Structure searching dwpi using stn express

STRUCTURE SEARCHING DERWENT WORLD
PATENTS INDEX® (DWPISM) USING STN
EXPRESS®: Part I
INTELLECTUAL PROPERTY SOLUTIONS BRIAN LARNER JANUARY 2013 – THE PROBLEM; WHY IS IT DIFFICULT TO SEARCH CHEMICAL STRUCTURES IN PATENTS? – SOLUTION; DWPI STRUCTURAL INDEXING – DWPI PATENT COVERAGE – COMPOUND COVERAGE – WHICH COMPOUNDS ARE – DETAILED LOOK AT BCE FRAGMENTATION CODING – DETAILED LOOK AT DCR – STRUCTURAL MANUAL CODES – CHEMICAL STRUCTURE SEARCH EXAMPLE – CHEMICAL FRAGMENTATION CODE SEARCH EXAMPLE – MULTIFILE STRUCTURE SEARCH EXAMPLE Problems in searching for chemical information • There is no consistent way of representing chemical information in patents • A chemical compound could be referred to using any of the following – A systematic chemical name – A semi-systematic or trivial chemical name – A trade or proprietary name or for drugs an approved name or trial prep code – A drawn out chemical structure – As one possibility within a generic chemical structure – As one possibility when only a generic class of compounds is referred to Cellosolve could be represented as …. • 2-ETHOXYETHANOL • CELLOSOLVE; • EKTASOLUE-EE • 2-ETHOXYETHANOL, • ETHOXYETHANOL-2; • ETHOXYETHANOL-BETA; • ETHYLENE GLYCOL ETHYL • ETHYLENE GLYCOL MONOETHYL ETHER; • POLY-SOLV-EE All the names diclofenac is known by ABITREN; ADEFURONIC; AFLAMIN; ALLVORAN; ALMIRAL; AM-DICLOFENAC; ANFENAX; ANTHRAXITON; ARTHRIFEN; ARTHRODERM; ARTHROPEN; ARTHROTEC; ARTREN; ARTRILAT; ARTRITAREN; ASPZONE; ASSAREN; ATHROFEN; BA-47210; BATAFIL; BENFOFEN; BIOFNAC; BLESIN; BOLABOMIN; CATAFLAM; CHLORGY; CIBA-47210; COLIRI; CONTRALG; CORDRALAN; CT-DICLO; CURINFLAM; CURINFLAM-A.P.; DAISPAS;DEFLAMAT; DELIMON; DELPHIMIX; DELPHIMIX-1; DELPHINAC; DENBAL; DESINFLAM; DFNA; DFP; DFP-60; DICHRONIC; DICLAC; DICLO; DICLO-ATTRITIN; DICLO-BASAN; DICLO-OPT; DICLO-PHLOGONT; DICLO-PUREN; DICLO-REKTAL; DICLO-SPONDRYL; DICLO-SPONDYRIL; DICLO-TABLINEN; DICLOBENIN; DICLOD; DICLOFEN; DICLOFENAC; DICLOFENAC - SODIUM SALT; DICLOFENAC SODIUM; DICLOFENAC-OPT; DICLOFENAC-SODIUM; DICLOFENACO; DICLOFLEX; DICLOMAX; DICLOMELAN; DICLOPHLOGONT; DICLOREUM; DICLOSIAN; DICLOWAL; DICSANAL; DIFENAC; DIGNOFENAC; DIRALON; DOCELL; DOGNOFENAC; DOLOBASAN; DOLOTREN; DOLOVISANO-DICLO; DONJUST-A; DORAGON; DURAVOLTEN; ECOFENAC; EFFEKTON; EVINOPON; FELORAN; FENACIDON; FENAMED; FENOFLAM; FENYTAREN; FLAMERIL: FLEFARMINA; FLEFARMINE; FLOGOFENAC; FORGENAC; GAUTELIN; GP-45840; GROFENAC; GROSALGEN; HIZEMIN; IMBUN; INFLAMAC; INFLANAC; INFLAREN; IRINATOLON; JAVIPREN; KLAST; KRIPLEX; LINOBOL; MAGLUFEN; MAGLUPHEN; MILNAC; MIYADREN; MONOFLAM; MP-DICLOFENAC; MYOGIT; N-RHEUMAVINCIN; NABOAL; NABOAL-SR; NACLOF; NAKLOFEN; NERIODIN; NIFLERIEL; NOVAPIRINA; OLFEN; OLFEN-GEL; OLPHEN; ORTOPHEN; OXA; PANAMOR; PARSAL; PENNSAID; PENTIATE; POLTAJEN; PRIMOFENAC; PROPHENATIN; REMETHAN; REOXEL; REWODINA; RHEUFENAC; RHEUMAREN; RHEUMASAN-D; RHEUMAVEK; RHEUMAVINCIN; RHEUMAVINCIN-N; RHUMALGAN; RUVOMINOX; SAFFRAC; SANNAX; SAVISMIN; SEECOREN; SGESTONE; SHIGNOL; SILINO; SODIUM DICLOFENAC; SODIUM-DICLOFENAC; SOFARIN; SOLARAZE; SORELMON; SR-318; SR-318A; SR-318B; TAKS; THICATAREN; TORYXIL; TP-318 TRABONA; TRATUL; TSUDOHMIN; URIGON; VALETAN; VERAL; VERICE; VIAVOX; VILONIT; VOLDAL; VOLFENAC; VOLMAGEN; VOLRAMAN; VOLTAREN; VOLTAREN-QS; VOLTAREN-SR; VOLTARENE; VOLTARN-EMULGEL; VOLTAROL; VOLTAROL-EMULGEL; VOLTAROL-OPHTHA; VONAFEC; VOREN; VOTAXIL; VURDON; XENID; YOUFENAC • 2-(2-((2,6-dichlorophenyl)-amino)-phenyl)-acetic – THE PROBLEM; WHY IS IT DIFFICULT TO SEARCH CHEMICAL STRUCTURES IN PATENTS? – SOLUTION; DWPI STRUCTURAL INDEXING – DWPI PATENT COVERAGE – COMPOUND COVERAGE – WHICH COMPOUNDS ARE – DETAILED LOOK AT BCE FRAGMENTATION CODES – DETAILED LOOK AT DCR – STRUCTURAL MANUAL CODES – CHEMICAL STRUCTURE SEARCH EXAMPLE – CHEMICAL FRAGMENTATION CODE SEARCH EXAMPLE – MULTIFILE STRUCTURE SEARCH EXAMPLE Solution : DWPI structural indexing • There are 3 main types – Derwent Chemistry Resource (DCR) Indexing – Markush Indexing – BCE Fragmentation codes - (Now auto-generated from Markush or DCR indexing to ensure consistency) • In each case our analysts create the indexing by reading through the document and converting the chemical structural information into the appropriate type of indexing using clearly defined rules ensuring consistent representation • In addition structural manual codes from Sections B, C & E can be of limited assistance in some cases Benefits of DWPI indexing - concrete example • Search on Diclofenac or its most common synonyms (Voltarol or Voltaren) using Key words in DWPI title & abstract - Find 2748 documents • Search on Diclofenac via DCR record – We find – 414 of these were not found by the keyword search • Search on Diclofenac via BCE Fragmentation codes – We find 2763 documents – 1136 of these were not found by the keyword search – Hits include cases were diclofenac is a possible structure covered by a Markush formula Some of the inventions found only by the keyword search are of minimal interest e.g. Device for disposing transdermal analgesic patch with e.g. pharmaceutical product, from patient by doctor, has non-linear patch disposal slot extending through containment, and transdermal patch placed within internal chamber NOVELTY - The device has an internal chamber placed within a containment. A non-linear patch disposal slot extends completely through the containment and accesses the internal chamber. A transdermal patch is placed within the internal chamber. The containment comprises a wall that comprises the patch disposal slot. USE - Device for disposing a transdermal analgesic patch with pharmaceutical product from a patient by a doctor. Uses include but are not limited to non-steroidal anti-inflammatory drugs (NSAIDs) such as ketoprofen, diclofenac, flurbiprofen and ibuprofen, steroids such as testosterone and estradiol, psychoactive drugs such as buspirone, vitamin such as vitamin 812, vasodilators such as nitroglycerin and nicotine. ADVANTAGE - The device has a cover aperture sized and/or configured to reduce potential of the transdermal patch to be removed from a compartment and to impede ability of an individual to remove the transdermal patch from the compartment, thus reducing the potential to withdraw the transdermal patch back out of the internal chamber through the patch disposal slot, and hence facilitating disposal of transdermal patches contained with the internal chamber. But ones found only by DCR search are highly relevant • Multicomponent crystals useful e.g. for treating and preventing acute and chronic pain comprise (2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester and 2-(2-((2,6-dichlorophenyl)-amino)-phenyl)-acetic acid NOVELTY – Multi-component crystals comprise((2-amino-6- (4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester and 2-(2-((2,6-dichlorophenyl)-amino)-phenyl)-acetic acid. ADVANTAGE - The multicomponent crystals: are stable and easy to formulate; exhibit physicochemical properties which influence e.g. solubility, stability, hygroscopicity, handling and tabletting; and does not exhibit typical problems of physical mixtures i.e. different bioavailability or decomposition during the production. – THE PROBLEM; WHY IS IT DIFFICULT TO SEARCH CHEMICAL STRUCTURES IN PATENTS? – SOLUTION; DWPI STRUCTURAL INDEXING – DWPI PATENT COVERAGE – COMPOUND COVERAGE – WHICH COMPOUNDS ARE – DETAILED LOOK AT BCE FRAGMENTATION CODES – DETAILED LOOK AT DCR – BCE STRUCTURAL MANUAL CODES – CHEMICAL STRUCTURE SEARCH EXAMPLE – CHEMICAL FRAGMENTATION CODE SEARCH EXAMPLE – MULTIFILE STRUCTURE SEARCH EXAMPLE

