Carmeda.eu

CARMEDA® BIOACTIVE SURFACE REFERENCE LIST Table of content Hoffman, J.; Larm, O.; Scholander, E., A new method for covalent coupling of heparin and
other glycosaminoglycans to substances containing primary amino groups. Carbohydr Res
1983, 117, 328-331.
Pejler, G.; Lindahl, U.; Larm, O.; Scholander, E.; Sandgren, E.; Lundblad, A., Monoclonal
antibodies specific for oligosaccharides prepared by partial nitrous acid deamination of hepa-
rin. J Biol Chem 1988, 263, (11), 5197-5201.
Bertilsson, L.;. Elwing, H.; Liedberg, B.; Larm, O.; Riesenfeld, J.; Scholander, E.; Infrared
characterization of complex sandwich structures: heparin immobilization on polyethylene
surfaces. Molecular Engineering 1991, 1, 49-57.
Experimental in vitro – Biocompatibility Larm, O.; Larsson, R.; Olsson, P., A new non-thrombogenic surface prepared by selective
covalent binding of heparin via a modified reducing terminal residue
Biomater Med Devices Artif Organs, 1983, 11, 161-173.
Pasche, B.; Kodama, K.; Larm, O.; Olsson, P.; Swedenborg, J., Thrombin inactivation on
surfaces with covalently bonded heparin. Thromb Res 1986, 44, (6), 739-748.
Arnander, C.; Dryjski, M.; Larsson, R.; Olsson, P.; Swedenborg, J., Thrombin uptake and
inhibition on endothelium and surfaces with a stable heparin coating: a comparative in vitro
study. J Biomed Mater Res 1986, 20, (2), 235-246.
Larm, O.; Lins, L. E.; Olsson, P., An approach to antithrombosis by surface modification.
Progress in Artificial Organs 1986, , 313-318.
Arnander, C.; Pasche, B.; Kodama, K.; Rasmuson, A.; Olsson, P., Influence of high and low
wall shear rates on the inhibition of factor Xa and thrombin at surfaces coated with immobi-
lized heparin. Artif Organs 1989, 13, (6), 521-526.
Pasche, B.; Elgue, G.; Olsson, P.; Riesenfeld, J.; Rasmuson, A., Binding of antithrombin to
immobilized heparin under varying flow conditions. Artif Organs 1991, 15, (6), 481-491.
Kodama, K.; Pasche, B.; Olsson, P.; Swedenborg, J.; Adolfsson, L.; Larm, O.; Riesenfeld, J.,
Antithrombin III binding to surface immobilized heparin and its relation to F Xa inhibition.
Thromb Haemost 1987, 58, (4), 1064-1067.
Videm, V.; Mollnes, T. E.; Garred, P.; Svennevig, J. L., Biocompatibility of extracorporeal
circulation. In vitro comparison of heparin-coated and uncoated oxygenator circuits. J Thorac
Cardiovasc Surg 1991, 101, (4), 654-660.
Videm, V.; Nilsson, L.; Venge, P.; Svennevig, J. L., Reduced granulocyte activation with a
heparin-coated device in an in vitro model of cardiopulmonary bypass. Artif Organs 1991, 15,
(2), 90-95.
Stenach, N.; Korn, R. L.; Fisher, C. A.; Jeevanandam, V.; Addonizio, V. P., The effects of
heparin bound surface modification (Carmeda Bioactive Surface) on human platelet altera-
tions during simulated extracorporeal circulation. J Extra Corpor Technol 1992, 24, (3), 97-
102.
Nilsson, U. R.; Larm, O.; Nilsson, B.; Storm, K. E.; Elwing, H.; Nilsson Ekdahl, K., Modifica-
tion of the complement binding properties of polystyrene: effects of end-point heparin at-
tachment. Scand J Immunol 1993, 37, (3), 349-354.
Elgue, G.; Sanchez, J.; Egberg, N.; Olsson, P.; Riesenfeld, J., Effect of surface-immobilized
heparin on the activation of adsorbed factor XII. Artif Organs 1993, 17, (8), 721-726.
Elgue, G.; Blomback, M.; Olsson, P.; Riesenfeld, J., On the mechanism of coagulation inhibi-
tion on surfaces with end point immobilized heparin. Thromb Haemost 1993, 70, (2), 289-
293.
Wendel, H. P.; Heller, W.; Gallimore, M. J.; Hoffmeister, H. E., Heparin-coated oxygenators
significantly reduce contact system activation in an in vitro cardiopulmonary bypass model.
Blood Coagul Fibrinolysis 1994, 5, (5), 673-678.
Mollnes, T. E.; Riesenfeld, J.; Garred, P.; Nordstrom, E.; Hogasen, K.; Fosse, E.; Gotze, O.;
Harboe, M., A new model for evaluation of biocompatibility: combined determination of ne-
oepitopes in blood and on artificial surfaces demonstrates reduced complement activation by
immobilization of heparin. Artif Organs 1995, 19, (9), 909-917.
Sanchez, J.; Elgue, G.; Riesenfeld, J.; Olsson, P., Control of contact activation on end-point
immobilized heparin: the role of antithrombin and the specific antithrombin-binding sequence.
J Biomed Mater Res 1995, 29, (5), 655-661.
Orvim, U.; Barstad, R. M.; Vlasuk, G. P.; Sakariassen, K. S., Effect of selective factor Xa in-
hibition on arterial thrombus formation triggered by tissue factor/factor VIIa or collagen in an
ex vivo model of shear-dependent human thrombogenesis. Arterioscler Thromb Vasc Biol
1995, 15, (12), 2188-2194.
Korn, R. L.; Fisher, C. A.; Livingston, E. R.; Stenach, N.; Fishman, S. J.; Jeevanadam, V.;
Addonizio, V. P., The effects of Carmeda Bioactive Surface on human blood components
during simulated extracorporeal circulation. J Thorac Cardiovasc Surg 1996, 111, (5), 1073-
1084.
Moen, O.; Fosse, E.; Braten, J.; Andersson, C.; Hogasen, K.; Mollnes, T. E.; Venge, P.;
Kierulf, P., Differences in blood activation related to roller/centrifugal pumps and heparin-
coated/uncoated surfaces in a cardiopulmonary bypass model circuit. Perfusion 1996, 11,
(2), 113-123.
Yii, M.; Gourlay, T.; Fleming, J.; Matata, B.; Taylor, K. M., Evaluation of Carmeda bioactive
surface (CBAS), Duraflo II and a novel nonspecific protease-modified surface using a new in
vitro model simulating cardiopulmonary bypass. Perfusion JT - Perfusion 1996, 11, (3), 229-
240.
Wendel, H. P.; Heller, W.; Gallimore, M. J., Heparin-coated devices and high-dose aprotinin
optimally inhibit contact system activation in an in vitro cardiopulmonary bypass model. Im-
munopharmacology 1996, 32, (1-3), 128-130.
Baba, T.; Morisita, K.; Sakata, J.; Ito, T.; Hachiro, Y.; Kazui, T.; Abe, A.; Komatu, S., Experi-
mental studies on three types of heparin-coated cardiopulmonary bypass circuits. Artif Or-
gans 1997, 21, (7), 779-781.
Hogevold, H. E.; Moen, O.; Fosse, E.; Venge, P.; Braten, J.; Andersson, C.; Lyberg, T., Ef-
fects of heparin coating on the expression of CD11b, CD11c and CD62L by leucocytes in
extracorporeal circulation in vitro. Perfusion 1997, 12, (1), 9-20.
Borowiec, J. W.; Venge, P.; Henze, A.; Nilsson, B.; Stiernstrom, H., Biomaterial-dependent
blood activation during simulated extracorporeal circulation: a study of heparin-coated and
uncoated circuits. Thorac Cardiovasc Surg 1997, 45, (6), 295-301.
Borowiec, J.; Jaramillo, A.; Venge, P.; Nilsson, L.; Thelin, S., Effects of heparin-coating of
cardiopulmonary bypass circuits on leukocytes during simulated extracorporeal circulation.
Cardiovasc Surg 1997, 5, (6), 568-573.
Garred, P.; Mollnes, T. E., Immobilized heparin inhibits the increase in leukocyte surface ex-
pression of adhesion molecules. Artif Organs 1997, 21, (4), 293-299.
Sanchez, J.; Elgue, G.; Riesenfeld, J.; Olsson, P., Inhibition of the plasma contact activation
system of immobilized heparin: relation to surface density of functional antithrombin binding
sites. J Biomed Mater Res 1997, 37, (1), 37-42.
Hachiro, Y.; Morishita, K.; Ito, T.; Sakata, J.; Baba, T.; Tsukamoto, M.; Abe, T., The method
for keeping low perfusion flow weaning from centrifugal pumps: an evaluation of hemolysis in
the circulator units. Artif Organs 1997, 21, (7), 710-713.
Bannan, S.; Danby, A.; Cowan, D.; Ashraf, S.; Gesinde, M.; Martin, P., Cell activation and
thrombin generation in heparin bonded cardiopulmonary bypass circuits using a novel in vitro
model. Eur J Cardiothorac Surg 1997, 12, (2), 268-275.
Bannan, S.; Martin, P. G., Aprotinin complements heparin bonding in an in vitro model of
cardiopulmonary bypass. Br J Haematol 1998, 101, (3), 455-461.
Hayashi, Y.; Sawa, Y.; Nishimura, M.; Chang, J. C.; Amemiya, A.; Kagisaki, K.; Taketani, S.;
Yamaguchi, T.; Hirata, N.; Ohtake, S.; Matsuda, H., Nitric oxide gas infusion to the oxygen-
ator enhances the biocompatibility of heparin coated extracorporeal bypass circuits. ASAIO J
1998, 44, (5), M456-61.
Sanchez, J.; Elgue, G.; Riesenfeld, J.; Olsson, P., Studies of adsorption, activation, and inhi-
bition of factor XII on immobilized heparin. Thromb Res 1998, 89, (1), 41-50.
Lundberg, F.; Falkenback, D.; Bekassy, A. N.; Jennerberg, M.; Riesenfeld, J.; Ljungh, A.,
Doxorubicin reversibly decreases the antithrombogenicity of heparin immobilized on central
venous catheters. Pediatr Hematol Oncol 1998, 15, (1), 23-35.
Barstad, R. M.; Hamers, M. J.; Moller, A. S.; Sakariassen, K. S., Monocyte procoagulant ac-
tivity induced by adherence to an artificial surface is reduced by end-point immobilized hepa-
rin-coating of the surface. Thromb Haemost 1998, 79, (2), 302-305.
Niimi, Y.; Ichinose, F.; Ishiguro, Y.; Terui, K.; Uezono, S.; Morita, S.; Yamane, S., The effects
of heparin coating of oxygenator fibers on platelet adhesion and protein adsorption. Anesth
Analg 1999, 89, (3), 573-579
Wendel, H. P.; Scheule, A. M.; Eckstein, F. S.; Ziemer, G., Haemocompatibility of paediatric
membrane oxygenators with heparin-coated surfaces. Perfusion 1999, 14, (1), 21-28.
Mollnes, T. E.; Videm, V.; Christiansen, D.; Bergseth, G.; Riesenfeld, J.; Hovig, T., Platelet
compatibility of an artificial surface modified with functionally active heparin. Thromb Hae-
most 1999, 82, (3), 1132-1136.
Wendel, H. P.; Schulze, H. J.; Heller, W.; Hoffmeister, H. M., Platelet protection in coronary
artery surgery: benefits of heparin-coated circuits and high-dose aprotinin therapy. J Cardio-
thorac Vasc Anesth 1999, 13, (4), 388-392.
Hammaren, E.; Rosenberg, P. H.; Hynynen, M., Coating of extracorporeal circuit with heparin
does not prevent sequestration of propofol in vitro. Br J Anaesth 1999, 82, (1), 38-40.
Baksaas, S. T.; Videm, V.; Pedersen, T.; Karlsen, H.; Mollnes, T. E.; Brosstad, F.;
Svennevig, J. L., Comparison of three oxygenator-coated and one total-circuit-coated extra-
corporeal devices. Perfusion 1999, 14, (2), 119-127.
Wendel, H. P.; Weber, N.; Ziemer, G., Increased adsorption of high molecular weight kinino-
gen to heparin-coated artificial surfaces and correlation to hemocompatibility. Immunophar-
macology JT - Immunopharmacology 1999, 43, (2-3), 149-153.
Weber, N.; Wendel, H. P.; Ziemer, G., Quality assessment of heparin coatings by their bind-
ing capacities of coagulation and complement enzymes. J Biomater Appl 2000, 15, (1), 8-22.
Munch, K.; Wolf, M. F.; Gruffaz, P.; Ottenwaelter, C.; Bergan, M.; Schroeder, P.; Fogt, E. J.,
Use of simple and complex in vitro models for multiparameter characterization of human
blood-material/device interactions. J Biomater Sci Polym Ed 2000, 11, (11), 1147-1163.
Wendel, H. P.; Weber, N.; Ziemer, G., Comparative studies of the adsorption behavior of
plasma proteins to heparin-coated surfaces. Biomed Tech (Berl) 2000, 45, (10), 282-287.
Scholz, T.; Solberg, R.; Okkenhaug, C.; Videm, V.; Gallimore, M. J.; Mathisen, O.; Pedersen,
T.; Mollnes, T. E.; Bergan, A.; Soreide, O.; Klintmalm, G. B.; Aasen, A. O., Veno-venous by-
pass in liver transplantation: heparin-coated perfusion circuits reduce the activation of hu-
moral defense systems in an in vitro model. Perfusion 2001, 16, (4), 285-292.
Niimi, Y.; Ishiguro, Y.; Nakata, Y.; Goto, T.; Morita, S.; Yamane, S., Platelet adhesion to hep-
arin coated oxygenator fibers under in vitro static conditions: impact of temperature. ASAIO J
2001, 47, (4), 361-364.
Scholz, T.; Solberg, R.; Okkenhaug, C.; Videm, V.; Gallimore, M. J.; Mathisen, O.; Pedersen,
T.; Mollnes, T. E.; Bergan, A.; Soreide, O.; Klintmalm, G. B.; Aasen, A. O., Veno-venous by-
pass in liver transplantation: heparin-coated perfusion circuits reduce the activation of hu-
moral defense systems in an in vitro model. Perfusion 2001, 16, (4), 285-292.
Weber, N.; Wendel, H. P.; Ziemer, G., Hemocompatibility of heparin-coated surfaces and the
role of selective plasma protein adsorption. Biomaterials 2002, 23, (2), 429-439.
Kopp, R.; Mottaghy, K.; Kirschfink, M., Mechanism of complement activation during extracor-
poreal blood-biomaterial interaction: effects of heparin coated and uncoated surfaces. ASAIO
J 2002, 48, (6), 598-605.
Hayashi, Y.; Sawa, Y.; Hirata, N.; Nishimura, M.; Ueda, H.; Naka, Y.; Yamaguchi, T.; Ohtake,
S.; Matsuda, H., Improvement of bypass circuit biocompatibility: comparison and combination
of heparin-coated circuit and nitric oxide gas infusion. J Card Surg 2002, 17, (6), 477-484
Cornelius, R. M.; Sanchez, J.; Olsson, P.; Brash, J. L., Interactions of antithrombin and pro-
teins in the plasma contact activation system with immobilized functional heparin. J Biomed
Mater Res 2003, 67A, (2), 475-483.
Weber, N.; Caliebe, J.; Ziemer, G.; Wendel, H. P., Material-dependent levels of heat-shock
protein 70 (hsp70) in human plasma following contact of blood with artificial surfaces. J Bio-
mater Sci Polym Ed 2003, 14, (8), 747-760.
Videm, V., Endpoint-attached heparin blocks neutrophil sticking and spreading. Biomaterials
2004, 25, (1), 43-51.
Lappegard, K. T.; Fung, M.; Bergseth, G.; Riesenfeld, J.; Lambris, J. D.; Videm, V.; Mollnes,
T. E., Effect of complement inhibition and heparin coating on artificial surface-induced leuko-
cyte and platelet activation. Ann Thorac Surg 2004, 77, (3), 932-941.
