)
d glucopyranosyl oxy benzene ethylamine
Bilas Paswan and Agriculture
192826. Council Of Scientific And Industrial
High yielding substrate for cultivation of
Minister Shri Sharad Pawar.
Research New Delhi (278/DEL/00)
mushrooms using coir waste
Central Chronicle, August 27, 2004
192827. Council Of Scientific And Industrial
A process for the preparation of 3 sulfanyl
Research New Delhi (299/DEL/00)
Music piracy level in India is
192828. Council Of Scientific And Industrial
A process for the preparation of pyridine
estimated at over 25%, according
Research New Delhi (407/DEL/01)
o a recent study by Pricewaterhouse-
192829. Council Of Scientific And Industrial
A process for preparation of an artificial
Coopers (PwC). Among Asian
Research New Delhi (3322/DEL/98)
countries, Hong Kong, the
192830. Council Of Scientific And Industrial
A process for the preparation of a
Philippines, Taiwan and Thailand
Research New Delhi (2713/DEL/98)
are at India's level. Piracy in Indonesia,
192831. Council Of Scientific And IndustrialResearch New Delhi (1772/DEL/98)
A synergistic composition of polymeric
Malaysia and Pakistan is much
blend useful for preparation of
higher at over 50%. China tops the
192832. Council Of Scientific And Industrial
biodegradable polymer device
list in the region with over 90%
Research New Delhi (3692/DEL/98)
A process for the preparation of a
piracy rate.
composition useful for increasing shelf
The Financial Express, August 26, 2004
192833. Council Of Scientific And Industrial
life of fruits and vegetables
Research New Delhi (730/DEL/00)
An improved process for the isolation of
The estimated loss to the Indian
192834. Council Of Scientific And Industrial
bixin dye from bixa orellana (anneto)
film industry due to pirated video
Research New Delhi (1162/DEL/00)
A process for preparation of a composition
cassettes and discs per year was
useful for effective protection against
Rs 400 crore. Information in this
192835. Council Of Scientific And Industrial
the ultraviolet uv radiation
regard was provided to Rajya Sabha
Research New Delhi (358/DEL/00)
A method for the preparation of antimicrobial composition useful in the treatment
by FICCI. The Government has
of drug resistant bacterial infections
been receiving from time to time
Visit us at www.indianpatents.org.in
192836. Council Of Scientific And Industrial
A process for the preparation of
Contd from.8
Research New Delhi (727/DEL/00)
Domestic News .
homo 7 oxastigmastan 6 one
representatives from the film industry
192837. Council Of Scientific And Industrial
An improved process for preparation of
vis-à-vis the need for strict action
Research New Delhi (129/DEL/00)
against piracy. The responsibility
192838. Council Of Scientific And Industrial
An improved process for the preparation
Research New Delhi (93/DEL/00)
of a alpha formyl aryl acetates
of dealing with offences under the
192839. Council Of Scientific And Industrial
An improved culture medium for
Copyright Act rests with the police
Research New Delhi (267/DEL/0)0
haematococcus useful for enhanced
authorities of the state government
carotenoid production by heamatococcus
and the Union territory Administration.
The Assam Tribune, August 18,
192840. Council Of Scientific And Industrial
A process for the isolation of trans tetracos
Research New Delhi (379/DEL/0)0
15 enoic acid having hepatoprotective
activity from indigofera sp
India and US signed a letter of
192841. Council Of Scientific And Industrial
An improved process for the preparation
intent to work together to bring out
Research New Delhi (570/DEL/9)9
of 2 aryl propionic acid
"drought and saline resistant high-
192842. Council Of Scientific And Industrial
A process for preparation of odourless
yielding crop varieties through
Research New Delhi (1195/DEL/99)
biotechnology, that will have more
192843. Council Of Scientific And Industrial
A method for simultaneous recovery of
Research New Delhi (540/DEL/99)
cephalosporin c and deacetyl cephalosporin
nutritious contents like iron and
c from fermentation both
vitamins. After signing the agreement
192844. Council Of Scientific And Industrial
An improved process for the preparation
the Union Minister for Science and
Research New Delhi (1561/DEL/99)
of cycloalkylphenols
Technology, Mr. Kapil Sibal, told
192845. Council Of Scientific And Industrial
A process for the preparation of
that the two sides would not take
Research New Delhi (413/DEL/01)
intracellular phenyalalanine ammonia-lyaseenzyme
any matter involving issues of
192846. Council Of Scientific And Industrial
An improved process for preparation of
intellectual property rights and the
Research New Delhi (370/DEL/01)
paste from onion and garlic bulbs having
farmers will be free to use the seeds.
