Liquid Chromatograph Mass Spectrometer −−Seeing is Believing. Rapid 15 msec Polarity Switching Superior Sensitivity from UFLC 15,000 u/sec Fast Scanning Speed

GCMS-QP2010 Ultra From HPLC to UFLC. Then to UFLC/MS. UFLC achieves excellent speed and resolution, while offering the high precision not available with conventional HPLC and expandability options. Ultra FastNot only high-speed analysis, but increased overall speed through rapid sample injection and fully automatic analysis functions. Unquestionable Fidelity UFLC offers exceptional injection reproducibility as well as ultra high-speed operation. In terms of minimizing sample carryover, essential in LC/MS analysis, the LCMS-2020 stays ahead of the competition. Ultra FlexibleCovers an extensive range from ultra-fast analysis to conventional HPLC and semi-preparative analysis. Ultra Fast
Liquid Chromatograph Mass Spectrometer Speed is Power.
Greater speed. Greater sensitivity To detect both positive and negative ions, analysis is performed while switching between the positive and negative ionization modes. The LCMS-2020 adopts patented high-voltage power supply technology (Patent: US7855355) to achieve an ultra-fast polarity switching time of just 15 ms. Polarity switching time Polarity switching time m/z 321: Chloramphenicolm/z 344: Dibucainem/z 329: Furosemidem/z 231: Isopropylantipyline Accurate mass analysis of sharp chromatographic peaks obtained by UFLC requires ultra-fast MS detection capabilities. detection capabilities. The LCMS-2020 offers UFswitching for rapid switching between the positive and negative ionization The LCMS-2020 offers UFswitching for rapid switching between the positive and negative ionizati modes and UFscanning for ultra-fast scan measurements to capture the sharpest UFLC peaks. modes and UFscanning for ultra-fast scan measurements to capture the sharpest UFLC peaks. Enhances sensitivity by preventing ion divergence The newly developed Qarray® Optics achieves superior Controls the voltage applied to the Quadrupole sensitivity, reproducibility, and linearity. according to the scan speed and m/z. Shimadzu's proprietary scanning technology (Patent: US8188426) maintains resolution and achieves high ion transmittance even at high scanning speeds. Calibration curve m/z 414: L-α-Narcotinem/z 256: Diphenhydraminem/z 267: Desipraminem/z 278: Amitriptyline LCMS 2020
Liquid Chromatograph Mass Spectrometer UFscanning & UFswitching
Ultra-fast detection (MS measurement) is required for ultra-fast analysis with elution of six components per minute, for example. The UFswitching and UFscanning functions permit the required ultra-fast mass spectrometry. Polarity switching time Polarity switching time MS Spectra of Bentazone MS Spectra of Dymuron MS Spectra of Carpropamid Hardware Features that to Powerfully Support
Three UFs

In order to check the toughness of the LCMS-2020 against dirty The desolvation line (DL) that introduces the sample from the ion samples, plasma samples simply precipitated with only source into the vacuum can be installed and uninstalled without acetonitrile were injected 2,500 times over 10 days (1 µL volume breaking the vacuum, which dramatically enhances per injection). Excellent reproducibility of peak area was ease-of-maintenance. demonstrated and its RSD was 2.26%.
%RSD2.26Internal standardAnalysis time 6 min2500 injections over 10 days Retaining the vacuum even if the DL is uninstalled In-source CID (collision-induced dissociation) is effective for confirming the molecular weight of synthetic compounds and
for the quantification of impurities.
MS Chromatogram for Erythromycin Measurements Using in-source CID allows the generation of fragment ions. This DL=0V, Qarray DC=0V example shows the structure of impurities in erythromycin estimated from fragment ions generated by in-source CID. Erythromycin (major component) The multi-sequence mode permits several other methods within a single analysis, such as CID, positive/negative ion switching modes, and SCAN/SIM modes. Precisely setting the parameters reduces the risk of erroneous evaluations and enhances the reliability of analysis results. Erythromycin (major component) MS Spectra (Normal mode) DL=0V, Qarray DC=0V MS Spectra (In-source CID mode) DL=0V, Qarray DC=60V Erythromycin (major component) Liquid Chromatograph Mass Spectrometer Diverse Ionization Methods Expand the Range
of Applications

