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Full Length Article Amit Pandey* , Neha Rajput , Mohammad Nadeem Aslam and Bharat Choudhary 1. 1R&D Division, MRD LifeSciences, Lucknow, India. 2. Alpine Institute of Management and Technology, Dehradun, India. 3. APS University, Rewa, M.P., India Five MDR cultures of bacteria were isolated from four different locations of Lucknow and Kanpur, respectively. Based upon Gram staining four isolates (A1, A2, C2 and G3) were identified as Gram negative out of which A1 was mixed culture that is cocci + rod and A2 and G3 were Gram negative rods. Culture N was identified as Gram positive mixed culture that is cocci + rod. Based upon the biochemical analysis G3 bacterial culture was identified as Pseudomonas aeruginosa (Table 1), for multi-drug resistance (MDR) test seven different antibiotics in different concentration were used. It was observed that A1 bacterial culture showed resistance to amoxycilline (100 µg/ml), cefixime (100 µg/ml), ofloxacin (50 µg/ml), roxithromycin (20 µg/ml), ampicilline (50 µg/ml) and tetracycline (50 µg/ml) while A2 culture was resistant to amoxycilline (50 µg/ml) and cefixime (1 mg/ml). C2 was resistant to amoxycilline (10 mg/ml), cefixime (1 mg/ml), roxithromycin (10 mg/ml), ampicilline (20 µg/ml) and tetracycline (20 µg/ml). G3 was resistant to amoxycillin (1 mg/ml) and cefixime (1 mg/ml). And N culture was resistant to amoxycilline (100 µg/ml), cefixime (1 mg/ml), roxithromycin (50 µg/ml), ampicilline (50 µg/ml) and tetracycline (20 µg/ml).

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Rev. Medicina y Humanidades. Vol. II N° 2-3 (Mayo-Diciembre) 2010 Derechos Humanos, Bioética y reinserción comunitaria en psiquiatría1. Resumen: El presente trabajo se introduce en el análisis que puede desarrollar la bioética en el área específica de las implicancias de la psiquiatría en la trasformación de los proyectos de vida de las personas y el difícil trabajo de ellas para alcanzar una revalidación social de sus derechos, después de un largo tiempo de tratamientos. En este contexto, es factible considerar como variables, la responsabilidad ética del profesional que diseña programas de reinserción comunitaria, incorporación de psicofármacos, dependencia constante de los aparatos sanitarios, integración a nuevos barrios, involuntaria convivencia con otros, reaprendizaje de la participación civil, que se vinculan a este fenómeno. El trabajo que presentamos, busca articular tres dimensiones culturales, el rol social del profesional de la salud (Terapeuta Ocupacional), la reflexión bioética y la declaración rectora de la dignidad humana expresada como Derechos Humanos; que conectan en la validación, protección y reintegración de las personas afectadas por las intervenciones psiquiátricas. Palabras Claves: Bioética, Psiquiatría, Derechos Humanos. Abstract

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HIV in Primary Care An essential guide for GPs, practice nurses and other members of the primary healthcare team by Dr Sara Madge, Dr Philippa Matthews, Dr Surinder Singh and Dr Nick Theobald a charity supported by the British Medical Association by Dr Sara Madge, Dr Philippa Matthews, Dr Surinder Singh and Dr Nick Theobald Medical Foundation for AIDS & Sexual Health (MedFASH)*