longer shelf stability
The Tribune, June 30, 2004
192847. Council Of Scientific And Industrial
An improved process for the preparation
Research New Delhi (41/DEL/01)
Thanks to a technique patented
of food grade sodium benzoate
192848. Council Of Scientific And Industrial
by a young Indian researcher Ajai
A process for the preparation of novel
Research New Delhi (166/DEL/0)1
K Sonkar, India may replace Japan,
192849. Council Of Scientific And Industrial
A process for the preparation of a novel
Australia, America and several island
Research New Delhi (92/DEL/01)
cis cis 3 hydroxy 5 methylcarbonyloxy
countries as the home for the world's
cyclohexylacetate useful as an intermediate
largest culture pearls. Dr. Sonkar
for 6 hydroxymethyl 4 tertbutyldimethylsilyloxy 4 4r 6s tetra hydro
has developed a special technique
of implantation using the Pinctada
192850. Council Of Scientific And Industrial
An improved process for the preparation
margaritifera also known as the
Research New Delhi (474/DEL/01)
of 2 methyl 1 4 naphthoquinone
black lip oyster to produce pearls.
192851. Council Of Scientific And Industrial
A process for the preparation of a
The results of the first batch were
Research New Delhi (94/DEL/01)
formulation useful for the insect freestorage of cereals
stunning wherein of the 1000 oysters
192852. Council Of Scientific And Industrial
A process for the preparation of novel
that were implanted, 905 produced
Research New Delhi (0047/DEL/00)
4 alkyl 7 o acetamid 2 yl 2h 1 benzopyran
pearls and none of them died.
Hindustan Times, July 24, 2004
192853. Council Of Scientific And Industrial
A process for the preparation of alkyl
A scientist from the National
Research New Delhi (0048/DEL/01)
aryl 3 amino 3 glycosylated propanoatesand corresponding propanoic acids
Geophysical Research Laboratory
192854.Council Of Scientific And Industrial
A process for the production of verbenol
in Hyderabad, Dr. Vishnubhotla
Research New Delhi (412/DEL/01)
Chakravarthi, has obtained a US
192855. Council Of Scientific And Industrial
A process for the preparation of purified
patent to develop software that will
Research New Delhi (414/DEL/01)
lecithin from crude rice bran oil
help make accurate predictions of
192856. Council Of Scientific And Industrial
A process for the preparation of an
the distance at which hydrocarbons
Research New Delhi (787/DEL/97)
improved coating useful for coating thesurfaces of stainless steel and super
(petrol, natural gas) are available
192857. Council Of Scientific And Industrial
under the earth. The software would
Research New Delhi (371/DEL/00)
A process for the preparation of 4
be a great help in oil and gas
192858. Council Of Scientific And Industrial
isobutylacetophene 4 ibap
exploration as the margin of error
Research New Delhi (153/DE/00)
A process for the preparation of 4 aryl
in the method is just 4% as compared
2 6 dimethyl 3 karboethoxy 5 carbomethoxy
to 34% by conventional methods.
1 4 dihydropyridines useful as therapeuticagents
Hindustan Times, July 19, 2004.