DWPI PATENT COVERAGE • Pharmaceutical (Section B) – Patents stated to be of pharmaceutical or veterinary interest, as well as those that refer to compounds used as intermediates in the manufacture of pharmaceutical or veterinary products. – Patents on compositions used for diagnosis or analysis in the pharmaceutical and/or veterinary fields (e.g. stains for bacterial pathogens). – Patents on artificial sweeteners, chemical warfare agents, and plaque-disclosing compositions. – Patents dealing with the production of formulations, e.g. tablets, pills, capsules, suppositories, aerosols, etc. Also patents on devices specifically designed for dispensing pharmaceuticals, e.g. syringes, child-proof closures, calendar pill boxes, aerosol devices, etc.

DWPI PATENT COVERAGE • Agricultural and veterinary (section C) Pest control agents such as insecticides, miticides, rodenticides, molluscicides, slugicides, vermicides (nematocides, anthelmintics, etc.), pest repellents and attractants, and soil fumigants. Also biological control using microorganisms, predators, or natural products. Chemical warfare agents Plant growth control agents such as herbicides, weedicides, defoliants, desiccants, fruit drop and set controllers, rooting compounds, sprouting inhibitors, growth stimulants and retardants, moss and lichen controllers. Also plant genetics. Plant disease control agents such as fungicides, viricides, timber preservatives, and bactericides. Soil improvement agents such as fertilisers, trace metal additives, bacterial action control stimulants, and soil consolidation agents (if used for agricultural purposes). Veterinary products such as disease control agents, nutritional agents, and veterinary vaccines.