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Temporally and Regionally Disparate Differences inPlasmin Activity by Tranexamic Acid Daryl L. Reust, MD,* Scott T. Reeves, MD,* James H. Abernathy, III, MD,* Jennifer A. Dixon, MD,‡William F. Gaillard, II, BS,‡ Rupak Mukherjee, PhD,‡ Christine N. Koval, BS,‡ Robert E. Stroud, MS,‡and Francis G. Spinale, MD, PhD†‡ BACKGROUND: A major complication associated with cardiac surgery is excessive and pro-longed bleeding in the perioperative period. Improving coagulation by inhibiting fibrinolysis,primarily through inhibition of plasmin activity (PLact) with antifibrinolytics such as tranexamicacid (TXA), has been a pharmacological mainstay in cardiac surgical patients. Despite its almostubiquitous use, the temporal and regional modulation of PLact profiles by TXA remainsunexplored. Accordingly, we developed a fluorogenic-microdialysis system to measure in vivodynamic changes in PLact after TXA administration in a large animal model.METHODS: Pigs (25–35 kg) were randomly assigned to receive TXA (30 mg/kg, diluted into 50mL normal saline; n ⫽ 9) or vehicle (50 mL normal saline; n ⫽ 7). Microdialysis probes wereplaced in the liver, myocardium, kidney, and quadriceps muscle compartments. The microdialy-sate infusion contained a validated plasmin-specific fluorogenic peptide. The fluorescenceemission (standard fluorogenic units [SFU]) of the interstitial fluid collected from the microdialy-sis probes, which directly reflects PLact, was determined at steady-state baseline and 30, 60,90, and 120 min after TXA/vehicle infusion. Plasma PLact was determined at the same timepoints using the same fluorogenic substrate approach.RESULTS: TXA reduced plasma PLact at 30 min after infusion by ⬎110 SFU compared withvehicle values (P ⬍ 0.05). Specifically, there was a decrease in liver PLact at 90 and 120 minafter TXA infusion of ⬎150 SFU (P ⬍ 0.05) and 175 SFU (P ⬍ 0.05), respectively. The decreasein liver PLact occurred 60 min after the maximal decrease in plasma PLact. In contrast, kidney,heart, and quadriceps PLact transiently increased followed by an overall decrease at 120 min.CONCLUSIONS: Using a large animal model and in vivo microdialysis measurements of PLact,the unique findings from this study were 2-fold. First, TXA induced temporally distinct PLactprofiles within the plasma and selected interstitial compartments. Second, TXA causedregion-specific changes in PLact profiles. These temporal and regional differences in the effectsof TXA may have important therapeutic considerations when managing fibrinolysis in theperioperative period. (Anesth Analg 2010;110:694 –701)

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Human Pathology (2007) 38, 185 – 189 Temozolomide therapy in a man with an aggressiveprolactin-secreting pituitary neoplasm:morphological findings Kalman Kovacs MD, PhDa,*, Eva Horvath PhDa, Luis V. Syro MDb, Humberto Uribe MDc,Luis C. Penagos MDd, Leon D. Ortiz MDe, Camilo E. Fadul MDf aDepartment of Laboratory Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada M5B 1W8bDepartment of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, ColombiacDepartment of Neurosurgery, Clinica SOMA, Medellin, ColombiadDivision of Otolaryngology, Clinica Medellin, Medellin, ColombiaeSection of Neuro-oncology, Instituto de Cancerologia, Clinica Las Americas, Medellin, ColombiafSections of Hematology/Oncology and Neurology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA

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Meat Science 69 (2005) 509–518 Conjugated linoleic acid concentration in M. Longissimus dorsi from heifers offered sunflower oil-based concentrates and conserved forages F. Noci a,b, P. OÕKiely a, F.J. Monahan b, C. Stanton c, A.P. Moloney a,* a Teagasc, Grange Research Centre, Dunsany, Co. Meath, Ireland b Department of Food Science, University College Dublin, Dublin 4, Ireland

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MOLECULAR CARCINOGENESIS 45:461–478 (2006) Checkpoint Kinase 1-Mediated Phosphorylationof Cdc25C and Bad Proteins Are Involved inAntitumor Effects of Loratadine-Induced G2/MPhase Cell-Cycle Arrest and Apoptosis Jinn-Shiun Chen,1 Shyr-Yi Lin,2 Wei-Ling Tso,3 Geng-Chang Yeh,4 Wen-Sen Lee,5 How Tseng,6Li-Ching Chen,7 and Yuan-Soon Ho3* 1Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan2Department of Internal Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan3Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan4Graduate Institute of Medical Sciences, and Department of Pediatrics, School of Medicine, Taipei Medical University,Taipei, Taiwan5Graduate Institute of Medical Sciences, and Department of Physiology, School of Medicine, Taipei Medical University,Taipei, Taiwan6Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei, Taiwan7Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