Visit us at www.indianpatents.org.in
192859. Steel Authority Of India Limited
An improved semi dry gunning mix for
Research And Development Centre For
repairing the eroded refractory linings
Iron And Steel New Delhi (576/DEL/96)
of steel teeming ladles and a method of
The New Zealand Court of Appeal
preparing the same
has upheld a ruling by the High
192860. Steel Authority Of India Limited
An improved method for cast iron ingot
Court that claims for medical
Research And Development Centre For
Iron And Steel New Delhi (66/DEL/96)
treatment for human beings are
192861. Ranbaxy Laboratories Ltd India
An improved process for the isolation of
not patentable. The Court of Appeal
decided that "a claim to a method
192862. Ranbaxy Laboratories Ltd India
A process for the preparation of 3 ethoxy
of medical treatment did not satisfy
4 ethoxycarbonyl phenyl acetic acid
the definition of ‘invention' in the
192863. Ranbaxy Laboratories Ltd India
Process for the synthesis of novel
New Zealand Patents Act." The
New Zealand Government is also
192864. Ranbaxy Laboratories Ltd India
A process for the preparation of controlled
examining the issue as part of a
release formulations of ofloxacin
three-stage review of the Patents
192865. Bharat Heavy Electricals Ltd India
An improved impeller for centrifugall
Patent World, July/August 2004
192866. Ambika Prasad And Trinetra New
AC DC electro magnet device as
Delhi (730/DEL/96)
constitutional remedy for promotion of
Biotechnology and pharma-
ceutical patenting has finally leveled
192867. Fil Terwerk Mann Hummel Gmbh
A fluid powered centrifugal cleaner device
off after significant growth throughout
Germany (195/DEL/96)
the 1990s according to the latest
192868. Sony Corporation Japan (281/
Liquid crystal display device
Biotechnology Innovation Report
by Finnegan Henderson, released
192869. I M A Industria Macchine
A method of manufacturing a filter bag
Automatiche S P A Italy (749/DEL/96)
by pleating and folding an elongatedly
at BIO 2004. The report also found
shaped tubular blank of filter paper
that the ‘Biotech patent ownership'
192870. Smithkline Beecham P L C England
A process for preparing 5 4 2 n methyl
has shifted further in favour of the
n 2 pyridyl amino ethoxy benzyl 2 4
private sector and away from the
thiazolidinedione or a tautomeric form
ownership by universities and the
thereof or a salt thereof or a solvate
May 29, 2004
Patent World, July/August 2004
192871. Praxair Technology Inc Brazil
A process for preparing an improved
Intellectual Property Rights are
192872. Indian Council Of Medical
A process for the production of
a key element of US trade policy
Research India (179/DEL/01)
mosquitocidal compound
and a major obstacle for Russia to
192873. Squires Meryl Joan USA (503/
A process for preparing a synergistic
overcome if it is to join the World
herbal pharmaceutical composition
Trade Organization (WTO). Piracy
192874. Bayer Corporation United States
A process for the preparation of synthetic
of software and video is thought to
Of America (601/DEL/97)
rob Russia's budget of between
192875. All India Institute Of Medical
A process of coating elisa plates with a
Science India (822/DEL/97)
novel antigen mixture of indian subtype
$1 billion to $4 billion year, according
c HIV 1 gp 120/gp 41 and HIV 2 gp 36
to the figures from the Trade and
envelop components and HIV 1 virus
Economic Development Ministry's
trade inspectorate. Russia is moving
192876. The Chief Controller Research
A process for preparation of soluble fibre
towards a trade deal with European
Development Ministry Of Defence India
enriched baked product for reducing blood
sugar and blood cholesterol
Union that would bring it close to
192877. Hovione Inter Ltd Switzerland
A process for the preparation of 4 des
joining the WTO. Even if the EU
and Russia agree accession terms,
192878. Tencel Limited England (487/DEL/
Apparatus for the communication of sheets
the United States and others still
of wood pulp feedstock into platelets of
have to give their approval.
Hindustan Times, June 3, 2004
192879. Centre For Development Of
A forward error correction decoder device
Telematics India (1696/DEL/94)
for correcting upto two errors and
Drug company Eli Lilly's research
detecting three errors using modified rate
and development centre is located
7 8 bch 128 112 coding scheme in a
in Singapore inspite of the fact that
satellite communication system
the company has many Indians as
192880. K G M Associates India (88/
staff members. Singapore has
marched ahead of India by not just
192881. Nippon Shokubai Co Ltd Japan
A process for manufacturing a detergent
creating a conducive environment,
192882. Basf Aktiengesellschaft Germany
A process for the preparation of the
but also by establishing the
Visit us at www.indianpatents.org.in
192883. Central Sericultural Research
A process for the preparation of a
Contd from.10
And Training Institute India (1419/MAS/
International News .
necessary infrastructure to ‘entice'
192884. Katsu Manufacturing Co Ltd Japan
An agitation apparatus for agitating pellets
research-oriented companies to flock
of synthetic resin
to Singapore. A primary reason why
192885. Haraeus Electro Nite International
A measuring cell to measure an electro
Nv Belgium (314/MAS/96)
chemical activity
Singapore is chosen over India is
192886. Ciba Specialty Chemicals Holdings
because they protect IPRs and there
Inc Switzerland (293/MAS/96)
exists clarity in regulation, besides
192887. Natco Pharma Limited India (876/
An improved process for the preparation
other financial benefits. Besides
companies such as Pfizer, Schering
192888. National Gypsum Properties LlC,
A fiber board and a method of producing
Plough, Wyeth and Siemens that
have operation in Singapore, local
192889. Surendra Kumar Sood India (410/
A process for the preparation of deep
and international biotech companies
fat fried potato chips
looking at drug discovery are also
192890. F Hoffmann La Roche Ag
A process for the preparation of a 4 5
making a beeline to the city.