DWPI PATENT COVERAGE • General chemistry (Section E) • Any non-polymeric chemical compound not exclusively used as a pharmaceutical or agrochemical, as well as the apparatus and novel catalysts for producing them. For example, compounds used in cosmetics, fuels, dyes and more). • Includes their production, purification, use, detection, removal, and Monomers taking part in a polymerisation reaction unless the patent is concerned with the production or purification of the monomer Starting materials for a chemical reaction unless the patent is concerned with the production or purification of the starting material. Polymerisation catalysts are not normally classified in Section E unless the novelty of the invention is the catalyst. Mixtures of compounds described as a cut (i.e. hydrocarbon feedstock) in a petrochemical process (usually) Highly complex, non-stoichiometric compounds, e.g. those used as fluorescent materials, might not bem but simpler compounds normally are. Solvents and very common reagents, e.g. water Metals in their elemental form or alloys thereof – THE PROBLEM; WHY IS IT DIFFICULT TO SEARCH CHEMICAL STRUCTURES IN PATENTS? – SOLUTION; DWPI STRUCTURAL INDEXING – DWPI PATENT COVERAGE – COMPOUND COVERAGE – WHICH COMPOUNDS ARE – COMPOUND COVERAGE – WHAT INFORMATION ABOUT THE COMPOUNDS IS COVERED? – STRUCTURE OF A DCR RECORD – CHEMICAL STRUCTURE SEARCH EXAMPLE – CHEMICAL FRAGMENTATION CODE SEARCH EXAMPLE – MULTIFILE STRUCTURE SEARCH EXAMPLE Compound coverage – Which compounds are indexed? • The following compounds are selected for indexing – all compounds claimed to be new, including both specific compounds and Markush structures – known products produced by a new process – known compounds having a new use – components of compositions – novel catalysts and known specific catalysts – known specific reagents and starting materials in production – materials detected, detecting agents, detection media – materials recovered or purified in new ways – materials removed and removing agents COMPOUND COVERAGE – WHICH COMPOUNDS ARE COVERED? The following specific structures are also indexed with the Derwent
Chemistry Resource • All claimed compounds up to a maximum of 99. This number is reduced if a Markush is also needed. (Max no. of DCR + Markush records =99.). • At least 1 example, which should be the best example illustrating the invention (usually the one in the abstract). If the abstract (best) example is also claimed, then another should be selected. • Further examples input at analysts discretion, but more should be selected if there are examples which are structurally dissimilar from those claimed, but still representative of the Markush. • Selected examples should be "real" not prophetic; i.e. should have supporting data such as preparative data, activity data etc. • Compounds from the disclosure can be indexed at the Analysts discretion. Usually these would be if there are no (or few) claimed or exemplified compounds, or if there are novel disclosed compounds that are not claimed. COMPOUND COVERAGE – WHICH COMPOUNDS ARE COVERED? The following specific structures are also indexed with Derwent
Registry numbers • This is a list of 2080 commonly used compounds • Significant compounds or significant non-metallic elements mentioned in the claims or examples – An example of an insignificant compound is a solvent mentioned in a process in which any solvent may be used. • These have been indexed since 1981 but all have corresponding DCR records which will give the same number of hits as a DRN search More details are in "CPI Chemical Indexing Guidelines Indexing of Chemical and Pharmaceutical Patents", How does coverage differ between the types of indexing • B CE fragmentation codes cover both Markush (generic) structures and specific compounds back to 1963 (Section B), 1965 (Section C) or 1970 (section E) • DCR covers specific compounds only back to 1999/2000 (for comprehensive coverage) or as far back as 1981 for selected compounds – Precursor database - Derwent registry numbers (DRN) go back to 1981 – Precursor database – Derwent Compound Numbers (DCN) goes back to • MMS goes back as far as 1987 and covers both generic compounds and specific compounds – MMS structures can not be searched on STN but the compound numbers you get as answers from an MMS search do form part of the records and can be searched on STN – Patents with MMS indexing are tagged with the fragmentation code M904 COMPOUND COVERAGE – WHICH COMPOUNDS ARE COVERED? , for example where R1=H, R2=H [i.e. Penicillin G] (a specific example of the A specific which is not part of a BCE, MMS, DRN1, DCR Note 1; DRNs are applied if there is a number representing the compound – THE PROBLEM; WHY IS IT DIFFICULT TO SEARCH CHEMICAL STRUCTURES IN PATENTS? – SOLUTION; DWPI STRUCTURAL REPRESENTATIONS – DWPI PATENT COVERAGE – COMPOUND COVERAGE – WHICH COMPOUNDS ARE – DETAILED LOOK AT BCE FRAGMENTATION CODES – DETAILED LOOK AT DCR – STRUCTURAL MANUAL CODES – CHEMICAL STRUCTURE SEARCH EXAMPLE – CHEMICAL FRAGMENTATION CODE SEARCH EXAMPLE – MULTIFILE STRUCTURE SEARCH EXAMPLE BCE Fragmentation coding This is a system which uses alphanumeric codes to describe a chemical structure in terms of the fragments present and how they are connected • It has been applied to pharmaceutical patents since 1963, agrochemical patents since 1965 and general chemistry patents since 1970 • Both generic (markush) and specific compounds are covered by this indexing • Search strategy can be generated using software present in STN express by drawing a structure query Fragmentation codes example Aromatic Thioether (H594) Also 2 aromatic rings linked via S (M122 & M142) Two aromatic halogens (H642)Which are Fluroine (H601) her notable features coverd by codes Napthalene ring has one substituent at the beta position (G021)Benzene ring has 3 substituents at positions 1,2 & 4 (G015)A total of 2 aromatic rings (M532)No carbon chains of any type present (M280 & M320)No heterocyclic rings present (M510 & M520)No alicyclic rings present (M540)Compound is classed as aromatic (M414) But that is not all • In addition the following non-structural fragmentation codes can also be applied to a structure to describe how it fits into the invention – Role of the compound in the invention (e.g. compound is produced by the inventive process (M720)) – All structures will have at least one of these applied – Pharmaceutical / agrochemical activities (e.g. Hypotensive (P526)) – applied only to active substances that possess this activity – Chemical or physical property of substance relevant to the invention (e.g. surfactant (Q616)) – applied when relevant – Area of technology the invention is related to (e.g. Detergents (Q273)) – Applied when relevant – Process conditions / description (e.g. C-Hal bond broken (N225) or reaction temperature below 10⁰C (N511) ) – mandatory when the substance is produced, detected or removed – Physical form of a composition / formulation (e.g. Crystalline form (R032)) – applied to all claimed non-pharmaceutical compositions "Galenical" indexing for pharmaceutical patents • In pharmaceutical patents when the dosage form of a drug or it's means of production is the inventive feature a separate paragraph of indexing is created to describe this • The codes added describe the following – The physical form of the formulation (e.g. Capsule (R031)) – The mode of administration (e.g. Oral (R280)) – Any non-active components which are significant features of the invention (e.g. Coating (R307)) – If the invention is about manufacturing the formulation any physical process used in the manufacture (e.g. grinding (R525)) What this means you can do • So with fragmentation codes (or a combination of fragmentation codes and DCR) you can do all of the following – Search for a substance produced by a specific chemical reaction (e.g. cyclohexene produced by dehydrogenation) or under specific conditions (e.g. convert graphite into diamond at room temperature and pressure) – Search for the original product patent of a drug (using New role in DCR or BCE fragmentation code M710) – Search for drugs used for treating a particular condition (e.g. diclofenac to treat arthritis) – Search for a substance used in a particular technology area (e.g. Compounds containing a quinoline ring used in detergents) – Search for patents about drugs administered in a particular dosage form (e.g, oral administration of insulin) Example patent for oral administration of paclitaxel • Title Stable oral pharmaceutical composition of taxoid for administration to a • mammal comprises taxoids, solubilizer, stabilizing agent, surfactants, • solvents and oil • M6 *01* Q615 Q616 Q620 R111 R280 R315 R319 M905 Indexing for oral administration • M2 *12* D021 D024 D025 D026 D030 D220 G010 G019 G100 H4 H403 H462 H481 • H8 J0 J014 J2 J221 J231 J262 J3 J331 J5 J561 M1 M123 M136 M210 • M211 M240 M262 M282 M283 M312 M321 M332 M344 M349 M371 M391 M412 M431 M511 M520 M533 M540 M782 M800 M905 M904 • DCN: R18653-K R18653-M DCR record and fragmentation codes for paclitaxel • DCR: 103128-K 103128-M • To find this record first search for Paclitaxel patents (see part 2 of this presentation) snd then combine your answer set with the R2xx code (e.g. if your answer set was L2 then S L2 And R280/M6 Why use DWPI fragmentation codes? • Retrieve hits which cannot be picked up easily by keywords – due to chemical nomenclature, synonyms, generic disclosures, chemical structure representations etc. • Retrieve information not found in the online abstract – full patent specification and DWPI documentation abstract is used • Index of Markush and specific compounds in DWPI back to – a larger backfile of Markush indexing than either MMS or MARPAT • No structure search charge – THE PROBLEM; WHY IS IT DIFFICULT TO SEARCH CHEMICAL STRUCTURES IN PATENTS? – SOLUTION; DWPI STRUCTURAL REPRESENTATIONS – DWPI PATENT COVERAGE – COMPOUND COVERAGE – WHICH COMPOUNDS ARE – DETAILED LOOK AT BCE FRAGMENTATION CODES – DETAILED LOOK AT DCR – STRUCTURAL MANUAL CODES – CHEMICAL STRUCTURE SEARCH EXAMPLE – CHEMICAL FRAGMENTATION CODE SEARCH EXAMPLE – MULTIFILE STRUCTURE SEARCH EXAMPLE DWPI Chemistry Resource (DCR) • This is a database of specific chemical substances mentioned in • They are also organised into families of closely related compounds as – basic compound – salts, isotopes, mixtures, isomers • Substance records include structure diagrams and substance data, e.g. – IUPAC-name, synonyms – molecular formula, molecular weight • The DCR numbers are associated with the relevant fragmentation codes for the substance so they can be searched in conjunction with non-structural fragmentation codes • They also have roles associated with them (e.g. produced, detected)so that you can limit your answers by the role of the compound STRUCTURE OF A DCR RECORD DCR number (used to find the biblio ecord covering this cpd) DCSE 90406-0-0-0 Preferred chemical name CN.P CEPHALOSPORIN-C Systematic chemical name SY CEPHALOSPORIN C; CEPHALOSPORIN-C; Molecular formula Segment molecular formulae SMF C16 H21 N3 O8 S *1; TOTAL *1; TYPE *1 Molecular weight Structure Derwent Compound Number SDCN R00220 Structure Derwent Registry Number Class of compound Means of searching the database • The DCR database can be searched using the following options – Chemical structure – Chemical name – Molecular formula – Elements present – Number of fragments present – Compound class (only for those classes of structures that are hard to define in terms of a structural query such as terpenes or alkaloids) Substance descriptors • Certain classes of substance have special keywords applied to them called substance structures • These are applied to every substance that is of that type and in addition a blank record called a substance descriptor record is indexed for any patent which refers to this class of substance without giving a specific example • To search for these use the /CC field – S metallocenes/cc – Will retrieve all records in which metallocenes are indexed even if no specific compounds are given Complete list of substance descriptors OTHER NATURAL PRODUCTS POLYSACCHARIDES see CARBOHYDRATES CYCLIC PEPTIDES see PEPTIDES CYCLODEXTRINS see CARBOHYDRATES ENZYME see PROTEINS FATTY ACID see also UNSATURATED FATTY ACIDS STEROIDS see SAPONINS GLYCOPROTEINS see CARBOHYDRATES and PROTEINS HETEROFULLERENES UNSATURATED FATTY ACIDS see also FATTY ACIDS HETEROPOLY ACIDS – THE PROBLEM; WHY IS IT DIFFICULT TO SEARCH CHEMICAL STRUCTURES IN PATENTS? – SOLUTION; DWPI STRUCTURAL REPRESENTATIONS – DWPI PATENT COVERAGE – COMPOUND COVERAGE – WHICH COMPOUNDS ARE – DETAILED LOOK AT BCE FRAGMENTATION CODES – DETAILED LOOK AT DCR – STRUCTURAL MANUAL CODES – CHEMICAL STRUCTURE SEARCH EXAMPLE – CHEMICAL FRAGMENTATION CODE SEARCH EXAMPLE – MULTIFILE STRUCTURE SEARCH EXAMPLE BCE structural manual codes • These are applied to all patents classified in Sections B, C or E that contain chemical structures as an important feature of the invention • They provide a high level summary of the chemical content only based on identifying the most significant chemical group present in a structure • However certain codes can be very useful – B04-A03 Ergot alkaloids – E31-H01 removal of nitrogen oxides from exhaust gases When structural codes may be useful – natural products • Vitamin's in Pharmaceutical patents • Certain classes of alkaloid (Belladonna, Cinchona, Ergot, Opium, Rauwolfia & Xanthines) • Nucleosides & nucleotides • Prostaglandins • Polysaccharides such as starch and chondroitin • Peptides & Proteins When structural codes may be useful – inorganic compounds • Hydrogen peroxide • Common non-metallic elements e.g.Hydrogen, halogens, oxygen, carbon (separate codes for different allotropes), Silicon, Boron • Phosphoric acid & Boric acid • Nitrogen and Sulfur oxides • Nanoparticles DWPI is 50 years old this year The Derwent record in a form similar to the one we use today was first launched in 1963 as a pharmaceutical patent service • 50 years later we now cover all technologies with more detailed abstracts and more extensive indexing • We have added our 50 millionth record • We have just added our 50th data source (Indonesia) FOR SUPPORT and TRAINING Offices around the World • Customer Service US, Canada & Latin America For subscriptions, pricing and renewals Phone: +1 800 336 4474 • Technical Support Europe, Middle East and Africa For access, content, searching, troubleshooting Tel: +44 (0)20 7433 4000 and technical issues. Fax: +44 (0)20 7433 4001 Japan Phone: +81 3 5218 6500 For product or IP-related training options. [email protected] Asia Pacific (Singapore office) Phone: +65 6411 6888