Lappegard, K. T.; Fung, M.; Bergseth, G.; Riesenfeld, J.; Mollnes, T. E., Artificial surface-
induced cytokine synthesis: effect of heparin coating and complement inhibition. Ann Thorac
Surg 2004, 78, (1), 38-44.
Lappegard, K. T.; Riesenfeld, J.; Brekke, O. L.; Bergseth, G.; Lambris, J. D.; Mollnes, T. E.,
Differential effect of heparin coating and complement inhibition on artificial surface-induced
eicosanoid production. Ann Thorac Surg JT - The Annals of thoracic surgery. 2005, 79, (3),
917-923.
Heyligers, J. M.; Verhagen, H. J.; Rotmans, J. I.; Weeterings, C.; de Groot, P. G.; Moll, F. L.;
Lisman, T., Heparin immobilization reduces thrombogenicity of small-caliber expanded poly-
tetrafluoroethylene grafts. J Vasc Surg JT - Journal of vascular surgery : official publication,
the Society for Vascular Surgery [and] International Society for Cardiovascular 2006, 43, (3),
587-591.
Lappegard, K. T.; Bergseth, G.; Riesenfeld, J.; Pharo, A.; Magotti, P.; Lambris, J. D.; Moll-
nes, T. E., The artificial surface-induced whole blood inflammatory reaction revealed by in-
creases in a series of chemokines and growth factors is largely complement dependent. J
Biomed Mater Res A 2008, 87, (1), 129-135.
Bergseth, G.; Lambris, J. D.; Mollnes, T. E.; Lappegard, K. T., Artificial surface-induced in-
flammation relies on complement factor 5: proof from a deficient person. Ann Thorac Surg
2011, 91, (2), 527-533.
Experimental in vitro – Other Mottaghy, K.; Oedekoven, B.; Starmans, H.; Muller, B.; Kashefi, A.; Hoffmann, B.; Bohm, S.,
Technical aspects of plasma leakage prevention in microporous capillary membrane oxy-
genators. ASAIO Trans 1989, 35, (3), 640-643.
Vocelka, C. R.; Thomas, R.; Verrier, E.; Kunzelman, K., An in vitro comparison of gas trans-
fer and pressure drop of the Bentley Duraflo Coated Spiral Gold and the Medtronic Carmeda
Coated Maxima hollow fiber membrane oxygenators. J Extra Corpor Technol 1997, 29, (4),
185-188.
Zdanowski, Z.; Koul, B.; Hallberg, E.; Schalen, C., Influence of heparin coating on in vitro
bacterial adherence to poly(vinyl chloride) segments. J Biomater Sci Polym Ed 1997, 8, (11),
825-832.
Walczak, R.; Lawson, D. S.; Kaemmer, D.; McRobb, C.; McDermott, P.; Smigla, G.; Shearer,
I.; Lodge, A.; Jaggers, J., Evaluation of a preprimed microporous hollow-fiber membrane for
rapid response neonatal extracorporeal membrane oxygenation. Perfusion JT - Perfusion
2005, 20, (5), 269-75.
Hildenbrand, S. L.; Lehmann, H. D.; Wodarz, R.; Ziemer, G.; Wendel, H. P., PVC-plasticizer
DEHP in medical products: do thin coatings really reduce DEHP leaching into blood? Perfu-
sion 2005, 20, (6), 351-357.
Alexander, P. J.; Lawson, D. S.; Cornell, J.; Craig, D. M.; Cheifetz, I. M., Insensible water
loss from the medtronic minimax oxygenator: an In Vitro study. ASAIO J 2006, 52, (2), 206-
210.
Dwyer, A.; Sukavaneshvar, S.; Nimkar, S.; Aronoff, G. In Surface heparinization of hemodial-
ysis catheters reduces thrombus and fibrin sheath formation, ASDIN Annual scientific meet-
ing, 2006.
Sakariassen, K. S., Thrombus formation on apex of arterial stenosis: the need for a fluid high
shear stenosis diagnostic device. Future cardiology 2007, 3, (2), 193-201.
Urban, K.; Redford, D.; Larson, D. F., Insulin binding to the cardiopulmonary bypass bio-
materials. Perfusion 2007, 22, (3), 207-210.
Sakariassen, K. S., Validation of the human tissue factor/FVIIa complex as an antithrombotic
target and the discovery of a synthetic peptide. Future cardiology 2007, 3, (3), 249-262.
Burkhart, H. M.; Joyner, N.; Niles, S.; Ploessl, J.; Everett, J.; Iannettoni, M.; Richenbacher,
W., Presence of plasticizer di-2(ethylhexyl)phthalate in primed extracorporeal circulation cir-
cuits. ASAIO J 2007, 53, (3), 365-367.
Zhao, X.; Courtney, J. M.; Yin, H. Q.; West, R. H.; Lowe, G. D., Blood interactions with plasti-
cised poly (vinyl chloride): influence of surface modification. J Mater Sci Mater Med 2008, 19,
(2), 713-719.
Experimental in vivo – Extracorporeal circulation; Cardiovascu-lar surgery Bagge, L.; Thelin, S.; Hultman, J.; Nilsson, L.; Thorelius, J.; Hillstrom, P. A., Heparin-coated
CPB-sets increase biocompatibility and reduce endothelial cell damage in pigs. J Cardiotho-
rac Anesth 1989, 3, (5 Suppl 1), 84.
Nilsson, L.; Storm, K. E.; Thelin, S.; Bagge, L.; Hultman, J.; Thorelius, J.; Nilsson, U., Hepa-
rin-coated equipment reduces complement activation during cardiopulmonary bypass in the
pig. Artif Organs 1990, 14, (1), 46-48.
von Segesser, L. K.; Lachat, M.; Leskosek, B.; Turina, M.; Gallino, A.; von Felten, A.; Pei, P.,
Cardiopulmonary bypass with low systemic heparinization: an experimental study. Perfusion
1990, 5, (4), 267-276.
von Segesser, L. K.; Weiss, B. M.; Gallino, A.; Leskosek, B.; Redha, F.; von Felten, A.; Tu-
rina, M., Superior hemodynamics in left heart bypass without systemic heparinization. Eur J
Cardiothorac Surg 1990, 4, (7), 384-8; discussion 389.
von Segesser, L. K.; Lachat, M.; Gallino, A.; Weiss, B. M.; Leskosek, B.; Garcia, E.; Han-
seler, E.; von Felten, A.; Turina, M., Performance characteristics of centrifugal pumps with
heparin surface coating. Thorac Cardiovasc Surg 1990, 38, (4), 224-228.
Thelin, S.; Bagge, L.; Hultman, J.; Borowiec, J.; Nilsson, L.; Thorelius, J., Heparin-coated
cardiopulmonary bypass circuits reduce blood cell trauma. Experiments in the pig. Eur J
Cardiothorac Surg 1991, 5, (9), 486-491.
Campanella, C.; Cameron, E.; Sinclair, C.; Feilberg, V. L.; Hider, C.; Prasad, S.; Boulton, F.;
Lamb, D., Preliminary results of left heart bypass in pigs using a heparin-coated centrifugal
pump. Ann Thorac Surg 1991, 52, (2), 245-249.
von Segesser, L. K.; Weiss, B. M.; Pasic, M.; Leskosek, B.; von Felten, A.; Pei, P.; Turina,
M., Experimental evaluation of heparin-coated cardiopulmonary bypass equipment with low
systemic heparinization and high-dose aprotinin. Thorac Cardiovasc Surg 1991, 39, (5), 251-
256.
Plotz, F. B.; van Oeveren, W.; Hultquist, K. A.; Miller, C.; Bartlett, R. H.; Wildevuur, C. R., A
heparin-coated circuit reduces complement activation and the release of leukocyte inflamma-
tory mediators during extracorporeal circulation in a rabbit. Artif Organs 1992, 16, (4), 366-
370.
Redmond, J. M.; Gillinov, A. M.; Stuart, R. S.; Zehr, K. J.; Winkelstein, J. A.; Herskowitz, A.;
Cameron, D. E.; Baumgartner, W. A., Heparin-coated bypass circuits reduce pulmonary inju-
ry. Ann Thorac Surg 1993, 56, (3), 474-8; discussion 479.
Bhujle, R.; Li, J.; Shastri, P.; Gaffke, J. N.; Clift, J. E.; Ye, Y. W.; Dollar, M. L.; Ching, P.;
Chao, R.; Constantinescu, A.; Kulkarni, P. V.; Cheng, Q. C.; Wians, F.; Jessen, M. E.; Eber-
hart, R. C., Influence of cardiopulmonary bypass on platelet and neutrophil accumulations in
internal organs. ASAIO J 1997, 43, (5), M739-44.
Bagge, L.; Borowiec, J. W.; Thelin, S.; Hultman, J., Haemostasis at low heparin dosage dur-
ing cardiopulmonary bypass with heparin-coated circuits in pigs. Scand Cardiovasc J 1997,
31, (5), 275-281.
Weerwind, P. W.; van der, V. e. F.; Lindhout, T.; de Jong, D. S.; Cahalan, P. T., Ex vivo test-
ing of heparin-coated extracorporeal circuits: bovine experiments. Int J Artif Organs 1998, 21,
(5), 291-298.
Hussaini, B. E.; Treanor, P. R.; Healey, N. A.; Tilahun, D.; Srey, R.; Lu, X. G.; Khuri, S. F.;
Thatte, H. S., Evaluation of blood components exposed to coated arterial filters in extracor-
poreal circuits. Perfusion 2009, 24, (5), 317-323.
Hussaini, B. E.; Treanor, P. R.; Healey, N. A., Multifactorial Comparison of Modified and
Conventional Perfusion Strategies in A Porcine Model of Cardiopulmonary Bypass. J Surg
Res 2010, .
Teligui, L.; Dalmayrac, E.; Mabilleau, G.; Macchi, L.; An ex vivo evaluation of blood coagula-
tion and thromboresistance of two extracorporeal circuit coatings with reduced and full hepa-
rin dose. Interact Cardiovasc Thorac Surg 2014, 18, (6).
Experimental in vivo – Extracorporeal circulation; Long term assist Bindslev, L.; Gouda, I.; Inacio, J.; Kodama, K.; Lagergren, H.; Larm, O.; Nilsson, E.; Olsson,
P., Extracorporeal elimination of carbon dioxide using a surface-heparinized veno-venous
bypass system. ASAIO Trans 1986, 32, (1), 530-533.
Klein, M. D.; Arensman, R. M.; Weber, T. R.; Mottaghy, K.; Langer, R.; Nolte, S. H., Pediatric
ECMO. Directions for new developments. ASAIO Trans 1988, 34, (4), 978-985.
Durham, S. J.; Borovetz, H. S.; Leonard, R.; Griffith, B. P., Right ventricular perfusion and
heparin bonding of a cross-flow membrane oxygenator. ASAIO Trans 1988, 34, (3), 817-819.
Mottaghy, K.; Oedekoven, B.; Schaich-Lester, D.; Poppel, K.; Kupper, W., Application of sur-
faces with end point attached heparin to extracorporeal circulation with membrane lungs.
ASAIO Trans 1989, 35, (2), 146-152.
Mottaghy, K.; Oedekoven, B.; Poppel, K.; Bruchmuller, K.; Kovacs, B.; Spahn, A.; Geisen, C.,
Heparin free long-term extracorporeal circulation using bioactive surfaces. ASAIO Trans
1989, 35, (3), 635-637.
Marcolin, R.; Cugno, M.; Pesenti, A.; Uziel, L.; Giuffrida, A.; Vitale, G.; Keim, R.; Meda, F.;
Fabrizi, I.; Gattinoni, L., Extracorporeal circulation in sheep with normal bleeding time using a
surface heparinized circuit. ASAIO Trans 1991, 37, (4), 584-587.
Koul, B.; Willen, H.; Sjoberg, T.; Wetterberg, T.; Kugelberg, J.; Steen, S., Pulmonary seque-
lae of prolonged total venoarterial bypass: evaluation with a new experimental model. Ann
Thorac Surg 1991, 51, (5), 794-799.
Koul, B.; Wetterberg, T.; Sjoberg, T.; Kimblad, P. O.; Kugelberg, J.; Steen, S., Veno-right
ventricular bypass as total extracorporeal lung assistance. An experimental study. J Thorac
Cardiovasc Surg 1991, 101, (4), 719-723.
Plotz, F. B.; van Oeveren, W.; Aloe, L. S.; Riley, M. K.; Hultquist, K. A.; Bartlett, R. H.;
Wildevuur, C. R., Prophylactic administration of tranexamic acid preserves platelet numbers
during extracorporeal circulation in rabbits. ASAIO Trans 1991, 37, (3), M416-7.
Mottaghy, K.; Oedekoven, B.; Poppel, K.; Kovacs, B.; Kirschfink, M.; Bruchmuller, K.; Ka-
shefi, A.; Geisen, C., Heparin-coated versus non-coated surfaces for extracorporeal circula-
tion. Int J Artif Organs 1991, 14, (11), 721-728.
Frenckner, B.; Ehren, H.; Palmer, K.; Gouda, I.; Larm, O.; Olsson, P., Surface-heparinized
neonatal ECMO circuit--an experimental animal study. Perfusion 1992, 7, (1), 47-51.
Shanley, C. J.; Hultquist, K. A.; Rosenberg, D. M.; McKenzie, J. M.; Shah, N. L.; Bartlett, R.
H., Prolonged extracorporeal circulation without heparin. Evaluation of the Medtronic Mini-
max oxygenator. ASAIO J 1992, 38, (3), M311-6.
Koul, B.; Vesterqvist, O.; Egberg, N.; Steen, S., Twenty-four-hour heparin-free veno-right
ventricular ECMO: an experimental study. Ann Thorac Surg 1992, 53, (6), 1046-1051.
Kirschfink, M.; Kovacs, B.; Mottaghy, K., Extracorporeal circulation: in vivo and in vitro analy-
sis of complement activation by heparin-bonded surfaces. Circ Shock 1993, 40, (3), 221-226.
Palmer, K.; Ehren, H.; Benz, R.; Frenckner, B., Carmeda surface heparinization in neonatal
ECMO systems: long-term experiments in a sheep model. Perfusion 1995, 10, (5), 307-313.
Crotti, S.; Tubiolo, D.; Pelosi, P.; Chiumello, D.; Mascheroni, D.; Gattinoni, L., Long-term
evaluation of gas exchange and hydrodynamic performance of a heparinized artificial lung:
comparison of two different hollow fiber pore sizes. Int J Artif Organs 1997, 20, (1), 22-28.
Urlesberger, B.; Zobel, G.; Rodl, S.; Dacar, D.; Friehs, I.; Leschnik, B.; Muntean, W., Activa-
tion of the clotting system: heparin-coated versus non coated systems for extracorporeal
circulation. Int J Artif Organs 1997, 20, (12), 708-712.
Ao, H.; Tajiri, A.; Yanagi, F.; Okamoto, T.; Tashiro, M.; Sakanashi, Y.; Tanimoto, H.; Moon, J.
K.; Terasaki, H., Heparin bonding of the extracorporeal circuit reduces thrombosis during
prolonged lung assist in goats. ASAIO J 2000, 46, (6), 723-729.
Kopp, R.; Bensberg, R.; Henzler, D.; Niewels, A.; Randerath, S.; Rossaint, R.; Kuhlen, R.,
Hemocompatibility of a miniaturized extracorporeal membrane oxygenation and a pumpless
interventional lung assist in experimental lung injury. Artif Organs 2010, 34, (1), 13-
Experimental in vivo – Extracorporeal circulation; Other Lins, L. E.; Olsson, P.; Hjelte, M. B.; Larsson, R.; Larm, O., Haemodialysis in dogs with a
heparin coated hollow fibre dialyser. Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985,
21, 270-275.
Sistino, J. J.; Michler, R. E.; Mongero, L. B.; Schwartz, A.; Marboe, C.; Geiman, R.; Kwiat-
kowski, P., Safety of heparin-coated circuits in primates during deep hypothermic cardiopul-
monary bypass. J Extra Corpor Technol 1993, 25, (1), 15-21.