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Social and Personality Psychology Compass 6/1 (2012): 1–17, 10.1111/j.1751-9004.2011.00415.x How Reward and Emotional Stimuli Induce DifferentReactions Across the Menstrual Cycle Michiko Sakaki* and Mara MatherUniversity of Southern California AbstractDespite widespread belief that moods are affected by the menstrual cycle, researchers on emotionand reward have not paid much attention to the menstrual cycle until recently. However, recentresearch has revealed different reactions to emotional stimuli and to rewarding stimuli across thedifferent phases of the menstrual cycle. The current paper reviews the emerging literature on howovarian hormone fluctuation during the menstrual cycle modulates reactions to emotional stimuliand to reward. Behavioral and neuroimaging studies in humans suggest that estrogen and proges-terone have opposing influences. That is, it appears that estrogen enhances reactions to reward,but progesterone counters the facilitative effects of estrogen and decreases reactions to rewards. Incontrast, reactions to emotionally arousing stimuli (particularly negative stimuli) appear to bedecreased by estrogen but enhanced by progesterone. Potential factors that can modulate theeffects of the ovarian hormones (e.g., an inverse quadratic function of hormones' effects; the struc-tural changes of the hippocampus across the menstrual cycle) are also discussed.

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Chemistry & Biology Perturbation of Estrogen Receptor a Localizationwith Synthetic Nona-Arginine LXXLL-Peptide Coactivator Binding Inhibitors Mae¨lle Carraz,Wilbert Zwart,Trang Rob Michalides,and Luc 1Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany2Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600MB Eindhoven,The Netherlands3Division of Cell Biology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands*Correspondence: DOI 10.1016/j.chembiol.2009.06.009

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Advocate Spot-on Solution Animal Health DivisionBayer House, Straw berry Hill,New buryBerkshire RG14 1JA Incorporating the data sheets for the follow ing products:Advocate 40 mg + 4 mg spot-on solution for smal cats and ferretsAdvocate 80 mg + 8 mg spot-on solution for large catsAdvocate 40 mg + 10 mg spot-on solution for smal dogsAdvocate 100 mg + 25 mg spot-on solution for medium dogsAdvocate 250 mg + 62.5 mg spot-on solution for large dogsAdvocate 400 mg + 100 mg spot-on solution for extra-large dogsPresentationAdvocate spot-on solution for cats and ferrets is a clear yel ow to brow nish solution containing 100 mg/ml imidacloprid and 10mg/ml moxidectin w ith benzyl alcohol and Butylhydroxytoluene 1 mg/ml (E 321 as an antioxidant). Each pipette of the smal catand ferret presentations contains 0.4 ml (40 mg imidacloprid, 4 mg moxidectin), the large cat presentation contains 0.8 ml (80 mgimidacloprid, 8 mg moxidectin). Advocate spot-on solution for dogs is a clear yel ow to brow nish solution containing 100 mg/ml imidacloprid and 25 mg/mlmoxidectin w ith benzyl alcohol and Butylhydroxytoluene 1 mg/ml (E321 as an antioxidant). Each pipette of the dog presentationscontains either 0.4 ml (40 mg imidacloprid, 10 mg moxidectin), 1.0 ml (100 mg imidacloprid, 25 mg moxidectin), 2.5 ml (250 mgimidacloprid, 62.5 mg moxidectin) or 4.0 ml (400 mg imidacloprid, 100 mg moxidectin).UsesFor use in cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections: For cats: For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of ear mite infestation(Otodectes cynotis), prevention of heartw orm disease (L3 and L4 larvae of Dirofilaria immitis) and treatment of infections w ithgastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara cati and Ancylostoma tubaeforme). The productcan be used as part of a treatment strategy for flea al ergy dermatitis (FAD).For ferrets: For the treatment and prevention of flea infestation (Ctenocephalides felis) and the prevention of heartw ormdisease (L3 and L4 larvae of Dirofilaria immitis).For dogs: For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of biting lice (Trichodectescanis), treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis),demodicosis (caused by Demodex canis), prevention of heartw orm disease (L3 and L4 larvae of Dirofilaria immitis) andangiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum), treatment of Angiostrongylus vasorum andCrenosoma vulpis and treatment of infections w ith gastrointestinal nematodes (L4 larvae, immature adults and adults ofToxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis). Theproduct can be used as part of a treatment strategy for flea al ergy dermatitis (FAD).Dosage and administration

me.gov.ar

Año 4 • Número 30 Revista gratuita • Prohibida su venta OS DIARIOS ARGENTINOS RE, UN RESUMEN QUE TE A CUANDO UN ACTOR SE DIVIERTE UN GENIO ANDA SUELTO 1 INVASION DEL MUNDO AMOR POR CONTRATO Con Mark Lester y Geoffrey Jankins Con Demi Moore y David Duchovny Extraterrestres invaden la tierra y la batalla