Structure Searching DWPISM
using STN Express® : Part II
• Chemical structure search example – The DWPI Chemistry Resource (DCR) • Chemical fragmentation code search example – Generating and searching queries using STN Express • Multifile structure search example – Searching in combination with REGISTRY/CAplusSM Chemical structure search example Search Question:
Search for DWPI patent references to specific
carbapenem derivatives of substructure (I)
Learn more about the basics of structure searching: Chemical structure search options Exact search (EXA) ‒ Retrieves specific compounds and isotopes Family search (FAM) ‒ Retrieves specific compounds, isotopes, salts and mixtures Closed Substructure Search (CSS) ‒ Allows for substitution at defined positions Substructure Search (SSS) ‒ Allows for substitution at any position Sample search (SAM) ‒ Free-of-charge pre-search Subset search (SUBSET) ‒ Structure search on a database subset Batch search (BATCH) ‒ For broad structure queries which may reach system limits How to run a structure search in DWPI 1. Draw & save the structure query in standard format with STN Express (or STN on the Web) 2. Upload the structure query to DWPI on STN 3. Run the structure search, e.g.: a. Sample search => S L1 SSS SAM => S L1 SSS FULL 4. Retrieve DWPI patent records E.g.: => S L2/DCR 5. Display DWPI patent records with DCR hit structures (HITSTR) in-context E.g.: => D L3 1- FULLG HITSTR Draw & save the structure query in standard format with STN Express Upload the structure query to DWPI on STN Upload the query with the ‘Q' button. Run a sample structure search
=>
Uploading C: . . My Documents STN Express 8.5 Queries CARBAPENEM.str
L1 STRUCTURE UPLOADED
The uploaded structure query (L1).
=> D
L1 HAS NO ANSWERS
L1 STR