Experimental in vivo – Ventricular assist von Segesser, L. K.; Weiss, B. M.; Bisang, B.; Leskosek, B.; Turina, M. I., Ventricular assist
with heparin surface coated devices. ASAIO Trans 1991, 37, (3), M278-9.
von Segesser, L. K.; Weiss, B. M.; Hanseler, E.; Bisang, B.; Leskosek, B.; von Felten, A.;
Turina, M., Improved biocompatibility of heparin surface-coated ventricular assist devices. Int
J Artif Organs 1992, 15, (5), 301-306.
Wagner-Mann, C.; Curtis, J.; Mann, F. A.; Turk, J.; Demmy, T.; Turpin, T., Subchronic cen-
trifugal mechanical assist in an unheparinized calf model. Artif Organs 1996, 20, (6), 666-
669.
Experimental in vivo – Peripheral vascular surgery Begovac, P. C.; Thomson, R. C.; Fisher, J. L.; Hughson, A.; Gallhagen, A., Improvements in
GORE-TEX(R) Vascular Graft Performance by Carmeda(R) BioActive Surface Heparin Im-
mobilization. Eur J Vasc Endovasc Surg 2003, 25, (5), 432-437.
Lin, P. H.; Bush, R. L.; Yao, Q.; Lumsden, A. B.; Chen, C., Evaluation of platelet deposition
and neointimal hyperplasia of heparin-coated small-caliber ePTFE grafts in a canine femoral
artery bypass model(1). J Surg Res 2004, 118, (1), 45-52.
Lin, P. H.; Chen, C.; Bush, R. L.; Yao, Q.; Lumsden, A. B.; Hanson, S. R., Small-caliber hep-
arin-coated ePTFE grafts reduce platelet deposition and neointimal hyperplasia in a baboon
model. J Vasc Surg 2004, 39, (6), 1322-8.
Pedersen, G.; Laxdal, E.; Ellensen, V.; Jonung, T.; Mattsson, E., Improved patency and re-
duced intimal hyperplasia in PTFE grafts with luminal immobilized heparin compared with
standard PTFE grafts at six months in a sheep model. J Cardiovasc Surg (Torino) 2010, 51,
(3), 443-448.
Experimental in vivo – Coronary stenting Hardhammar, P.; Albertsson, P.; Emanuelsson, H., [May heparinization of stents eliminate
the risk of thrombosis? Development of coronary angioplasty may be changed]. Lakartid-
ningen JT - Lakartidningen 1995, 92, (14), 1477-1478.
Hardhammar, P. A.; van Beusekom, H. M.; Emanuelsson, H. U.; Hofma, S. H.; Albertsson, P.
A.; Verdouw, P. D.; Boersma, E.; Serruys, P. W.; van der Giessen, W. J., Reduction in
thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary ar-
teries. Circulation 1996, 93, (3), 423-430.
Lin, P. H.; Chronos, N. A.; Marijianowski, M. M.; Chen, C.; Conklin, B.; Bush, R. L.; Lumsden,
A. B.; Hanson, S. R., Carotid stenting using heparin-coated balloon-expandable stent reduc-
es intimal hyperplasia in a baboon model. J Surg Res 2003, 112, (1), 84-90.
Lin, P. H.; Chronos, N. A.; Marijianowski, M. M.; Chen, C.; Bush, R. L.; Conklin, B.; Lumsden,
A. B.; Hanson, S. R., Heparin-coated balloon-expandable stent reduces intimal hyperplasia
in the iliac artery in baboons. J Vasc Interv Radiol 2003, 14, (5), 603-611
Zhao J, Falotico R, Nguyen T, Cheng Y, Parker T, Dave V, Rogers C, Riesenfeld J. A none-
lutable low-molecular weight heparin stent coating for improved thromboresistance. J Biomed
Mater Res B Appl Biomater 2012;100:1274-82.
Experimental in vivo – Peripheral stenting Levy, E. I.; Boulos, A. S.; Hanel, R. A.; Tio, F. O.; Alberico, R. A.; Fronckowiak, M. D.;
Nemes, B.; Paciorek, A. M.; Guterman, L. R.; Hopkins, L. N., In vivo model of intracranial
stent implantation: a pilot study to examine the histological response of cerebral vessels after
randomized implantation of heparin-coated and uncoated endoluminal stents in a blinded
fashion. J Neurosurg 2003, 98, (3), 544-553.
Experimental in vivo – Other Arnander, C., Hjelte, M-B., Lins, L-e., Larm, O., Larsson, R., Olsson, P., Blood compatibility
of a hollow-fiber dialyzer with a new coating of covalently bound heparin. Proceedings / Eu-
ropean Society for Artificial Organs, ESAO 1982, 9, 312-315.
Arnander, C.; Bagger-Sjoback, D.; Frebelius, S.; Larsson, R.; Swedenborg, J., Long-term
stability in vivo of a thromboresistant heparinized surface. Biomaterials 1987, 8, (6), 496-499.
Arnander, C.; Olsson, P.; Larm, O., Influence of blood flow and the effect of protamine on the
thromboresistant properties of a covalently bonded heparin surface. J Biomed Mater Res
1988, 22, (10), 859-868.
Arnander, C., Enhanced patency of small-diameter tubings after surface immobilization of
heparin fragments. A study in the dog. J Biomed Mater Res 1989, 23, (3), 285-294.
Steen, S.; Sjoberg, T.; Massa, G.; Ericsson, L.; Lindberg, L., Safe pulmonary preservation for
12 hours with low-potassium-dextran solution. Ann Thorac Surg 1993, 55, (2), 434-440.
Clutton-Brock, T. H.; Fink, S.; Markle, D.; Luthra, A. J.; Hendry, S. P., The evaluation of a
new intravascular blood gas monitoring system in the pig. J Clin Monit 1994, 10, (6), 387-
391.
Christiansson, L.; Hellberg, A.; Koga, I.; Thelin, S.; Bergqvist, D.; Wiklund, L.; Karacagil, S.,
A new method of intrathecal PO2, PCO2, and pH measurements for continuous monitoring
of spinal cord ischemia during thoracic aortic clamping in pigs. Surgery 2000, 127, (5), 571-
576
Foley, P. L.; Barthel, C. H.; Brausa, H. R., Effect of covalently bound heparin coating on pa-
tency and biocompatibility of long-term indwelling catheters in the rat jugular vein. Comp Med
2002, 52, (3), 243-248.
Levine, A.; Kenet, G.; Bruck, R.; Avni, Y.; Avinoach, I.; Aeed, H.; Matas, Z.; David, M.;
Yayon, A., Effect of heparin on tissue binding activity of fibroblast growth factor and heparin-
binding epidermal growth factor in experimental colitis in rats. Pediatr Res JT - Pediatric re-
search 2002, 51, (5), 635-40.
Piacentini, M. F.; Clinckers, R.; Meeusen, R.; Sarre, S.; Ebinger, G.; Michotte, Y., Effect of
bupropion on hippocampal neurotransmitters and on peripheral hormonal concentrations in
the rat. J Appl Physiol 2003, 95, (2), 652-656.
Buckwalter, J. B.; Curtis, V. C.; Valic, Z.; Ruble, S. B.; Clifford, P. S., Endogenous vascular
remodeling in ischemic skeletal muscle: a role for nitric oxide. J Appl Physiol 2003, 94, (3),
935-940.
Zareie, M.; Keuning, E. D.; ter Wee, P. M.; Beelen, R. H.; van den, B. o. J., Improvement of a
chronic rat model for peritoneal dialysis by using heparin-coated catheters. Adv Perit Dial JT
- Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 2004, 20, 150-154.
Wachtman, L. M.; Browning, M. D.; Bedja, D.; Pin, S.; Gabrielson, K. L., Validation of the use
of long-term indwelling jugular catheters in a rat model of cardiotoxicity. J Am Assoc Lab
Anim Sci JT - Journal of the American Association for Laboratory Animal Science : JAALAS.
2006, 45, (5), 55-64.
Bridges, C., New heparin coating reduces thrombosis and fibrin sheath formation in HD
catheters. Nephrol News Issues JT - Nephrology news & issues 2007, 21, (3), 32.
Vesely, T., Reviewing the benefits of a new heparin-coated hemodialysis catheter. Renal
Business Today 2007, 2, (3).
Fonseca, U. N.; Nielsen, S. G.; Hau, J.; Hansen, A. K., Permanent catheterization of the ca-
rotid artery induces kidney infection and inflammation in the rat. Lab Anim 2009, Oct 26, 1-8.
Clinical – Extracorporeal circulation; Cardiovascular surgery Mollnes, T. E.; Videm, V.; Gotze, O.; Harboe, M.; Oppermann, M., Formation of C5a during
cardiopulmonary bypass: inhibition by precoating with heparin. Ann Thorac Surg 1991, 52,
(1), 92-97.
Borowiec, J.; Thelin, S.; Bagge, L.; van der Linden, J.; Thorno, E.; Hansson, H. E., Heparin-
coated cardiopulmonary bypass circuits and 25% reduction of heparin dose in coronary ar-
tery surgery--a clinical study. Ups J Med Sci 1992, 97, (1), 55-66.
Videm, V.; Svennevig, J. L.; Fosse, E.; Semb, G.; Osterud, A.; Mollnes, T. E., Reduced com-
plement activation with heparin-coated oxygenator and tubings in coronary bypass opera-
tions. J Thorac Cardiovasc Surg 1992, 103, (4), 806-813.
von Segesser, L. K.; Weiss, B. M.; Garcia, E.; von Felten, A.; Turina, M. I., Reduction and
elimination of systemic heparinization during cardiopulmonary bypass. J Thorac Cardiovasc
Surg 1992, 103, (4), 790-8; discussion 798-9.
Borowiec, J.; Thelin, S.; Bagge, L.; Nilsson, L.; Venge, P.; Hansson, H. E., Heparin-coated
circuits reduce activation of granulocytes during cardiopulmonary bypass. A clinical study. J
Thorac Cardiovasc Surg 1992, 104, (3), 642-7.
Borowiec, J.; Thelin, S.; Bagge, L.; Hultman, J.; Hansson, H. E., Decreased blood loss fol-
lowing cardiopulmonary bypass using heparin-coated circuits and 50% reduction of heparin
dose. Scand J Thorac Cardiovasc Surg 1992, 26, (3), 177-85.
Hollingsed, M. J.; Hill, R.; Wittig, R.; Murray, G., Heparin-coated cardiopulmonary bypass: a
clinical case incorporating a standard cardiotomy. Perfusion 1992, 7, 305-314
Couyant, M. A.; Beemer, G. H., A proposed protocol for the management of cardiopulmonary
bypass for patients with heparin-induced thrombosis thrombocytopenia syndrome. Journal of
australasian perfusion society 1992
Borowiec, J. W.; Bylock, A.; van der Linden, J.; Thelin, S., Heparin coating reduces blood cell
adhesion to arterial filters during coronary bypass: a clinical study. Ann Thorac Surg 1993,
55, (6), 1540-1545.
von Segesser, L. K.; Garcia, E.; Turina, M. I., Low-dose heparin versus full-dose heparin with
high-dose aprotinin during cardiopulmonary bypass. A preliminary report. Tex Heart Inst J
1993, 20, (1), 28-32.
Chaiyaroj, S.; Couyant, M.; Angelopoulos, P.; Tatoulis, J., Cardiac surgery with low systemic
heparinisation using aheparin bonded tubing circuit. AustralAs. J. Cardiac Thorac. Surg.
1993, 2, (1), 30-31.
Belboul, A.; Al-Khaja, N.; Gudmundsson, M.; Karlsson, H.; Uchino, T.; Liu, B.; El-Gatit, A.;
Bjell, A.; Roberts, D.; William-Olsson, G., The influence of heparin-coated and uncoated ex-
tracorporeal circuits on blood rheology during cardiac surgery. J Extra Corpor Technol 1993,
25, (2), 40-46.
von Segesser, L. K., Use of heparin-bonded surfaces in cardiopulmonary bypass. Perfusion
1993, 8 (suppl), 21-27.
Jones, D. R.; Hill, R. C.; Hollingsed, M. J.; Stullken, E.; Graeber, G. M.; Gustafson, R. A.;
Murray, G. F., Use of heparin-coated cardiopulmonary bypass. Ann Thorac Surg 1993, 56,
(3), 566-568.
Dowling, R. D.; Brown, M. E.; Whittington RO, J. r.; Quinlan, J. J.; Armitage, J. M., Clinical
cardiopulmonary bypass without systemic anticoagulation. Ann Thorac Surg 1993, 56, (5),
1176-7; discussion 1177-8.
Shigemitsu, O.; Hadama, T.; Takasaki, H.; Mori, Y.; Kimura, T.; Miyamoto, S.; Sako, H.;
Soeda, T.; Kawawaki, Y.; Uchida, Y., Biocompatibility of a heparin-bonded membrane oxy-
genator (Carmeda MAXIMA) during the first 90 minutes of cardiopulmonary bypass: clinical
comparison with the conventional system. Artif Organs 1994, 18, (12), 936-941.
Fosse, E.; Moen, O.; Johnson, E.; Semb, G.; Brockmeier, V.; Mollnes, T. E.; Fagerhol, M. K.;
Venge, P., Reduced complement and granulocyte activation with heparin-coated cardiopul-
monary bypass. Ann Thorac Surg 1994, 58, (2), 472-477.
Kuki, S.; Yoshida, K.; Suzuki, K.; Matsumura, R.; Okuda, A., A successful case of left heart
bypass with biocompatible bypass circuit and minimal heparin for severe heart failure after
open mitral commissurotomy]. Nippon Kyobu Geka Gakkai Zasshi 1994, 42, (7), 1108-1112.
Sellevold, O. F.; Berg, T. M.; Rein, K. A.; Levang, O. W.; Iversen, O. J.; Bergh, K., Heparin-
coated circuit during cardiopulmonary bypass. A clinical study using closed circuit, centrifugal
pump and reduced heparinization. Acta Anaesthesiol Scand 1994, 38, (4), 372-9.
Wagner, W. R.; Johnson, P. C.; Thompson, K. A.; Marrone, G. C., Heparin-coated cardio-
pulmonary bypass circuits: hemostatic alterations and postoperative blood loss. Ann Thorac
Surg 1994, 58, (3), 734-40; discussion 741.
Pekna, M.; Borowiec, J.; Fagerhol, M. K.; Venge, P.; Thelin, S., Biocompatibility of heparin-
coated circuits used in cardiopulmonary bypass. Scand J Thorac Cardiovasc Surg 1994, 28,
(1), 5-11.
Cheung, A. T.; Levin, S. K.; Weiss, S. J.; Acker, M. A.; Stenach, N., Intracardiac thrombus: a
risk of incomplete anticoagulation for cardiac operations. Ann Thorac Surg 1994, 58, (2),
541-542.
Hatori, N.; Yoshizu, H.; Haga, Y.; Kusama, Y.; Takeshima, S.; Segawa, D.; Tanaka, S., Bio-
compatibility of heparin-coated membrane oxygenator during cardiopulmonary bypass. Artif
Organs 1994, 18, (12), 904-910.
Jones, D. R.; Hill, R. C.; Vasilakis, A.; Hollingsed, M. J.; Graeber, G. M.; Gustafson, R. A.;
Cruzzavala, J. L.; Murray, G. F., Safe use of heparin-coated bypass circuits incorporating a
pump-oxygenator. Ann Thorac Surg 1994, 57, (4), 815-8; discussion 818-9.
Ovrum, E.; Mollnes, T. E.; Fosse, E.; Holen, E. A.; Tangen, G.; Abdelnoor, M.; Ringdal, M.
A.; Oystese, R.; Venge, P., Complement and granulocyte activation in two different types of
heparinized extracorporeal circuits. J Thorac Cardiovasc Surg 1995, 110, (6), 1623-32.
Moen, O.; Fosse, E.; Brockmeier, V.; Andersson, C.; Mollnes, T. E.; Hogasen, K.; Venge, P.,
Disparity in blood activation by two different heparin-coated cardiopulmonary bypass sys-
tems. Ann Thorac Surg 1995, 60, (5), 1317-23.
Nilsson, L.; Peterson, C.; Venge, P.; Borowiec, J. W.; Thelin, S., Eosinophil granule proteins
in cardiopulmonary bypass with and without heparin coating. Ann Thorac Surg 1995, 59, (3),
713-6.