LCMS-2020 offers APCI and DUIS in addition to ESI. Diverse ionization methods support a wide range of applications. Selecting the most appropriate Ionization Method
Aromatic hydrocarbons Aliphatic hydrocarbons Extremely suitable Analysis possible with appropriate parameters Inherently unsuitable While the water-soluble vitamins thiamine and riboflavin can be APCI but ESI does not offer adequate detection sensitivity. detected by ESI, they are virtually undetectable by APCI. DUIS-2020 allows detection of a mixture of compounds suited to Conversely, the fat-soluble vitamin calciferol can be detected by ESI or APCI, without missing any compounds. MS Spectra from DUIS Measurements
Mixed Sample of Three Water-soluble/Fat-soluble Vitamins1. Thiamine: m/z 265; cation, generated by ionization, water-soluble vitamin2. Riboflavin: m/z 377; protonated molecule, water-soluble vitamin3. Calciferol: m/z 397; protonated molecule, fat-soluble vitamin LabSolutions LCMS
Rapidly analyzes huge volumes of data in browser windows. The comprehensive, clear display provides a stress-free working environment. Manual peak integration bar Comparison of Control and Target
Multiple data items are displayed sequentially on the same screen. Manual peak integration can be conducted on both LC and MS To view the diverse information in a data file in the optimal layout chromatograms simultaneously. Both the peak table and MS for comparison, the data can be browsed like flipping through the spectrum table are displayed. The peak table and pages of a book to discover differences between the data. chromatograms/spectra are interlinked for easier operation. Optimization of Analysis Parameters
Automatically searches and sets the voltages that affect the ion transmittance (DL/Qarray voltage) to the optimal values for the target Analytical
SIM Table
Method Optimization Window
Method Optimization
SIM Table
Enter the target m/z Specify the conditions to search for the The optimal voltage value is The Search results of the optimal set into the SIM table voltage value are displayed Automatic analysis execution Liquid Chromatograph Mass Spectrometer Open Solution Analytical
‘Adaptive' open access software
• Multiple options for sample log-in (Wizard, Table or Simple sample log-in mode) • Advanced column management support (pH switching, column washing and parking) • File management (including copy locations) • Instrument use (including night time operation, sleep mode) • Method management (advanced options for pre- and post-run options • Global sample and instrument status and message board feedback Log-in options
Can be configured for user name, password (or none)
Time remaining
Large display for clarity
Color coded updates
Select Method Add description
Name can be automatically generated
Updates system messages Updates system messages 2 Steps only!
teps only!
Click to submit and finish
Sample queue analysis
‘Dynamic' data review experience
• Data review can be launched on any remote PC without software installation.
• Click on the link in an e-mail and the data will be shown.
• Supports multiple data presentations (including 2 panels for data comparison) for simple, clear data • Advanced users can reprocess raw data or quickly review processed XML results.
• Spectral integrity; unique mode for checking for co-elution. Automatically checks mass spectral data across a detected peak.
Spectral integrity score
Copy/Paste Text Structure display
Highlights possible co-elution Target views
Each m/z target
colored green,
yellow or red
mass spectrum
Target ions labelled
in the mass spectrum
No installation
Only requires free Microsoft components
Number of user licenses can be easily expanded
Liquid Chromatograph Mass Spectrometer Company names, product/service names and logos used in this publication are trademarks and trade names of Shimadzu Corporation or its affiliates, whether or not they are used with trademark symbol "TM" or "®".
Third-party trademarks and trade names may be used in this publication to refer to either the entities or their products/services. Shimadzu disclaims any proprietary interest in trademarks and trade names other than its own.
For Research Use Only. Not for use in diagnostic procedures. The contents of this publication are provided to you "as is" without warranty of any kind, and are subject to change without notice. Shimadzu does not assume any responsibility or liability for any damage, whether direct or indirect, relating to the use of this publication.
Shimadzu Corporation, 2014 Printed in Japan 3655-07408-20ANS


The Network December 2009 Edition 20 Papua New Guinea Millennium Development Goals: Is Papua New Guinea meeting them? What are the Millennium Development Goals ? page 1 Goal 1: Eradicate Poverty and Hunger Goal 2: Achieve Universal Primary Education page 12

Giovanni ContiniLa Resistenza a Firenze tra celebrazione e attualizzazione politica Negli ultimi anni il tema della memoria ha preso sempre più campo negli studi sulla storia politica recente1. Si sono infatti messe in evidenza le trasfor-mazioni che la memoria di eventi particolarmente significativi subisce di anno in anno, di decennio in decennio, afferrata dal discorso politico nel suo progres-sivo mutare. Così la memoria stessa finisce per diventare oggetto storiografico, perché il modo attraverso il quale si parla di quegli eventi, e li si descrive da par-te della stampa, fornisce allo storico importanti informazioni indirette su come vada mutando non solo il discorso politico alto, quello della proposta generale, ma, direi, la sensibilità sociale per la politica, il ruolo insomma dei suoi temi nel gioco della sociabilità e della vita quotidiana.