Option: display the query (L1), to
verify that the Upload was successful.
Structure attributes must be viewed using STN Express query preparation.
=> S L1 SSS SAM
Run a substructure (SSS) sample SAMPLE SEARCH INITIATED 16:11:06 FILE 'WPIX'
(SAM) search using the query (L1). SAMPLE SCREEN SEARCH COMPLETED - 173 TO ITERATE
100.0% PROCESSED 173 ITERATIONS 50 ANSWER
. .
L2 50 SEA SSS SAM L1
50 compounds are retrieved (L2). Review some answers using D SCAN
=> D SCAN
L2 50 ANSWERS WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
CN.S 3-{5-[2-(7-Fluoro-2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-
pyrrolidin-3-ylsulfanyl}-6-(1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-
bicyclo[3.2.0]hept-2-ene-2-carboxylic acid
MF C25 H30 F N3 O7 S

The effectiveness of the query (L1) may be assessed by reviewing some records (L2), e.g. using the free-of- charge SCAN format.
HOW MANY MORE ANSWERS DO YOU WISH TO SCAN? (1):3
L2 50 ANSWERS WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
CN.S 3-{5-[2-(7-Fluoro-2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-
pyrrolidin-3-ylsulfanyl}-6-(1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-
bicyclo[3.2.0]hept-2-ene-2-carboxylic acid
MF C25 H30 F N3 O7 S
. .

Run a full structure search => S L1 SSS FUL
Run a substructure (SSS) full-file FULL SEARCH INITIATED 16:13:30 FILE 'WPIX'
(FUL) search using the query (L1). FULL SCREEN SEARCH COMPLETED - 1602 TO ITERATE
100.0% PROCESSED 1602 ITERATIONS 1332 ANSWERS
SEARCH TIME: 00.00.04
L3 1332 SEA SSS FUL L1
1332 compounds are retrieved (L3). => S L3/DCR
783 DWPI patent records are retrieved (L4). L4 783 L3/DCR
Retrieve and display DWPI patent records => D BIB HITSTR
L4 ANSWER 1 OF 783 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
AN 2012-M63076 [201267] WPIX
TI Detecting carbapenemase producing bacteria in a sample, comprises
incubating the sample in a reaction medium comprising a carbapenem and
cloxacillin for growing the bacteria and detecting the strains
corresponding to the bacteria
DC B04; D16
Display the DWPI patent IN GHIRARDI S; PERRY J; ZAMBARDI G
records with in-context hit PA (INMR-C) BIOMERIEUX SA
CYC 116
structures (HITSTR). PIA FR 2973041 A1 20120928 (201267)* FR 25[0]
WO 2012131217 A1 20121004 (201267) FR
ADT FR 2973041 A1 FR 2011-52476 20110325; WO 2012131217 A1 WO 2012-FR50557
20120316
PRAI FR 2011-52476 20110325
AN.S DCR-402340
CN.P ERTAPENEM
CN.S 3-[5-(3-Carboxy-phenylcarbamoyl)-pyrrolidin-3-ylsulfanyl]-6-(1-
hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-
carboxylic acid
SDCN RA9TLK
. .
Searches may be refined using roles • "Roles" in DWPI describe the function of a compound in the patent, e.g. ‒ Compound is prepared, purified or part of a mixture ‒ Compound is claimed or from the examples • DCR compounds can have two types of roles assigned in DWPI ‒ 2-3-letter codes in the IT-display (DCR Roles) ‒ Single-letter codes in the CMC display (DCN Roles) • Roles can be linked to DCR numbers in the DCR search field using the (T)-proximity operator Example: DCR role searching for preparations => S L3/DCR (T) (PRD OR P OR NEW OR N)/DCR
L5 332 L3/DCR (T) (PRD OR P OR NEW OR N)/DCR
=> D TRIAL HIT
Use (T)-operator to link DCR L5 ANSWER 1 OF 332 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
numbers to their roles (/DCR). AN 2012-L02061 [201260] WPIX
TI Preparation of meropenem trihydrate comprises subjecting meropenem
compound to hydrogen extricated protective reaction in the presence of
catalyst and under mixed solvent system
DC B02
IPCI C07D0477-06 [I,A]; C07D0477-08 [I,A]; C07D0477-20 [I,A]
MC CPI: B02-M; B02-P; B06-D04; B14-Y; N02-F01; N07-F06A
IT UPIT 20120919
2364594-CL 2364594-PRD; 71-CL 71-RGT; 2211-CL 2211-RGT; 1216294-CL
1216294-RCT
CMC UPB 20120927
M2 *01* D011 D013 D014 D016 D030 D690 F012 F014 F423 H4 H401 H481 H5
PRD, P – preparation roles. H592 H8 H9 J0 J012 J1 J111 J3 J311 J5 J521 L9 L941 M1 M126
M142 M210 M211 M240 M273 M2
NEW81 M282
om 321 M33
pound r 1 M3
M373 M391 M412 M511 M521 M530 M540 M640 M720 M800 N231 N241
N341 N361 N441 N512 N513 N520 N521 N522 N523 M905 M904
RIN: 41252
DCN: RB936T-K RB936T-P
DCR: 2364594-K 2364594-P
Meropenem trihydrate. DCR searches may also be refined using chemical fragmentation codes (CMC) => S L3/DCR (P) (Q262 OR Q263 OR P94!)/M0,M2,M3,
L6 71 L3/DCR (P) (Q262 OR Q263 OR P94!)/M0,M2,M
=> D AN TI HIT