Borowiec, J. W.; Hagman, L.; Totterman, T. H.; Pekna, M.; Venge, P.; Thelin, S., Circulating
cytokines and granulocyte-derived enzymes during complex heart surgery. A clinical study
with special reference to heparin-coating of cardiopulmonary bypass circuits. Scand J Thorac
Cardiovasc Surg 1995, 29, (4), 167-74.
Ernofsson, M.; Thelin, S.; Siegbahn, A., Thrombin generation during cardiopulmonary bypass
using heparin-coated or standard circuits. Scand J Thorac Cardiovasc Surg 1995, 29, (4),
157-65.
Steinberg, B. M.; Grossi, E. A.; Schwartz, D. S.; McLoughlin, D. E.; Aguinaga, M.; Bizekis,
C.; Greenwald, J.; Flisser, A.; Spencer, F. C.; Galloway, A. C.; et, a. l., Heparin bonding of
bypass circuits reduces cytokine release during cardiopulmonary bypass. Ann Thorac Surg
1995, 60, (3), 525-529.
Moen, O.; Fosse, E.; Dregelid, E.; Brockmeier, V.; Andersson, C.; Hogasen, K.; Venge, P.;
Mollnes, T. E.; Kierulf, P., Centrifugal pump and heparin coating improves cardiopulmonary
bypass biocompatibility. Ann Thorac Surg 1996, 62, (4), 1134-1140.
von Segesser, L. K., Surface coating of cardiopulmonary bypass circuits. Perfusion 1996, 11,
(3), 241-245
Rao, P. S.; Palazzo, R. S.; Harlow, G. L.; Bocchieri, K. A.; Metz, H. N.; Wilson, D. W.; Rao,
S. K.; Graver, L. M., Myocardial preservation, redox potential maintenance and oxidant injury
by heparin-coated Carmeda circuit. Ann N Y Acad Sci 1996, 793, 511-513.
Fukutomi, M.; Kobayashi, S.; Niwaya, K.; Hamada, Y.; Kitamura, S., Changes in platelet,
granulocyte, and complement activation during cardiopulmonary bypass using heparin-
coated equipment. Artif Organs 1996, 20, (7), 767-76.
Toda, R.; Saigenji, H.; Nishida, T.; Moriyama, Y.; Masuda, H.; Taira, A., A case of ASD with
SLE treated with Carmeda BioActive surface circuit in cardiopulmonary bypass system.
Kyobu Geka 1996, 49, (5), 389-391.
Saenz, A.; Larranaga, G.; Alvarez, L.; Greco, E.; Marrero, A.; Lunar, M.; Elosegui, C.; Ubago,
J. L.; Gallo, I., Heparin-coated circuit in coronary surgery. A clinical study. Eur J Cardiothorac
Surg 1996, 10, (1), 48-53.
Gorman, R. C.; Ziats, N.; Rao, A. K.; Gikakis, N.; Sun, L.; Khan, M. M.; Stenach, N.; Sapat-
nekar, S.; Chouhan, V.; Gorman JH, 3. r.; Niewiarowski, S.; Colman, R. W.; Anderson, J. M.;
Edmunds LH, J. r., Surface-bound heparin fails to reduce thrombin formation during clinical
cardiopulmonary bypass. J Thorac Cardiovasc Surg 1996, 111, (1), 1-11; discussion 11-2.
Watanabe, H.; Miyamura, H.; Hayashi, J.; Ohzeki, H.; Sugawara, M.; Takahashi, Y.; Eguchi,
S., The influence of a heparin-coated oxygenator during cardiopulmonary bypass on postop-
erative lung oxygenation capacity in pediatric patients with congenital heart anomalies. J
Card Surg 1996, 11, (6), 396-401.
Bozdayi, M.; Borowiec, J.; Nilsson, L.; Venge, P.; Thelin, S.; Hansson, H. E., Effects of hepa-
rin coating of cardiopulmonary bypass circuits on in vitro oxygen free radical production dur-
ing coronary bypass surgery. Artif Organs 1996, 20, (9), 1008-16.
Ovrum, E.; Brosstad, F.; Am Holen, E.; Tangen, G.; Abdelnoor, M.; Oystese, R., Complete
heparin-coated (CBAS) cardiopulmonary bypass and reduced systemic heparin dose; effects
on coagulation and fibrinolysis. Eur J Cardiothorac Surg 1996, 10, (6), 449-55.
Matheve, C., Clinical evidence of improved biocompatibility using heparin-coated surfaces.
Perfusion 1996, 11, (3), 264-269.
Shapira, O. M.; Aldea, G. S.; Zelingher, J.; Volpe, C.; Fitzgerald, C.; DeAndrade, K.; Lazar,
H. L.; Shemin, R. J., Enhanced blood conservation and improved clinical outcome after valve
surgery using heparin-bonded cardiopulmonary bypass circuits. J Card Surg 1996, 11, (5),
307-317.
Aldea, G. S.; Doursounian, M.; O'Gara, P.; Treanor, P.; Shapira, O. M.; Lazar, H. L.; Shemin,
R. J., Heparin-bonded circuits with a reduced anticoagulation protocol in primary CABG: a
prospective, randomized study. Ann Thorac Surg 1996, 62, (2), 410-7; discussion 417-8.
Aldea, G. S.; Shapira, O. M.; Treanor, P. R.; Lazar, H. L.; Shemin, R. J., Effective use of
heparin-bonded circuits and lower anticoagulation for coronary artery bypass grafting in Je-
hovah's Witnesses. J Card Surg 1996, 11, (1), 12-17.
Aldea, G. S.; Zhang, X.; Memmolo, C. A.; Shapira, O. M.; Treanor, P. R.; Kupferschmid, J.
P.; Lazar, H. L.; Shemin, R. J., Enhanced blood conservation in primary coronary artery by-
pass surgery using heparin-bonded circuits with lower anticoagulation. J Card Surg 1996, 11,
(2), 85-95.
Ovrum, E.; Fosse, E.; Mollnes, T. E.; Am Holen, E.; Tangen, G.; Abdelnoor, M.; Ringdal, M.
A.; Oystese, R.; Venge, P., Complete heparin-coated cardiopulmonary bypass and low hepa-
rin dose reduce complement and granulocyte activation. Eur J Cardiothorac Surg 1996, 10,
(1), 54-60.
Ganjoo, A. K.; Harloff, M. G.; Johnson, W. D., Cardiopulmonary bypass for heparin-induced
thrombocytopenia: management with a heparin-bonded circuit and enoxaparin. J Thorac
Cardiovasc Surg 1996, 112, (5), 1390-1392
Gorman, R. C.; Ziats, N.; Rao, A. K.; Gikakis, N.; Sun, L.; Khan, M. M.; Stenach, N.; Sapat-
nekar, S.; Chouhan, V.; Gorman JH, 3. r.; Niewiarowski, S.; Colman, R. W.; Anderson, J. M.;
Edmunds LH, J. r., Surface-bound heparin fails to reduce thrombin formation during clinical
cardiopulmonary bypass. J Thorac Cardiovasc Surg 1996, 111, (1), 1-11; discussion 11-2.
Peters, F. P., Treatment of heparin-induced thrombocytopenia. J Thorac Cardiovasc Surg
1997, 114, (3), 517-518.
Aldea, G. S.; Lilly, K.; Gaudiani, J. M.; O'Gara, P.; Stein, D.; Bao, Y.; Treanor, P.; Osman, A.;
Shapira, O. M.; Lazar, H. L.; Shemin, R. J., Heparin-bonded circuits improve clinical out-
comes in emergency coronary artery bypass grafting. J Card Surg 1997, 12, (6), 389-397.
Rao, S. K.; Palazzo, R. S.; Metz, H. N.; Wilson, D. W.; Nikolic, S. D.; Graver, M.; Rao, P. S.,
Redox potential measurements of plasma in patients undergoing coronary artery bypass
graft and its clinical significance. J Pharmacol Toxicol Methods 1997, 38, (3), 151-156.
Misoph, M.; Babin-Ebell, J.; Schwender, S., A comparative evaluation of the effect of pump
type and heparin-coated surfaces on platelets during cardiopulmonary bypass. Thorac Car-
diovasc Surg 1997, 45, (6), 302-6.
Lundblad, R.; Moen, O.; Fosse, E., Endothelin-1 and neutrophil activation during heparin-
coated cardiopulmonary bypass. Ann Thorac Surg 1997, 63, (5), 1361-7.
Borowiec, J.; Bagge, L.; Saldeen, T.; Thelin, S., Biocompatibility reflected by haemostasis
variables during cardiopulmonary bypass using heparin-coated circuits. Thorac Cardiovasc
Surg 1997, 45, (4), 163-7.
Svenmarker, S.; Haggmark, S.; Jansson, E.; Lindholm, R.; Appelblad, M.; Aberg, T., The
relative safety of an oxygenator. Perfusion 1997, 12, (5), 289-292.
Kagisaki, K.; Masai, T.; Kadoba, K.; Sawa, Y.; Nomura, F.; Fukushima, N.; Ichikawa, H.;
Ohata, T.; Suzuki, K.; Taketani, S.; Matsuda, H., Biocompatibility of heparin-coated circuits in
pediatric cardiopulmonary bypass. Artif Organs 1997, 21, (7), 836-40.
Ljunghusen, O.; Cederholm, I.; Lundahl, J.; Nilsson, B.; Olin, C.; Sjogren, F.; Stendahl, O.,
Phenotypic alterations in circulating monocytes induced by open heart surgery using hepa-
rinized and nonheparinized cardiopulmonary bypass systems. Artif Organs 1997, 21, (10),
1091-7.
Ashraf, S.; Tian, Y.; Cowan, D.; Entress, A.; Martin, P. G.; Watterson, K. G., Release of pro-
inflammatory cytokines during pediatric cardiopulmonary bypass: heparin-bonded versus
nonbonded oxygenators. Ann Thorac Surg 1997, 64, (6), 1790-4.
Belboul, A.; al-Khaja, N., Does heparin coating improve biocompatibility? A study on com-
plement, blood cells and postoperative morbidity during cardiac surgery. Perfusion 1997, 12,
(6), 385-391.
Bannan, S.; Danby, A.; Cowan, D.; Ashraf, S.; Martin, P. G., Low heparinization with heparin-
bonded bypass circuits: is it a safe strategy? Ann Thorac Surg 1997, 63, (3), 663-668.
Svenmarker, S.; Sandstrom, E.; Karlsson, T.; Jansson, E.; Haggmark, S.; Lindholm, R.; Ap-
pelblad, M.; Aberg, T., Clinical effects of the heparin coated surface in cardiopulmonary by-
pass. Eur J Cardiothorac Surg JT - European journal of cardio-thoracic surgery : official
journal of the European Association for Cardio-thoracic Surgery 1997, 11, (5), 957-64.
Schreurs, H. H.; Wijers, M. J.; Gu, Y. J.; van Oeveren, W.; van Domburg, R. T.; de Boer, J.
H.; Bogers, A. J., Heparin-coated bypass circuits: effects on inflammatory response in pediat-
ric cardiac operations. Ann Thorac Surg 1998, 66, (1), 166-71.
Spiess, B. D.; Vocelka, C.; Cochran, R. P.; Soltow, L.; Chandler, W. L., Heparin-coated by-
pass circuits (Carmeda) suppress the release of tissue plasminogen activator during normo-
thermic coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth 1998, 12, (3), 299-
304.
Baufreton, C.; Moczar, M.; Intrator, L.; Jansen, P. G.; te Velthuis, H.; Le Besnerais, P.; Far-
cet, J. P.; Wildevuur, C. R.; Loisance, D. Y., Inflammatory response to cardiopulmonary by-
pass using two different types of heparin-coated extracorporeal circuits. Perfusion 1998, 13,
(6), 419-27.
Misoph, M.; Schwender, S.; Babin-Ebell, J., Response of the cellular immune system to car-
diopulmonary bypass is independent of the applied pump type and of the use of heparin-
coated surfaces. Thorac Cardiovasc Surg 1998, 46, (4), 222-7.
Gott, J. P.; Cooper, W. A.; Schmidt FE, J. r.; Brown WM, 3. r.; Wright, C. E.; Merlino, J. D.;
Fortenberry, J. D.; Clark, W. S.; Guyton, R. A., Modifying risk for extracorporeal circulation:
trial of four antiinflammatory strategies. Ann Thorac Surg 1998, 66, (3), 747-53; discussion
753-4.
Wahba, A.; Philipp, A.; Behr, R.; Birnbaum, D. E., Heparin-coated equipment reduces the
risk of oxygenator failure. Ann Thorac Surg 1998, 65, (5), 1310-1312.
Mahoney, C. B., Heparin-bonded circuits: clinical outcomes and costs. Perfusion 1998, 13,
(3), 192-204.
Stammers, A. H.; Christensen, K. A.; Lynch, J.; Zavadil, D. P.; Deptula, J. J.; Sydzyik, R. T.,
Quantitative evaluation of heparin-coated versus non-heparin-coated bypass circuits during
cardiopulmonary bypass. J Extra Corpor Technol 1999, 31, (3), 135-141.
Mahoney, C. B.; Lemole, G. M., Transfusion after coronary artery bypass surgery: the impact
of heparin-bonded circuits. Eur J Cardiothorac Surg 1999, 16, (2), 206-10.
Palanzo, D. A.; Zarro, D. L.; Manley, N. J.; Montesano, R. M.; Quinn, M.; Gustafson, P. A.,
Effect of surface coating on platelet count drop during cardiopulmonary bypass. Perfusion
1999, 14, (3), 195-200.
Suehiro, S.; Shibata, T.; Sasaki, Y.; Hattori, K.; Kumano, H.; Hosono, M.; Kinoshita, H., Use
of heparin-coated cardiopulmonary bypass circuit with low-dose heparin reduces postopera-
tive bleeding. Ann Thorac Cardiovasc Surg 1999, 5, (4), 225-229.
Suehiro, S.; Shibata, T.; Sasaki, Y.; Hattori, K.; Kumano, H.; Hosono, M.; Fujii, H.; Kinoshita,
H., Heparin-coated circuits prevent renal dysfunction after open heart surgery. Osaka City
Med J 1999, 45, (2), 149-157.
Olsson, C.; Siegbahn, A.; Henze, A.; Nilsson, B.; Venge, P.; Joachimsson, P. O.; Thelin, S.,
Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and
interleukin-6 in paediatric heart surgery. Scand Cardiovasc J 2000, 34, (1), 33-40.
Grossi, E. A.; Kallenbach, K.; Chau, S.; Derivaux, C. C.; Aguinaga, M. G.; Steinberg, B. M.;
Kim, D.; Iyer, S.; Tayyarah, M.; Artman, M.; Galloway, A. C.; Colvin, S. B., Impact of heparin
bonding on pediatric cardiopulmonary bypass: a prospective randomized study. Ann Thorac
Surg 2000, 70, (1), 191-6.
Collart, F.; Caus, T.; Pomane, C.; Pellissier, V.; Chi, Y.; Monties, J. R.; Mesana, T., Clinical
evaluation of heparin-coated circuits for routine coronary artery bypass grafting surgery: a
prospective randomized study. Artif Organs 2000, 24, (8), 611-3.
Miyaji, K.; Hannan, R. L.; Ojito, J.; Jacobs, J. P.; White, J. A.; Burke, R. P., Heparin-coated
cardiopulmonary bypass circuit: clinical effects in pediatric cardiac surgery. J Card Surg
2000, 15, (3), 194-198.
Ralley, F. E.; De Varennes, B., Use of heparinase I in a patient with protamine allergy under-
going redo myocardial revascularization. J Cardiothorac Vasc Anesth 2000, 14, (6), 710-711
Svenmarker, S.; Sandstrom, E.; Karlsson, T.; Haggmark, S.; Jansson, E.; Appelblad, M.;
Lindholm, R.; Aberg, T., Neurological and general outcome in low-risk coronary artery by-
pass patients using heparin coated circuits. Eur J Cardiothorac Surg 2001, 19, (1), 47-53.
von Segesser, L. K., Safety and efficacy of heparin-bonded surfaces in cardiopulmonary by-
pass. J Thorac Cardiovasc Surg 2001, 121, (2), 200-201.