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Benchmarking To Excellence: Using Quality Indicators To Improve Performance begin to distinguish appropriate, high- detail and a predict- quality endoscopy from inappropriate, able improvement in To err is Human: Building a Safer Health System" is the title of areport released by the Institute of poorly performed procedures. This will performance. Bench- Medicine (IOM) in 1999. The report

mccordresearch.com

Pediatr Infect Dis J, 2001;20:104–7 Copyright © 2001 by Lippincott Williams & Wilkins, Inc. Printed in U.S.A. Safety of ofloxacin otic and other ototopicaltreatments in animal models and in humans GEORGE A. GATES, MD To assess the safety of topical agents in the terna.4 Their consensus is based on the failure of trial middle ear, animal studies were reviewed. Com-

Microsoft word - 8_r356bl.doc

Diffusion of Mobile Technology in Healthcare Liz Burley Helana Scheepers Julie Fisher Faculty of Information and School of Information School of Information Communication Technologies Management and Sys. Management and Sys. Swinburne Univ.of Technology 900 Dandenong Rd, 900 Dandenong Rd John Street, Hawthorn,

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Carsten Thomsen Professor Overlæge CV Radiologisk afdeling X • Wagner A, Burchardt A-J. MR Imaging in advanced abdominal pregnancy. A case report of fetal death. Acta Radiol 1995;36:193-5. • Bagi P, Vejborg I, Colstrup H, Kristensen JK. Pressure/cross-sectional area relations in the proximal urethra of healthy males. Eur Urol 1995;28:51-7.

Codex - the sickness industry's last stand

CODEX – THE SICKNESS INDU$TRY's LAST STAND An Article By Eve Hillary Special Release April 1, 2005 Sydney Revised April 23, 2005 Preamble What is CODEX? (34) In short it is an annual World Health Organisation (WHO) sponsored gathering of delegates in Europe, many of them trans-national pharmaceutical corporations who are primarily focused on increasing their market share, by pushing their desired and arbitrary regulatory "standards" into a global standard and forcing it onto the smaller local supplement industry, all in the name of "international regulatory excellence". The Codex Committee is also bound by the World Trade Organisation (WTO) treaties. The WTO is a global commercial police that ensures countries are required to purchase from trans-national corporations in favour of their own locally produced goods, in the name of "lowering trade barriers". This WHO/WTO joint effort called CODEX is in the process of wiping out local supplement companies and natural health care practices, to bring in more drug based medicine, in what is euphemistically known as "creating a level playing field", while primarily giving the public a misleading impression that someone in the World Health Organisation (WTO) is looking after its health and safety. CODEX recommendations are then adopted by regulators such as the Australian TGA or the US FDA by various direct or indirect means that end up as Acts and amendments that are passed into law by Parliaments or Congress, usually without public debate. In 2002 I unveiled Codex to a Brisbane, Australia audience of 300 people. Only 3 knew anything about it - the same three I'd spoken with before the lecture. I then wrote a chapter on CODEX in my book "Health Betrayal". Primary data about CODEX is not easy to find. (34) And there remains deliberate misinformation emanating from government sources with close ties to trans-national corporations. Meanwhile, the Australian regulator, the TGA (Therapeutic Goods Administration) is deeply involved in the corporate agenda as this article will track. The Australian Health Minister, Mr. Abbott, has recently called a Sydney talkback radio program to "reassure" the presenter and listening audience that CODEX is not an issue in Australia. At the same time there has been no effort on the part of the government to publicly reveal the extraordinary events that have delivered Australia into corporate governance in health care. This includes the very real possibility that many cheap and effective natural remedies may no longer be available to the public after July 1 when drastic changes that have never been openly debated, are set to be implemented by Parliament. It is my intention to reveal the fact that trans-national pharmaceutical corporations have already assumed the role of government at least where health care is concerned. I intend to highlight what steps have already been taken by corporate interests to move Australia and New Zealand toward CODEX and toward international corporate governance in the Asia Pacific region. This being true, it would alter the basic premise and agreement which Australian governance was founded upon – Democracy. This agreement cannot be altered except with the informed consent of the majority and only after public debate and referendum. It is my educated guess that most Australians want democracy for themselves and that they would want to preserve it for future generations. It is my guess that Australians do not want to be governed by trans-national corporations. It is my intention to allow these issues to be debated, understood and corrected by the electors, the only legitimate proprietors of government at this time.