WPIDS/WPIX-users can link DCR L6 ANSWER 1 OF 71 WPIX COPYRIGHT 2012 TH
number OMSO
h f EUTERS
entati TN
AN 2012-L13457 [201259] WPIX
via the (P)-proximity operator. TI New firmocidin compounds, useful for e.g. inhibiting the growth of a
fungus or bacterium, and treating bacterial, fungal, parasitic or
viral infection, or a dermatological disorder including e.g. diabetic
ulcers, acne, rosacea and pyodermas
CMC UPB 20120917
M2 *86* D013 D014 D690 F012 F014 F423 H4 H401 H481 H5 H592 H8 H9 J0
J012 J1 J111 J3 J311 J5 J521 L9 L941 M1 M126 M142 M210 M211
M240 M273 M281 M282 M312 M321 M331 M340 M342 M373 M391 M412
M431 M511 M521 M530 M541 M782 M800 P210 P220 P241 P330 P420
P941 P942 P943 Q232 M905 M904
RIN: 41252
DCN: R23271-K R23271-M
DCR-100514: Meropenem. DCR: 100514-K 100514-M
Example: Q263 = sunscreen agent. Q262 = skin protection (except Q263). P94+ = burn, wound and skin treatments.
Chemical fragmentation code search example Search Question:
Search for DWPI patent references to all
carbapenem derivatives of substructure (I)
How to run a fragmentation code search 1. Draw & save the structure query in WPI format 2. Select Query and Generate WPI strategy from the main STN Express window 3. Select the fields to be searched, e.g. /M0,M2, and the strategy is generated and saved 4. Logon to STN, access WPIDS or WPIX, then select Query and Run Command File 5. Select the command file – this runs line-by-line automatically – and review the results Open, Draw and save the query structure in "WPI" format Open a new WPI format drawing window. Draw and save the WPI structure. Note: By convention, unlike an STN
structure search, all unsubstituted
positions are assumed to be H.
Alternatively a standard format structure can be converted to a WPI format structure A standard STN structure query can usually be converted to WPI format, for generating a fragmentation code query. Use STN Express to generate the fragmentation code script Select the search fields (subheadings) and generate the fragmentation codes STN Express search field options: /M2 1970-date Pharma/agrochem /M3 1970-date Other chemicals (excl. M4) /M4 1970-date Dyes & pigments Other fragmentation code fields 1970-date Natural products 1963-1999 Steroids 1976-date Galenicals/formulations DWPI fragmentation code strategy is generated in Command File format Tip: Check that any manual edits
you make are valid codes, with
Utilities, Check Command File.
Use Run Command File to execute the fragmentation code search online The command file code query runs automatically line-by-line
=> S (D690(P)H401(P)H481(P)J111(P)J521(P)M331(P)M412)/M0,M2,M3,M4
L7 2435 (D690(P)H401(P)H481(P)J111(P)J521(P)M331(P)M412)/M0,M2,M3,M4
=> S L7(P)(M511(P)M520(P)M530(P)M540)/M2
The Command File runs L8 1381 L7(P)(M511(P)M520(P)M530(P)M540)/M2
automatically line-by-line.
=> S L8(P)(M280(P)M312(P)M321(P)M340(P)M342(P). . )/M2,M3,M4
L9 832 L8(P)(M280(P)M312(P)M321(P)M340(P)M342(P). . )/M2,M3,M4
=> S L9(P)41252/RIN
STN Express links and groups codes L10 236 L9(P)41252/RIN
together into correctly formatted queries.
=> S L10(P)(D011(P)D013(P)J011(P)"L941")/M2,M3,M4
L11 147 L10(P)(D011(P)D013(P)J011(P)"L941")/M2,M3,M4
. .

Note: A relatively small answer
=> S L15(NOTP)("L8" OR M1)/M2,M3,M4 set (L17) is retrieved because this
L17 95 L15(NOTP)("L8" OR M1)/M2,M3,M4

is not a substructure search. Fragmentation code searches may also be refined with role codes => S L17 (P) (M720 OR M710)/M2
L18 79 L17 (P) (M710 OR M720)/M2

=> D AN TI HITCMC

L18 ANSWER 1 OF 79 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
M720 – preparation role code. AN 2012-D24668 [201224] WPIX
TI Composition useful for producing semi synthetic cephalosporin
M710 – new compound role code. comprising cephalexin, cefadroxil or cephradine, comprises N-
deacylated cephalosporin compounds, acyl group and 6-aminopenicillanic
acid
CMC UPB 20120412
M2 *08* C216 C316 D010 D011 D013 D014 D016 D019 D020 D040 D690
E460 E670 F010 F020 G003 G010 G013 G019 G020 G021 G030 G033
G034 G035 G040 G050 G100
he 11 G221
HITCMC G55
mat 563 H10
pful H102
H121 H161 H181 H182 H401 H402 H441 H461 H481 H521 H522 H581
displaying hit fragmentation paragraphs. H582 H598 H600 H621 H661 H681 H682 H683 H721 H722 H731 H732
J0 J011 J012 J1 J111 J321 J5 J521 J522 J581 K441 L640 L650
L660 L699 L9 L941 L942 L943 M113 M115 M116 M123 M125 M132
M135 M210 M211 M212 M213 M214 M215 M216 M220 M221 M222 M223
M224 M225 M226 M231 M232 M233 M240 M262 M271 M272 M273 M280
M281 M282 M311 M312 M313 M314 M315 M316 M320 M321 M322 M323
M331 M332 M333 M340 M342 M343 M349 M353 M362 M371 M372 M373
M381 M383 M391 M392 M412 M511 M512 M520 M521 M530 M531 M532
M540 M541 M720 N134 N261 N331 N511 N512 N513 M905 M904
RIN: 41252 41250
This hit is a Markush compound. MCN: 1128-58002-K 1128-58002-P
Option: Edit the fragmentation code query, to run a full substructure search…. Manually edit, check and save a broader, substructure query. Run the edited fragmentation code query
=> S (D690(P)J11!(P)J52!(P)(M412 OR M411))/M0,M2
L19 3608 (D690(P)J11!(P)J52!(P)(M412 OR M411))/M0,M2