Palanzo, D. A.; Zarro, D. L.; Manley, N. J.; Montesano, R. M.; Quinn, M.; Elmore, B. A.; Gus-
tafson, P. A.; Castagna, J. M., Effect of Carmeda BioActive Surface coating versus Trillium
Biopassive Surface coating of the oxygenator on circulating platelet count drop during cardi-
opulmonary bypass. Perfusion 2001, 16, (4), 279-83.
Ovrum, E.; Tangen, G.; Oystese, R.; Ringdal, M. A.; Istad, R., Comparison of two heparin-
coated extracorporeal circuits with reduced systemic anticoagulation in routine coronary ar-
tery bypass operations. J Thorac Cardiovasc Surg 2001, 121, (2), 324-30.
Mongero, L. B.; Beck, J. R.; Manspeizer, H. E.; Heyer, E. J.; Lee, K.; Spanier, T. A.; Smith,
C. R., Cardiac surgical patients exposed to heparin-bonded circuits develop less postopera-
tive cerebral dysfunction than patients exposed to non-heparin-bonded circuits. Perfusion
2001, 16, (2), 107-111.
Wendel, H. P.; Philipp, A.; Weber, N.; Birnbaum, D. E.; Ziemer, G., Oxygenator thrombosis:
worst case after development of an abnormal pressure gradient--incidence and pathway.
Perfusion 2001, 16, (4), 271-278.
Svenmarker, S.; Sandstrom, E.; Karlsson, T.; Haggmark, S.; Jansson, E.; Appelblad, M.;
Lindholm, R.; Aberg, T., Neurological and general outcome in low-risk coronary artery by-
pass patients using heparin coated circuits. Eur J Cardiothorac Surg 2001, 19, (1), 47-53.
Flom-Halvorsen, H. I.; Ovrum, E.; Brosstad, F.; Tangen, G.; Ringdal, M.; Oystese, R., Effects
of two differently heparin-coated extracorporeal circuits on markers for brain and myocardial
dysfunction. Perfusion 2002, 17, (5), 339-345.
Svenmarker, S.; Haggmark, S.; Jansson, E.; Lindholm, R.; Appelblad, M.; Sandstrom, E.;
Aberg, T., Use of heparin-bonded circuits in cardiopulmonary bypass improves clinical out-
come. Scand Cardiovasc J 2002, 36, (4), 241-6.
Heyer, E. J.; Lee, K. S.; Manspeizer, H. E.; Mongero, L.; Spanier, T. B.; Caliste, X.; Esrig, B.;
Smith, C., Heparin-bonded cardiopulmonary bypass circuits reduce cognitive dysfunction. J
Cardiothorac Vasc Anesth 2002, 16, (1), 37-42.
Mullen, J. C.; Bentley, M. J.; Gelfand, E. T.; Koshal, A.; Modry, D. L.; Guenther, C. R.; Etch-
es, W. S.; Stang, L. J.; Lopushinsky, S. R., Coronary artery bypass surgery with heparin-
coated perfusion circuits and low-dose heparinization. Can J Surg 2002, 45, (3), 166-172.
Jensen, E.; Andreasson, S.; Bengtsson, A.; Berggren, H.; Ekroth, R.; Lindholm, L.; Ouchter-
lony, J., Influence of two different perfusion systems on inflammatory response in pediatric
heart surgery. Ann Thorac Surg 2003, 75, (3), 919-25.
Ovrum, E.; Tangen, G.; Tollofsrud, S.; Ringdal, M. A., Heparin-coated circuits and reduced
systemic anticoagulation applied to 2500 consecutive first-time coronary artery bypass graft-
ing procedures. Ann Thorac Surg 2003, 76, (4), 1144-8; discussion 1148.
van den, G. o. J.; van den, B. r. A.; Nieuwland, R.; van Oeveren, W.; Rutten, P. M.; Tepaske,
R.; Tijssen, J. G.; Sturk, A.; de Mol, B. A.; Eijsman, L., Generation of platelet-derived micro-
particles in patients undergoing cardiac surgery is not affected by complement activation. J
Thorac Cardiovasc Surg 2003, 126, (4), 1101-1106.
Lilly, K. J.; O'Gara, P. J.; Treanor, P. R.; Reardon, D.; Crowley, R.; Hunter, C.; Shapira, O.
M.; Aldea, G. S.; Lazar, H. L.; Shemin, R. J., Cardiopulmonary bypass: it's not the size, it's
how you use it! Review of a comprehensive blood-conservation strategy. J Extra Corpor
Technol 2004, 36, (3), 263-268.
Lindholm, L.; Westerberg, M.; Bengtsson, A.; Ekroth, R.; Jensen, E.; Jeppsson, A., A closed
perfusion system with heparin coating and centrifugal pump improves cardiopulmonary by-
pass biocompatibility in elderly patients. Ann Thorac Surg 2004, 78, (6), 2131-8; discussion
2138.
van den, G. o. J.; Nieuwland, R.; van den, B. r. A.; van Oeveren, W.; Rutten, P.; Tijssen, J.;
Eijsman, L., Reduced complement activation during cardiopulmonary bypass does not affect
the postoperative acute phase response. Eur J Cardiothorac Surg 2004, 26, (5), 926-931.
Boning, A.; Scheewe, J.; Ivers, T.; Friedrich, C.; Stieh, J.; Freitag, S.; Cremer, J. T., Phos-
phorylcholine or heparin coating for pediatric extracorporeal circulation causes similar biolog-
ic effects in neonates and infants. J Thorac Cardiovasc Surg 2004, 127, (5), 1458-1465.
Eisses, M. J.; Seidel, K.; Aldea, G. S.; Chandler, W. L., Reducing hemostatic activation dur-
ing cardiopulmonary bypass: a combined approach. Anesth Analg 2004, 98, (5), 1208-16,
table of content.
Jensen, E.; Andreasson, S.; Bengtsson, A.; Berggren, H.; Ekroth, R.; Larsson, L. E.; Ouch-
terlony, J., Changes in hemostasis during pediatric heart surgery: impact of a biocompatible
heparin-coated perfusion system. Ann Thorac Surg 2004, 77, (3), 962-967.
Baufreton, C.; Allain, P.; Chevailler, A.; Etcharry-Bouyx, F.; Corbeau, J. J.; Legall, D.; de
Brux, J. L., Brain injury and neuropsychological outcome after coronary artery surgery are
affected by complement activation. Ann Thorac Surg 2005, 79, (5), 1597-1605.
Kreisler, K. R.; Vance, R. A.; Cruzzavala, J.; Mahnken, J. D., Heparin-bonded cardiopulmo-
nary bypass circuits reduce the rate of red blood cell transfusion during elective coronary
artery bypass surgery. J Cardiothorac Vasc Anesth 2005, 19, (5), 608-611.
Jessen, M. E., Pro: Heparin-coated circuits should be used for cardiopulmonary bypass.
Anesth Analg JT - Anesthesia and analgesia 2006, 103, (6), 1365-1372.
Taneja, R.; Cheng, D. C., Con: Heparin-bonded cardiopulmonary bypass circuits should be
routine for all cardiac surgical procedures. Anesth Analg 2006, 103, (6), 1370-1372.
Schneider, S.; Sakert, T.; Lucke, J.; McKeown, P.; Sharma, A., Cardiopulmonary bypass for
a coronary artery bypass graft patient with heterozygous protein C deficiency and protein S
deficiency. Perfusion JT - Perfusion 2006, 21, (2), 117-120.
Eisses, M. J.; Velan, T.; Aldea, G. S.; Chandler, W. L., Strategies to reduce hemostatic acti-
vation during cardiopulmonary bypass. Thromb Res 2006, 117, (6), 689-703.
Poynter, J. A., Thromboresistant cardiopulmonary bypass circuits: room for improvement? J
Surg Res 2010, 163, (2), e51-2.
Preston, T. J.; Ratliff, T. M.; Gomez, Modified surface coatings and their effect on drug ad-
sorption within the extracorporeal life support circuit. J Extra Corpor Technol 2010, 42, (3),
199-202.
Singh, A. K.; Stearns, G.; Maslow, A.; Feng, W. C.; Schwartz, C., Redo Sternotomy for Car-
diac Reoperations Using Peripheral Heparin-Bonded Cardiopulmonary Bypass Circuits With-
out Systemic Heparinization: Technique and Results. J Cardiothorac Vasc Anesth 2010
Ovrum, E.; Tangen, G.; Tollofsrud, S.; Skeie, B.; Ringdal, M. A.; Istad, R.; Oystese, R., Hep-
arinized cardiopulmonary bypass circuits and low systemic anticoagulation: An analysis of
nearly 6000 patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg
2010.
Hussaini, B. E.; Thatte, H. S.; Rhodes, B. A.; Treanor, P. R.; Birjiniuk, V., Thromboresistant
surfaces with low-dose anticoagulation alleviate clopidogrel-related complications in patients
undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 2011, 141, (3), 782-
788.
Yu K, Long C, Hei F, Li J, Liu J, Ji B, Gao G, Zhang H, Song Y, Wang W. Clinical evaluation
of two different extracorporeal membrane oxygenation systems: a single center report. Artif
Organs 2011;35:733.
Nozohoor S, Johnsson P, Scicluna S, Wallentin P, Andell E, Nilsson J. A case-controlled
evaluation of the Medtronic Resting Heart System compared with conventional cardiopulmo-
nary bypass in patients undergoing isolated coronary artery bypass surgery. Interact Cardio-
vasc Thorac Surg 2012;14:599-604.
Nilsson, J.; Scicluna, S.; Malmkvist, G.; Pierre, L.; A randomized study of coronary artery
bypass surgery performed with the Resting Heart System utilizing a low vs a standard dos-
age of heparin. Interact Cardiovasc Thorac Surg 2012, 15, (5).
Clinical – Extracorporeal circulation; Long term assist Bindslev, L.; Eklund, J.; Norlander, O.; Swedenborg, J.; Olsson, P.; Nilsson, E.; Larm, O.;
Gouda, I.; Malmberg, A.; Scholander, E., Treatment of acute respiratory failure by extracor-
poreal carbon dioxide elimination performed with a surface heparinized artificial lung. Anes-
thesiology 1987, 67, (1), 117-120.
Peters, J.; Radermacher, P.; Kuntz, M. E.; Rosenbauer, K. A.; Breulmann, M.; Burrig, K. F.;
Hopf, H. B.; Rossaint, R.; Schulte, H. D.; Olsson, P.; et, a. l., Extracorporeal CO2-removal
with a heparin coated artificial lung. Intensive Care Med 1988, 14, (5), 578-584.
Bindslev, L., Adult ECMO performed with surface-heparinized equipment. ASAIO Trans
1988, 34, (4), 1009-1013.
Rossaint, R.; Slama, K.; Bauer, R.; Nienhaus, M.; Barth, H.; Weidemann, H.; Falke, K. J.,
Extracorporeal CO2-removal with a heparin coated extracorporeal system. Intensive Care
Med 1990, 16, (5), 344-5.
Bjertnaes, L. J.; Olafsen, K.; Nilsen, P. A.; Brondbo, A.; Thoner, J.; Vaage, J.; Solbo, J.;
Hansen, K.; Jolin, A., [Extracorporeal membrane oxygenation. A therapeutic alternative in
acute heart and/or pulmonary failure?]. Tidsskr Nor Laegeforen 1991, 111, (12), 1477-1480.
Bindslev, L.; Bohm, C.; Jolin, A.; Hambraeus Jonzon, K.; Olsson, P.; Ryniak, S., Extracorpo-
real carbon dioxide removal performed with surface-heparinized equipment in patients with
ARDS. Acta Anaesthesiol Scand Suppl 1991, 95, 125-30; discussion 130-1.
Koul, B.; Wetterberg, T.; Ohqvist, G.; Olsson, P., Veno-venous extracorporeal membrane
oxygenation with a heparin-coated system in adult respiratory distress syndrome. Scand J
Thorac Cardiovasc Surg 1991, 25, (3), 199-206.
Wetterberg, T.; Steen, S., Total extracorporeal lung assist--a new clinical approach. Intensive
Care Med 1991, 17, (2), 73-77.
Knoch, M.; Kollen, B.; Dietrich, G.; Muller, E.; Mottaghy, K.; Lennartz, H., Progress in veno-
venous long-term bypass techniques for the treatment of ARDS. Controlled clinical trial with
the heparin-coated bypass circuit. Int J Artif Organs 1992, 15, (2), 103-8.
Rossaint, R.; Slama, K.; Lewandowski, K.; Frey, D. J.; Weidemann, H.; Fuchs, J.; Nienhaus,
M.; Henin, P.; Falke, K., Major thoracic surgery during long-term extracorporeal lung assist
for treatment of severe adult respiratory distress syndrome (ARDS). Eur J Cardiothorac Surg
1992, 6, (1), 43-45.
Rossaint, R.; Slama, K.; Lewandowski, K.; Streich, R.; Henin, P.; Hopfe, T.; Barth, H.;
Nienhaus, M.; Weidemann, H.; Lemmens, P.; et, a. l., Extracorporeal lung assist with hepa-
rin-coated systems. Int J Artif Organs 1992, 15, (1), 29-34.
Willms, D.; Dembitsky, W., Prolonged extracorporeal support for ARDS using surface-
heparinized equipment. Chest 1992, 102, (3), 968-970.
Bennett, J.; Hill, J.; Long, W.; Parsons, J.; Bruhn, P.; Starr, A.; Hovaguimian, H.; Okies, J. E.,
Biocompatible circuits: an adjunct to non-cardiac extracorporeal cardiopulmonary support. J
Extra Corpor Technol 1992, 24, (2), 6-11.
Aranki, S. F.; Adams, D. H.; Rizzo, R. J.; Couper, G. S.; DeCamp, M. M.; Fitzgerald, D. J.;
Cohn, L. H., Femoral veno-arterial extracorporeal life support with minimal or no heparin.
Ann Thorac Surg 1993, 56, (1), 149-155.
Tsuno, K.; Terasaki, H.; Otsu, T.; Okamoto, T.; Sakanashi, Y.; Morioka, T., Newborn extra-
corporeal lung assist using a novel double lumen catheter and a heparin-bonded membrane
lung. Intensive Care Med 1993, 19, (2), 70-72.
Fjalldal, O.; Torfason, B.; Onundarson, P. T.; Thorsteinsson, A.; Vigfusson, G.; Stefansson,
T.; Magnusson, V., Prolonged total extracorporeal lung assistance without systemic heparini-
zation. Acta Anaesthesiol Scand 1993, 37, (1), 115-120.
Lazzara, R. R.; Magovern, J. A.; Benckart, D. H.; Maher TD, J. r.; Sakert, T.; Magovern GJ,
J. r., Extracorporeal membrane oxygenation for adult post cardiotomy cardiogenic shock us-
ing a heparin bonded system. ASAIO J 1993, 39, (3), M444-7.
Bennett, J. B.; Hill, J. G.; Long WB, 3. r.; Bruhn, P. S.; Haun, M. M.; Parsons, J. A., Interhos-
pital transport of the patient on extracorporeal cardiopulmonary support. Ann Thorac Surg
1994, 57, (1), 107-111.
Willms, D. C.; Wachtel, T. L.; Daleiden, A. L.; Dembitsky, W. P.; Schibanoff, J. M.; Gibbons,
J. A., Venovenous extracorporeal life support in traumatic bronchial disruption and adult res-
piratory distress syndrome using surface-heparinized equipment: case report. J Trauma
1994, 36, (2), 252-254.
Magovern GJ, J. r.; Magovern, J. A.; Benckart, D. H.; Lazzara, R. R.; Sakert, T.; Maher TD,
J. r.; Clark, R. E., Extracorporeal membrane oxygenation: preliminary results in patients with
postcardiotomy cardiogenic shock. Ann Thorac Surg 1994, 57, (6), 1462-8; discussion 1469-
7.
Muehrcke, D. D.; McCarthy, P. M.; Stewart, R. W.; Seshagiri, S.; Ogella, D. A.; Foster, R. C.;
Cosgrove, D. M., Complications of extracorporeal life support systems using heparin-bound
surfaces. The risk of intracardiac clot formation. J Thorac Cardiovasc Surg 1995, 110, (3),
843-851.