7th kelantan health conference 15 –16th june 201

Volume 11(Suppl 3) 2011 Official Journal of Malaysian P ublic Health Physicians'Association EDITORIAL BOARD Chief Editor Prof. Dato' Dr. Syed Mohamed Aljunid (Unit ed Nations University – International Institute for Global Health) Deputy Chief Editor Assc. Prof. Dr. Sharifa Ezat Wan Puteh

medandcare.pl

Joint Implant Surgery & Research Foundation Chagrin Falls, Ohio, USA Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection and Revision The Use of Synthetic Pure Calcium Sulfate (Stimulan®) Impregnated with Vancomycin & Tobramycin Edward J. McPherson, MD, FACS† • Matthew V. Dipane, BA† • Sherif M. Sherif, MD†

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Hum. Reprod. Advance Access published August 18, 2010 Human Reproduction, Vol.0, No.0 pp. 1 – 5, 2010 ORIGINAL ARTICLE Infertility Decreased pregnancy rate is linkedto abnormal uterine peristalsis causedby intramural fibroids O. Yoshino1,2,*, T. Hayashi3, Y. Osuga1, M. Orisaka4, H. Asada5,S. Okuda6, M. Hori7, M. Furuya5, H. Onuki2, Y. Sadoshima2, H. Hiroi1,

Jpgm_oct_dec_11 cover

Prevalence of diabetes, obesity, and metabolic syndrome in subjects with and without schizophrenia (CURES-104)Subashini R, Deepa M, Padmavati R1, Thara R1, Mohan V Epidemiology and Background: There are some reports that diabetes and metabolic syndrome (MS) are more prevalent among Diabetology, Madras Diabetes Research schizophrenia patients. However, there are very few studies in India which have estimated the prevalence

meggle-pharma.de

TATABLETING →DIRECT COMPRESSION → CO-PROCESSED LACTOSE echnical brochure MEGGLE co-processed hypromel ose lactose (4000 mPa∙s) for direct compression (DC): RetaLac® General information Modified release applications continue to be a development In the hypromellose chemical structure diagram (shown below), strategy for the global pharmaceutical industry. Products nearing

molpharm.aspetjournals.org

Copyright © 2004 The American Society for Pharmacology and Experimental Therapeutics Mol Pharmacol 66:144–152, 2004 Printed in U.S.A. Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to thePhosphodiesterase-5 Catalytic Site Displays Potency,Specificity, Heterogeneity, and cGMP Stimulation Mitsi A. Blount, Alfreda Beasley, Roya Zoraghi, Konjeti R. Sekhar, Emmanuel P. Bessay,Sharron H. Francis, and Jackie D. Corbin

maisondesassociations.lu

LITERATOUR 25–27 avril 2014 Les événements sont gratuits, sauf pour ceux se déroulant au Parc Merveilleux où le droit d'entrée habituel devra être payé. Lesen – das Gefühl, wenn auskleinen schwarzen Buchstaben Bilderentstehen, ferne Welten sich vordem inneren Auge entfalten und diebeschriebenen Figuren zu Freundenwerden .

medice.at

für Patienten mit Fragen, Antworten und wertvolle Tipps zu den Themen Ihre Nieren und wie sie arbeiten .5 Nierenerkrankung durch Diabetes .21 Was tun meine Nieren? .5 Zwei Formen von Diabetes .21 Was bedeutet Nierenfunktion? .6 Effekte des hohen Blutdrucks .23 Warum versagen meine Nieren? .6 Vorbeugung und Verzögerung der Nierenerkrankung .23