=> S L19(P)(M511 OR M512 OR M513)/M2
The Command File runs L20 3591 L19(P)(M511 OR M512 OR M513)/M2
automatically line-by-line. => S L20(P)(M321 OR M322 OR M323)/M2
L21 3444 L20(P)(M321 OR M322 OR M323)/M2

=> S L21(P)41252/RIN
L22 1379 L21(P)41252/RIN

=> S L22(P)(D013(P)(D011 OR D019 OR D014)(P)"L941")/M2
L23 1371 L22(P)(D013(P)(D011 OR D019 OR D014)(P)"L941")/M2

=> S L25(NOTP)"L1"/M2,M3,M4
Note: This is a substructure search (L26).
L26 1390 L25(NOTP)"L1"/M2,M3,M4
Review fragmentation code answers => D AN TI HITCMC FRAGHITSTR

The fragmentation code hit L26 ANSWER 1 OF 1390 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
structure (FRAGHITSTR) format AN 2012-M63076 [201267] WPIX
TI Detecting carbapenemase producing bacteria i
display n a
he D ple, co
CR str mpri
uctur ses
incubating the sample in a reaction medium comprising a carbapenem and
specific compounds retrieved. cloxacillin for growing the bacteria and detecting the strains
corresponding to the bacteria
CMC UPB 20121018
M2 *02* D011 D013 D014 D016 D030 D690 F012 F014 F423 G012 G100
H4 H401 H481 H5 H592 H8 H9 J0 J013 J1 J111 J131 J3 J311 J5
J521 L9 L941 M1 M123 M126 M136 M142 M210 M211 M240 M281 M312
M321 M331 M340 M342 M373 M391 M412 M511 M521 M531 M540
M750 N102 Q233 M905 M904
RIN: 41252
DCN: RA9TLK-A RA9TLK-K
DCR: 402340-A 402340-K
AN.S DCR-402340
CN.P ERTAPENEM
CN.S 3-[5-(3-Carboxy-phenylcarbamoyl)-pyrrolidin-3-ylsulfanyl]-6-(1-
hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-
carboxylic acid
SDCN RA9TLK
. .
Option: Use the (NOTP) operator to exclude hits already found via the DCR structure search => S L26 (NOTP) L4
L27 833 L26 (NOTP) L4
=> D AN TI HITCMC
L27 ANSWER 1 OF 833 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
AN 2012-J52671 [201250] WPIX
TI Manufacturing solution of mercapto-pyrrolidine-carboxylic acid amide
compounds, comprises dissolving carbonate source and base in . .
CMC UPB 20120808
M2 *22* C116 C216 C316 D013 D014 D019 D690 F012 F014 F423 G011 G012
G014 G015 G016 G017 G100 H100 H101 H102 H103 H141 H142 H341
H342 H401 H402 H403 H441 H442 H481 H5 H541 H542 H592 H594
H599 H600 H601 H608 H641 H642 H681 H685 H689 H9 J0 J013 J014
J111 J131 J132 J133 J211 J231 J232 J3 J311 J331 J332 J341
J342 J5 J521 K353 K399 K423 K433 K499 L143 L199 L9 L941 M1
M123 M126 M136 M142 M210 M211 M212 M213 M214 M215 M216 M220
M221 M222 M223 M224 M225 M226 M231 M232 M233 M240 M262 M271
M272 M273 M280 M281 M282 M283 M311 M312 M321 M322 M323 M332
M342 M344 M353 M373 M391 M392 M393 M412 M511 M521 M531 M540
M720 N231 N361 N511 N512 N513 P220 M905 M904
RIN: 41252
MCN: 1137-67601-K 1137-67601-P
his hit is a Markush compound. If we explore this answer further… => D IFULLG
L27 ANSWER 1 OF 833 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
ACCESSION NUMBER: 2012-J52671 [201250] WPIX
TITLE: Manufacturing solution of mercapto-pyrrolidine-
carboxylic acid amide compounds, comprises dissolving
carbonate source and base in diluent, and mixing
mercapto-pyrrolidine-carboxylic acid amide compounds
with first solution
DERWENT CLASS: B02
Use the IFULLG format to INVENTOR: CHANG W; CHUANG S; TSENG W; CHANG W H; CHUANG S T;
TSENG W H
see patent family, abstract, PATENT ASSIGNEE: (SAVI-N) SAVIOR LIFETEC CORP; (LIFE-N) LIFE
and selected drawing image. TECHNOLOGIES INC
COUNTRY COUNT: 44
PATENT INFO ABBR.:
PATENT NO KIND DATE WEEK LA PG MAIN IPC
-----------------------------------------------------------------
EP 2479177 A1 20120725 (201250)* EN 16[0]
. .
APPLICATION DETAILS:
PATENT NO KIND APPLICATION DATE
------------------------------------------------------------------
EP 2479177 A1 EP 2011-173509 20110712
. .
PRIORITY APPLN. INFO: US 2011-168569 20110624
US 2011-12171 20110124
Display formats for reviewing chemical fragmentation codes in DWPI All codes, indexing and classes All chemical codes, M0-M6 Pharma/Agrochem only, etc Ring Index Numbers only The hit fragmentation code paragraph(s) found in a fragmentation code search D FRAGHITSTR The DCR structure for any specific compounds retrieved in a fragmentation code search Multifile structure search example Search Question:
Search for all patent references of cetirizine,
including salts and mixtures
Multifile structure searching using DCR/DWPI and REGISTRY/CAplus 1. Prepare a suitable standard structure query for REGISTRY/CAplus and DCR/DWPI 2. Run the structure search in REGISTRY/CAplus 3. Display CAplus records of interest 4. Run the structure search in DCR/DWPI, and remove duplicates between CAplus and DWPI 5. Display any additional DWPI records Note: A comprehensive STN search would also include
CAS MARPAT and DWPI Chemical Fragmentation Codes.
Run a sample structure search => FILE REGISTRY
=>
Uploading C: . . My Documents STN Express 8.5 Queries cetirizine.str
L1 STRUCTURE UPLOADED
The uploaded structure query (L1).
=> D
L1 HAS NO ANSWERS
L1 STR

Option: display the query (L1), to
verify that the Upload was successful.
Structure attributes must be viewed using STN Express query preparation.
=> S L1 FAM SAM
Run a family (FAM) sample (SAM) SAMPLE SEARCH INITIATED 12:57:49 FILE 'REGISTRY'
search using the query (L1). SAMPLE SCREEN SEARCH COMPLETED - 14 TO ITERATE
. .
L2 3 SEA FAM SAM L1
3 compounds are retrieved (L2). Review some answers using D SCAN => D SCAN

L2 3 ANSWERS REGISTRY COPYRIGHT 2012 ACS on STN
IN Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-
piperazinyl]ethoxy]-, sodium salt (1:1)
MF C21 H25 Cl N2 O3 . Na
The effectiveness of Absolute stereochemistry.
the query (L1) may be assessed by reviewing some records (L2), e.g. using the free-of- charge SCAN format.
HOW MANY MORE ANSWERS DO YOU WISH TO SCAN? (1):2
L2 3 ANSWERS REGISTRY COPYRIGHT 2012 ACS on STN
IN Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-
piperazinyl]ethoxy]-, 4-methylbenzenesulfonate (1:1)
MF C21 H25 Cl N2 O3 . C7 H8 O3 S
. .