Ehren, H.; Palmer, K.; Eriksson, M.; Frenckner, B., Pediatric ECMO for pulmonary support:
experience from 12 cases. Acta Paediatr 1995, 84, (4), 442-446.
Yamanishi, H.; Watanabe, S.; Hayashi, K., [Relatively long time use of percutaneous cardio-
pulmonary support after unsuccessful weaning from intra-operative extracorporeal circula-
tion--clinical considerations from an experience of 5 patients]. Nippon Kyobu Geka Gakkai
Zasshi JT - [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai 1995, 43, (10), 1783-7.
Wang, S. S.; Chen, Y. S.; Ko, W. J.; Chu, S. H., Extracorporeal membrane oxygenation sup-
port for postcardiotomy cardiogenic shock. Artif Organs 1996, 20, (12), 1287-91
del Nido, P. J., Extracorporeal membrane oxygenation for cardiac support in children. Ann
Thorac Surg 1996, 61, (1), 336-9; discussion 340-1.
Muehrcke, D. D.; McCarthy, P. M.; Stewart, R. W.; Foster, R. C.; Ogella, D. A.; Borsh, J. A.;
Cosgrove DM, 3. r., Extracorporeal membrane oxygenation for postcardiotomy cardiogenic
shock. Ann Thorac Surg 1996, 61, (2), 684-691.
Musch, G.; Verweij, M.; Bombino, M.; Banfi, G.; Fumagalli, R.; Pesenti, A., Small pore size
microporous membrane oxygenator reduces plasma leakage during prolonged extracorpore-
al circulation: a case report. Int J Artif Organs 1996, 19, (3), 177-180.
Ko, W. J.; Chen, Y. S.; Chou, N. K.; Wang, S. S.; Chu, S. H., Extracorporeal membrane oxy-
genation in the perioperative period of heart transplantation. J Formos Med Assoc 1997, 96,
(2), 83-90.
Gerlach, M.; Fohre, B.; Keh, D.; Riess, H.; Falke, K. J.; Gerlach, H., Global and extended
coagulation monitoring during extracorporeal lung assist with heparin-coated systems in
ARDS patients. Int J Artif Organs 1997, 20, (1), 29-36.
Usui, A.; Murakami, F.; Ooshima, H.; Tomita, Y.; Yoshida, K.; Hibi, M.; Kawamura, M.; Mu-
ras, M., A clinical study for the durability of oxygenators on cardiopulmonary support. Artif
Organs 1997, 21, (7), 772-778.
Karle, V. A.; Short, B. L.; Martin, G. R.; Bulas, D. I.; Getson, P. R.; Luban, N. L.; O'Brien, A. M.; Rubin, R. J., Extracorporeal membrane oxygenation exposes infants to the plasticizer, di(2-ethylhexyl)phthalate. Crit Care Med 1997, 25, (4), 696-703.
Jacobs, J. P.; Ojito, J. W.; McConaghey, T. W.; Boden, B. D.; Chang, A. C.; Aldousany, A.;
Zahn, E. M.; Burke, R. P., Rapid cardiopulmonary support for children with complex congeni-
tal heart disease. Ann Thorac Surg 2000, 70, (3), 742-9; discussion 749-50.
Chou, N. K.; Chen, Y. S.; Ko, W. J.; Huang, S. C.; Chao, A.; Jan, G. J.; Lin, F. Y.; Wang, S.
S.; Chu, S. H., Application of extracorporeal membrane oxygenation in adult burn patients.
Artif Organs 2001, 25, (8), 622-626.
Pereszlenyi, A.; Lang, G.; Steltzer, H.; Hetz, H.; Kocher, A.; Neuhauser, P.; Wisser, W.;
Klepetko, W., Bilateral lung transplantation with intra- and postoperatively prolonged ECMO
support in patients with pulmonary hypertension. Eur J Cardiothorac Surg 2002, 21, (5), 858-
863.
Lin, R.; Tan, L. H.; Zhang, Z. W.; Sun, M. Y.; Du, L. Z., [Extracorporeal membrane oxygena-
tion treatment of a neonate with severe low cardiac output syndrome following open heart
surgery]. Zhonghua Er Ke Za Zhi 2008, 46, (1), 26-29.
Zhao, J.; Liu, J.; Feng, Z.; Hu, S.; Liu, Y.; Sheng, X.; Li, S.; Wang, X.; Long, C., Clinical out-
comes and experience of 20 pediatric patients treated with extracorporeal membrane oxy-
genation in Fuwai Hospital. ASAIO J 2008, 54, (3), 302-305.
Clinical – Extracorporeal circulation; Other Jolin, A.; Eden, E.; Berggren, H.; Roos, A.; von Essen, C.; Stephensen, H.; Hedstrom, A.;
Karlsson, H.; Lindholm-Fransson, L.; Ricksten, S. E., Management of a giant intracranial
aneurysm using surface-heparinized extracorporeal circulation and controlled deep hypo-
thermic low flow perfusion. A case report. Acta Anaesthesiol Scand 1993, 37, (8), 756-760.
Contino, J. P.; Follette, D. M.; Berkoff, H. A.; Pollock, M. E.; Bogren, H.; Wisner, D. H., Use
of Carmeda-coated femoral-femoral bypass during repair of traumatic aortic pseudoaneu-
rysms. Arch Surg 1994, 129, (9), 933-7; discussion 937-9.
Sander-Jensen, K.; Krogager, G.; Pettersson, G., Left atrial-aortic/femoral bypass with a cen-
trifugal pump without systemic heparin during surgery on the descending aorta. Artif Organs
1995, 19, (7), 774-6.
Tyndal CM, J. r.; Rose, M. W.; McFalls, R. E.; Jacks, A.; Pinson, T.; Athanasuleas, C. L.,
Profound accidental hypothermia in the deep South: clinical experience. Perfusion 1996, 11,
(1), 57-60.
Morishita, K.; Inoue, S.; Baba, T.; Sakata, J.; Kazui, T.; Abe, T., Our distal aortic perfusion
system in descending thoracic and thoracoabdominal aortic aneurysm repairs. Artif Organs
1997, 21, (7), 822-4.
Sasaki, A.; Kazui, T.; Ohkawa, Y.; Doi, H.; Sugiki, K.; Ohno, T., A case of two stage opera-
tion of thoracic and thoracoabdominal aortic aneurysm of a patient in late phase with
Behcet's disease. Kyobu Geka 1997, 50, (11), 954-957.
Mesana, T.; Collart, F.; Caus, T.; Pomane, C.; Graziani, N.; Bruder, N.; Dufour, H.; Grisoli,
F.; Monties, J. R., Centrifugal pumps and heparin-coated circuits in surgical treatment of gi-
ant cerebral aneurysms. Artif Organs 2000, 24, (6), 431-436.
Hattori, K.; Suehiro, S.; Shibata, T.; Sasaki, Y.; Kumano, H.; Kinoshita, H., Use of A heparin-
coated circuit for extracorporeal circulation with selective cerebral perfusion. Osaka City Med
J 2000, 46, (2), 111-118.
Ko, W. J.; Chen, Y. S.; Lee, Y. C., Replacing cardiopulmonary bypass with extracorporeal
membrane oxygenation in lung transplantation operations. Artif Organs 2001, 25, (8), 607-
612.
Scholz, T.; Solberg, R.; Okkenhaug, C.; Videm, V.; Gallimore, M. J.; Mathisen, O.; Mollnes,
T. E.; Bergan, A.; Soreide, O.; Klintmalm, G. B.; Aasen, A. O., The significance of heparin-
coated veno-venous bypass circuits in liver transplantation. Perfusion 2002, 17, (1), 45-50.
Hachiro, Y.; Morishita, K.; Koshima, R.; Nakashima, S.; Takagi, N.; Tsukamoto, M.; Abe, T.;
Hashi, K., Hypothermia with heparin-coated circuits and low dose systemic heparinization in
neurosurgery. Artif Organs 2002, 26, (6), 551-5.
Morishita, K.; Kawaharada, N.; Fukada, J.; Hachiro, Y.; Kurimoto, Y.; Fujisawa, Y.; Saito, T.;
Abe, T., Descending thoracic aortic aneurysm repair with the aid of partial cardiopulmonary
bypass: heparin-coated circuits versus nonheparin-coated circuits. Artif Organs 2005, 29, (4),
300-305.
Miraziz, R.; Hines, L.; Brouwer, M.; Steel, R.; Klineberg, P., Bridging circuit for the resection
of retroperitoneal sarcoma involving the aorta and the IVC- veno-venous to veno-arterial per-
fusion. Perfusion 2008, 23, (1), 65-69.
Clinical – Ventricular assist Bianchi, J. J.; Swartz, M. T.; Raithel, S. C.; Braun, P. R.; Illes, M. Z.; Barnett, M. G.; Penning-
ton, D. G., Initial clinical experience with centrifugal pumps coated with the Carmeda pro-
cess. ASAIO J 1992, 38, (3), M143-6.
Nishida, H.; Koyanagi, H.; Hashimoto, A.; Endo, M.; Aomi, S.; Koyanagi, T.; Hirota, J.; Ta-
gusari, O.; Yamaki, F., Clinical experience of assisted circulation with a centrifugal pump at
Tokyo Women's Medical College. Artif Organs 1993, 17, (7), 625-629.
Magovern GJ, J. r., The biopump and postoperative circulatory support. Ann Thorac Surg
1993, 55, (1), 245-249.
Williams, M. R.; Quaegebeur, J. M.; Hsu, D. T.; Addonizio, L. J.; Kichuk, M. R.; Oz, M. C.,
Biventricular assist device as a bridge to transplantation in a pediatric patient. Ann Thorac
Surg 1996, 62, (2), 578-580.
Kaufmann, F.; Hennig, E.; Loebe, M.; Hetzer, R., Improving the Antithrombogenity of Artificial
Surfaces through Heparin Coating - Clinical experience with the pneumatic extracorporeal
Berlin Heart Assist Device. Cardiovascular engineering 1996, 1, (1), 40-44.
Hetzer, R.; Loebe, M.; Potapov, E. V.; Weng, Y.; Stiller, B.; Hennig, E.; Alexi-Meskishvili, V.;
Lange, P. E., Circulatory support with pneumatic paracorporeal ventricular assist device in
infants and children. Ann Thorac Surg 1998, 66, (5), 1498-1506
Pavie, A.; Leger, P.; Nzomvuama, A.; Szefner, J.; Regan, M.; Vaissier, E.; Gandjbakhch, I.,
Left centrifugal pump cardiac assist with transseptal percutaneous left atrial cannula. Artif
Organs 1998, 22, (6), 502-507.
Koster, A.; Sanger, S.; Hansen, R.; Sodian, R.; Mertzlufft, F.; Harke, C.; Kuppe, H.; Hetzer,
R.; Loebe, M., Prevalence and persistence of heparin/platelet factor 4 antibodies in patients
with heparin coated and noncoated ventricular assist devices. ASAIO J 2000, 46, (3), 319-
322.
Drews, T.; Loebe, M.; Hennig, E.; Kaufmann, F.; Muller, J.; Hetzer, R., The 'Berlin Heart' as-
sist device. Perfusion 2000, 15, (4), 387-396.
Koster, A.; Loebe, M.; Sodian, R.; Potapov, E. V.; Hansen, R.; Muller, J.; Mertzlufft, F.; Crys-
tal, G. J.; Kuppe, H.; Hetzer, R., Heparin antibodies and thromboembolism in heparin-coated
and noncoated ventricular assist devices. J Thorac Cardiovasc Surg 2001, 121, (2), 331-335.
Bonaros, N. E., Carmeda biocative surface minimizes platelet activation after implantation of
the Micromed debakey VAD. ASAIO 2003, 49, (2), 154-154.
Goldstein, D. J., Worldwide experience with the MicroMed DeBakey Ventricular Assist De-
vice as a bridge to transplantation. Circulation 2003, 108, (10 Suppl 1), 272-277.
Merkle, F.; Boettcher, W.; Stiller, B.; Hetzer, R., Pulsatile mechanical cardiac assistance in
pediatric patients with the Berlin heart ventricular assist device. J Extra Corpor Technol 2003,
35, (2), 115-120.
Kucukaksu, D. S.; Sener, E.; Undar, A.; Noon, G. P.; Tasdemir, O., First Turkish experience
with the MicroMed DeBakey VAD. Tex Heart Inst J 2003, 30, (2), 114-120.
Stiller, B.; Hetzer, R.; Weng, Y.; Hummel, M.; Hennig, E.; Nagdyman, N.; Ewert, P.;
Lehmkuhl, H.; Lange, P. E., Heart transplantation in children after mechanical circulatory
support with pulsatile pneumatic assist device. J Heart Lung Transplant 2003, 22, (11), 1201-
1208.
Hetzer, R.; Potapov, E. V.; Weng, Y.; Sinawski, H.; Knollmann, F.; Komoda, T.; Hennig, E.;
Pasic, M., Implantation of MicroMed DeBakey VAD through left thoracotomy after previous
median sternotomy operations. Ann Thorac Surg 2004, 77, (1), 347-350.
Dewald, O.; Schmitz, C.; Diem, H.; Goehring, P.; Vetter, H. O.; Roell, W.; Goedje, O.;
Tschoepe, D.; Reichart, B., Platelet activation markers in patients with heart assist device.
Artif Organs 2005, 29, (4), 292-299.
Thoennissen, N. H.; Schneider, M.; Allroggen, A.; Ritter, M.; Dittrich, R.; Schmid, C.; Scheld,
H. H.; Ringelstein, E. B.; Nabavi, D. G., High level of cerebral microembolization in patients
supported with the DeBakey left ventricular assist device. J Thorac Cardiovasc Surg 2005,
130, (4), 1159-1166.
Stiller, B.; Weng, Y.; Hubler, M.; Lemmer, J.; Nagdyman, N.; Redlin, M.; Lange, P. E.; Het-
zer, R., Pneumatic pulsatile ventricular assist devices in children under 1 year of age. Eur J
Cardiothorac Surg 2005, 28, (2), 234-239
Eghtesady, P.; Nelson, D.; Schwartz, S. M.; Wheeler, D.; Pearl, J. M.; Cripe, L. H.; Manning,
P. B., Heparin-Induced Thrombocytopenia Complicating Support by the Berlin Heart. ASAIO
J 2005, 51, (6), 820-825.
Hetzer, R.; Alexi-Meskishvili, V.; Weng, Y.; Hubler, M.; Potapov, E.; Drews, T.; Hennig, E.;
Kaufmann, F.; Stiller, B., Mechanical cardiac support in the young with the Berlin Heart EX-
COR pulsatile ventricular assist device: 15 years' experience. Semin Thorac Cardiovasc
Surg Pediatr Card Surg Annu JT - Seminars in thoracic and cardiovascular surgery. Pediat-
ric cardiac surgery annual. 2006, , 99-108.
Hetzer, R.; Potapov, E. V.; Stiller, B.; Weng, Y.; Hubler, M.; Lemmer, J.; Alexi-Meskishvili, V.;
Redlin, M.; Merkle, F.; Kaufmann, F.; Hennig, E., Improvement in survival after mechanical
circulatory support with pneumatic pulsatile ventricular assist devices in pediatric patients.
Ann Thorac Surg JT - The Annals of thoracic surgery 2006, 82, (3), 917-24; discussion 924-
5.
Potapov, E. V.; Hetzer, R., Pediatric Berlin heart excor. Ann Thorac Cardiovasc Surg JT -
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic
and Cardiovascular Su 2006, 12, (2), 155.
Riesenfeld, J.; Ries, D.; Hetzer, R., Analysis of the heparin coating of an EXCOR Ventricular
Assist Device after 855 days in a patient. Society for Biomaterials Transactions of the 32rd
annual meeting 2007
Gandhi, S. K.; Huddleston, C. B.; Balzer, D. T.; Epstein, D. J.; Boschert, T. A.; Canter, C. E.,
Biventricular assist devices as a bridge to heart transplantation in small children. Circulation
2008, 118, (14 Suppl), S89-93.