Switzerland (153/MAS/01)
diamino shikimic acid derivative
Business Line, June 29, 2004
192891. Dow Global Technologies Inc
A process for preparing a supported
USA (1572/MAS/95)
catalyst component
Shaolin Temple, the home of
192892. Aluminium Pechiney France (1694/
A process for preparing iron-free
Kung Fu, has extended its self
supersaturated sodium-aluminate solutions
defense strategy from martial arts
192893. Andritz Oy Finland (142/MAS/
A method of producing black liquor from
to trademark protection. Monks at
a pulping process
the 1,500-year-old Buddhist temple
192894. Palitex Project Company Gmbh
A textile machine
in Henan province plan to register
Germany (288/MAS/96)
the Shaolin name in more than 80
192895. Mudalthirumaligai Srinivasa
A method of and an apparatus for
Nandakumar India (427/MAS/96)
continuous manufacture of steel
countries to prevent what they claim
192896. Bottari Marco Italy (758/MAS/
A yarn center made from molded
is its improper use to promote
thermoplastic resin
cigarettes, beer, lingerie and bogus
192897. Shell Internationale Research
A process for the preparation of a
The Netherlands (770/MAS/96)
lubricating base oil
Hindustan Times, July 7, 2004
192898. Luxfer Group Limited United
A method of preparing a magnesium base
Microsoft has been awarded US
Kingdom (188/MAS/96)
alloy for high pressure die casting
patent 6,754,472, entitled: Method
192899. F Hoffmann La Roche Ag
A process for preparing a pharmaceutical
and apparatus for transmitting power
Switzerland (763/MAS/00)
composition having enhancedbioavailability
and data using the human body.
192900. American Home Products
A method of manufacturing pharmaceutical
Microsoft envisages using the human
Corporation USA (560/MAS/97)
capsule and an apparatus thereof
skin's conductive properties to link
192901. Maumee Research And
A process for treating metal oxide fines
a host of electronic devices around
Engineering Incorporated USA (1428/MAS/
to recover elemental iron
the body, from pagers to personal
data assistants to mobile phones
192902. Mobil Oil Corporation United States
A process for the polymerization of cyclic
and microphones. The technology
Of America (1340/MAS/95)
ether monomers for the production ofpolyoxyalkylene polymer
could usher in a new class of portable
192903. C S R Prabhu India (1334/MAS/
A process for the preparation of herbal
and wearable electronic gizmos such
biodegradable liquid fire extinguisher and
as earrings that deliver sounds sent
imparter of fire burn resistance
from a phone worn on the belt, and
192904. Elf Atochem S.A. France (1153/
Process for the purification of
special spectacles with screens that
flash up accompanying images and
192905. Mitsubishi Denki Kabushiki Kaisha
A stator of a magnet type rotating machine
video footage. The patent says the
Japan (1077/MAS/95)
body could generate the power needed
192906. S K Corporation Korea (1040/
Process for separating the high boiling
to run its various attached devices
fraction from a crude butyne diol solution
in a similar way to self-winding
192907. Robert Bosch Gmbh Germany
A fuel injection valve for internal combustion
watches. Most futuristically, it proposes
192908. Henkel Corporation USA (859/
A coated metal article and a method of
that an area of skin could even act
producing the same
as a keypad, whereby you could
192909. Toshiba Lighting And Technology
A compact fluorescent lamp unit
type by tapping on your forearm.
Corporation Japan (798/MAS/95)
Hindustan Times, July 7, 2004
192910. Indian Institute Of Science
A process of preparing molybdenum
Mylan laboratories acquired King
Bangalore India (788/MAS/95)
disilicide (MoSi )
Pharmaceuticals Inc for about $4
Visit us at www.indianpatents.org.in
Contd from.4
Contd from.5
Contd from.11
No more needles .
Cadila's combination .