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Incipient Fault Detection in 33/11kV Power Transformers by Using Combined Dissolved Gas Analysis Technique and Acoustic Partial Discharge Measurement and Validated Through Untanking Mohd Raffi Samsudin Ahmad Qisti Ramli Ahmad Berhanuddin Young Zaidey Yang Researcher, High Voltage Tenaga Nasional Bhd Universiti Tenaga Tenaga Nasional Bhd TNB Research Sdn Bhd

maillard.umin.jp

JMARS News Letter Vol. 1, April 22, 2006 Maillard Reaction Society (IMARS) Japan Maillard Reaction Society) The Maillard Reaction and Free Radicals: Discovery of the Namiki Pathway Nagoya University I graduated from university (in Tokyo, 1945) in the great confusion just after the Second World War and fortunately found work at the Institute of Physical and Chemical Research. The Institute was established in 1917 as the first general research institute in Japan and

Doi:10.1016/j.cell.2008.06.050

SIRT1 Regulates Circadian Clock GeneExpression through PER2 Deacetylation Gad Asher,David Gatfield,Markus Hans Reinke,Charna Florian Kreppel,Raul Mostoslavsky,Frederick W. Alt,and Ueli 1Department of Molecular Biology, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland2Division of Gene Therapy, University of Ulm, Helmholtzstrasse 8/1, D-89081 Ulm, Germany3Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA4Howard Hughes Medical Institute, Children's Hospital, Center for Blood Research, and Department of Genetics,Harvard University Medical School, Boston, MA 02115, USA*Correspondence: DOI 10.1016/j.cell.2008.06.050

medcon.gr

CORNEAL IONTOPHORESIS EXPERIMENTAL EVIDENCE CLINICAL EVIDENCE CORNEAL IONTOPHORESIS EXPERIMENTAL EVIDENCE CLINICAL EVIDENCE CORNEAL IONTOPHORESIS Iontophoresis consists of the transfer of molecules, with an ionic charge, inside the tissues to treat, thanks to a low intensity electric field. Among these molecules various drugs are included. The rapidity of passage of the ionic molecules can be

61-72-380b_monicure_comboinsert_cleanpdf

MONISTAT DERM™ CREAM CRÈME MONISTAT DERM™ Fluconazole Capsule 150 mg Miconazole Nitrate Cream USP 2% Capsule de Fluconazole 150 mg Crème de nitrate de miconazole à 2 % USP IMPORTANT : VEUILLEZ LIRE ATTENTIVEMENT IMPORTANT PLEASE READ La présente notice est la partie III d'une « monographie de produit » en trois parties This leaflet is part III of a three-part "Product Monograph" published when

La neuroprotección en disfunción neurológica aguda. nuevos enfoques terapéuticos dentro del campo de la inmunología del sistema nervioso central

Chávez, Flores, Chacon, et al. MEDICRIT Revista de Medicina Interna y Medicina Crítica Indexada en IMBIOMED Revisión La Neuroprotección en Disfunción Neurológica Aguda. Nuevos Enfoques Terapéuticos Dentro del Campo de la nmunología del Sistema Nervioso Central Olivia M Chávez Grimaldi, M.D.1, María Elisa Flores Chávez, M.D.2, María de los Reyes Chacón de

Nsp022 313.327

SCAN (2009) 4, 313–327 Medial cortex activity, self-reflection anddepression Marcia K. Johnson, Susan Nolen-Hoeksema, Karen J. Mitchell, and Yael LevinDepartment of Psychology, Yale University, PO Box 208205, New Haven, CT 06520-8205, USA Using functional magnetic resonance imaging, we investigated neural activity associated with self-reflection in depressed[current major depressive episode (MDE)] and healthy control participants, focusing on medial cortex areas previously shownto be associated with self-reflection. Both the MDE and healthy control groups showed greater activity in anterior medial cortex(medial frontal gyrus, anterior cingulate gyrus) when cued to think about hopes and aspirations compared with duties andobligations, and greater activity in posterior medial cortex (precuneus, posterior cingulate) when cued to think about dutiesand obligations (Experiment 1). However, the MDE group showed less activity than controls in the same area of medial frontalcortex when self-referential cues were more ambiguous with respect to valence (Experiment 2), and less deactivation in a non-self-referential condition in both experiments. Furthermore, individual differences in rumination were positively correlated withactivity in both anterior and posterior medial cortex during non-self-referential conditions. These results provide convergingevidence for a dissociation of anterior and posterior medial cortex depending on the focus of self-relevant thought. They alsoprovide neural evidence consistent with behavioral findings that depression is associated with disruption of positively valencedthoughts in response to ambiguous cues, and difficulty disengaging from self-reflection when it is appropriate to do so.