Krokstrom, A. K.; Higgins, T.; Johansson, S.; Jogi, P., Use of pediatric Berlin Heart EXCOR
biventricular device as a bridge to retransplantation in a 10-month-old infant with acute graft
failure after cardiac transplantation. ASAIO J 2009, 55, (5), 525-526.
Januszewska, K.; Malec, E.; Birnbaum, J.; Loeff, M.; Sodian, R.; Schmitz, C.; Netz, H.;
Reichart, B., Ventricular assist device as a bridge to heart transplantation in children. Interact
Cardiovasc Thorac Surg 2009 Nov, 807-810.
Tjan, T. D.; Hoffmeier, A.; Scheld, H. H.; Klotz, S., Ventricular assist device implantation in
neonates: adjustment of the BerlinHeart EXCOR arterial cannula with bovine pericardium. J
Thorac Cardiovasc Surg 2010, 139, (3), 783-784
Brancaccio, G.; Amodeo, A.; Ricci, Z.; Morelli, S, Mechanical assist device as a bridge to
heart transplantation in children less than 10 kilograms. Ann Thorac Surg 2010, 90, (1), 58-
62.
Morales, D. L.; Almond, C. S.; Jaquiss, R. D.; Rosenthal, D. N., Bridging children of all sizes
to cardiac transplantation: The initial multicenter North American experience with the Berlin
Heart EXCOR ventricular assist device. J Heart Lung Transplant 2011, 30, (1), 1-8.
Hetzer, R.; Potapov, E. V.; Alexi-Meskishvili, V.; Weng, Y.; Miera, O.; Berger, F.; Hennig, E.;
Hubler, M., Single-center experience with treatment of cardiogenic shock in children by pedi-
atric ventricular assist devices. J Thorac Cardiovasc Surg 2011, 141, (3), 616-623.e1.
Almond CS, Buchholz H, Massicotte P, Ichord R, Rosenthal DN, Uzark K, Jaquiss RD,
Kroslowitz R, Kepler MB, Lobbestael A, Bellinger D, Blume ED, Fraser CD, Jr., Bartlett RH,
Thiagarajan R, Jenkins K. Berlin Heart EXCOR Pediatric ventricular assist device Investiga-
tional Device Exemption study: Study design and rationale. Am Heart J 2011;162:425-435.
Fraser, C. D., Jr.; Jaquiss, R. D.; Rosenthal, D. N.; Humpl, T.; Canter, C. E.;, Prospective
trial of a pediatric ventricular assist device. N Engl J Med 2012, 367, (6), 532-41
Clinical – Peripheral vascular surgery Mayer, B.; Kretschmer, R.; Gunzenhausser, E., Interposition connectors with heparin coating
for vascular anastomosis of microsurgical tissue flaps]. Laryngorhinootologie 1992, 71, (7),
359-361.
Peeters, P.; Bosiers, M.; Verbist, J.; Deloose, K., Adressing Early graft failure: Midterm re-
sults with the Gore-Tex propaten Vascular Graft. J Endovasc Ther 2004, 11 (supplement),
31-32.
Walluscheck, K. P.; Bierkandt, S.; Brandt, M.; Cremer, J., Infrainguinal ePTFE vascular graft
with bioactive surface heparin bonding. First clinical results. J Cardiovasc Surg (Torino)
2005, 46, (4), 425-430.
Dorigo, W., Lower limb below-knee revacsularization with a new bioactive prosthetic graft. A
case-control study. J Vasc Endovasc Surg 2005, , (12), 75-81.
Bosiers, M.; Deloose, K.; Verbist, J.; Schroe, H.; Lauwers, G.; Lansink, W.; Peeters, P., Hep-arin-bonded expanded polytetrafluoroethylene vascular graft for femoropopliteal and femorocrural bypass grafting: 1-year results. J Vasc Surg JT - Journal of vascular surgery :
official publication, the Society for Vascular Surgery [and] International Society for Cardio-
vascular 2006, 43, (2), 313-318.
Battaglia, G.; Tringale, R.; Monaca, V., Retrospective comparison of a heparin bonded ePT-
FE graft and saphenous vein for infragenicular bypass: implications for standard treatment
protocol. J Cardiovasc Surg (Torino) JT - The Journal of cardiovascular surgery. 2006, 47,
(1), 41-47.
Peeters, P.; Verbist, J.; Deloose, K.; Bosiers, M., Results with heparin bonded polytetrafluo-
roethylene grafts for femorodistal bypasses. J Cardiovasc Surg (Torino) JT - The Journal of
cardiovascular surgery. 2006, 47, (4), 407-413.
Walluscheck, Heparin bonded expanded polytetrafluoroethylene vascular graft for occulsive
vascular disease of the lower extremity. The Italian Journal of Vascular and Endovascular
Surgery 2006, 13, (3), 137-147.
Dorigo, W.; Di Carlo, F.; Troisi, N.; Pratesi, G.; Innocenti, A. A.; Pulli, R.; Pratesi, C., Lower
limb revascularization with a new bioactive prosthetic graft: early and late results. Ann Vasc
Surg 2008, 22, (1), 79-87.
Heyligers, J. M.; Lisman, T.; Verhagen, H. J.; Weeterings, C.; de Groot, P. G.; Moll, F. L., A
heparin-bonded vascular graft generates no systemic effect on markers of hemostasis acti-
vation or detectable heparin-induced thrombocytopenia-associated antibodies in humans. J
Vasc Surg 2008, 47, (2), 324-329.
Dorrucci, V.; Griselli, F.; Petralia, G.; Spinamano, L.; Adornetto, R., Heparin-bonded expand-
ed polytetrafluoroethylene grafts for infragenicular bypass in patients with critical limb ische-
mia: 2-year results. J Cardiovasc Surg (Torino) 2008, 49, (2), 145-149.
Peeters, P.; Verbist, J.; Deloose, K.; Bosiers, M., Will heparin-bonded PTFE replace autolo-
gous venous conduits in infrapopliteal bypass? J Vasc Endovasc Surg 2008, 15, 143-148
Thakur, S.; Pigott, J. P.; Comerota, A. J., Heparin-induced thrombocytopenia after implanta-
tion of a heparin-bonded polytetrafluoroethylene lower extremity bypass graft: A case report
and plan for management. J Vasc Surg 2009, 49, (4), 1037-1040
Daenens, K.; Schepers, S.; Fourneau, I.; Houthoofd, S.; Nevelsteen, A., Heparin-bonded
ePTFE grafts compared with vein grafts in femoropopliteal and femorocrural bypasses: 1-
and 2-year results. J Vasc Surg 2009, 49, (5), 1210-1216.
Hugl, B.; Nevelsteen, A.; Daenens, K.; Alonso Perez, M.; Heider, P.; Railo, M.; Schelzig, H.;
Gluecklich, B.; Balzer, K.; Vermassen, F.; De Smit, P.; Fraedrich, G., PEPE II - A multicenter
study with an end-point heparin-bonded expanded polytetrafluoroethylene vascular graft for
above and below knee bypass surgery: determinants of patency. J Cardiovasc Surg (Torino)
2009, 50, (2), 195-203
Neville, R.; Babrowicz, J.; Deaton, D. H., Surgical approaches to chronic limb ischemia.
Endovascular today 2009, 8, (5), 48-56.
Davidson, I.; Hackerman, C.; Kapadia, A.; Minhajuddib, A., Heparin bonded hemodialysis e-
PTFE grafts result in 20% clot free survival benefit. J Vasc Access 2009, 10, (3), 153-156.
Pulli, R.; Dorigo, W.; Castelli, P.; Dorrucci, V, Midterm results from a multicenter registry on
the treatment of infrainguinal critical limb ischemia using a heparin-bonded ePTFE graft. J
Vasc Surg 2010, 51, (5), 1167-1177.e1.
Thermann, F.; Wollert, U.; Ukkat, J.; Dralle, H., Proximalization of the arterial inflow (PAI) in
patients with dialysis access-induced ischemic syndrome: First report on long-term clinical
results. J Vasc Access 2010, 11, (2), 143-149.
Kasirajan K. Outcomes Following Heparin-Induced Thrombocytopenia in Patients with Hepa-
rin Bonded Vascular Grafts. Journal of Vascular Surgery Abstracts of the 2011 Vascular An-
nual Meeting, 2011 Vascular Annual Meeting 2011;53:17S-8S
Gabrielli R, Siani A, Rosati MS, Antonelli R, Accrocca F, Giordano GA, Marcucci G. Heparin-
induced thrombocytopenia type II because of heparin-coated polytetrafluoroethylene graft
used to bypass. Ann Vasc Surg 2011;25:840
Dorigo W, Pulli R, Castelli P, Dorrucci V, Ferilli F, De Blasis G, Monaca V, Vecchiati E,
Pratesi C, CN - PIRG. A multicenter comparison between autologous saphenous vein and
heparin-bonded expanded polytetrafluoroethylene (ePTFE) graft in the treatment of critical
limb ischemia in diabetics. J Vasc Surg 2011;54:1332-8.
Chan MG, Miller FJ, Valji K, Kuo MD. Evaluation of expanded polytetrafluoroethylene-
covered stents for the treatment of venous outflow stenosis in hemodialysis access grafts. J
Vasc Interv Radiol 2011;22:647-53
Lindholt JS, Gottschalksen B, Johannesen N. The Scandinavian Propaten((R)) trial - 1-year
patency of PTFE vascular prostheses with heparin-bonded luminal surfaces compared to
ordinary pure PTFE vascular prostheses - a randomised clinical controlled multi-centre trial.
Eur J Vasc Endovasc Surg 2011;41:668-73.
Charlton-Ouw KM, Nosrati N, Miller CC, Coogan SM, Safi HJ, Azizzadeh A. Outcomes of
arteriovenous fistulae compared with heparin-bonded and conventional grafts for hemodialy-
sis access. J Vasc Access 2012;13:163-7.
Tatterton, M.; Wilshaw, S. P.; Ingham, E.; Homer-Vanniasinkam, S., The use of antithrombot-
ic therapies in reducing synthetic small-diameter vascular graft thrombosis.
Vasc Endovascular Surg 2012, 46, (3), 212-22.
Kasirajan, K., Outcomes after heparin-induced thrombocytopenia in patients with Propaten
vascular grafts. Ann Vasc Surg 2012, 26, (6).
Dorigo, W.; Pulli, R.; Piffaretti, G.; Castelli, P.; Griselli, F.;Results from an Italian multicentric
registry comparing heparin-bonded ePTFE graft and autologous saphenous vein in below-
knee femoro-popliteal bypasses. J Cardiovasc Surg (Torino) 2012, 53, (2), 187-194.
Neville, R. F.; Capone, A.; Amdur, R.; A comparison of tibial artery bypass performed with
heparin-bonded expanded polytetrafluoroethylene and great saphenous vein to treat critical
limb ischemia. J Vasc Surg 2012, 56, (4).
Bellosta, R.; Natalini, G.; Luzzani, L.Comparison of precuffed expanded polytetra-
fluorothylene and heparin-bonded polytetrafluorothylene graft in crural bypass. Ann Vasc
Surg 2013, 27, (2).
Allemang, M. T.; Schmotzer, B.; Wong, V. L., Heparin bonding does not improve patency of
polytetrafluoroethylene arteriovenous grafts. Ann Vasc Surg 2014, 28, (1).
Clinical – Coronary stenting Emanuelsson, H.; van der Giessen, W. J.; Serruys, P. W., Benestent II: back to the future. J
Interv Cardiol 1994, 7, (6), 587-92.
Serruys, P., A Progress Report from BENESTENT II: Heparin Coating, Restenosis and Cost-
Effectiveness. J Invasive Cardiol 1996, 8 Suppl E, 22E-24E.
Serruys, P. W.; Emanuelsson, H.; van der Giessen, W. J.; Lunn, A. C.; Kiemeney, F.; Macaya, C.; Rutsch, W.; Heyndrickx, G.; Suryapranata, H.; Legrand, V.; Goy, J. J.; Materne, P.; Bonnier, H.; Morice, M. C.; Fajadet, J.; Belardi, J.; Colombo, A., Heparin-coated Palmaz- Schatz stents in human coronary arteries. Early outcome of the Benestent-II Pilot Study. Cir-
culation 1996, 93, (3), 412-22.
Williams, D. O., Dressing up the Palmaz-Schatz stent. Circulation 1996, 93, (3), 400-2.
Stone, G. W.; Brodie, B. R.; Griffin, J. J.; Morice, M. C.; Costantini, C.; St Goar, F. G.; Over-
lie, P. A.; Popma, J. J.; McDonnell, J.; Jones, D.; O'Neill, W. W.; Grines, C. L., Prospective,
multicenter study of the safety and feasibility of primary stenting in acute myocardial infarc-
tion: in-hospital and 30-day results of the PAMI stent pilot trial. Primary Angioplasty in Myo-
cardial Infarction Stent Pilot Trial Investigator. J Am Coll Cardiol 1998, 31, (1), 23-30.
van der Giessen, W. J.; van Beusekom, H. M.; Eijgelshoven, M. H.; Morel, M. A.; Serruys, P.
W., Heparin-coating of coronary stents. Semin Interv Cardiol 1998, 3, (3-4), 173-176.
Serruys, P. W.; van Hout, B.; Bonnier, H.; Legrand, V.; Garcia, E.; Macaya, C.; Sousa, E.;
van der Giessen, W. J.; Colombo, A.; Seabra-Gomes, R.; Kiemeneij, F.; Ruygrok, P.;
Ormiston, J.; Emanuelsson, H., Randomised comparison of implantation of heparin-coated
stents with balloon angioplasty in selected patients with coronary artery disease (Benestent
II). Lancet 1998, 352, (9129), 673-81.
Dzavik, V.; Carere, R. G.; Teo, K. K.; Knudtson, M. L.; Marquis, J. F.; Buller, C. E., An open
design, multicentre, randomized trial of percutaneous transluminal coronary angioplasty ver-
sus stenting, with a heparin-coated stent, of totally occluded coronary arteries: rationale, trial
design and baseline patient characteristics. Total O. Can J Cardiol 1998, 14, (6), 825-32.
Serruys, P.; Grines, C.; Stone, G.; Garcia, E.; Kiemeney, F.; Morice, M.; Sousa, J.; Hamm,
C.; Costantini, C.; Probst, P.; Rutsch, W.; Penn, I.; Fernandez-Aviles, F.; Vandormael, M.;
Bartorelli, A.; Bilodeau, L.; Eijgelshoven, M., Stent implantation in acute myocardial infarction
using a heparin-coated stent: a pilot study as a preamble to a randomized trial comparing
balloon angioplasty and stenting. Int J Cardiovasc Intervent 1998, 1, (1), 19-27.
Buller, C. E.; Dzavik, V.; Carere, R. G.; Mancini, G. B.; Barbeau, G.; Lazzam, C.; Anderson,
T. J.; Knudtson, M. L.; Marquis, J. F.; Suzuki, T.; Cohen, E. A.; Fox, R. S.; Teo, K. K., Prima-
ry stenting versus balloon angioplasty in occluded coronary arteries: the Total Occlusion
Study of Canada (TOSCA). Circulation 1999, 100, (3), 236-42.
Grines, C. L.; Cox, D. A.; Stone, G. W.; Garcia, E.; Mattos, L. A.; Giambartolomei, A.; Brodie,
B. R.; Madonna, O.; Eijgelshoven, M.; Lansky, A. J.; O'Neill, W. W.; Morice, M. C., Coronary
angioplasty with or without stent implantation for acute myocardial infarction. Stent Primary
Angioplasty in Myocardial Infarction Study Group. N Engl J Med 1999, 341, (26), 1949-56.
van der Giessen, W. J., Heparin-Coated Coronary Stents. Current Interventional Cardiology
Reports 1999, 1, 234-240.
Dzavik, V.; Carere, R. G.; Mancini, G. B.; Cohen, E. A.; Catellier, D.; Anderson, T. E.; Bar-
beau, G.; Lazzam, C.; Title, L. M.; Berger, P. B.; Labinaz, M.; Teo, K. K.; Buller, C. E.; CN , -.
. T. O. S. o. C. I., Predictors of improvement in left ventricular function after percutaneous
revascularization of occluded coronary arteries: a report from the Total Occlusion Study of
Canada (TOSCA). Am Heart J 2001, 142, (2), 301-8.