Run a full structure search => S L1 FAM FUL
Run a family (FAM) full-file (FUL) FULL SEARCH INITIATED 12:58:16 FILE 'REGISTRY'
search using the query (L1). FULL SCREEN SEARCH COMPLETED - 413 TO ITERATE
100.0% PROCESSED 413 ITERATIONS 99 ANSWERS
SEARCH TIME: 00.00.01
L3 99 SEA FAM FUL L1
The full file structure search retrieves 99 REGISTRY records (L3). => FILE HCAPLUS
The full file structure search (L3) retrieves => S L3 AND P/DT
870 patent records (P/DT) in CAplus (L4). L4 870 L3 AND P/DT
Example: CAplus answer retrieved => D BIB HITSTR
L4 ANSWER 1 OF 870 HCAPLUS COPYRIGHT 2012 ACS on STN
AN 2012:1492869 HCAPLUS Full-text
TI Chewable tablet of levocetirizine hydrochloride
IN Yao, Liangyuan; Yuan, Xiuju; Zhong, Aijun; Wang, Xuejiao; Wang,
Chaolei; Su, Liang; Song, Wei
PA Hunan Qianjin Xiangjiang Pharmaceutical Joint Stock Co., Ltd., Peop.
Rep. China
SO Faming Zhuanli Shenqing, 28pp.
Display CAplus patent CODEN: CNXXEV
DT Patent
records with in-context LA Chinese
hit structures (HITSTR). FAN.CNT 1
PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
PI CN 102716099 A 20121010 CN 2012-10232209 20120705
PRAI CN 2012-10232209 20120705
IT INDEXING IN PROGRESS
IT 823178-28-5
RL: PKT (Pharmacokinetics); PRP (Properties); THU (Therapeutic use);
BIOL (Biological study); USES (Uses)
(chewable tablet of levocetirizine hydrochloride)
RN 823178-28-5 HCAPLUS
CN Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-
piperazinyl]ethoxy]-, hydrochloride (1:1) (CA INDEX NAME)
Repeat the structure search in DCR => FILE WPIX
Access the Derwent World Patents Index (DWPI) (files WPINDEX, WPIDS or WPIX). => S L1 FAM FUL
FULL SEARCH INITIATED 13:01:24 FILE 'WPIX'
Repeat the structure search FULL SCREEN SEARCH COMPLETED - 58 TO ITERATE
using the same query (L1). 100.0% PROCESSED 58 ITERATIONS 46 ANSWERS
SEARCH TIME: 00.00.03
The full file family search L5 46 SEA FAM FUL L1
retrieves 46 DCR records (L5). => S L5/DCR
L6 689 L5/DCR
The 46 DCR records (L5) retrieve 689 patent records (L6). Retrieve the unique DWPI records => TRANSFER L4 1- PNK
Use TRANSFER PNK to L7 TRANSFER L4 1- PNK : 5371 TE
crosso RMS
results (L4) to DWPI (L8). => S L6 NOT L8
The DCR/DWPI search (L6) adds L9 120 L6 NOT L8
120 unique inventions (L9) to the REGISTRY/CAplus results (L4). PNK = The patent number/kind code field. This is the most precise field to use when crossing over results between STN patent databases. Review the unique DWPI records
=> D AN TI 1-50
L9 ANSWER 1 OF 120 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
AN 2012-C62644 [201240] WPIX
TI Resolution of L-levocetirizine involves adding racemic benzyl
piperazine compound and chiral ionic liquid to reaction container,
reacting, extracting, separating, concentrating and crystallizing
. .
L9 ANSWER 17 OF 120 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
AN 2010-F66310 [201037] WPIX
TI Making levocetirizine involves resolving pair of diastereomer of
piperazine compound into single diastereomer, and converting single
diastereomer of piperazine compound with
1-((4-chloro-phenyl)-phenyl-methyl)-piperazine into levocetirizine
. .
L9 ANSWER 42 OF 120 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
AN 2009-J67366 [200936] WPIX
TI Orally disintegrating tablet useful for delivering main ingredient
e.g. cetirizine hydrochloride for treating allergy, comprises main
ingredient having specified water solubility and does not contain
binder
. .
L9 ANSWER 50 OF 121 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
AN 2009-E73509 [200916] WPIX
TI Medical products useful for treating respiratory disorders, comprises
dry powder medicament dose containing tiotropium and container
adapted for use in dry powder inhaler

Example: DWPI answer retrieved => D BIB HITSTR 17

L9 ANSWER 17 OF 120 WPIX COPYRIGHT 2012 THOMSON REUTERS on STN
AN 2010-F66310 [201037] WPIX
TI Making levocetirizine involves resolving pair of diastereomer of
piperazine compound into single diastereomer, and converting single
diastereomer of piperazine compound with
1-((4-chloro-phenyl)-phenyl-methyl)-piperazine into levocetirizine
DC B03; B05
IN FIRET J J; ZHU J
PA (SYNT-N) SYNTHON BV
PIA WO 2010057515 A1 20100527 (201037)* EN 35[0]
NL 1037485 C 20100727 (201140) NL
ADT WO 2010057515 A1 WO 2008-EP9977 20081121; NL 1037485 C NL 2009-1037485
20091120
PRAI WO 2008-EP9977 20081121
AN.S DCR-174423
CN.P LEVOCETIRIZINE
SDCN RA0WVA
• Chemical structure search example – The DWPI Chemistry Resource (DCR) • Chemical fragmentation code search example – Generating and searching queries using STN Express • Multifile structure search example – Searching in combination with REGISTRY/CAplus A recording of this e-Seminar will be available at: For more information … Support and Training: Support and Training:

Source: https://partners.fiz-karlsruhe.de/uploads/tx_ptgsarelatedfiles/DWPI_structure_search_es_092014_01.pdf