International News .
sequentially. For example, a
billion, adding a few branded drugs
a combination drug of penicillin
corticosteroid contained in one
to Mylan's generic-drug offerings.
of the reservoirs can be
The deal would help Mylan make
lactobacilli (microorganism) may
the jump from copy-cat drugs to
administered to a subject having
have been patented for the first
more profitable patent-protected
stable reactive airway disease
time but what is patented is the
drugs, a transition that almost every
and if symptoms persist, then
process and not the combination
generic drug company aims to make.
the beta-agonist contained in
drug itself. Thus, prima facie, the
The Economic Times, July 27, 2004
another reservoir also can be
process evolved by Cadila is not
delivered. The multiple reservoirs
Forgent Network Inc, a modest
found to be patentable and Instacare
software company, has found
thus provide the flexibility to
cannot be restrained from using
goldmine in patents. Forgent has
dispense drug compositions
the process for its products and
been hiring lawyers to extract revenue
based on changing clinical
marketing them. The court was
from the company's store of old
also of the opinion that the trial
patents. The company has already
• The applicator can be used for
judge in vacating the ex parte ad
reaped nearly $50 million by claiming
intranasal or inhalation
interim injunction and rejecting the
that one of its patents cover JEPG,
administration of both simple
application for interim injunction
the popular standard for digital
and complex drug regimens to
was justified.
images. The company is now
treat various diseases, eg.,
Despite so much dispute in India
demanding payment for a patent it
vasopressin can be administered
for this process patent, Cadila
says underlies the digital-recorder
intranasally to treat central
Pharmaceuticals were successful
diabetes insipidus, and opiods
in getting their process patent granted
The Financial Express, July
or benzodiazeprins can be
by the British Patent Office and
delivered by pulmonary inhalation
United States Patent and Trademark
Pfizer Inc failed to get a restraining
for treatment of anxiety in lung
Office in the year 2001 (PFC's
order blocking Ivax Corp from selling
cancer patients.
finding). Cadila Pharmaceuticals
a copy of its Neurontin seizure
• The controller in the applicator
has also filed a complaint in the
medicine, which generated $2.7
can be programmed to adjust
Supreme Court seeking action
billion in sales last year. Ivax is
dosage of an administered drug
against the patent infringement.
selling a tablet form of gobapentin,
depending on the clinical
Obtaining, maintaining and enforcing
the main ingredient of Neurontin.
circumstances. The dosage can
patents are not simple activities.
Since Pfizer sells Neurontin in the
In this case Cadila may use the
capsule form, doctors have to specify
be adjusted for a particular time
wisdom of British and the US patent
that Ivax's version is acceptable
period, or based on an event
offices to push its case in the
before pharmacists can substitute
that require a dosage modification
Supreme Court . It would be an
the Ivax drug when filling Neurontin
(eg., an adverse drug reaction
interesting battle to watch as it
prescriptions. Pfizer will continue
that requires reduction of drug
may involve many technical brains
with other legal options.
administration). The invention
to establish/de establish the claims
Business line, August 22, 2004
thus enables complex drugadministration.
of Cadila.
Please send us questions and topics you
would like to see in the coming issues
Published by: Patent Facilitating Centre (PFC)
Technology Information, Forecasting and Assessment Council (TIFAC)
Department of Science and Technology (DST)Technology Bhavan, New Mehrauli Road, New Delhi - 110 016
• Case Study
Tel.: 26859581, 26863877, 26967458 Fax: 26863866e-mail: [email protected] website: www.indianpatents.org.in and www.tifac.org.in
• Case Law
Editor: R. Saha, Director, PFC
Bulletin Team : Sangeeta Talwar & Yashawant Dev Panwar
• Patents for Opposition
Printed by Reliant Press Pvt. Ltd., New Delhi-110 020Telefax: 2638 4567, 2638 9593 e-mail : [email protected]
Visit us at www.indianpatents.org.in
Source: http://www.pfc.org.in/fac/aug04.pdf
Brain Advance Access published December 3, 2007 Brain (2007) Page 1 of 15 Neural correlates of tic severity and cognitivecontrol in children with Tourette syndrome C. L. Baym,1,4, B. A. Corbett,1,2,3, S. B. Wright1,5 and S. A. Bunge1,5,6 1Center for Mind and Brain, 2Department of Psychiatry and Behavioral Sciences, 3MIND Institute, University of Californiaat Davis, 4Department of Psychology, University of Illinois at Urbana-Champaign, 5Helen Wills Neuroscience Institute and6Department of Psychology, University of California at Berkeley, USA
LIVING IN KARST Iowa Geological Survey Guidebook Series No. 25 IOWA FIELD CONFERENCE FOR PUBLIC POLICY MAKERS OCTOBER 11-12, 2005 Iowa Department of Natural Resources Jeffrey R. Vonk, Director October 2005 The collapse of rock and soil into underground crevices and caves causes sinkholes (circular pits)