Berger, P. B.; Dzavik, V.; Penn, I. M.; Catellier, D.; Buller, C. E., Does ticlopidine reduce re-
occlusion and other adverse events after successful balloon angioplasty of occluded coro-
nary arteries? Results from the Total Occlusion Study of Canada (TOSCA). Am Heart J
2001, 142, (5), 776-81.
Kedev, S.; Guagliumi, G.; Valsechi, O.; Tespili, M., Heparin-coated versus uncoated Palmaz-
Schatz stent in native coronary circulation. A randomized study with blind angioscopic as-
sessment. Int J Artif Organs 2002, 25, (5), 461-9.
Mehran, R.; Aymong, E. D.; Ashby, D. T.; Fischell, T.; Whitworth H, J. r.; Siegel, R.; Thomas, W.; Wong, S. C.; Narasimaiah, R.; Lansky, A. J.; Leon, M. B., Safety of an aspirin-alone reg-imen after intracoronary stenting with a heparin-coated stent: final results of the HOPE (HEPACOAT and an Antithrombotic Regimen of Aspirin Alone) study. Circulation 2003, 108,
(9), 1078-83.
Gurbel, P. A.; Bliden, K. P., Platelet activation after stenting with heparin-coated versus non-
coated stents. Am Heart J 2003, 146, (4).
Carrozza JP, J. r., Preventing subacute stent thrombosis--is there a role for heparin-coated
stents? J Invasive Cardiol 2003, 15, (8), 442-443.
Ruygrok, P. N.; Sim, K. H.; Chan, C.; Rachman, O. J.; Adipranoto, J. D.; Trisnohadi, H. B.;
Stewart, J. T.; Ahmad, N.; Mak, K. H.; Yusak, M.; Boestan, I.; Santoso, T.; Suryapranata, H.,
Coronary intervention with a heparin-coated stent and aspirin only. J Invasive Cardiol 2003,
15, (8), 439-41.
Cruz, D.; Karlsberg, R.; Takano, Y.; Vora, D.; Tobis, J., Subacute stent thrombosis associat-
ed with a heparin-coated stent and heparin-induced thrombocytopenia. Catheter Cardiovasc
Interv 2003, 58, (1), 80-83
Bittl, J. A., Heparin-coated stent and heparin-induced thrombocytopenia: true, true, and con-
ceivably related. Catheter Cardiovasc Interv 2003, 58, (1), 84-5
Lev, E. I.; Assali, A. R.; Teplisky, I.; Rechavia, E.; Hasdai, D.; Sela, O.; Shor, N.; Battler, A.;
Kornowski, R., Comparison of outcomes up to six months of Heparin-Coated with noncoated
stents after percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol
2004, 93, (6), 741-3.
Gupta, V.; Aravamuthan, B. R.; Baskerville, S.; Smith, S. K.; Gupta, V.; Lauer, M. A.; Fisch-
ell, T. A., Reduction of subacute stent thrombosis (SAT) using heparin-coated stents in a
large-scale, real world registry. J Invasive Cardiol 2004, 16, (6), 304-310.
Madduri, J.; Assali, A.; Solodky, A.; Teplizky, I.; Shor, N.; Battler, A.; Kornowski, R., Acute
and intermediate-term clinical outcomes following Heparin coated BX coronary stent implan-
tation in patients with thrombus containing lesions. Int J Cardiovasc Intervent 2004, 6, (2),
77-81.
Di Mario, C.; Mara, S.; Flavio, A.; Imad, S.; Antonio, M.; Anna, P.; Emanuela, P.; Stefano de,
S.; Angelo, R.; Stefania, C.; Anna, F.; Carmelo, C.; Antonio, C.; Monzini, N.; Bonardi, M. A.,
Single vs multivessel treatment during primary angioplasty: results of the multicentre ran-
domised HEpacoat for cuLPrit or multivessel stenting for Acute Myocardial Infarction (HELP
AMI) Study. Int J Cardiovasc Intervent JT - International journal of cardiovascular interven-
tions. 2004, 6, (3-4), 128-33.
Mehran, R.; Nikolsky, E.; Camenzind, E.; Zelizko, M.; Kranjec, I.; Seabra-Gomes, R.; Nego-
ita, M.; Slack, S.; Lotan, C., An Internet-based registry examining the efficacy of heparin
coating in patients undergoing coronary stent implantation. Am Heart J JT - American heart
journal. 2005, 150, (6), 1171-1176.
Sharma, J.; Kanei, Y.; Kwan, T. W., A case of giant coronary artery aneurysm after place-
ment of a heparin-coated stent. J Invasive Cardiol 2009, 21, (2), E22-3
Clinical – Peripheral stenting Parkinson, R. J.; Demers, C. P.; Adel, J. G.; Levy, E. I.; Sauvageau, E.; Hanel, R. A.; Shai-
bani, A.; Guterman, L. R.; Hopkins, L. N.; Batjer, H. H.; Bendok, B. R., Use of heparin-coated
stents in neurovascular interventional procedures: preliminary experience with 10 patients.
Neurosurgery JT - Neurosurgery. 2006, 59, (4), 812-21; discussion 821.
Chadda, N.; Museitif, R.; Djelmami-Hani, M.; Ahmed, M.; Saeed, A.; Kostopoulos, L.; Bangash, A.; Saeed, A.; Gupta, A.; Tumuluri, R.; Shalev, Y.; Allaqaband, S.; Bajwa, T., Hep- arin-bonded VIABAHN stent graft for SFA lesions: Incidence of stent thrombosis and hepa-
rin-induced thrombocytopenia. American Journal of Cardiology 2008, 102, (8), TCT-586.
Elpiniki, T.; Salviato, E.; Rocca, T.; Braccini, L.; Galeotti, R.; Mascoli, F., Heparin surface
stent-graft for the treatment of a carotid pseudoaneurysm. Ann Vasc Surg 2010, 24, (7).
Kuhan, G.; Abisi, S.; Braithwaite, B. D.; MacSweeney, S. T.; Whitaker, S. C.; Habib, S. B.,
Early results with the use of heparin-bonded stent graft to rescue failed angioplasty of chron-
ic femoropopliteal occlusive lesions: TASC D lesions have a poor outcome. Cardiovasc In-
tervent Radiol 2012, 35, (5), 1023-1028.
Lensvelt, M. M.; Fritschy, W. M.; van Oostayen, J. A.; Results of heparin-bonded ePTFE-
covered stents for chronic occlusive superficial femoral artery disease. J Vasc Surg 2012, 56,
(1).
Geraghty, P. J.; Mewissen, M. W.; Jaff, M. R.; Ansel, G. M., Three-year results of the VI-
BRANT trial of VIABAHN endoprosthesis versus bare nitinol stent implantation for complex
superficial femoral artery occlusive disease. J Vasc Surg 2013, 58, (2).
Saxon, R. R.; Chervu, A.; Jones, P. A.; Bajwa, T. K.; Heparin-bonded, expanded polytetra-
fluoroethylene-lined stent graft in the treatment of femoropopliteal artery disease: 1-year re-
sults of the VIPER (Viabahn Endoprosthesis with Heparin Bioactive Surface in the Treatment
of Superficial Femoral Artery O. J Vasc Interv Radiol 2013, 24, (2).
Lammer, J.; Zeller, T.; Hausegger, K. A.; Schaefer, P. J.; Gschwendtner, M.; Heparin-bonded
covered stents versus bare-metal stents for complex femoropopliteal artery lesions: the ran-
domized VIASTAR trial (Viabahn endoprosthesis with PROPATEN bioactive surface [VIA]
versus bare nitinol stent in the treatment of long lesions i. J Am Coll Cardiol 2013, 62, (15).
Clinical – Other Albertsson-Wikland, K.; Rosberg, S., Analyses of 24-hour growth hormone profiles in chil-
dren: relation to growth. J Clin Endocrinol Metab 1988, 67, (3), 493-500.
Albertsson-Wikland, K.; Rosberg, S.; Libre, E.; Lundberg, L. O.; Groth, T., Growth hormone
secretory rates in children as estimated by deconvolution analysis of 24-h plasma concentra-
tion profiles. Am J Physiol 1989, 257, (6 Pt 1), E809-14.
Appelgren, P.; Ransjo, U.; Bindslev, L.; Larm, O., Does surface heparinisation reduce bacte-
rial colonisation of central venous catheters? Lancet 1995, 345, (8942), 130.
Venkatesh, B.; Clutton-Brock, T. H.; Hendry, S. P., Evaluation of the Paratrend 7 intravascu-
lar blood gas monitor during cardiac surgery: comparison with the C4000 in-line blood gas
monitor during cardiopulmonary bypass. J Cardiothorac Vasc Anesth 1995, 9, (4), 412-419.
Appelgren, P.; Ransjo, U.; Bindslev, L.; Espersen, F.; Larm, O., Surface heparinization of
central venous catheters reduces microbial colonization in vitro and in vivo: results from a
prospective, randomized trial. Crit Care Med 1996, 24, (9), 1482-9.
Weiss, I. K.; Fink, S.; Edmunds, S.; Harrison, R.; Donnelly, K., Continuous arterial gas moni-
toring: initial experience with the Paratrend 7 in children. Intensive Care Med 1996, 22, (12),
1414-1417.
Bagge, E.; Bengtsson, B. A.; Carlsson, L.; Carlsson, J., Low growth hormone secretion in
patients with fibromyalgia--a preliminary report on 10 patients and 10 controls. J Rheumatol
JT - The Journal of rheumatology 1998, 25, (1), 145-148.
Weiss, I. K.; Fink, S.; Harrison, R.; Feldman, J. D.; Brill, J. E., Clinical use of continuous arte-
rial blood gas monitoring in the pediatric intensive care unit. Pediatrics 1999, 103, (2), 440-
445.
Cannavo, S.; Bartolone, L.; Lapa, D.; Venturino, M.; Almoto, B.; Violi, A.; Trimarchi, F., Ab-
normalities of GH secretion in a young girl with Floating-Harbor syndrome. J Endocrinol In-
vest 2002, 25, (1), 58-64.
Bridges, C., New heparin coating reduces thrombosis and fibrin sheath formation in HD
catheters. Nephrol News Issues JT - Nephrology news & issues 2007, 21, (3), 32.
Kvarnstrom, A.; Schmidt, A.; Tylman, M.; Jacobsson, M.; Bengtsson, A., Complement split
products and proinflammatory cytokines in intraoperatively salvaged unwashed blood during
hip replacement: comparison between heparin-coated and non-heparin-coated autotransfu-
sion systems. Vox Sang 2008, 95, (1), 33-38.
Clark, T. W.; Jacobs, D.; Charles, H. W.; Kovacs, S.; Aquino, T.; Erinjeri, J.; Benstein, J. A.,
Comparison of heparin-coated and conventional split-tip hemodialysis catheters. Cardiovasc
Intervent Radiol 2009, 32, (4), 703-706.
Jain, G.; Allon, M.; Saddekni, S.; Barker, J. F.; Maya, I. D., Does heparin coating improve
patency or reduce infection of tunneled dialysis catheters? Clin J Am Soc Nephrol 2009, 4,
(11), 1787-1790.
Horer, J.; Cleuziou, J.; Kasnar-Samprec, J.; Schreiber, A Comparative Histopathological
Study of Heparin Coated and Uncoated Polytetrafluoroethylene Shunts in Children With
Congenital Heart Defect. World J Pediatr Congenit Heart Surg 2014, 5, (3), 385-390.
Olsson, P.; Larm, O.; Larsson, R.; Lins, L. E.; Nilsson, E.; Swedenborg, J., Requirements for
thromboresistance of surface-heparinized materials. Ann N Y Acad Sci 1983, 416, 525-537.
Larsson, R.; Larm, O.; Olsson, P., The search for thromboresistance using immobilized hep-
arin. Ann N Y Acad Sci 1987, 516, 102-115.
Larm, O.; Larsson, R.; Olsson, P., Surface-immobilized heparin. In Heparin: Chemical and Biological Properties, Clinical Applications, Lane, D.; Lindahl, U., Eds. Edward Arnold Press: 1989, pp 597-608. von Segesser, L. K.; Weiss, B. M.; Turina, M. I., Perfusion with heparin-coated equipment:
potential for clinical use. Semin Thorac Cardiovasc Surg 1990, 2, (4), 373-380.
Olsson, P.; Larm, O., Biologically active heparin coating in medical devices. Int J Artif Organs
1991, 14, (8), 453-6.
Mollnes, T. E.; Videm, V.; Riesenfeld, J.; Garred, P.; Svennevig, J. L.; Fosse, E.; Hogasen,
K.; Harboe, M., Complement activation and bioincompatibility. The terminal complement
complex for evaluation and surface modification with heparin for improvement of biomateri-
als. Clin Exp Immunol 1991, 86 Suppl 1, 21-26.
von Segesser, L. K.; Schilling, J.; Leskosek, B.; Marquardt, K.; Turina, M., Surface treat-
ments for perfusion devices. Perfusion 1994, 9, (3), 197-205.
Riesenfeld, J.; Olsson, P.; Sanchez, J.; Mollnes, T. E., Surface modification with functionally
active heparin. Med Device Technol 1995, 6, (2), 24-31.
von Segesser, L. K., Heparin-bonded surfaces in extracorporeal membrane oxygenation for
cardiac support. Ann Thorac Surg 1996, 61, (1), 330-5; discussion 340-1
Palmaz, J. C., New advances in endovascular technology. Tex Heart Inst J 1997, 24, (3),
156-159.
Wendel, H. P.; Ziemer, G., Coating-techniques to improve the hemocompatibility of artificial
devices used for extracorporeal circulation. Eur J Cardiothorac Surg 1999, 16, (3), 342-350.
Kocsis, J. F.; Llanos, G.; Holmer, E., Heparin-coated stents. J Long Term Eff Med Implants
2000, 10, (1-2), 19-45.
Olsson, P.; Sanchez, J.; Mollnes, T. E.; Riesenfeld, J., On the blood compatibility of end-
point immobilized heparin. J Biomater Sci Polym Ed 2000, 11, (11), 1261-1273.
Riesenfeld, J.; Scholander, E. In Heparin coating of medical devices, Polymers for the Medi-
cal Industry, Brussels, Belgium, 14th - 15th May, Rapra Technologies, Brussels, Belgium,
2001, pp 1-4
Reinhartz, O.; Stiller, B.; Eilers, R.; Farrar, D. J., Current clinical status of pulsatile pediatric
circulatory support. ASAIO J 2002, 48, (5), 455-459.
Larsson, R., Heparin-binding to improve biocompatibility. Encycl Biomat Biomedical Eng
Marcel Dekker: 2005.
Tanzi, M. C., Bioactive technologies for hemocompatibility. Expert Review of Medical Devic-
es 2005, 2,(4), 473-492.
Potapov, E. V.; Stiller, B.; Hetzer, R., Ventricular assist devices in children: current achieve-
ments and future perspectives. Pediatr Transplant JT - Pediatric transplantation 2007, 11,
(3), 241-255.
Sakariassen, K. S., Blood flow devices in medical research and clinical testing in humans:
are we approaching personalized medicine? Future cardiology 2007, 3, (1), 71-90.
Sakariassen, K. S., Thrombus formation and hyperplasia triggered by vascular stents im-
planted in man. Int. Rev. of Thromb 2008.
Pupka, A.; Janczak, D.; Szyber, P. P., The heparin-bonded ePTFE grafts in revascularisation
of the lower limbs. Polim Med 2010, 40, (1), 9-14.
Timms D.; A review of clinical ventricular assist devices, Med Eng Phys 2011; 33:1041-7
Mahmood S, Bilal H, Zaman M, Tang A. Is a fully heparin-bonded cardiopulmonary bypass
circuit superior to a standard cardiopulmonary bypass circuit? Interact Cardiovasc Thorac
Surg 2012; 14:406-14.
Shah, P. S.; Shah, N., Heparin-bonded catheters for prolonging the patency of central ve-
nous catheters in children. Cochrane Database Syst Rev 2014, 2-25 pages.

Source: http://www.carmeda.eu/upl/files/105863.pdf